2v5m - Revision history

OCA at 20:57, 20 October 2021

2021-10-20T20:57:46Z

←Older revision		Revision as of 20:57, 20 October 2021
Line 3:		Line 3:
	<StructureSection load='2v5m' size='340' side='right'caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2v5m' size='340' side='right'caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [~~http~~://pdbe.org/2v5m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v5m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [https://pdbe.org/2v5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [https://www.ebi.ac.uk/pdbsum/2v5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5m ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:13, 23 October 2019

2019-10-23T07:13:01Z

←Older revision		Revision as of 07:13, 23 October 2019
Line 1:		Line 1:

	==Structural basis for Dscam isoform specificity==		==Structural basis for Dscam isoform specificity==
-	<StructureSection load='2v5m' size='340' side='right' caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='2v5m' size='340' side='right'caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Liu, J H]]		[[Category: Liu, J H]]
	[[Category: Meijers, R]]		[[Category: Meijers, R]]

OCA at 08:31, 12 September 2018

2018-09-12T08:31:28Z

←Older revision		Revision as of 08:31, 12 September 2018
Line 1:		Line 1:
-	==~~STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY~~==	+
		+	==Structural basis for Dscam isoform specificity==
	<StructureSection load='2v5m' size='340' side='right' caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2v5m' size='340' side='right' caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://pdbe.org/2v5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://pdbe.org/2v5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5m ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5m_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5m_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:28, 8 February 2016

2016-02-08T18:28:01Z

←Older revision		Revision as of 18:28, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2v5m' size='340' side='right' caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2v5m' size='340' side='right' caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://pdbe.org/2v5m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v5m ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v5m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Liu, J H]]		[[Category: Liu, J H]]
	[[Category: Meijers, R]]		[[Category: Meijers, R]]

OCA at 15:31, 19 January 2015

2015-01-19T15:31:36Z

←Older revision		Revision as of 15:31, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Liu, J H.]]	+	[[Category: Liu, J H]]
-	[[Category: Meijers, R.]]	+	[[Category: Meijers, R]]
-	[[Category: Puettmann-Holgado, R.]]	+	[[Category: Puettmann-Holgado, R]]
-	[[Category: Schmucker, D.]]	+	[[Category: Schmucker, D]]
-	[[Category: Skiniotis, G.]]	+	[[Category: Skiniotis, G]]
-	[[Category: Walz, T.]]	+	[[Category: Walz, T]]
-	[[Category: Wang, J H.]]	+	[[Category: Wang, J H]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]

OCA at 02:01, 1 October 2014

2014-10-01T02:01:35Z

←Older revision		Revision as of 02:01, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2v5m.~~png\|left~~\|200px]]	+	==STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY==
		+	<StructureSection load='2v5m' size='340' side='right' caption='[[2v5m]], [[Resolution\|resolution]] 1.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5m RCSB], [http://www.ebi.ac.uk/pdbsum/2v5m PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5m_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Dscam gene gives rise to thousands of diverse cell surface receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring and immune responses. Mutually exclusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domains, D2, D3 and D7. We report X-ray structures of the amino-terminal four immunoglobulin domains (D1-D4) of two distinct Dscam isoforms. The structures reveal a horseshoe configuration, with variable residues of D2 and D3 constituting two independent surface epitopes on either side of the receptor. Both isoforms engage in homo-dimerization coupling variable domain D2 with D2, and D3 with D3. These interactions involve symmetric, antiparallel pairing of identical peptide segments from epitope I that are unique to each isoform. Structure-guided mutagenesis and swapping of peptide segments confirm that epitope I, but not epitope II, confers homophilic binding specificity of full-length Dscam receptors. Phylogenetic analysis shows strong selection of matching peptide sequences only for epitope I. We propose that peptide complementarity of variable residues in epitope I of Dscam is essential for homophilic binding specificity.

