2vca - Revision history

OCA at 09:57, 9 May 2024

2024-05-09T09:57:42Z

←Older revision		Revision as of 09:57, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2vca' size='340' side='right'caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2vca' size='340' side='right'caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus~~ perfringens~~" veillon and zuber 1898~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [https://pdbe.org/2vca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [https://www.ebi.ac.uk/pdbsum/2vca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [https://pdbe.org/2vca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [https://www.ebi.ac.uk/pdbsum/2vca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2YU91_CLOP1 A0A0H2YU91_CLOP1]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ perfringens ~~veillon and zuber 1898]]~~	+	[[Category: Clostridium perfringens]]
-	~~[[Category: Alpha-N-acetylglucosaminidase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berg, O]]	+	[[Category: Berg O]]
-	[[Category: Boraston~~, A B~~]]	+	[[Category: Boraston AB]]
-	[[Category: Ficko-Blean, E]]	+	[[Category: Ficko-Blean E]]
-	[[Category: Stubbs~~, K A~~]]	+	[[Category: Stubbs KA]]
-	[[Category: Vocadlo~~, D J]]~~	+	[[Category: Vocadlo DJ]]
-	~~[[Category: Alpha-n-acetylglucosaminidase]]~~	+
-	~~[[Category: Beta-n-acetyl-d-glucosamine]]~~	+
-	~~[[Category: Family 89 glycoside hydrolase]]~~	+
-	~~[[Category: Gh89]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mucopolysaccharidosis]]~~	+
-	~~[[Category: Naglu]]~~	+
-	~~[[Category: Sanfilippo disease~~]]	+

OCA at 11:34, 30 March 2022

2022-03-30T11:34:03Z

←Older revision		Revision as of 11:34, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='2vca' size='340' side='right'caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2vca' size='340' side='right'caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VCA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [~~http~~://pdbe.org/2vca PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vca PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [https://pdbe.org/2vca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [https://www.ebi.ac.uk/pdbsum/2vca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:44, 25 June 2020

2020-06-25T07:44:05Z

←Older revision		Revision as of 07:44, 25 June 2020
Line 1:		Line 1:

	==Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine==		==Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine==
-	<StructureSection load='2vca' size='340' side='right' caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='2vca' size='340' side='right'caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VCA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VCA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://pdbe.org/2vca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://pdbe.org/2vca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 34:		Line 34:
	[[Category: Bacillus perfringens veillon and zuber 1898]]		[[Category: Bacillus perfringens veillon and zuber 1898]]
	[[Category: Alpha-N-acetylglucosaminidase]]		[[Category: Alpha-N-acetylglucosaminidase]]
		+	[[Category: Large Structures]]
	[[Category: Berg, O]]		[[Category: Berg, O]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]

OCA at 20:41, 19 September 2018

2018-09-19T20:41:56Z

←Older revision		Revision as of 20:41, 19 September 2018
Line 1:		Line 1:
-	==~~FAMILY~~ 89 ~~GLYCOSIDE HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH BETA~~-N-~~ACETYL~~-D-~~GLUCOSAMINE~~==	+
		+	==Family 89 glycoside hydrolase from Clostridium perfringens in complex with beta-N-acetyl-D-glucosamine==
	<StructureSection load='2vca' size='340' side='right' caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2vca' size='340' side='right' caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://pdbe.org/2vca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://pdbe.org/2vca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vca ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vca_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vca_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:06, 8 February 2016

2016-02-08T18:06:35Z

←Older revision		Revision as of 18:06, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2vca' size='340' side='right' caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2vca' size='340' side='right' caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_perfringens Clostridium~~ perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://pdbe.org/2vca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vca ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vca" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus perfringens veillon and zuber 1898]]
	[[Category: Alpha-N-acetylglucosaminidase]]		[[Category: Alpha-N-acetylglucosaminidase]]
-	[[Category: Clostridium perfringens]]
	[[Category: Berg, O]]		[[Category: Berg, O]]
	[[Category: Boraston, A B]]		[[Category: Boraston, A B]]

OCA at 15:06, 19 January 2015

2015-01-19T15:06:21Z

←Older revision		Revision as of 15:06, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Alpha-N-acetylglucosaminidase]]		[[Category: Alpha-N-acetylglucosaminidase]]
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
-	[[Category: Berg, O.]]	+	[[Category: Berg, O]]
-	[[Category: Boraston, A B.]]	+	[[Category: Boraston, A B]]
-	[[Category: Ficko-Blean, E.]]	+	[[Category: Ficko-Blean, E]]
-	[[Category: Stubbs, K A.]]	+	[[Category: Stubbs, K A]]
-	[[Category: Vocadlo, D J.]]	+	[[Category: Vocadlo, D J]]
	[[Category: Alpha-n-acetylglucosaminidase]]		[[Category: Alpha-n-acetylglucosaminidase]]
	[[Category: Beta-n-acetyl-d-glucosamine]]		[[Category: Beta-n-acetyl-d-glucosamine]]

