2rv3 - Revision history

OCA at 07:06, 1 May 2024

2024-05-01T07:06:41Z

←Older revision		Revision as of 07:06, 1 May 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [https://pdbe.org/2rv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [https://pdbe.org/2rv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).		[https://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	ZFAT is a transcriptional regulator, containing eighteen C2H2-type zinc-fingers and one AT-hook, involved in autoimmune thyroid disease, apoptosis, and immune-related cell survival. We determined the solution structures of the thirteen individual ZFAT zinc-fingers (ZF) and the tandemly arrayed zinc-fingers in the regions from ZF2 to ZF5, by NMR spectroscopy. ZFAT has eight uncommon bulged-out helix-containing zinc-fingers, and six of their structures (ZF4, ZF5, ZF6, ZF10, ZF11, and ZF13) were determined. The distribution patterns of the putative DNA-binding surface residues are different among the ZFAT zinc-fingers, suggesting the distinct DNA sequence preferences of the N-terminal and C-terminal zinc-fingers. Since ZFAT has three to five consecutive tandem zinc-fingers, which may cooperatively function as a unit, we also determined two tandemly arrayed zinc-finger structures, between ZF2 to ZF4 and ZF3 to ZF5. Our NMR spectroscopic analysis detected the interaction between ZF4 and ZF5, which are connected by an uncommon linker sequence, KKIK. The ZF4-ZF5 linker restrained the relative structural space between the two zinc-fingers in solution, unlike the other linker regions with determined structures, suggesting the involvement of the ZF4-ZF5 interfinger linker in the regulation of ZFAT function.
-
-	Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.,Tochio N, Umehara T, Nakabayashi K, Yoneyama M, Tsuda K, Shirouzu M, Koshiba S, Watanabe S, Kigawa T, Sasazuki T, Shirasawa S, Yokoyama S J Struct Funct Genomics. 2015 Mar 24. PMID:25801860<ref>PMID:25801860</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2rv3" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:53, 12 April 2023

2023-04-12T20:53:46Z

←Older revision		Revision as of 20:53, 12 April 2023
Line 1:		Line 1:

	==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==		==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==
-	<StructureSection load='2rv3' size='340' side='right'caption='[[2rv3~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='2rv3' size='340' side='right'caption='[[2rv3]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZFAT, KIAA1485, ZFAT1, ZNF406 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [https://pdbe.org/2rv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [https://pdbe.org/2rv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN]] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).	+	[https://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kigawa, T]]	+	[[Category: Kigawa T]]
-	[[Category: Tochio, N]]	+	[[Category: Tochio N]]
-	[[Category: Umehara, T]]	+	[[Category: Umehara T]]
-	[[Category: Yokoyama, S]]	+	[[Category: Yokoyama S]]
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Zfat]]~~	+
-	~~[[Category: Zinc finger~~]]	+

OCA at 10:37, 7 July 2021

2021-07-07T10:37:22Z

←Older revision		Revision as of 10:37, 7 July 2021
Line 1:		Line 1:

	==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==		==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==
-	<StructureSection load='2rv3' size='340' side='right' caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2rv3' size='340' side='right'caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZFAT, KIAA1485, ZFAT1, ZNF406 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZFAT, KIAA1485, ZFAT1, ZNF406 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [~~http~~://pdbe.org/2rv3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [https://pdbe.org/2rv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN]] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).	+	[[https://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN]] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]
	[[Category: Tochio, N]]		[[Category: Tochio, N]]

OCA at 09:43, 26 September 2018

2018-09-26T09:43:26Z

←Older revision		Revision as of 09:43, 26 September 2018
Line 3:		Line 3:
	<StructureSection load='2rv3' size='340' side='right' caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rv3' size='340' side='right' caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ZFAT, KIAA1485, ZFAT1, ZNF406 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [http://pdbe.org/2rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [http://pdbe.org/2rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]
	[[Category: Tochio, N]]		[[Category: Tochio, N]]

OCA at 14:52, 22 December 2016

2016-12-22T14:52:19Z

←Older revision		Revision as of 14:52, 22 December 2016
Line 1:		Line 1:
		+
	==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==		==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==
	<StructureSection load='2rv3' size='340' side='right' caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2rv3' size='340' side='right' caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/2rv3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [http://pdbe.org/2rv3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/2rv3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2rv3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:05, 8 April 2015

