2v0s - Revision history

OCA at 15:00, 13 December 2023

2023-12-13T15:00:55Z

←Older revision		Revision as of 15:00, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2v0s' size='340' side='right'caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2v0s' size='340' side='right'caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vyb\|1vyb]], [[2v0r\|2v0r]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [https://pdbe.org/2v0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [https://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [https://pdbe.org/2v0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [https://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LORF2_HUMAN LORF2_HUMAN] Has a reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome.<ref>PMID:7516468</ref> <ref>PMID:8945517</ref> <ref>PMID:9140393</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Layer~~, L E~~]]	+	[[Category: Layer LE]]
-	[[Category: Perrakis, A]]	+	[[Category: Perrakis A]]
-	[[Category: Repanas, K]]	+	[[Category: Repanas K]]
-	[[Category: Schumann~~, G G~~]]	+	[[Category: Schumann GG]]
-	[[Category: Weichenrieder, O]]	+	[[Category: Weichenrieder O]]
-	[[Category: Zingler, N]]	+	[[Category: Zingler N]]
-	~~[[Category: Ape-1 type]]~~	+
-	~~[[Category: Endonuclease]]~~	+
-	~~[[Category: Hypothetical protein]]~~	+
-	~~[[Category: Protein engineering]]~~	+
-	~~[[Category: Retrotransposition]]~~	+
-	~~[[Category: Retrotransposon]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 12:35, 23 March 2022

2022-03-23T12:35:40Z

←Older revision		Revision as of 12:35, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='2v0s' size='340' side='right'caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2v0s' size='340' side='right'caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V0S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1vyb\|1vyb]], [[2v0r\|2v0r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [~~http~~://pdbe.org/2v0s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [https://pdbe.org/2v0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [https://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:16, 17 June 2020

2020-06-17T11:16:27Z

←Older revision		Revision as of 11:16, 17 June 2020
Line 1:		Line 1:

	==crystal structure of a hairpin exchange variant (LR1) of the targeting LINE-1 retrotransposon endonuclease==		==crystal structure of a hairpin exchange variant (LR1) of the targeting LINE-1 retrotransposon endonuclease==
-	<StructureSection load='2v0s' size='340' side='right' caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2v0s' size='340' side='right'caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V0S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://pdbe.org/2v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://pdbe.org/2v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Layer, L E]]		[[Category: Layer, L E]]
	[[Category: Perrakis, A]]		[[Category: Perrakis, A]]

OCA at 08:33, 12 September 2018

2018-09-12T08:33:47Z

←Older revision		Revision as of 08:33, 12 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF A HAIRPIN EXCHANGE VARIANT~~ (LR1) ~~OF THE TARGETING~~ LINE-1 ~~RETROTRANSPOSON ENDONUCLEASE~~==	+
		+	==crystal structure of a hairpin exchange variant (LR1) of the targeting LINE-1 retrotransposon endonuclease==
	<StructureSection load='2v0s' size='340' side='right' caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2v0s' size='340' side='right' caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://pdbe.org/2v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://pdbe.org/2v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v0s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:02, 7 February 2016

2016-02-07T15:02:23Z

←Older revision		Revision as of 15:02, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2v0s' size='340' side='right' caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2v0s' size='340' side='right' caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://pdbe.org/2v0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v0s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v0s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Layer, L E]]		[[Category: Layer, L E]]
	[[Category: Perrakis, A]]		[[Category: Perrakis, A]]

OCA at 16:44, 19 January 2015

2015-01-19T16:44:43Z

←Older revision		Revision as of 16:44, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Layer, L E.]]	+	[[Category: Layer, L E]]
-	[[Category: Perrakis, A.]]	+	[[Category: Perrakis, A]]
-	[[Category: Repanas, K.]]	+	[[Category: Repanas, K]]
-	[[Category: Schumann, G G.]]	+	[[Category: Schumann, G G]]
-	[[Category: Weichenrieder, O.]]	+	[[Category: Weichenrieder, O]]
-	[[Category: Zingler, N.]]	+	[[Category: Zingler, N]]
	[[Category: Ape-1 type]]		[[Category: Ape-1 type]]
	[[Category: Endonuclease]]		[[Category: Endonuclease]]

