2vcx - Revision history

OCA at 15:15, 13 December 2023

2023-12-13T15:15:40Z

←Older revision		Revision as of 15:15, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vcx' size='340' side='right'caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vcx' size='340' side='right'caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)~~-1~~,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [https://pdbe.org/2vcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [https://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [https://pdbe.org/2vcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [https://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>	+	[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Prostaglandin-D synthase]]~~	+	[[Category: Dahmen J]]
-	[[Category: Dahmen, J]]	+	[[Category: Edman K]]
-	[[Category: Edman, K]]	+	[[Category: Folmer RHA]]
-	[[Category: Folmer~~, R H.A~~]]	+	[[Category: Groth-Clausen I]]
-	[[Category: Groth-Clausen, I]]	+	[[Category: Hawtin P]]
-	[[Category: Hawtin, P]]	+	[[Category: Hohwy M]]
-	[[Category: Hohwy, M]]	+	[[Category: Lundquist B]]
-	[[Category: Lundquist, B]]	+	[[Category: Persdotter S]]
-	[[Category: Persdotter, S]]	+	[[Category: Spadola L]]
-	[[Category: Spadola, L]]	+	[[Category: Von Wachenfeldt K]]
-	[[Category: Wachenfeldt, K ~~von]]~~	+
-	~~[[Category: Asthma]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Pgd]]~~	+
-	~~[[Category: Prostaglandin biosynthesis]]~~	+
-	~~[[Category: Prostaglandin d2 synthase~~]]	+

OCA at 11:34, 30 March 2022

2022-03-30T11:34:21Z

←Older revision		Revision as of 11:34, 30 March 2022
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	<StructureSection load='2vcx' size='340' side='right'caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vcx' size='340' side='right'caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VCX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [~~http~~://pdbe.org/2vcx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [https://pdbe.org/2vcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [https://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>	+	[[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:46, 25 June 2020

2020-06-25T07:46:03Z

←Older revision		Revision as of 07:46, 25 June 2020
Line 1:		Line 1:

	==Complex structure of prostaglandin D2 synthase at 2.1A.==		==Complex structure of prostaglandin D2 synthase at 2.1A.==
-	<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2vcx' size='340' side='right'caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VCX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://pdbe.org/2vcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://pdbe.org/2vcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Glutathione S-transferase\|Glutathione S-transferase]]	+	*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
	[[Category: Dahmen, J]]		[[Category: Dahmen, J]]

OCA at 20:34, 19 September 2018

2018-09-19T20:34:30Z

←Older revision		Revision as of 20:34, 19 September 2018
Line 1:		Line 1:
-	==~~COMPLEX STRUCTURE OF PROSTAGLANDIN~~ D2 ~~SYNTHASE AT~~ 2.1A.==	+
		+	==Complex structure of prostaglandin D2 synthase at 2.1A.==
	<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://pdbe.org/2vcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://pdbe.org/2vcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	==See Also==		==See Also==
	*[[Glutathione S-transferase\|Glutathione S-transferase]]		*[[Glutathione S-transferase\|Glutathione S-transferase]]
-	*[[Prostaglandin D synthase\|Prostaglandin D synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 48:		Line 48:
	[[Category: Persdotter, S]]		[[Category: Persdotter, S]]
	[[Category: Spadola, L]]		[[Category: Spadola, L]]
-	[[Category: Wachenfeldt, K ~~Von~~]]	+	[[Category: Wachenfeldt, K von]]
	[[Category: Asthma]]		[[Category: Asthma]]
		+	[[Category: Cytoplasm]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 00:31, 9 February 2016

2016-02-09T00:31:19Z

←Older revision		Revision as of 00:31, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://pdbe.org/2vcx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~PTGD2_HUMAN PTGD2_HUMAN~~]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>	+	[[http://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vcx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vcx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
	[[Category: Dahmen, J]]		[[Category: Dahmen, J]]

OCA at 03:13, 25 December 2014

2014-12-25T03:13:17Z

←Older revision		Revision as of 03:13, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTGD2_HUMAN PTGD2_HUMAN]] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
-	[[Category: Dahmen, J.]]	+	[[Category: Dahmen, J]]
-	[[Category: Edman, K.]]	+	[[Category: Edman, K]]
-	[[Category: Folmer, R H.A.]]	+	[[Category: Folmer, R H.A]]
-	[[Category: Groth-Clausen, I.]]	+	[[Category: Groth-Clausen, I]]
-	[[Category: Hawtin, P.]]	+	[[Category: Hawtin, P]]
-	[[Category: Hohwy, M.]]	+	[[Category: Hohwy, M]]
-	[[Category: Lundquist, B.]]	+	[[Category: Lundquist, B]]
-	[[Category: Persdotter, S.]]	+	[[Category: Persdotter, S]]
-	[[Category: Spadola, L.]]	+	[[Category: Spadola, L]]
-	[[Category: Wachenfeldt, K Von.]]	+	[[Category: Wachenfeldt, K Von]]
	[[Category: Asthma]]		[[Category: Asthma]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]

