2rmf - Revision history

OCA at 19:14, 29 May 2024

2024-05-29T19:14:04Z

←Older revision		Revision as of 19:14, 29 May 2024
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	==Human Urocortin 1==		==Human Urocortin 1==
-	<StructureSection load='2rmf' size='340' side='right'caption='[[2rmf~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rmf' size='340' side='right'caption='[[2rmf]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'>[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</div~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [https://pdbe.org/2rmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [https://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [https://pdbe.org/2rmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [https://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/UCN1_HUMAN UCN1_HUMAN]] Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.	+	[https://www.uniprot.org/uniprot/UCN1_HUMAN UCN1_HUMAN] Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cantle~~, J P~~]]	+	[[Category: Cantle JP]]
-	[[Category: Grace~~, C R.R~~]]	+	[[Category: Grace CRR]]
-	[[Category: Perrin~~, M H~~]]	+	[[Category: Perrin MH]]
-	[[Category: Riek, R]]	+	[[Category: Riek R]]
-	[[Category: Rivier~~, J E~~]]	+	[[Category: Rivier JE]]
-	[[Category: Vale~~, W W]]~~	+	[[Category: Vale WW]]
-	~~[[Category: Amidation]]~~	+
-	~~[[Category: Astressin2b]]~~	+
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Crf ligand]]~~	+
-	~~[[Category: Crf receptor]]~~	+
-	~~[[Category: Hormone]]~~	+
-	~~[[Category: Neuropeptide]]~~	+
-	~~[[Category: Sauvagine]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Urocortin]]~~	+
-	~~[[Category: Urotensin~~]]	+

OCA at 06:52, 16 March 2022

2022-03-16T06:52:29Z

←Older revision		Revision as of 06:52, 16 March 2022
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	<StructureSection load='2rmf' size='340' side='right'caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rmf' size='340' side='right'caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2RMF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [~~http~~://pdbe.org/2rmf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [https://pdbe.org/2rmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [https://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/UCN1_HUMAN UCN1_HUMAN]] Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.	+	[[https://www.uniprot.org/uniprot/UCN1_HUMAN UCN1_HUMAN]] Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:13, 10 June 2020

2020-06-10T07:13:15Z

←Older revision		Revision as of 07:13, 10 June 2020
Line 1:		Line 1:

	==Human Urocortin 1==		==Human Urocortin 1==
-	<StructureSection load='2rmf' size='340' side='right' caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rmf' size='340' side='right'caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RMF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://pdbe.org/2rmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://pdbe.org/2rmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Cantle, J P]]		[[Category: Cantle, J P]]
	[[Category: Grace, C R.R]]		[[Category: Grace, C R.R]]

OCA at 11:19, 5 September 2018

2018-09-05T11:19:42Z

←Older revision		Revision as of 11:19, 5 September 2018
Line 1:		Line 1:
		+
	==Human Urocortin 1==		==Human Urocortin 1==
	<StructureSection load='2rmf' size='340' side='right' caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rmf' size='340' side='right' caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://pdbe.org/2rmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://pdbe.org/2rmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rmf_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rmf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:33, 9 February 2016

2016-02-09T01:33:07Z

←Older revision		Revision as of 01:33, 9 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://pdbe.org/2rmf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rmf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rmf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:30, 25 December 2014

2014-12-25T03:30:56Z

←Older revision		Revision as of 03:30, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/UCN1_HUMAN UCN1_HUMAN]] Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cantle, J P.]]	+	[[Category: Cantle, J P]]
-	[[Category: Grace, C R.R.]]	+	[[Category: Grace, C R.R]]
-	[[Category: Perrin, M H.]]	+	[[Category: Perrin, M H]]
-	[[Category: Riek, R.]]	+	[[Category: Riek, R]]
-	[[Category: Rivier, J E.]]	+	[[Category: Rivier, J E]]
-	[[Category: Vale, W W.]]	+	[[Category: Vale, W W]]
	[[Category: Amidation]]		[[Category: Amidation]]
	[[Category: Astressin2b]]		[[Category: Astressin2b]]

