2vft - Revision history

OCA at 15:18, 13 December 2023

2023-12-13T15:18:54Z

←Older revision		Revision as of 15:18, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vft' size='340' side='right'caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vft' size='340' side='right'caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Strco Strco~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFT FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [https://pdbe.org/2vft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [https://www.ebi.ac.uk/pdbsum/2vft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [https://pdbe.org/2vft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [https://www.ebi.ac.uk/pdbsum/2vft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/XYOA_STRCO XYOA_STRCO] Oxidase that performs selective oxidation of the terminal primary hydroxyl group of several alditols, with a reduction of O2 to H2O2. Shows highest activity on xylitol and D-sorbitol, and a poor efficiency with D-mannitol and L-threitol.<ref>PMID:17517896</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alditol oxidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Strco]]~~	+	[[Category: Forneris F]]
-	[[Category: Forneris, F]]	+	[[Category: Mattevi A]]
-	[[Category: Mattevi, A]]	+
-	~~[[Category: Fad]]~~	+
-	~~[[Category: Flavin]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Oxidase]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Polyol]]~~	+
-	~~[[Category: Sugar~~]]	+

OCA at 11:36, 30 March 2022

2022-03-30T11:36:28Z

←Older revision		Revision as of 11:36, 30 March 2022
Line 3:		Line 3:
	<StructureSection load='2vft' size='340' side='right'caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vft' size='340' side='right'caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [~~http~~://pdbe.org/2vft PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vft PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [https://pdbe.org/2vft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [https://www.ebi.ac.uk/pdbsum/2vft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:52, 25 June 2020

2020-06-25T07:52:21Z

←Older revision		Revision as of 07:52, 25 June 2020
Line 1:		Line 1:

	==Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sorbitol==		==Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sorbitol==
-	<StructureSection load='2vft' size='340' side='right' caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2vft' size='340' side='right'caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VFT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://pdbe.org/2vft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://pdbe.org/2vft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Alditol oxidase]]		[[Category: Alditol oxidase]]
		+	[[Category: Large Structures]]
	[[Category: Strco]]		[[Category: Strco]]
	[[Category: Forneris, F]]		[[Category: Forneris, F]]

OCA at 21:27, 19 September 2018

2018-09-19T21:27:06Z

←Older revision		Revision as of 21:27, 19 September 2018
Line 1:		Line 1:
-	==~~ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR~~ A3(2): ~~COMPLEX WITH SORBITOL~~==	+
		+	==Alditol Oxidase from Streptomyces coelicolor A3(2): Complex with Sorbitol==
	<StructureSection load='2vft' size='340' side='right' caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vft' size='340' side='right' caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://pdbe.org/2vft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://pdbe.org/2vft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vft ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vft_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vft_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:02, 8 February 2016

2016-02-08T14:02:58Z

←Older revision		Revision as of 14:02, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2vft' size='340' side='right' caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vft' size='340' side='right' caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptomyces_coelicolor Streptomyces coelicolor~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strco Strco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://pdbe.org/2vft PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vft ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vft" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Alditol oxidase]]		[[Category: Alditol oxidase]]
-	[[Category: ~~Streptomyces coelicolor~~]]	+	[[Category: Strco]]
	[[Category: Forneris, F]]		[[Category: Forneris, F]]
	[[Category: Mattevi, A]]		[[Category: Mattevi, A]]

OCA at 17:12, 19 January 2015

2015-01-19T17:12:14Z

←Older revision		Revision as of 17:12, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFT FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Alditol oxidase]]		[[Category: Alditol oxidase]]
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
-	[[Category: Forneris, F.]]	+	[[Category: Forneris, F]]
-	[[Category: Mattevi, A.]]	+	[[Category: Mattevi, A]]
	[[Category: Fad]]		[[Category: Fad]]
	[[Category: Flavin]]		[[Category: Flavin]]

