2uwr - Revision history

OCA at 14:56, 13 December 2023

2023-12-13T14:56:24Z

←Older revision		Revision as of 14:56, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2uwr' size='340' side='right'caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2uwr' size='340' side='right'caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1cdq\|1cdq]]~~, [[~~1cdr~~\|~~1cdr~~]]~~, [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.34Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [https://pdbe.org/2uwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [https://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [https://pdbe.org/2uwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [https://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[https://omim.org/entry/612300 612300].<ref>PMID:1382994</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Johnson, S]]	+	[[Category: Johnson S]]
-	[[Category: Lea~~, S M~~]]	+	[[Category: Lea SM]]
-	[[Category: Leath~~, K J~~]]	+	[[Category: Leath KJ]]
-	[[Category: Morgan~~, B P~~]]	+	[[Category: Morgan BP]]
-	[[Category: Roversi, P]]	+	[[Category: Roversi P]]
-	[[Category: Smith~~, R A.G]]~~	+	[[Category: Smith RAG]]
-	~~[[Category: Cd59]]~~	+
-	~~[[Category: Complement regulator]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Gpi-anchor]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Mac]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Mirl~~]]	+

OCA at 12:32, 23 March 2022

2022-03-23T12:32:23Z

←Older revision		Revision as of 12:32, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='2uwr' size='340' side='right'caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2uwr' size='340' side='right'caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2UWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [~~http~~://pdbe.org/2uwr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [https://pdbe.org/2uwr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [https://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:12, 17 June 2020

2020-06-17T11:12:50Z

←Older revision		Revision as of 11:12, 17 June 2020
Line 1:		Line 1:

	==High resolution structure of human CD59==		==High resolution structure of human CD59==
-	<StructureSection load='2uwr' size='340' side='right' caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>	+	<StructureSection load='2uwr' size='340' side='right'caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://pdbe.org/2uwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://pdbe.org/2uwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]
	[[Category: Lea, S M]]		[[Category: Lea, S M]]

OCA at 08:13, 12 September 2018

2018-09-12T08:13:37Z

←Older revision		Revision as of 08:13, 12 September 2018
Line 1:		Line 1:
-	==~~HIGH RESOLUTION STRUCTURE OF HUMAN~~ CD59==	+
		+	==High resolution structure of human CD59==
	<StructureSection load='2uwr' size='340' side='right' caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2uwr' size='340' side='right' caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://pdbe.org/2uwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://pdbe.org/2uwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uwr ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwr_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwr_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:32, 9 February 2016

2016-02-09T00:32:29Z

←Older revision		Revision as of 00:32, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2uwr' size='340' side='right' caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2uwr' size='340' side='right' caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://pdbe.org/2uwr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uwr ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uwr" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]
	[[Category: Lea, S M]]		[[Category: Lea, S M]]

OCA at 14:52, 19 January 2015

2015-01-19T14:52:32Z

←Older revision		Revision as of 14:52, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Johnson, S.]]	+	[[Category: Johnson, S]]
-	[[Category: Lea, S M.]]	+	[[Category: Lea, S M]]
-	[[Category: Leath, K J.]]	+	[[Category: Leath, K J]]
-	[[Category: Morgan, B P.]]	+	[[Category: Morgan, B P]]
-	[[Category: Roversi, P.]]	+	[[Category: Roversi, P]]
-	[[Category: Smith, R A.G.]]	+	[[Category: Smith, R A.G]]
	[[Category: Cd59]]		[[Category: Cd59]]
	[[Category: Complement regulator]]		[[Category: Complement regulator]]

OCA at 01:50, 1 October 2014

2014-10-01T01:50:41Z

←Older revision		Revision as of 01:50, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2uwr~~\| ~~PDB~~=2uwr \| ~~SCENE~~= }}	+	==HIGH RESOLUTION STRUCTURE OF HUMAN CD59==
-	===~~HIGH RESOLUTION STRUCTURE OF HUMAN CD59~~===	+	<StructureSection load='2uwr' size='340' side='right' caption='[[2uwr]], [[Resolution\|resolution]] 1.34Å' scene=''>
-	~~{{ABSTRACT_PUBMED_17671359}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UWR FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1cdq\|1cdq]], [[1cdr\|1cdr]], [[1cds\|1cds]], [[1erg\|1erg]], [[1erh\|1erh]], [[2j8b\|2j8b]], [[2ux2\|2ux2]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uwr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uwr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uwr RCSB], [http://www.ebi.ac.uk/pdbsum/2uwr PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uw/2uwr_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CD59 is a membrane-bound glycoprotein that protects host cells from lysis by inhibiting the terminal pathway of complement, preventing the formation and insertion of the membrane attack complex (MAC). Crystals of bacterially expressed and nonglycosylated recombinant soluble human CD59 have been obtained from three crystallization conditions, each of which gave rise to a distinct crystal form. Each crystal form led to a crystal structure at high resolution (1.15, 1.35 and 1.8 A). In one of these structures the electron-density map shows an as yet unidentified small molecule in the predicted C8/C9-binding site. The presence/absence of this ligand is linked to alternate conformations of the amino acids implicated in C8/C9 binding.

-	~~==About this Structure==~~	+	High-resolution structures of bacterially expressed soluble human CD59.,Leath KJ, Johnson S, Roversi P, Hughes TR, Smith RA, Mackenzie L, Morgan BP, Lea SM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt, 8):648-52. Epub 2007 Jul 28. PMID:17671359<ref>PMID:17671359</ref>
-	~~[[2uwr]] is a~~ 1 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group~~=~~"xtra">PMID:017671359</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+
		+	==See Also==
		+	*[[CD59\|CD59]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johnson, S.]]		[[Category: Johnson, S.]]

OCA at 23:52, 24 March 2013

2013-03-24T23:52:27Z

←Older revision		Revision as of 23:52, 24 March 2013
Line 1:		Line 1:
-	[[Image:2uwr.png\|left\|200px]]
-
	{{STRUCTURE_2uwr\| PDB=2uwr \| SCENE= }}		{{STRUCTURE_2uwr\| PDB=2uwr \| SCENE= }}
-
	===HIGH RESOLUTION STRUCTURE OF HUMAN CD59===		===HIGH RESOLUTION STRUCTURE OF HUMAN CD59===
-
	{{ABSTRACT_PUBMED_17671359}}		{{ABSTRACT_PUBMED_17671359}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:017671359</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017671359</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johnson, S.]]		[[Category: Johnson, S.]]

OCA: Protected "2uwr" [edit=sysop:move=sysop]

2013-01-07T18:30:09Z

Protected "2uwr" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:30, 7 January 2013

OCA at 18:30, 7 January 2013

2013-01-07T18:30:07Z

←Older revision		Revision as of 18:30, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2uwr.png\|left\|200px]]		[[Image:2uwr.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2uwr", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2uwr\| PDB=2uwr \| SCENE= }}		{{STRUCTURE_2uwr\| PDB=2uwr \| SCENE= }}

	===HIGH RESOLUTION STRUCTURE OF HUMAN CD59===		===HIGH RESOLUTION STRUCTURE OF HUMAN CD59===

		+	{{ABSTRACT_PUBMED_17671359}}

	==About this Structure==		==About this Structure==
-	~~2UWR~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA].	+	[[2uwr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWR OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:017671359</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Johnson, S.]]		[[Category: Johnson, S.]]
Line 31:		Line 28:
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Mirl]]		[[Category: Mirl]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:54:39 2009''