2015-04-08T11:05:34Z

←Older revision		Revision as of 11:05, 8 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT==
		+	<StructureSection load='2rv3' size='340' side='right' caption='[[2rv3]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2rv3]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RV3 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2elr\|2elr]], [[2rut\|2rut]], [[2ruu\|2ruu]], [[2ruv\|2ruv]], [[2ruw\|2ruw]], [[2rux\|2rux]], [[2ruy\|2ruy]], [[2ruz\|2ruz]], [[2rv0\|2rv0]], [[2rv1\|2rv1]], [[2rv2\|2rv2]], [[2rv4\|2rv4]], [[2rv5\|2rv5]], [[2rv6\|2rv6]], [[2rv7\|2rv7]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/2rv3 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ZFAT_HUMAN ZFAT_HUMAN]] May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ZFAT is a transcriptional regulator, containing eighteen C2H2-type zinc-fingers and one AT-hook, involved in autoimmune thyroid disease, apoptosis, and immune-related cell survival. We determined the solution structures of the thirteen individual ZFAT zinc-fingers (ZF) and the tandemly arrayed zinc-fingers in the regions from ZF2 to ZF5, by NMR spectroscopy. ZFAT has eight uncommon bulged-out helix-containing zinc-fingers, and six of their structures (ZF4, ZF5, ZF6, ZF10, ZF11, and ZF13) were determined. The distribution patterns of the putative DNA-binding surface residues are different among the ZFAT zinc-fingers, suggesting the distinct DNA sequence preferences of the N-terminal and C-terminal zinc-fingers. Since ZFAT has three to five consecutive tandem zinc-fingers, which may cooperatively function as a unit, we also determined two tandemly arrayed zinc-finger structures, between ZF2 to ZF4 and ZF3 to ZF5. Our NMR spectroscopic analysis detected the interaction between ZF4 and ZF5, which are connected by an uncommon linker sequence, KKIK. The ZF4-ZF5 linker restrained the relative structural space between the two zinc-fingers in solution, unlike the other linker regions with determined structures, suggesting the involvement of the ZF4-ZF5 interfinger linker in the regulation of ZFAT function.

-	~~The entry 2rv3 is ON HOLD until Paper Publication~~	+	Solution structures of the DNA-binding domains of immune-related zinc-finger protein ZFAT.,Tochio N, Umehara T, Nakabayashi K, Yoneyama M, Tsuda K, Shirouzu M, Koshiba S, Watanabe S, Kigawa T, Sasazuki T, Shirasawa S, Yokoyama S J Struct Funct Genomics. 2015 Mar 24. PMID:25801860<ref>PMID:25801860</ref>

-	~~Authors: Tochio~~, N.~~, Umehara, T~~.~~, Kigawa, T., Yokoyama, S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kigawa, T]]		[[Category: Kigawa, T]]
		+	[[Category: Tochio, N]]
	[[Category: Umehara, T]]		[[Category: Umehara, T]]
	[[Category: Yokoyama, S]]		[[Category: Yokoyama, S]]
-	[[Category: ~~Tochio, N~~]]	+	[[Category: Transcription]]
		+	[[Category: Zfat]]
		+	[[Category: Zinc finger]]

OCA at 07:55, 18 February 2015

2015-02-18T07:55:43Z

←Older revision		Revision as of 07:55, 18 February 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2rv3 is ON HOLD	+	The entry 2rv3 is ON HOLD until Paper Publication

	Authors: Tochio, N., Umehara, T., Kigawa, T., Yokoyama, S.		Authors: Tochio, N., Umehara, T., Kigawa, T., Yokoyama, S.

OCA: Protected "2rv3" [edit=sysop:move=sysop]

2015-02-07T10:55:36Z

Protected "2rv3" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:55, 7 February 2015

OCA: New page: '''Unreleased structure''' The entry 2rv3 is ON HOLD Authors: Tochio, N., Umehara, T., Kigawa, T., Yokoyama, S. Description: Solution structures of the DNA-binding domain (ZF15) of imm...

2015-02-07T10:55:35Z

New page: '''Unreleased structure''' The entry 2rv3 is ON HOLD Authors: Tochio, N., Umehara, T., Kigawa, T., Yokoyama, S. Description: Solution structures of the DNA-binding domain (ZF15) of imm...

New page

'''Unreleased structure'''

The entry 2rv3 is ON HOLD

Authors: Tochio, N., Umehara, T., Kigawa, T., Yokoyama, S.

Description: Solution structures of the DNA-binding domain (ZF15) of immune-related zinc-finger protein ZFAT
[[Category: Unreleased Structures]]
[[Category: Kigawa, T]]
[[Category: Umehara, T]]
[[Category: Yokoyama, S]]
[[Category: Tochio, N]]