OCA at 01:29, 1 October 2014

2014-10-01T01:29:33Z

←Older revision		Revision as of 01:29, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2v0s.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF A HAIRPIN EXCHANGE VARIANT (LR1) OF THE TARGETING LINE-1 RETROTRANSPOSON ENDONUCLEASE==
		+	<StructureSection load='2v0s' size='340' side='right' caption='[[2v0s]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V0S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1vyb\|1vyb]], [[2v0r\|2v0r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0s RCSB], [http://www.ebi.ac.uk/pdbsum/2v0s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v0s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human LINE-1 endonuclease (L1-EN) is the targeting endonuclease encoded by the human LINE-1 (L1) retrotransposon. L1-EN guides the genomic integration of new L1 and Alu elements that presently account for approximately 28% of the human genome. L1-EN bears considerable technological interest, because its target selectivity may ultimately be engineered to allow the site-specific integration of DNA into defined genomic locations. Based on the crystal structure, we generated L1-EN mutants to analyze and manipulate DNA target site recognition. Crystal structures and their dynamic and functional analysis show entire loop grafts to be feasible, resulting in altered specificity, while individual point mutations do not change the nicking pattern of L1-EN. Structural parameters of the DNA target seem more important for recognition than the nucleotide sequence, and nicking profiles on DNA oligonucleotides in vitro are less well defined than the respective integration site consensus in vivo. This suggests that additional factors other than the DNA nicking specificity of L1-EN contribute to the targeted integration of non-LTR retrotransposons.

-	~~{{STRUCTURE_2v0s\| PDB=2v0s \| SCENE= }}~~	+	Determinants for DNA target structure selectivity of the human LINE-1 retrotransposon endonuclease.,Repanas K, Zingler N, Layer LE, Schumann GG, Perrakis A, Weichenrieder O Nucleic Acids Res. 2007;35(14):4914-26. Epub 2007 Jul 10. PMID:17626046<ref>PMID:17626046</ref>

-	~~===CRYSTAL STRUCTURE OF A HAIRPIN EXCHANGE VARIANT (LR1) OF THE TARGETING LINE-1 RETROTRANSPOSON ENDONUCLEASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17626046}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2v0s]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017626046<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Layer, L E.]]		[[Category: Layer, L E.]]

OCA: Protected "2v0s" [edit=sysop:move=sysop]

2013-01-07T22:10:44Z

Protected "2v0s" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:10, 7 January 2013

OCA at 22:10, 7 January 2013

2013-01-07T22:10:41Z

←Older revision		Revision as of 22:10, 7 January 2013
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-	{{Seed}}
	[[Image:2v0s.png\|left\|200px]]		[[Image:2v0s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v0s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v0s\| PDB=2v0s \| SCENE= }}		{{STRUCTURE_2v0s\| PDB=2v0s \| SCENE= }}

	===CRYSTAL STRUCTURE OF A HAIRPIN EXCHANGE VARIANT (LR1) OF THE TARGETING LINE-1 RETROTRANSPOSON ENDONUCLEASE===		===CRYSTAL STRUCTURE OF A HAIRPIN EXCHANGE VARIANT (LR1) OF THE TARGETING LINE-1 RETROTRANSPOSON ENDONUCLEASE===

		+	{{ABSTRACT_PUBMED_17626046}}

	==About this Structure==		==About this Structure==
-	~~2V0S~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA].	+	[[2v0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:017626046</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Layer, L E.]]		[[Category: Layer, L E.]]
Line 29:		Line 26:
	[[Category: Retrotransposon]]		[[Category: Retrotransposon]]
	[[Category: Transcription]]		[[Category: Transcription]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:38:48 2009''

OCA at 12:38, 16 February 2009

2009-02-16T12:38:50Z

←Older revision		Revision as of 12:38, 16 February 2009
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	2V0S is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA].	+	2V0S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V0S OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Layer, L E.]]		[[Category: Layer, L E.]]
	[[Category: Perrakis, A.]]		[[Category: Perrakis, A.]]
Line 31:		Line 30:
	[[Category: Transcription]]		[[Category: Transcription]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 10 12~~:52:~~31 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:38:48 2009''