OCA at 01:45, 1 October 2014

2014-10-01T01:45:35Z

←Older revision		Revision as of 01:45, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vft.~~png~~\|~~left~~\|200px]]	+	==ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH SORBITOL==
		+	<StructureSection load='2vft' size='340' side='right' caption='[[2vft]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VFT FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SOR:D-SORBITOL'>SOR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vfr\|2vfr]], [[2vfs\|2vfs]], [[2vfu\|2vfu]], [[2vfv\|2vfv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alditol_oxidase Alditol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.3.41 1.1.3.41] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vft OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vft RCSB], [http://www.ebi.ac.uk/pdbsum/2vft PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vf/2vft_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Alditol oxidase (AldO) from Streptomyces coelicolor A3(2) is a soluble monomeric flavin-dependent oxidase that performs selective oxidation of the terminal primary hydroxyl group of several alditols. Here, we report the crystal structure of the recombinant enzyme in its native state and in complex with both six-carbon (mannitol and sorbitol) and five-carbon substrates (xylitol). AldO shares the same folding topology of the members of the vanillyl-alcohol oxidase family of flavoenzymes and exhibits a covalently linked FAD which is located at the bottom of a funnel-shaped pocket that forms the active site. The high resolution of the three-dimensional structures highlights a well-defined hydrogen-bonding network that tightly constrains the substrate in the productive conformation for catalysis. Substrate binding occurs through a lock-and-key mechanism and does not induce conformational changes with respect to the ligand-free protein. A network of charged residues is proposed to favor catalysis through stabilization of the deprotonated form of the substrate. A His side chain acts as back door that "pushes" the substrate-reactive carbon atom toward the N5-C4a locus of the flavin. Analysis of the three-dimensional structure reveals possible pathways for diffusion of molecular oxygen and a small cavity on the re side of the flavin that may host oxygen during FAD reoxidation. These features combined with the tight shape of the catalytic site provide insights into the mechanism of AldO-mediated regioselective oxidation reactions and its substrate specificity.

-	~~{{STRUCTURE_2vft\| PDB=2vft \| SCENE= }}~~	+	Structural Analysis of the Catalytic Mechanism and Stereoselectivity in Streptomyces coelicolor Alditol Oxidase(,).,Forneris F, Heuts DP, Delvecchio M, Rovida S, Fraaije MW, Mattevi A Biochemistry. 2008 Jan 22;47(3):978-85. Epub 2007 Dec 23. PMID:18154360<ref>PMID:18154360</ref>

-	~~===ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH SORBITOL===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18154360}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vft]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018154360<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Alditol oxidase]]		[[Category: Alditol oxidase]]
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]

OCA: Protected "2vft" [edit=sysop:move=sysop]

2013-01-07T19:49:02Z

Protected "2vft" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:49, 7 January 2013

OCA at 19:48, 7 January 2013

2013-01-07T19:48:59Z

←Older revision		Revision as of 19:48, 7 January 2013
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-	{{Seed}}
	[[Image:2vft.png\|left\|200px]]		[[Image:2vft.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vft", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vft\| PDB=2vft \| SCENE= }}		{{STRUCTURE_2vft\| PDB=2vft \| SCENE= }}

	===ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH SORBITOL===		===ALDITOL OXIDASE FROM STREPTOMYCES COELICOLOR A3(2): COMPLEX WITH SORBITOL===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18154360}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18154360 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18154360}}		{{ABSTRACT_PUBMED_18154360}}

	==About this Structure==		==About this Structure==
-	~~2VFT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA].	+	[[2vft]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18154360~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018154360</ref><references group="xtra"/>
		+	[[Category: Alditol oxidase]]
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
-	[[Category: Xylitol oxidase]]
	[[Category: Forneris, F.]]		[[Category: Forneris, F.]]
	[[Category: Mattevi, A.]]		[[Category: Mattevi, A.]]
Line 35:		Line 23:
	[[Category: Polyol]]		[[Category: Polyol]]
	[[Category: Sugar]]		[[Category: Sugar]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:19:28 2009''

OCA at 21:19, 16 February 2009

2009-02-16T21:19:31Z

←Older revision		Revision as of 21:19, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VFT is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA].	+	2VFT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VFT OCA].

	==Reference==		==Reference==
-	Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase., Forneris F, Heuts DP, Delvecchio M, Rovida S, Fraaije MW, Mattevi A, Biochemistry. 2008 Jan 22;47(3):978-85. Epub 2007 Dec 23. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18154360 18154360]~~	+	<ref group="xtra">PMID:18154360</ref><references group="xtra"/>
-	~~[[Category: Single protein]]~~	+
	[[Category: Streptomyces coelicolor]]		[[Category: Streptomyces coelicolor]]
	[[Category: Xylitol oxidase]]		[[Category: Xylitol oxidase]]
Line 37:		Line 36:
	[[Category: Sugar]]		[[Category: Sugar]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 03~~:44:~~27 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:19:28 2009''