2vj0 - Revision history

OCA at 15:21, 13 December 2023

2023-12-13T15:21:25Z

←Older revision		Revision as of 15:21, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vj0' size='340' side='right'caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj0' size='340' side='right'caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [https://pdbe.org/2vj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [https://pdbe.org/2vj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~AMPH_RAT AMPH_RAT~~]~~] May participate in mechanisms~~ of ~~regulated exocytosis~~ in ~~synapses~~ and ~~certain endocrine cell types~~. ~~May control the properties of~~ the membrane associated ~~cytoskeleton~~ (~~By similarity~~). ~~[[https://www~~.~~uniprot~~.~~org/uniprot/SYNJ1_HUMAN SYNJ1_HUMAN~~]] ~~Inositol 5~~-~~phosphatase which has~~ a role in clathrin-~~mediated endocytosis~~.	+	[https://www.uniprot.org/uniprot/AP2A2_MOUSE AP2A2_MOUSE] Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.<ref>PMID:10459011</ref> <ref>PMID:14745134</ref> <ref>PMID:15473838</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Ford, M G.J~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~McMahon, H T~~]]	+	[[Category: Ford MGJ]]
-	[[Category: ~~Praefcke, G J.K~~]]	+	[[Category: McMahon HT]]
-	[[Category: ~~Alpha-adaptin]]~~	+	[[Category: Praefcke GJK]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Amphiphysin]]~~	+
-	~~[[Category: Ap2]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Coated pit]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Cytoplasmic vesicle]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Lipid-binding]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Synapse]]~~	+
-	~~[[Category: Synaptojanin]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 11:38, 30 March 2022

2022-03-30T11:38:13Z

←Older revision		Revision as of 11:38, 30 March 2022
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	<StructureSection load='2vj0' size='340' side='right'caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj0' size='340' side='right'caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [~~http~~://pdbe.org/2vj0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [https://pdbe.org/2vj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AMPH_RAT AMPH_RAT]] May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). [[~~http~~://www.uniprot.org/uniprot/SYNJ1_HUMAN SYNJ1_HUMAN]] Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.	+	[[https://www.uniprot.org/uniprot/AMPH_RAT AMPH_RAT]] May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). [[https://www.uniprot.org/uniprot/SYNJ1_HUMAN SYNJ1_HUMAN]] Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:00, 25 June 2020

2020-06-25T08:00:28Z

←Older revision		Revision as of 08:00, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex with an FXDNF peptide from amphiphysin1 and a WVXF peptide from synaptojanin P170==		==Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex with an FXDNF peptide from amphiphysin1 and a WVXF peptide from synaptojanin P170==
-	<StructureSection load='2vj0' size='340' side='right' caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2vj0' size='340' side='right'caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://pdbe.org/2vj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://pdbe.org/2vj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Adaptin\|Adaptin]]	+	*[[Adaptin 3D structures\|Adaptin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ford, M G.J]]		[[Category: Ford, M G.J]]

OCA at 20:46, 19 September 2018

2018-09-19T20:46:43Z

←Older revision		Revision as of 20:46, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE ALPHA~~-~~ADAPTIN APPENDAGE DOMAIN~~, ~~FROM THE~~ AP2 ~~ADAPTOR COMPLEX~~, ~~IN COMPLEX WITH AN~~ FXDNF ~~PEPTIDE FROM AMPHIPHYSIN1 AND A~~ WVXF ~~PEPTIDE FROM SYNAPTOJANIN~~ P170==	+
		+	==Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, in complex with an FXDNF peptide from amphiphysin1 and a WVXF peptide from synaptojanin P170==
	<StructureSection load='2vj0' size='340' side='right' caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj0' size='340' side='right' caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://pdbe.org/2vj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://pdbe.org/2vj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj0_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj0_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 38:
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Ford, M G.J]]		[[Category: Ford, M G.J]]
-	[[Category: ~~Mcmahon~~, H T]]	+	[[Category: McMahon, H T]]
	[[Category: Praefcke, G J.K]]		[[Category: Praefcke, G J.K]]
	[[Category: Alpha-adaptin]]		[[Category: Alpha-adaptin]]
		+	[[Category: Alternative splicing]]
	[[Category: Amphiphysin]]		[[Category: Amphiphysin]]
	[[Category: Ap2]]		[[Category: Ap2]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Coated pit]]		[[Category: Coated pit]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Cytoplasmic vesicle]]		[[Category: Cytoplasmic vesicle]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]

OCA at 07:50, 10 February 2016

2016-02-10T07:50:19Z

←Older revision		Revision as of 07:50, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2vj0' size='340' side='right' caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2vj0' size='340' side='right' caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://pdbe.org/2vj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vj0 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vj0" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Ford, M G.J]]		[[Category: Ford, M G.J]]
	[[Category: Mcmahon, H T]]		[[Category: Mcmahon, H T]]

OCA at 12:49, 25 December 2014

2014-12-25T12:49:23Z

←Older revision		Revision as of 12:49, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AMPH_RAT AMPH_RAT]] May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity). [[http://www.uniprot.org/uniprot/SYNJ1_HUMAN SYNJ1_HUMAN]] Inositol 5-phosphatase which has a role in clathrin-mediated endocytosis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Ford, M G.J.]]	+	[[Category: Ford, M G.J]]
-	[[Category: Mcmahon, H T.]]	+	[[Category: Mcmahon, H T]]
-	[[Category: Praefcke, G J.K.]]	+	[[Category: Praefcke, G J.K]]
	[[Category: Alpha-adaptin]]		[[Category: Alpha-adaptin]]
	[[Category: Amphiphysin]]		[[Category: Amphiphysin]]

