2uz3 - Revision history

OCA at 09:53, 9 May 2024

2024-05-09T09:53:29Z

←Older revision		Revision as of 09:53, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2uz3' size='340' side='right'caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2uz3' size='340' side='right'caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_27618 Atcc 27618~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=TTP:THYMIDINE-~~5~~-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[1xmr\|1xmr]], [[2b8t\|2b8t]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [https://pdbe.org/2uz3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [https://www.ebi.ac.uk/pdbsum/2uz3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz3 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [~~http~~://pdbe.org/2uz3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2uz3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KITH_UREPA KITH_UREPA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 31:

	==See Also==		==See Also==
-	*[[Thymidine kinase\|Thymidine kinase]]	+	*[[Thymidine kinase 3D structures\|Thymidine kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 27618]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thymidine kinase~~]]	+	[[Category: Ureaplasma urealyticum]]
-	[[Category: Carnrot, C]]	+	[[Category: Carnrot C]]
-	[[Category: Eklund, H]]	+	[[Category: Eklund H]]
-	[[Category: Eriksson, S]]	+	[[Category: Eriksson S]]
-	[[Category: Kosinska, U]]	+	[[Category: Kosinska U]]
-	[[Category: Mikkelsen~~, N E~~]]	+	[[Category: Mikkelsen NE]]
-	[[Category: Munch-Petersen, B]]	+	[[Category: Munch-Petersen B]]
-	[[Category: Wang, L]]	+	[[Category: Wang L]]
-	[[Category: Welin, M]]	+	[[Category: Welin M]]
-	[[Category: Zhu, C]]	+	[[Category: Zhu C]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Deoxyribonucleoside kinase]]~~	+
-	~~[[Category: Dna synthesis]]~~	+
-	~~[[Category: Dttp]]~~	+
-	~~[[Category: Feed-back inhibitor]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Lasso-domain]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Tk1]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Uu-tk]]~~	+
-	~~[[Category: Zinc-binding domain~~]]	+

OCA at 07:57, 4 November 2020

2020-11-04T07:57:17Z

←Older revision		Revision as of 07:57, 4 November 2020
Line 1:		Line 1:

	==Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum==		==Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum==
-	<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2uz3' size='340' side='right'caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27618 Atcc 27618]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27618 Atcc 27618]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://pdbe.org/2uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://pdbe.org/2uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 27618]]		[[Category: Atcc 27618]]
		+	[[Category: Large Structures]]
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Carnrot, C]]		[[Category: Carnrot, C]]

OCA at 08:15, 12 September 2018

2018-09-12T08:15:13Z

←Older revision		Revision as of 08:15, 12 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM~~ U. ~~UREALYTICUM~~==	+
		+	==Crystal Structure of Thymidine Kinase with dTTP from U. urealyticum==
	<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://pdbe.org/2uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://pdbe.org/2uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2uz3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:25, 9 February 2016

2016-02-09T16:25:34Z

←Older revision		Revision as of 16:25, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Ureaplasma_urealyticum Ureaplasma urealyticum~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27618 Atcc 27618]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://pdbe.org/2uz3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uz3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2uz3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 27618]]
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
-	[[Category: Ureaplasma urealyticum]]
	[[Category: Carnrot, C]]		[[Category: Carnrot, C]]
	[[Category: Eklund, H]]		[[Category: Eklund, H]]

OCA at 16:19, 19 January 2015

2015-01-19T16:19:23Z

←Older revision		Revision as of 16:19, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Ureaplasma urealyticum]]		[[Category: Ureaplasma urealyticum]]
-	[[Category: Carnrot, C.]]	+	[[Category: Carnrot, C]]
-	[[Category: Eklund, H.]]	+	[[Category: Eklund, H]]
-	[[Category: Eriksson, S.]]	+	[[Category: Eriksson, S]]
-	[[Category: Kosinska, U.]]	+	[[Category: Kosinska, U]]
-	[[Category: Mikkelsen, N E.]]	+	[[Category: Mikkelsen, N E]]
-	[[Category: Munch-Petersen, B.]]	+	[[Category: Munch-Petersen, B]]
-	[[Category: Wang, L.]]	+	[[Category: Wang, L]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
-	[[Category: Zhu, C.]]	+	[[Category: Zhu, C]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Deoxyribonucleoside kinase]]		[[Category: Deoxyribonucleoside kinase]]

