2v0d - Revision history

OCA at 09:54, 9 May 2024

2024-05-09T09:54:01Z

←Older revision		Revision as of 09:54, 9 May 2024
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	<StructureSection load='2v0d' size='340' side='right'caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2v0d' size='340' side='right'caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V0D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [~~http~~://pdbe.org/2v0d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [https://pdbe.org/2v0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [https://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>	+	[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dokurno, P]]	+	[[Category: Dokurno P]]
-	[[Category: Murray~~, J B~~]]	+	[[Category: Murray JB]]
-	[[Category: Richardson~~, C M~~]]	+	[[Category: Richardson CM]]
-	[[Category: Surgenor~~, A E]]~~	+	[[Category: Surgenor AE]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cdk2]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell division]]~~	+
-	~~[[Category: Cyclin]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Mitosis]]~~	+
-	~~[[Category: Nucleotide- binding]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Serine/threonine-protein kinase]]~~	+
-	~~[[Category: Thiazolidinone ligand]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 04:58, 19 November 2020

2020-11-19T04:58:11Z

←Older revision		Revision as of 04:58, 19 November 2020
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	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V0D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V0D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://pdbe.org/2v0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://pdbe.org/2v0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:57, 4 November 2020

2020-11-04T07:57:28Z

←Older revision		Revision as of 07:57, 4 November 2020
Line 1:		Line 1:

	==Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor==		==Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor==
-	<StructureSection load='2v0d' size='340' side='right' caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2v0d' size='340' side='right'caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V0D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V0D FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://pdbe.org/2v0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://pdbe.org/2v0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]	+	*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dokurno, P]]		[[Category: Dokurno, P]]
	[[Category: Murray, J B]]		[[Category: Murray, J B]]

OCA at 08:55, 12 September 2018

2018-09-12T08:55:35Z

←Older revision		Revision as of 08:55, 12 September 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF HUMAN~~ CDK2 ~~COMPLEXED WITH A THIAZOLIDINONE INHIBITOR~~==	+	==Crystal structure of human CDK2 complexed with a thiazolidinone inhibitor==
	<StructureSection load='2v0d' size='340' side='right' caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2v0d' size='340' side='right' caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0d_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:21, 5 August 2016

2016-08-05T23:21:48Z

←Older revision		Revision as of 23:21, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR==		==CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR==
	<StructureSection load='2v0d' size='340' side='right' caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2v0d' size='340' side='right' caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0D FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://pdbe.org/2v0d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v0d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v0d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Cell division protein~~ kinase 2\|~~Cell division protein~~ kinase 2]]	+	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Dokurno, P]]		[[Category: Dokurno, P]]
	[[Category: Murray, J B]]		[[Category: Murray, J B]]

OCA at 22:48, 25 December 2014

2014-12-25T22:48:54Z

←Older revision		Revision as of 22:48, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0D FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN]] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Dokurno, P.]]	+	[[Category: Dokurno, P]]
-	[[Category: Murray, J B.]]	+	[[Category: Murray, J B]]
-	[[Category: Richardson, C M.]]	+	[[Category: Richardson, C M]]
-	[[Category: Surgenor, A E.]]	+	[[Category: Surgenor, A E]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cdk2]]		[[Category: Cdk2]]

OCA at 10:26, 29 September 2014

2014-09-29T10:26:28Z

←Older revision		Revision as of 10:26, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2v0d.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR==
		+	<StructureSection load='2v0d' size='340' side='right' caption='[[2v0d]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0D FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C53:2-IMINO-5-(1-PYRIDIN-2-YL-METH-(E)-YLIDENE)-1,3-THIAZOLIDIN-4-ONE'>C53</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[1ykr\|1ykr]], [[2a0c\|2a0c]], [[2a4l\|2a4l]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2cch\|2cch]], [[2cci\|2cci]], [[2cjm\|2cjm]], [[2clx\|2clx]], [[2exm\|2exm]], [[2iw6\|2iw6]], [[2iw8\|2iw8]], [[2iw9\|2iw9]], [[2j9m\|2j9m]], [[2jgz\|2jgz]], [[2uue\|2uue]], [[2uzb\|2uzb]], [[2uzd\|2uzd]], [[2uze\|2uze]], [[2uzl\|2uzl]], [[2uzn\|2uzn]], [[2uzo\|2uzo]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0d RCSB], [http://www.ebi.ac.uk/pdbsum/2v0d PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0d_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Virtual screening against a pCDK2/cyclin A crystal structure led to the identification of a potent and novel CDK2 inhibitor, which exhibited an unusual mode of interaction with the kinase binding motif. With the aid of X-ray crystallography and modelling, a medicinal chemistry strategy was implemented to probe the interactions seen in the crystal structure and to establish SAR. A fragment-based approach was also considered but a different, more conventional, binding mode was observed. Compound selectivity against GSK-3beta was improved using a rational design strategy, with crystallographic verification of the CDK2 binding mode.

-	~~{{STRUCTURE_2v0d\| PDB=2v0d \| SCENE= }}~~	+	Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.,Richardson CM, Nunns CL, Williamson DS, Parratt MJ, Dokurno P, Howes R, Borgognoni J, Drysdale MJ, Finch H, Hubbard RE, Jackson PS, Kierstan P, Lentzen G, Moore JD, Murray JB, Simmonite H, Surgenor AE, Torrance CJ Bioorg Med Chem Lett. 2007 Jul 15;17(14):3880-5. Epub 2007 May 6. PMID:17570665<ref>PMID:17570665</ref>

-	~~===CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17570665}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2v0d]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA].~~	+

	==See Also==		==See Also==
-	*[[Cell ~~Division Protein Kinase~~ 2\|Cell ~~Division Protein Kinase~~ 2]]	+	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:017570665<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dokurno, P.]]		[[Category: Dokurno, P.]]

OCA at 22:35, 20 October 2012

2012-10-20T22:35:05Z

←Older revision		Revision as of 22:35, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2v0d]] is a 1 chain structure ~~of [[Cell Division Protein Kinase 2]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA].	+	[[2v0d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA].

	==See Also==		==See Also==

OCA: Protected "2v0d" [edit=sysop:move=sysop]

2012-07-27T16:48:42Z

Protected "2v0d" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:48, 27 July 2012

OCA at 16:48, 27 July 2012

2012-07-27T16:48:40Z

←Older revision		Revision as of 16:48, 27 July 2012
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-	{{Seed}}
	[[Image:2v0d.png\|left\|200px]]		[[Image:2v0d.png\|left\|200px]]

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	{{STRUCTURE_2v0d\| PDB=2v0d \| SCENE= }}		{{STRUCTURE_2v0d\| PDB=2v0d \| SCENE= }}

	===CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR===		===CRYSTAL STRUCTURE OF HUMAN CDK2 COMPLEXED WITH A THIAZOLIDINONE INHIBITOR===

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	{{ABSTRACT_PUBMED_17570665}}		{{ABSTRACT_PUBMED_17570665}}

	==About this Structure==		==About this Structure==
-	~~2V0D~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA].	+	[[2v0d]] is a 1 chain structure of [[Cell Division Protein Kinase 2]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0D OCA].
		+
		+	==See Also==
		+	*[[Cell Division Protein Kinase 2\|Cell Division Protein Kinase 2]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17570665~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017570665</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Dokurno, P.]]		[[Category: Dokurno, P.]]
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	[[Category: Thiazolidinone ligand]]		[[Category: Thiazolidinone ligand]]
	[[Category: Transferase]]		[[Category: Transferase]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 10:09:09 2009''