2v4o - Revision history

OCA at 15:05, 13 December 2023

2023-12-13T15:05:32Z

←Older revision		Revision as of 15:05, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2v4o' size='340' side='right'caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='2v4o' size='340' side='right'caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Salty Salty~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v4n\|2v4n]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [https://pdbe.org/2v4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [https://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [https://pdbe.org/2v4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [https://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SURE_SALTY SURE_SALTY] Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.[HAMAP-Rule:MF_00060]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Salty~~]]	+	[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
-	[[Category: Anju, P]]	+	[[Category: Anju P]]
-	[[Category: Murthy~~, M R.N~~]]	+	[[Category: Murthy MRN]]
-	[[Category: Savithri~~, H S]]~~	+	[[Category: Savithri HS]]
-	~~[[Category: Divalent metal ion]]~~	+
-	~~[[Category: Domain swapping]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Mononucleotidase]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphatase]]~~	+
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Stationary phase]]~~	+
-	~~[[Category: Sur e]]~~	+
-	~~[[Category: Survival protein~~]]	+

OCA at 12:38, 23 March 2022

2022-03-23T12:38:23Z

←Older revision		Revision as of 12:38, 23 March 2022
Line 3:		Line 3:
	<StructureSection load='2v4o' size='340' side='right'caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='2v4o' size='340' side='right'caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2V4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V4O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v4n\|2v4n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [~~http~~://pdbe.org/2v4o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [https://pdbe.org/2v4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [https://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:19, 17 June 2020

2020-06-17T11:19:34Z

←Older revision		Revision as of 11:19, 17 June 2020
Line 1:		Line 1:

	==Crystal structure of Salmonella typhimurium SurE at 2.75 angstrom resolution in monoclinic form==		==Crystal structure of Salmonella typhimurium SurE at 2.75 angstrom resolution in monoclinic form==
-	<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>	+	<StructureSection load='2v4o' size='340' side='right'caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2V4O FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://pdbe.org/2v4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://pdbe.org/2v4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Salty]]		[[Category: Salty]]
	[[Category: Anju, P]]		[[Category: Anju, P]]

OCA at 08:59, 12 September 2018

2018-09-12T08:59:28Z

←Older revision		Revision as of 08:59, 12 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM SURE AT~~ 2.75 ~~ANGSTROM RESOLUTION IN MONOCLINIC FORM~~==	+
		+	==Crystal structure of Salmonella typhimurium SurE at 2.75 angstrom resolution in monoclinic form==
	<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://pdbe.org/2v4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://pdbe.org/2v4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v4o ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4o_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4o_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:59, 9 February 2016

2016-02-09T15:59:51Z

←Older revision		Revision as of 15:59, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V4O FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://pdbe.org/2v4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v4o ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v4o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Salmonella enterica subsp. enterica serovar typhimurium~~]]	+	[[Category: Salty]]
	[[Category: Anju, P]]		[[Category: Anju, P]]
	[[Category: Murthy, M R.N]]		[[Category: Murthy, M R.N]]

OCA at 16:01, 19 January 2015

2015-01-19T16:01:37Z

←Older revision		Revision as of 16:01, 19 January 2015
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
-	[[Category: Anju, P.]]	+	[[Category: Anju, P]]
-	[[Category: Murthy, M R.N.]]	+	[[Category: Murthy, M R.N]]
-	[[Category: Savithri, H S.]]	+	[[Category: Savithri, H S]]
	[[Category: Divalent metal ion]]		[[Category: Divalent metal ion]]
	[[Category: Domain swapping]]		[[Category: Domain swapping]]

OCA at 06:55, 10 October 2014

2014-10-10T06:55:13Z

←Older revision		Revision as of 06:55, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. <br>	+	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V4O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 23:
	Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium.,Pappachan A, Savithri HS, Murthy MR FEBS J. 2008 Dec;275(23):5855-64. PMID:19021761<ref>PMID:19021761</ref>		Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium.,Pappachan A, Savithri HS, Murthy MR FEBS J. 2008 Dec;275(23):5855-64. PMID:19021761<ref>PMID:19021761</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 08:42, 7 May 2014