-	~~{{STRUCTURE_2v5m\| PDB=2v5m \| SCENE= }}~~	+	Structural basis of Dscam isoform specificity.,Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D Nature. 2007 Sep 27;449(7161):487-91. Epub 2007 Aug 26. PMID:17721508<ref>PMID:17721508</ref>

-	~~===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17721508}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2v5m]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017721508<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Liu, J H.]]		[[Category: Liu, J H.]]

OCA: Protected "2v5m" [edit=sysop:move=sysop]

2013-01-07T21:28:20Z

Protected "2v5m" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:28, 7 January 2013

OCA at 21:28, 7 January 2013

2013-01-07T21:28:19Z

←Older revision		Revision as of 21:28, 7 January 2013
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-	{{Seed}}
	[[Image:2v5m.png\|left\|200px]]		[[Image:2v5m.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v5m", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v5m\| PDB=2v5m \| SCENE= }}		{{STRUCTURE_2v5m\| PDB=2v5m \| SCENE= }}

	===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===		===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17721508}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17721508 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17721508}}		{{ABSTRACT_PUBMED_17721508}}

	==About this Structure==		==About this Structure==
-	~~2V5M~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA].	+	[[2v5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17721508~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017721508</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Liu, J H.]]		[[Category: Liu, J H.]]
Line 38:		Line 26:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Neurobiology spl]]		[[Category: Neurobiology spl]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:29:22 2009''

OCA at 23:29, 16 February 2009

2009-02-16T23:29:32Z

←Older revision		Revision as of 23:29, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2V5M is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA].	+	2V5M is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5M OCA].

	==Reference==		==Reference==
-	~~Structural basis of Dscam isoform specificity., Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D, Nature. 2007 Sep 27;449(7161):487-91. Epub 2007 Aug 26.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17721508 17721508]~~	+	<ref group="xtra">PMID:17721508</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Single protein]]
	[[Category: Liu, J H.]]		[[Category: Liu, J H.]]
	[[Category: Meijers, R.]]		[[Category: Meijers, R.]]
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	[[Category: Neurobiology spl]]		[[Category: Neurobiology spl]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 05~~:42:~~07 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:29:22 2009''

OCA at 02:42, 28 July 2008

2008-07-28T02:42:14Z

←Older revision		Revision as of 02:42, 28 July 2008
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-	[[Image:2v5m.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2v5m.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2v5m\| PDB=2v5m \| SCENE= }}		{{STRUCTURE_2v5m\| PDB=2v5m \| SCENE= }}

-	~~'''~~STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY~~'''~~	+	===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===


-	~~==Overview==~~	+	<!--
-	The Dscam gene gives rise to thousands of diverse cell surface receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring and immune responses. Mutually exclusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domains, D2, ~~D3 and D7. We report X-ray structures of~~ the ~~amino-terminal four immunoglobulin domains~~ (~~D1-D4) of two distinct Dscam isoforms. The structures reveal a horseshoe configuration, with variable residues of D2 and D3 constituting two independent surface epitopes~~ on ~~either side of the receptor~~. ~~Both isoforms engage in homo-dimerization coupling variable domain D2 with D2, and D3 with D3~~. ~~These interactions involve symmetric~~, ~~antiparallel pairing of identical peptide segments from epitope I that are unique to each isoform~~. ~~Structure~~-~~guided mutagenesis and swapping of peptide segments confirm that epitope I, but not epitope II, confers homophilic binding specificity of full~~-length Dscam receptors. Phylogenetic analysis shows strong selection of matching peptide sequences only for epitope I. We propose that peptide complementarity of variable residues in epitope I of Dscam is essential for homophilic binding specificity.	+	The line below this paragraph, {{ABSTRACT_PUBMED_17721508}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 17721508 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_17721508}}

	==About this Structure==		==About this Structure==
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	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Neurobiology spl]]		[[Category: Neurobiology spl]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:12:57 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:42:07 2008''