OCA at 18:57, 30 September 2014

2014-09-30T18:57:14Z

←Older revision		Revision as of 18:57, 30 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2rmf.~~png~~\|~~left~~\|200px]]	+	==Human Urocortin 1==
		+	<StructureSection load='2rmf' size='340' side='right' caption='[[2rmf]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RMF FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2rm9\|2rm9]], [[2rmd\|2rmd]], [[2rme\|2rme]], [[2rmg\|2rmg]], [[2rmh\|2rmh]], [[2rmi\|2rmi]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rmf RCSB], [http://www.ebi.ac.uk/pdbsum/2rmf PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/2rmf_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the corticoliberin family include the corticotropin releasing factors (CRFs), sauvagine, the urotensins, and urocortin 1 (Ucn1), which bind to both the CRF receptors CRF-R1 and CRF-R2, and the urocortins 2 (Ucn2) and 3 (Ucn3), which are selective agonists of CRF-R2. Structure activity relationship studies led to several potent and long-acting analogues with selective binding to either one of the receptors. NMR structures of six ligands of this family (the antagonists astressin B and astressin2-B, the agonists stressin1, and the natural ligands human Ucn1, Ucn2, and Ucn3) were determined in DMSO. These six peptides show differences in binding affinities, receptor-selectivity, and NMR structure. Overall, their backbones are alpha-helical, with a small kink or a turn around residues 25-27, resulting in a helix-loop-helix motif. The C-terminal helices are of amphipathic nature, whereas the N-terminal helices vary in their amphipathicity. The C-terminal helices thereby assume a conformation very similar to that of astressin bound to the ECD1 of CRF-R2 recently reported by our group.1 On the basis of an analysis of the observed 3D structures and relative potencies of [Ala]-substituted analogues, it is proposed that both helices could play a crucial role in receptor binding and selectivity. In conclusion, the C-terminal helices may interact along their hydrophobic faces with the ECD1, whereas the entire N-terminal helical surface may be involved in receptor activation. On the basis of the common and divergent features observed in the 3D structures of these ligands, multiple binding models are proposed that may explain their plurality of actions.

-	~~{{STRUCTURE_2rmf\| PDB=2rmf \| SCENE= }}~~	+	Common and divergent structural features of a series of corticotropin releasing factor-related peptides.,Grace CR, Perrin MH, Cantle JP, Vale WW, Rivier JE, Riek R J Am Chem Soc. 2007 Dec 26;129(51):16102-14. Epub 2007 Dec 6. PMID:18052377<ref>PMID:18052377</ref>

-	~~===Human Urocortin 1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18052377}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2rmf]] is~~ a ~~1 chain structure~~. ~~Full experimental information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2RMF OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018052377<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Cantle, J P.]]		[[Category: Cantle, J P.]]
	[[Category: Grace, C R.R.]]		[[Category: Grace, C R.R.]]

OCA: Protected "2rmf" [edit=sysop:move=sysop]

2013-01-07T18:56:33Z

Protected "2rmf" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:56, 7 January 2013

OCA at 18:56, 7 January 2013

2013-01-07T18:56:31Z

←Older revision		Revision as of 18:56, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2rmf.png\|left\|200px]]		[[Image:2rmf.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2rmf", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2rmf\| PDB=2rmf \| SCENE= }}		{{STRUCTURE_2rmf\| PDB=2rmf \| SCENE= }}

	===Human Urocortin 1===		===Human Urocortin 1===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18052377}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18052377 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18052377}}		{{ABSTRACT_PUBMED_18052377}}

	==About this Structure==		==About this Structure==
-	~~2RMF~~ is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA].	+	[[2rmf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18052377~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018052377</ref><references group="xtra"/>
	[[Category: Cantle, J P.]]		[[Category: Cantle, J P.]]
	[[Category: Grace, C R.R.]]		[[Category: Grace, C R.R.]]
Line 37:		Line 25:
	[[Category: Hormone]]		[[Category: Hormone]]
	[[Category: Neuropeptide]]		[[Category: Neuropeptide]]
-	[[Category: Nmr]]
	[[Category: Sauvagine]]		[[Category: Sauvagine]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Urocortin]]		[[Category: Urocortin]]
	[[Category: Urotensin]]		[[Category: Urotensin]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:23:06 2009''

OCA at 03:23, 17 February 2009

2009-02-17T03:23:07Z

←Older revision		Revision as of 03:23, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2RMF is a ~~[[Single protein]]~~ structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA].	+	2RMF is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMF OCA].

	==Reference==		==Reference==
-	Common and divergent structural features of a series of corticotropin releasing factor-related peptides., Grace CR, Perrin MH, Cantle JP, Vale WW, Rivier JE, Riek R, J Am Chem Soc. 2007 Dec 26;129(51):16102-14. Epub 2007 Dec 6. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18052377 18052377]~~	+	<ref group="xtra">PMID:18052377</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Cantle, J P.]]		[[Category: Cantle, J P.]]
	[[Category: Grace, C R.R.]]		[[Category: Grace, C R.R.]]
Line 44:		Line 43:
	[[Category: Urotensin]]		[[Category: Urotensin]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 08~~:43:~~32 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 05:23:06 2009''