2014-05-07T08:42:45Z

←Older revision		Revision as of 08:42, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2v4o.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM SURE AT 2.75 ANGSTROM RESOLUTION IN MONOCLINIC FORM==
		+	<StructureSection load='2v4o' size='340' side='right' caption='[[2v4o]], [[Resolution\|resolution]] 2.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v4n\|2v4n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v4o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v4o RCSB], [http://www.ebi.ac.uk/pdbsum/2v4o PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v4/2v4o_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SurE, the stationary-phase survival protein of Salmonella typhimurium, forms part of a stress survival operon regulated by the stationary-phase RNA polymerase alternative sigma factor. SurE is known to improve bacterial viability during stress conditions. It functions as a phosphatase specific to nucleoside monophosphates. In the present study we reported the X-ray crystal structure of SurE from Salmonella typhimurium. The protein crystallized in two forms: orthorhombic F222; and monoclinic C2. The two structures were determined to resolutions of 1.7 and 2.7 A, respectively. The protein exists as a domain-swapped dimer. The residue D230 is involved in several interactions that are probably crucial for domain swapping. A divalent metal ion is found at the active site of the enzyme, which is consistent with the divalent metal ion-dependent activity of the enzyme. Interactions of the conserved DD motif present at the N-terminus with the phosphate and the Mg(2+) present in the active site suggest that these residues play an important role in enzyme activity. The divalent metal ion specificity and the kinetic constants of SurE were determined using the generic phosphatase substrate para-nitrophenyl phosphate. The enzyme was inactive in the absence of divalent cations and was most active in the presence of Mg(2+). Thermal denaturation studies showed that S. typhimurium SurE is much less stable than its homologues and an attempt was made to understand the molecular basis of the lower thermal stability based on solvation free-energy. This is the first detailed crystal structure analysis of SurE from a mesophilic organism.

-	~~<!--~~	+	Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium.,Pappachan A, Savithri HS, Murthy MR FEBS J. 2008 Dec;275(23):5855-64. PMID:19021761<ref>PMID:19021761</ref>
-	~~The line below this paragraph, containing "STRUCTURE_2v4o", creates the "Structure Box"~~ on ~~the page.~~	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2v4o\| PDB=2v4o \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF SALMONELLA TYPHIMURIUM SURE AT 2.75 ANGSTROM RESOLUTION IN MONOCLINIC FORM===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19021761}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19021761 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19021761}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2v4o]] is a 4 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA].	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019021761<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]		[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Anju, P.]]		[[Category: Anju, P.]]

OCA: Protected "2v4o" [edit=sysop:move=sysop]

2011-08-24T06:46:30Z

Protected "2v4o" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:46, 24 August 2011

OCA at 06:46, 24 August 2011

2011-08-24T06:46:27Z

←Older revision		Revision as of 06:46, 24 August 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2v4o.png\|left\|200px]]
-	[[Image:2v4o.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2V4O~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/~~Salmonella_typhimurium~~ Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA].	+	[[2v4o]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V4O OCA].

	==Reference==		==Reference==
-	~~Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium., Pappachan A, Savithri HS, Murthy MR, FEBS J. 2008 Dec;275(23):5855-64.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19021761 19021761]~~	+	<ref group="xtra">PMID:019021761</ref><references group="xtra"/>
-	[[Category: Salmonella typhimurium]]	+	[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
	[[Category: Anju, P.]]		[[Category: Anju, P.]]
	[[Category: Murthy, M R.N.]]		[[Category: Murthy, M R.N.]]
	[[Category: Savithri, H S.]]		[[Category: Savithri, H S.]]
-	[[Category: Cytoplasm]]
	[[Category: Divalent metal ion]]		[[Category: Divalent metal ion]]
	[[Category: Domain swapping]]		[[Category: Domain swapping]]
Line 41:		Line 39:
	[[Category: Sur e]]		[[Category: Sur e]]
	[[Category: Survival protein]]		[[Category: Survival protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 14:53:44 2008''