2v2c - Revision history

OCA at 07:06, 1 May 2024

2024-05-01T07:06:55Z

←Older revision		Revision as of 07:06, 1 May 2024
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2c ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The flexible catalytic loop, loop-6, of TIM has evolved to preferably be open in the unliganded state and to preferably be closed in the liganded state. The N-terminal and C-terminal hinges of this loop are important for its opening/closing mechanism. In this study, a small conserved C-terminal hinge residue, Ala178, has been mutated into a residue with a larger side chain, Leu178. This mutation has been made in the dimeric trypanosomal wild-type TIM (wtTIM) and in its mutated catalytically competent monomeric variant (ml1TIM). The variants are referred to as A178L and ml1A178L, respectively. Crystal structures have been determined of unliganded A178L (at 2.2 A), liganded A178L (at 1.89 A), unliganded ml1A178L (at 2.3 A) and liganded ml1A178L (at 1.18 A) using the transition-state analogue 2-phosphoglycolate as a ligand. Structural characterization of the two variants shows that this mutation favours the closed conformation of the C-terminal hinge region, even in the absence of ligand. In the structure of the unliganded A178L variant a range of new loop-6 conformations are observed, including subunits in which the tip of loop-6 is completely disordered. The catalytic efficiency of A178L is lower than that of wtTIM, which correlates with the structural differences between the apo forms of wtTIM and A178L, in particular the more disordered loop-6 in the structure of unliganded A178L. In the liganded structures of A178L and ml1A178L the structural differences induced by the mutation are minimal. Structural characterization of the ml1A178L variant highlights its structural plasticity.
-
-	Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.,Alahuhta M, Casteleijn MG, Neubauer P, Wierenga RK Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):178-88. Epub 2008, Jan 16. PMID:18219118<ref>PMID:18219118</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2v2c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]		*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:02, 13 December 2023

2023-12-13T15:02:54Z

←Older revision		Revision as of 15:02, 13 December 2023
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	<StructureSection load='2v2c' size='340' side='right'caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2v2c' size='340' side='right'caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PGA:2~~-~~PHOSPHOGLYCOLIC+ACID'>PGA</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [https://pdbe.org/2v2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [https://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [https://pdbe.org/2v2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [https://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/TPIS_TRYBB TPIS_TRYBB]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Triose-phosphate isomerase]]~~	+	[[Category: Trypanosoma brucei brucei]]
-	~~[[Category: Trybb~~]]	+	[[Category: Alahuhta M]]
-	[[Category: Alahuhta, M]]	+	[[Category: Casteleijn MG]]
-	[[Category: Casteleijn~~, M G~~]]	+	[[Category: Neubauer P]]
-	[[Category: Neubauer, P]]	+	[[Category: Wierenga RK]]
-	[[Category: Wierenga~~, R K]]~~	+
-	~~[[Category: 2-phospho glycollate]]~~	+
-	~~[[Category: A178l]]~~	+
-	~~[[Category: Engineering]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Gluconeogenesis]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Glycosome]]~~	+
-	~~[[Category: Hinge]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Loop-6]]~~	+
-	~~[[Category: Loop6]]~~	+
-	~~[[Category: Pentose shunt]]~~	+
-	~~[[Category: Point mutation]]~~	+
-	~~[[Category: Tim]]~~	+
-	~~[[Category: Tim-barrel]]~~	+
-	~~[[Category: Triosephosphate isomerase~~]]	+

OCA at 12:36, 23 March 2022

2022-03-23T12:36:42Z

←Older revision		Revision as of 12:36, 23 March 2022
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	<StructureSection load='2v2c' size='340' side='right'caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2v2c' size='340' side='right'caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [~~http~~://pdbe.org/2v2c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [https://pdbe.org/2v2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [https://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:17, 17 June 2020

2020-06-17T11:17:33Z

←Older revision		Revision as of 11:17, 17 June 2020
Line 1:		Line 1:

	==The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM==		==The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM==
-	<StructureSection load='2v2c' size='340' side='right' caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='2v2c' size='340' side='right'caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://pdbe.org/2v2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://pdbe.org/2v2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Triose ~~Phosphate Isomerase~~\|Triose ~~Phosphate Isomerase~~]]	+	*[[Triose phosphate isomerase 3D structures\|Triose phosphate isomerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trybb]]		[[Category: Trybb]]

OCA at 08:20, 12 September 2018

2018-09-12T08:20:14Z

←Older revision		Revision as of 08:20, 12 September 2018
Line 1:		Line 1:
-	==~~THE~~ A178L ~~MUTATION IN THE~~ C-~~TERMINAL HINGE OF THE FLEXIBLE LOOP~~-6 ~~OF TRIOSEPHOSPHATE ISOMERASE~~ (TIM) ~~INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC~~ TIM==	+
		+	==The A178L mutation in the C-terminal hinge of the flexible loop-6 of triosephosphate isomerase (TIM) induces a more closed conformation of this hinge region in dimeric and monomeric TIM==
	<StructureSection load='2v2c' size='340' side='right' caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2v2c' size='340' side='right' caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://pdbe.org/2v2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://pdbe.org/2v2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2c ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2c_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2c_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:32, 8 February 2016