OCA at 01:53, 1 October 2014

2014-10-01T01:53:47Z

←Older revision		Revision as of 01:53, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vca.~~png~~\|~~left~~\|200px]]	+	==FAMILY 89 GLYCOSIDE HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH BETA-N-ACETYL-D-GLUCOSAMINE==
		+	<StructureSection load='2vca' size='340' side='right' caption='[[2vca]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vc9\|2vc9]], [[2vcb\|2vcb]], [[2vcc\|2vcc]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-N-acetylglucosaminidase Alpha-N-acetylglucosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.50 3.2.1.50] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vca OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vca RCSB], [http://www.ebi.ac.uk/pdbsum/2vca PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vca_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mucopolysaccharidosis III (MPS III) has four forms (A-D) that result from buildup of an improperly degraded glycosaminoglycan in lysosomes. MPS IIIB is attributable to the decreased activity of a lysosomal alpha-N-acetylglucosaminidase (NAGLU). Here, we describe the structure, catalytic mechanism, and inhibition of CpGH89 from Clostridium perfringens, a close bacterial homolog of NAGLU. The structure enables the generation of a homology model of NAGLU, an enzyme that has resisted structural studies despite having been studied for >20 years. This model reveals which mutations giving rise to MPS IIIB map to the active site and which map to regions distant from the active site. The identification of potent inhibitors of CpGH89 and the structures of these inhibitors in complex with the enzyme suggest small-molecule candidates for use as chemical chaperones. These studies therefore illuminate the genetic basis of MPS IIIB, provide a clear biochemical rationale for the necessary sequential action of heparan-degrading enzymes, and open the door to the design and optimization of chemical chaperones for treating MPS IIIB.

-	~~{{STRUCTURE_2vca\| PDB=2vca \| SCENE= }}~~	+	Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB.,Ficko-Blean E, Stubbs KA, Nemirovsky O, Vocadlo DJ, Boraston AB Proc Natl Acad Sci U S A. 2008 May 6;105(18):6560-5. Epub 2008 Apr 28. PMID:18443291<ref>PMID:18443291</ref>

-	~~===FAMILY 89 GLYCOSIDE HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH BETA-N-ACETYL-D-GLUCOSAMINE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18443291}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vca]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_perfringens Clostridium perfringens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018443291<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alpha-N-acetylglucosaminidase]]		[[Category: Alpha-N-acetylglucosaminidase]]
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]

OCA: Protected "2vca" [edit=sysop:move=sysop]

2013-01-07T21:20:48Z

Protected "2vca" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:20, 7 January 2013

OCA at 21:20, 7 January 2013

2013-01-07T21:20:45Z

←Older revision		Revision as of 21:20, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vca.png\|left\|200px]]		[[Image:2vca.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vca", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vca\| PDB=2vca \| SCENE= }}		{{STRUCTURE_2vca\| PDB=2vca \| SCENE= }}

	===FAMILY 89 GLYCOSIDE HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH BETA-N-ACETYL-D-GLUCOSAMINE===		===FAMILY 89 GLYCOSIDE HYDROLASE FROM CLOSTRIDIUM PERFRINGENS IN COMPLEX WITH BETA-N-ACETYL-D-GLUCOSAMINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18443291}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18443291 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18443291}}		{{ABSTRACT_PUBMED_18443291}}

	==About this Structure==		==About this Structure==
-	~~2VCA~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA].	+	[[2vca]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18443291~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018443291</ref><references group="xtra"/>
	[[Category: Alpha-N-acetylglucosaminidase]]		[[Category: Alpha-N-acetylglucosaminidase]]
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
Line 39:		Line 27:
	[[Category: Naglu]]		[[Category: Naglu]]
	[[Category: Sanfilippo disease]]		[[Category: Sanfilippo disease]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:00:18 2009''

OCA at 23:00, 16 February 2009

2009-02-16T23:00:19Z

←Older revision		Revision as of 23:00, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VCA is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA].	+	2VCA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCA OCA].

	==Reference==		==Reference==
-	Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB., Ficko-Blean E, Stubbs KA, Nemirovsky O, Vocadlo DJ, Boraston AB, Proc Natl Acad Sci U S A. 2008 May 6;105(18):6560-5. Epub 2008 Apr 28. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18443291 18443291]~~	+	<ref group="xtra">PMID:18443291</ref><references group="xtra"/>
	[[Category: Alpha-N-acetylglucosaminidase]]		[[Category: Alpha-N-acetylglucosaminidase]]
	[[Category: Clostridium perfringens]]		[[Category: Clostridium perfringens]]
-	[[Category: Single protein]]
	[[Category: Berg, O.]]		[[Category: Berg, O.]]
	[[Category: Boraston, A B.]]		[[Category: Boraston, A B.]]
Line 41:		Line 40:
	[[Category: Sanfilippo disease]]		[[Category: Sanfilippo disease]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 05~~:32:~~55 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 01:00:18 2009''