2v5s - Revision history

OCA at 15:06, 13 December 2023

2023-12-13T15:06:41Z

←Older revision		Revision as of 15:06, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2v5s' size='340' side='right'caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2v5s' size='340' side='right'caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5S FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2v5m\|2v5m]], [[2v5r\|2v5r]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [https://pdbe.org/2v5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [https://www.ebi.ac.uk/pdbsum/2v5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [https://pdbe.org/2v5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [https://www.ebi.ac.uk/pdbsum/2v5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5s ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9NBA1_DROME Q9NBA1_DROME]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, J H]]	+	[[Category: Liu J-H]]
-	[[Category: Meijers, R]]	+	[[Category: Meijers R]]
-	[[Category: Puettmann-Holgado, R]]	+	[[Category: Puettmann-Holgado R]]
-	[[Category: Schmucker, D]]	+	[[Category: Schmucker D]]
-	[[Category: Skiniotis, G]]	+	[[Category: Skiniotis G]]
-	[[Category: Walz, T]]	+	[[Category: Walz T]]
-	[[Category: Wang, J H]]	+	[[Category: Wang J-H]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Down syndrome]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Membrane~~]]	+

OCA at 20:58, 20 October 2021

2021-10-20T20:58:04Z

←Older revision		Revision as of 20:58, 20 October 2021
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	<StructureSection load='2v5s' size='340' side='right'caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2v5s' size='340' side='right'caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2V5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V5S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2v5m\|2v5m]], [[2v5r\|2v5r]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [~~http~~://pdbe.org/2v5s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2v5s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5s ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [https://pdbe.org/2v5s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [https://www.ebi.ac.uk/pdbsum/2v5s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:13, 23 October 2019

2019-10-23T07:13:06Z

←Older revision		Revision as of 07:13, 23 October 2019
Line 1:		Line 1:

	==Structural basis for Dscam isoform specificity==		==Structural basis for Dscam isoform specificity==
-	<StructureSection load='2v5s' size='340' side='right' caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2v5s' size='340' side='right'caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Liu, J H]]		[[Category: Liu, J H]]
	[[Category: Meijers, R]]		[[Category: Meijers, R]]

OCA at 08:45, 12 September 2018

2018-09-12T08:45:14Z

←Older revision		Revision as of 08:45, 12 September 2018
Line 1:		Line 1:
-	==~~STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY~~==	+
		+	==Structural basis for Dscam isoform specificity==
	<StructureSection load='2v5s' size='340' side='right' caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2v5s' size='340' side='right' caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://pdbe.org/2v5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://pdbe.org/2v5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2v5s ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5s_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5s_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:07, 7 February 2016

2016-02-07T03:07:28Z

←Older revision		Revision as of 03:07, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2v5s' size='340' side='right' caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2v5s' size='340' side='right' caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://pdbe.org/2v5s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v5s ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2v5s" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drosophila melanogaster~~]]	+	[[Category: Drome]]
	[[Category: Liu, J H]]		[[Category: Liu, J H]]
	[[Category: Meijers, R]]		[[Category: Meijers, R]]

OCA at 14:01, 19 January 2015

2015-01-19T14:01:11Z

←Older revision		Revision as of 14:01, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>		<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Liu, J H.]]	+	[[Category: Liu, J H]]
-	[[Category: Meijers, R.]]	+	[[Category: Meijers, R]]
-	[[Category: Puettmann-Holgado, R.]]	+	[[Category: Puettmann-Holgado, R]]
-	[[Category: Schmucker, D.]]	+	[[Category: Schmucker, D]]
-	[[Category: Skiniotis, G.]]	+	[[Category: Skiniotis, G]]
-	[[Category: Walz, T.]]	+	[[Category: Walz, T]]
-	[[Category: Wang, J H.]]	+	[[Category: Wang, J H]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]