2016-02-08T21:32:27Z

←Older revision		Revision as of 21:32, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2v2c' size='340' side='right' caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2v2c' size='340' side='right' caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei_brucei Trypanosoma brucei brucei~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://pdbe.org/2v2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2c ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v2c" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
-	[[Category: ~~Trypanosoma brucei brucei~~]]	+	[[Category: Trybb]]
	[[Category: Alahuhta, M]]		[[Category: Alahuhta, M]]
	[[Category: Casteleijn, M G]]		[[Category: Casteleijn, M G]]

OCA at 17:28, 19 January 2015

2015-01-19T17:28:05Z

←Older revision		Revision as of 17:28, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2C FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma brucei brucei]]		[[Category: Trypanosoma brucei brucei]]
-	[[Category: Alahuhta, M.]]	+	[[Category: Alahuhta, M]]
-	[[Category: Casteleijn, M G.]]	+	[[Category: Casteleijn, M G]]
-	[[Category: Neubauer, P.]]	+	[[Category: Neubauer, P]]
-	[[Category: Wierenga, R K.]]	+	[[Category: Wierenga, R K]]
	[[Category: 2-phospho glycollate]]		[[Category: 2-phospho glycollate]]
-	[[Category: 2pg]]
	[[Category: A178l]]		[[Category: A178l]]
	[[Category: Engineering]]		[[Category: Engineering]]

OCA at 01:54, 1 October 2014

2014-10-01T01:54:34Z

←Older revision		Revision as of 01:54, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2v2c\| PDB=2v2c \| SCENE= }}~~	+	==THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM==
-	===THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM===	+	<StructureSection load='2v2c' size='340' side='right' caption='[[2v2c]], [[Resolution\|resolution]] 1.89Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18219118}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2C FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ag1\|1ag1]], [[1dkw\|1dkw]], [[1iig\|1iig]], [[1iih\|1iih]], [[1kv5\|1kv5]], [[1ml1\|1ml1]], [[1mss\|1mss]], [[1mtm\|1mtm]], [[1tpd\|1tpd]], [[1tpe\|1tpe]], [[1tpf\|1tpf]], [[1trd\|1trd]], [[1tri\|1tri]], [[1tsi\|1tsi]], [[1tti\|1tti]], [[1ttj\|1ttj]], [[2j24\|2j24]], [[2j27\|2j27]], [[2v0t\|2v0t]], [[3tim\|3tim]], [[4tim\|4tim]], [[5tim\|5tim]], [[6tim\|6tim]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2c RCSB], [http://www.ebi.ac.uk/pdbsum/2v2c PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2c_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The flexible catalytic loop, loop-6, of TIM has evolved to preferably be open in the unliganded state and to preferably be closed in the liganded state. The N-terminal and C-terminal hinges of this loop are important for its opening/closing mechanism. In this study, a small conserved C-terminal hinge residue, Ala178, has been mutated into a residue with a larger side chain, Leu178. This mutation has been made in the dimeric trypanosomal wild-type TIM (wtTIM) and in its mutated catalytically competent monomeric variant (ml1TIM). The variants are referred to as A178L and ml1A178L, respectively. Crystal structures have been determined of unliganded A178L (at 2.2 A), liganded A178L (at 1.89 A), unliganded ml1A178L (at 2.3 A) and liganded ml1A178L (at 1.18 A) using the transition-state analogue 2-phosphoglycolate as a ligand. Structural characterization of the two variants shows that this mutation favours the closed conformation of the C-terminal hinge region, even in the absence of ligand. In the structure of the unliganded A178L variant a range of new loop-6 conformations are observed, including subunits in which the tip of loop-6 is completely disordered. The catalytic efficiency of A178L is lower than that of wtTIM, which correlates with the structural differences between the apo forms of wtTIM and A178L, in particular the more disordered loop-6 in the structure of unliganded A178L. In the liganded structures of A178L and ml1A178L the structural differences induced by the mutation are minimal. Structural characterization of the ml1A178L variant highlights its structural plasticity.

-	~~==About this Structure==~~	+	Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.,Alahuhta M, Casteleijn MG, Neubauer P, Wierenga RK Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):178-88. Epub 2008, Jan 16. PMID:18219118<ref>PMID:18219118</ref>
-	~~[[2v2c]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2V2C OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]		*[[Triose Phosphate Isomerase\|Triose Phosphate Isomerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018219118<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Triose-phosphate isomerase]]		[[Category: Triose-phosphate isomerase]]
	[[Category: Trypanosoma brucei brucei]]		[[Category: Trypanosoma brucei brucei]]

OCA at 10:52, 11 March 2013

2013-03-11T10:52:43Z

←Older revision		Revision as of 10:52, 11 March 2013
Line 1:		Line 1:
-	[[Image:2v2c.png\|left\|200px]]
-
	{{STRUCTURE_2v2c\| PDB=2v2c \| SCENE= }}		{{STRUCTURE_2v2c\| PDB=2v2c \| SCENE= }}
-
	===THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM===		===THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM===
-
	{{ABSTRACT_PUBMED_18219118}}		{{ABSTRACT_PUBMED_18219118}}

OCA at 11:32, 20 October 2012

2012-10-20T11:32:37Z

←Older revision		Revision as of 11:32, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2v2c]] is a 1 chain structure ~~of [[Triose Phosphate Isomerase]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA].	+	[[2v2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2C OCA].

	==See Also==		==See Also==