2v41 - Revision history

OCA at 15:05, 13 December 2023

2023-12-13T15:05:10Z

←Older revision		Revision as of 15:05, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2v41' size='340' side='right'caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2v41' size='340' side='right'caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arema Arema~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V41 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2v2g\|2v2g]], [[2v32\|2v32]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [https://pdbe.org/2v41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [https://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [https://pdbe.org/2v41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [https://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q1AN22_AREMA Q1AN22_AREMA]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arema]]
-	[[Category: Large Structures]]
-	[[Category: Peroxiredoxin]]
-	[[Category: Declercq, J P]]
-	[[Category: Smeets, A]]
-	[[Category: Antioxidant enzyme]]
	[[Category: Arenicola marina]]		[[Category: Arenicola marina]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Large Structures]]
		+	[[Category: Declercq JP]]
		+	[[Category: Smeets A]]

OCA at 12:38, 23 March 2022

2022-03-23T12:38:02Z

←Older revision		Revision as of 12:38, 23 March 2022
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	<StructureSection load='2v41' size='340' side='right'caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2v41' size='340' side='right'caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arema Arema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arema Arema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V41 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v2g\|2v2g]], [[2v32\|2v32]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [~~http~~://pdbe.org/2v41 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [https://pdbe.org/2v41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [https://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:19, 17 June 2020

2020-06-17T11:19:08Z

←Older revision		Revision as of 11:19, 17 June 2020
Line 1:		Line 1:

	==Crystal Structure of the C45S mutant of the Peroxiredoxin 6 of Arenicola Marina. Orthorhombic form==		==Crystal Structure of the C45S mutant of the Peroxiredoxin 6 of Arenicola Marina. Orthorhombic form==
-	<StructureSection load='2v41' size='340' side='right' caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='2v41' size='340' side='right'caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arema Arema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arema Arema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V41 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://pdbe.org/2v41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://pdbe.org/2v41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Peroxiredoxin\|Peroxiredoxin]]	+	*[[Peroxiredoxin 3D structures\|Peroxiredoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Arema]]		[[Category: Arema]]
		+	[[Category: Large Structures]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
	[[Category: Declercq, J P]]		[[Category: Declercq, J P]]

OCA at 08:39, 12 September 2018

2018-09-12T08:39:45Z

←Older revision		Revision as of 08:39, 12 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE~~ C45S ~~MUTANT OF THE PEROXIREDOXIN~~ 6 ~~OF ARENICOLA MARINA~~. ~~ORTHORHOMBIC FORM~~==	+
		+	==Crystal Structure of the C45S mutant of the Peroxiredoxin 6 of Arenicola Marina. Orthorhombic form==
	<StructureSection load='2v41' size='340' side='right' caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2v41' size='340' side='right' caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://pdbe.org/2v41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://pdbe.org/2v41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v41 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v41_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v41_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:58, 7 February 2016

2016-02-07T18:58:41Z

←Older revision		Revision as of 18:58, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2v41' size='340' side='right' caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2v41' size='340' side='right' caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arenicola_marina Arenicola marina~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V41 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arema Arema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V41 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://pdbe.org/2v41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v41 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v41" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arenicola marina~~]]	+	[[Category: Arema]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
	[[Category: Declercq, J P]]		[[Category: Declercq, J P]]
	[[Category: Smeets, A]]		[[Category: Smeets, A]]
	[[Category: Antioxidant enzyme]]		[[Category: Antioxidant enzyme]]
		+	[[Category: Arenicola marina]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 13:51, 19 January 2015

2015-01-19T13:51:06Z

←Older revision		Revision as of 13:51, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V41 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V41 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Arenicola marina]]		[[Category: Arenicola marina]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]
-	[[Category: Declercq, J P.]]	+	[[Category: Declercq, J P]]
-	[[Category: Smeets, A.]]	+	[[Category: Smeets, A]]
	[[Category: Antioxidant enzyme]]		[[Category: Antioxidant enzyme]]
-	[[Category: Arenicola marina]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Peroxiredoxin]]