OCA at 01:36, 1 October 2014

2014-10-01T01:36:01Z

←Older revision		Revision as of 01:36, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2v5s.~~png~~\|~~left~~\|200px]]	+	==STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY==
		+	<StructureSection load='2v5s' size='340' side='right' caption='[[2v5s]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V5S FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2v5m\|2v5m]], [[2v5r\|2v5r]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v5s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v5s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v5s RCSB], [http://www.ebi.ac.uk/pdbsum/2v5s PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v5/2v5s_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Dscam gene gives rise to thousands of diverse cell surface receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring and immune responses. Mutually exclusive splicing allows for the generation of sequence variability in three immunoglobulin ecto-domains, D2, D3 and D7. We report X-ray structures of the amino-terminal four immunoglobulin domains (D1-D4) of two distinct Dscam isoforms. The structures reveal a horseshoe configuration, with variable residues of D2 and D3 constituting two independent surface epitopes on either side of the receptor. Both isoforms engage in homo-dimerization coupling variable domain D2 with D2, and D3 with D3. These interactions involve symmetric, antiparallel pairing of identical peptide segments from epitope I that are unique to each isoform. Structure-guided mutagenesis and swapping of peptide segments confirm that epitope I, but not epitope II, confers homophilic binding specificity of full-length Dscam receptors. Phylogenetic analysis shows strong selection of matching peptide sequences only for epitope I. We propose that peptide complementarity of variable residues in epitope I of Dscam is essential for homophilic binding specificity.

-	~~{{STRUCTURE_2v5s\| PDB=2v5s \| SCENE= }}~~	+	Structural basis of Dscam isoform specificity.,Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D Nature. 2007 Sep 27;449(7161):487-91. Epub 2007 Aug 26. PMID:17721508<ref>PMID:17721508</ref>

-	~~===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_17721508}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2v5s]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:017721508<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Liu, J H.]]		[[Category: Liu, J H.]]

OCA: Protected "2v5s" [edit=sysop:move=sysop]

2013-01-07T18:14:49Z

Protected "2v5s" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:14, 7 January 2013

OCA at 18:14, 7 January 2013

2013-01-07T18:14:46Z

←Older revision		Revision as of 18:14, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2v5s.png\|left\|200px]]		[[Image:2v5s.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2v5s", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2v5s\| PDB=2v5s \| SCENE= }}		{{STRUCTURE_2v5s\| PDB=2v5s \| SCENE= }}

	===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===		===STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17721508}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17721508 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17721508}}		{{ABSTRACT_PUBMED_17721508}}

	==About this Structure==		==About this Structure==
-	~~2V5S~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA].	+	[[2v5s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17721508~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017721508</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Liu, J H.]]		[[Category: Liu, J H.]]
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	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
-	[[Category: Down syndrome ~~cell adhesion molecule dscam~~]]	+	[[Category: Down syndrome]]
	[[Category: Immunoglobulin domain]]		[[Category: Immunoglobulin domain]]
	[[Category: Membrane]]		[[Category: Membrane]]
-	[[Category: Neurobiology spl]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:38:44 2009''

OCA at 08:38, 16 February 2009

2009-02-16T08:38:46Z

←Older revision		Revision as of 08:38, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2V5S is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA].	+	2V5S is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V5S OCA].

	==Reference==		==Reference==
-	~~Structural basis of Dscam isoform specificity., Meijers R, Puettmann-Holgado R, Skiniotis G, Liu JH, Walz T, Wang JH, Schmucker D, Nature. 2007 Sep 27;449(7161):487-91. Epub 2007 Aug 26.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17721508 17721508]~~	+	<ref group="xtra">PMID:17721508</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
-	[[Category: Single protein]]
	[[Category: Liu, J H.]]		[[Category: Liu, J H.]]
	[[Category: Meijers, R.]]		[[Category: Meijers, R.]]
Line 40:		Line 39:
	[[Category: Neurobiology spl]]		[[Category: Neurobiology spl]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 12~~:50:~~32 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:38:44 2009''