OCA at 01:56, 1 October 2014

2014-10-01T01:56:18Z

←Older revision		Revision as of 01:56, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vj0.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF PEPTIDE FROM AMPHIPHYSIN1 AND A WVXF PEPTIDE FROM SYNAPTOJANIN P170==
		+	<StructureSection load='2vj0' size='340' side='right' caption='[[2vj0]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ0 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qtp\|1qtp]], [[1ky6\|1ky6]], [[1b9k\|1b9k]], [[1kyu\|1kyu]], [[1kyf\|1kyf]], [[1gw5\|1gw5]], [[1qts\|1qts]], [[1ky7\|1ky7]], [[1w80\|1w80]], [[2dnr\|2dnr]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj0 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj0_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Adaptor protein (AP) complexes bind to transmembrane proteins destined for internalization and to membrane lipids, so linking cargo to the accessory internalization machinery. This machinery interacts with the appendage domains of APs, which have platform and beta-sandwich subdomains, forming the binding surfaces for interacting proteins. Proteins that interact with the subdomains do so via short motifs, usually found in regions of low structural complexity of the interacting proteins. So far, up to four motifs have been identified that bind to and partially compete for at least two sites on each of the appendage domains of the AP2 complex. Motifs in individual accessory proteins, their sequential arrangement into motif domains, and partial competition for binding sites on the appendage domains coordinate the formation of endocytic complexes in a temporal and spatial manner. In this work, we examine the dominant interaction sequence in amphiphysin, a synapse-enriched accessory protein, which generates membrane curvature and recruits the scission protein dynamin to the necks of coated pits, for the platform subdomain of the alpha-appendage. The motif domain of amphiphysin1 contains one copy of each of a DX(F/W) and FXDXF motif. We find that the FXDXF motif is the main determinant for the high affinity interaction with the alpha-adaptin appendage. We describe the optimal sequence of the FXDXF motif using thermodynamic and structural data and show how sequence variation controls the affinities of these motifs for the alpha-appendage.

-	~~{{STRUCTURE_2vj0\| PDB=2vj0 \| SCENE= }}~~	+	Solitary and repetitive binding motifs for the AP2 complex alpha-appendage in amphiphysin and other accessory proteins.,Olesen LE, Ford MG, Schmid EM, Vallis Y, Babu MM, Li PH, Mills IG, McMahon HT, Praefcke GJ J Biol Chem. 2008 Feb 22;283(8):5099-109. Epub 2007 Nov 6. PMID:17986441<ref>PMID:17986441</ref>

-	~~===CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN~~, ~~FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF PEPTIDE FROM AMPHIPHYSIN1 AND A WVXF PEPTIDE FROM SYNAPTOJANIN P170===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_17986441}}~~	+	==See Also==
-		+	*[[Adaptin\|Adaptin]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2vj0~~]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:017986441<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Ford, M G.J.]]		[[Category: Ford, M G.J.]]

OCA: Protected "2vj0" [edit=sysop:move=sysop]

2013-01-07T20:04:47Z

Protected "2vj0" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:04, 7 January 2013

OCA at 20:04, 7 January 2013

2013-01-07T20:04:44Z

←Older revision		Revision as of 20:04, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vj0.png\|left\|200px]]		[[Image:2vj0.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vj0", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vj0\| PDB=2vj0 \| SCENE= }}		{{STRUCTURE_2vj0\| PDB=2vj0 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF PEPTIDE FROM AMPHIPHYSIN1 AND A WVXF PEPTIDE FROM SYNAPTOJANIN P170===		===CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF PEPTIDE FROM AMPHIPHYSIN1 AND A WVXF PEPTIDE FROM SYNAPTOJANIN P170===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_17986441}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 17986441 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_17986441}}		{{ABSTRACT_PUBMED_17986441}}

	==About this Structure==		==About this Structure==
-	~~2VJ0~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA].	+	[[2vj0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~17986441~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:017986441</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Ford, M G.J.]]		[[Category: Ford, M G.J.]]
Line 29:		Line 17:
	[[Category: Praefcke, G J.K.]]		[[Category: Praefcke, G J.K.]]
	[[Category: Alpha-adaptin]]		[[Category: Alpha-adaptin]]
-	[[Category: Alternative splicing]]
	[[Category: Amphiphysin]]		[[Category: Amphiphysin]]
	[[Category: Ap2]]		[[Category: Ap2]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
	[[Category: Coated pit]]		[[Category: Coated pit]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Cytoplasmic vesicle]]		[[Category: Cytoplasmic vesicle]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
Line 48:		Line 33:
	[[Category: Synaptojanin]]		[[Category: Synaptojanin]]
	[[Category: Transport]]		[[Category: Transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:37:51 2009''

OCA at 14:37, 17 February 2009

2009-02-17T14:37:53Z

←Older revision		Revision as of 14:37, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VJ0 is a ~~[[Protein complex]]~~ structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA].	+	2VJ0 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ0 OCA].

	==Reference==		==Reference==
-	Solitary and Repetitive Binding Motifs for the AP2 Complex {alpha}-Appendage in Amphiphysin and Other Accessory Proteins., Olesen LE, Ford MG, Schmid EM, Vallis Y, Babu MM, Li PH, Mills IG, McMahon HT, Praefcke GJ, J Biol Chem. 2008 Feb 22;283(8):5099-109. Epub 2007 Nov 6. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/17986441 17986441]~~	+	<ref group="xtra">PMID:17986441</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Protein complex]]
	[[Category: Ford, M G.J.]]		[[Category: Ford, M G.J.]]
	[[Category: Mcmahon, H T.]]		[[Category: Mcmahon, H T.]]
Line 50:		Line 49:
	[[Category: Transport]]		[[Category: Transport]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 23~~:21:~~06 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:37:51 2009''