OCA at 08:25, 29 September 2014

2014-09-29T08:25:51Z

←Older revision		Revision as of 08:25, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2uz3.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM==
		+	<StructureSection load='2uz3' size='340' side='right' caption='[[2uz3]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UZ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1xmr\|1xmr]], [[2b8t\|2b8t]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uz3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uz3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uz3 RCSB], [http://www.ebi.ac.uk/pdbsum/2uz3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uz/2uz3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytosolic thymidine kinase 1, TK1, is a well known cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs such as 3'-azido-3'-deoxythymidine (AZT). We have now determined the structures of the TK1 family, the human and Ureaplasma urealyticum enzymes, in complex with the feedback inhibitor dTTP. The TK1s have a tetrameric structure in which each subunit contains an alpha/beta-domain that is similar to ATPase domains of members of the RecA structural family and a domain containing a structural zinc. The zinc ion connects beta-structures at the root of a beta-ribbon that forms a stem that widens to a lasso-type loop. The thymidine of dTTP is hydrogen-bonded to main-chain atoms predominantly coming from the lasso loop. This binding is in contrast to other deoxyribonucleoside kinases where specific interactions occur with side chains. The TK1 structure differs fundamentally from the structures of the other deoxyribonucleoside kinases, indicating a different evolutionary origin.

-	~~{{STRUCTURE_2uz3\| PDB=2uz3 \| SCENE= }}~~	+	Structures of thymidine kinase 1 of human and mycoplasmic origin.,Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu C, Wang L, Eriksson S, Munch-Petersen B, Eklund H Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17970-5. Epub 2004 Dec 20. PMID:15611477<ref>PMID:15611477</ref>

-	~~===CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_15611477}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2uz3]] is~~ a ~~4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].~~	+

	==See Also==		==See Also==
	*[[Thymidine kinase\|Thymidine kinase]]		*[[Thymidine kinase\|Thymidine kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:015611477<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Ureaplasma urealyticum]]		[[Category: Ureaplasma urealyticum]]

OCA at 14:26, 20 October 2012

2012-10-20T14:26:44Z

←Older revision		Revision as of 14:26, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2uz3]] is a 4 chain structure ~~of [[Thymidine kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].	+	[[2uz3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].

	==See Also==		==See Also==

OCA: Protected "2uz3" [edit=sysop:move=sysop]

2012-07-26T15:10:07Z

Protected "2uz3" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:10, 26 July 2012

OCA at 15:10, 26 July 2012

2012-07-26T15:10:05Z

←Older revision		Revision as of 15:10, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2uz3.png\|left\|200px]]		[[Image:2uz3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2uz3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2uz3\| PDB=2uz3 \| SCENE= }}		{{STRUCTURE_2uz3\| PDB=2uz3 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM===		===CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_15611477}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 15611477 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_15611477}}		{{ABSTRACT_PUBMED_15611477}}

	==About this Structure==		==About this Structure==
-	~~2UZ3~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].	+	[[2uz3]] is a 4 chain structure of [[Thymidine kinase]] with sequence from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].
		+
		+	==See Also==
		+	*[[Thymidine kinase\|Thymidine kinase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~15611477~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:015611477</ref><references group="xtra"/>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Ureaplasma urealyticum]]		[[Category: Ureaplasma urealyticum]]
Line 47:		Line 38:
	[[Category: Uu-tk]]		[[Category: Uu-tk]]
	[[Category: Zinc-binding domain]]		[[Category: Zinc-binding domain]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:36:33 2009''

OCA at 05:36, 19 April 2009

2009-04-19T05:36:34Z

←Older revision		Revision as of 05:36, 19 April 2009
Line 12:		Line 12:
	===CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM===		===CRYSTAL STRUCTURE OF THYMIDINE KINASE WITH DTTP FROM U. UREALYTICUM===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_15611477}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 15611477 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_15611477}}

	==About this Structure==		==About this Structure==
	2UZ3 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].		2UZ3 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Ureaplasma_urealyticum Ureaplasma urealyticum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1xmr 1xmr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZ3 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:15611477</ref><references group="xtra"/>
	[[Category: Thymidine kinase]]		[[Category: Thymidine kinase]]
	[[Category: Ureaplasma urealyticum]]		[[Category: Ureaplasma urealyticum]]
Line 39:		Line 48:
	[[Category: Zinc-binding domain]]		[[Category: Zinc-binding domain]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Feb 17 11~~:10:11 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Apr 19 08:36:33 2009''