OCA at 06:52, 29 September 2014

2014-09-29T06:52:47Z

←Older revision		Revision as of 06:52, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2v41.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE C45S MUTANT OF THE PEROXIREDOXIN 6 OF ARENICOLA MARINA. ORTHORHOMBIC FORM==
		+	<StructureSection load='2v41' size='340' side='right' caption='[[2v41]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V41 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v2g\|2v2g]], [[2v32\|2v32]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v41 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v41 RCSB], [http://www.ebi.ac.uk/pdbsum/2v41 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v41_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The peroxiredoxins (PRDXs) define a superfamily of thiol-dependent peroxidases able to reduce hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite. Besides their cytoprotective antioxidant function, PRDXs have been implicated in redox signaling and chaperone activity, the latter depending on the formation of decameric high-molecular-weight structures. PRDXs have been mechanistically divided into three major subfamilies, namely typical 2-Cys, atypical 2-Cys, and 1-Cys PRDXs, based on the number and position of cysteines involved in the catalysis. We report the structure of the C45S mutant of annelid worm Arenicola marina PRDX6 in three different crystal forms determined at 1.6, 2.0, and 2.4 A resolution. Although A. marina PRDX6 was cloned during the search of annelid homologs of mammalian 1-Cys PRDX6s, the crystal structures support its assignment to the mechanistically typical 2-Cys PRDX subfamily. The protein is composed of two distinct domains: a C-terminal domain and an N-terminal domain exhibiting a thioredoxin fold. The subunits are associated in dimers compatible with the formation of intersubunit disulfide bonds between the peroxidatic and the resolving cysteine residues in the wild-type enzyme. The packing of two crystal forms is very similar, with pairs of dimers associated as tetramers. The toroid-shaped decamers formed by dimer association and observed in most typical 2-Cys PRDXs is not present. Thus, A. marina PRDX6 presents structural features of typical 2-Cys PRDXs without any formation of toroid-shaped decamers, suggesting that it should function more like a cytoprotective antioxidant enzyme or a modulator of peroxide-dependent cell signaling rather than a molecular chaperone.

-	~~{{STRUCTURE_2v41\| PDB=2v41 \| SCENE= }}~~	+	The crystal structure of the C45S mutant of annelid Arenicola marina peroxiredoxin 6 supports its assignment to the mechanistically typical 2-Cys subfamily without any formation of toroid-shaped decamers.,Smeets A, Loumaye E, Clippe A, Rees JF, Knoops B, Declercq JP Protein Sci. 2008 Apr;17(4):700-10. PMID:18359859<ref>PMID:18359859</ref>

-	~~===CRYSTAL STRUCTURE OF THE C45S MUTANT OF THE PEROXIREDOXIN 6 OF ARENICOLA MARINA. ORTHORHOMBIC FORM===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18359859}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2v41]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arenicola_marina Arenicola marina]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA].~~	+

	==See Also==		==See Also==
	*[[Peroxiredoxin\|Peroxiredoxin]]		*[[Peroxiredoxin\|Peroxiredoxin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018359859<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Arenicola marina]]		[[Category: Arenicola marina]]
	[[Category: Peroxiredoxin]]		[[Category: Peroxiredoxin]]

OCA at 07:35, 20 October 2012

2012-10-20T07:35:32Z

←Older revision		Revision as of 07:35, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2v41]] is a 8 chain structure ~~of [[Peroxiredoxin]]~~ with sequence from [http://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA].	+	[[2v41]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arenicola_marina Arenicola marina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V41 OCA].

	==See Also==		==See Also==

OCA at 16:48, 25 July 2012

2012-07-25T16:48:17Z

←Older revision		Revision as of 16:48, 25 July 2012
Line 1:		Line 1:
	[[Image:2v41.png\|left\|200px]]		[[Image:2v41.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v41", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v41\| PDB=2v41 \| SCENE= }}		{{STRUCTURE_2v41\| PDB=2v41 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE C45S MUTANT OF THE PEROXIREDOXIN 6 OF ARENICOLA MARINA. ORTHORHOMBIC FORM===		===CRYSTAL STRUCTURE OF THE C45S MUTANT OF THE PEROXIREDOXIN 6 OF ARENICOLA MARINA. ORTHORHOMBIC FORM===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18359859}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18359859 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18359859}}		{{ABSTRACT_PUBMED_18359859}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Peroxiredoxin]]	+	*[[Peroxiredoxin\|Peroxiredoxin]]

	==Reference==		==Reference==

OCA: Protected "2v41" [edit=sysop:move=sysop]

2011-08-24T06:05:22Z

Protected "2v41" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 24 August 2011