OCA at 07:19, 29 September 2014

2014-09-29T07:19:11Z

←Older revision		Revision as of 07:19, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2vcx.~~png~~\|~~left~~\|200px]]	+	==COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.==
		+	<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1v40\|1v40]], [[2vcq\|2vcq]], [[2vcw\|2vcw]], [[1iyh\|1iyh]], [[1iyi\|1iyi]], [[2vcz\|2vcz]], [[2vd0\|2vd0]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We describe the discovery of novel inhibitors of prostaglandin D2 synthase (PGDS) through fragment-based lead generation and structure-based drug design. A library of 2500 low-molecular-weight compounds was screened using 2D nuclear magnetic resonance (NMR), leading to the identification of 24 primary hits. Structure determination of protein-ligand complexes with the hits enabled a hit optimization process, whereby we harvested increasingly more potent inhibitors out of our corporate compound collection. Two iterative cycles were carried out, comprising NMR screening, molecular modeling, X-ray crystallography, and in vitro biochemical testing. Six novel high-resolution PGDS complex structures were determined, and 300 hit analogues were tested. This rational drug design procedure culminated in the discovery of 24 compounds with an IC 50 below 1 microM in the in vitro assay. The best inhibitor (IC 50 = 21 nM) is one of the most potent inhibitors of PGDS to date. As such, it may enable new functional in vivo studies of PGDS and the prostaglandin metabolism pathway.

-	~~{{STRUCTURE_2vcx\| PDB=2vcx \| SCENE= }}~~	+	Novel prostaglandin d synthase inhibitors generated by fragment-based drug design.,Hohwy M, Spadola L, Lundquist B, Hawtin P, Dahmen J, Groth-Clausen I, Nilsson E, Persdotter S, von Wachenfeldt K, Folmer RH, Edman K J Med Chem. 2008 Apr 10;51(7):2178-86. Epub 2008 Mar 15. PMID:18341273<ref>PMID:18341273</ref>

-	~~===COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18341273}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vcx]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA].~~	+

	==See Also==		==See Also==
		+	*[[Glutathione S-transferase\|Glutathione S-transferase]]
	*[[Prostaglandin D synthase\|Prostaglandin D synthase]]		*[[Prostaglandin D synthase\|Prostaglandin D synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:018341273<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]

OCA at 12:00, 20 October 2012

2012-10-20T12:00:32Z

←Older revision		Revision as of 12:00, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vcx]] is a 4 chain structure ~~of [[Prostaglandin D synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA].	+	[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA].

	==See Also==		==See Also==

OCA: Protected "2vcx" [edit=sysop:move=sysop]

2012-07-26T07:19:13Z

Protected "2vcx" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:19, 26 July 2012

OCA at 07:19, 26 July 2012

2012-07-26T07:19:11Z

←Older revision		Revision as of 07:19, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vcx.png\|left\|200px]]		[[Image:2vcx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vcx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vcx\| PDB=2vcx \| SCENE= }}		{{STRUCTURE_2vcx\| PDB=2vcx \| SCENE= }}

	===COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.===		===COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18341273}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18341273 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18341273}}		{{ABSTRACT_PUBMED_18341273}}

	==About this Structure==		==About this Structure==
-	~~2VCX~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA].	+	[[2vcx]] is a 4 chain structure of [[Prostaglandin D synthase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA].
		+
		+	==See Also==
		+	*[[Prostaglandin D synthase\|Prostaglandin D synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18341273~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018341273</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Prostaglandin-D synthase]]		[[Category: Prostaglandin-D synthase]]
Line 37:		Line 28:
	[[Category: Wachenfeldt, K Von.]]		[[Category: Wachenfeldt, K Von.]]
	[[Category: Asthma]]		[[Category: Asthma]]
-	[[Category: Cytoplasm]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
Line 44:		Line 34:
	[[Category: Prostaglandin biosynthesis]]		[[Category: Prostaglandin biosynthesis]]
	[[Category: Prostaglandin d2 synthase]]		[[Category: Prostaglandin d2 synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:54:17 2009''