2vj3 - Revision history

OCA at 15:21, 13 December 2023

2023-12-13T15:21:30Z

←Older revision		Revision as of 15:21, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vj3' size='340' side='right'caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2vj3' size='340' side='right'caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [https://pdbe.org/2vj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [https://pdbe.org/2vj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj3 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN] Defects in NOTCH1 are a cause of aortic valve disease 1 (AOVD1) [MIM:[https://omim.org/entry/109730 109730]. A common defect in the aortic valve in which two rather than three leaflets are present. It is often associated with aortic valve calcification and insufficiency. In extreme cases, the blood flow may be so restricted that the left ventricle fails to grow, resulting in hypoplastic left heart syndrome.<ref>PMID:16025100</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NOTC1_HUMAN NOTC1_HUMAN] Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May enhance HIF1A function by sequestering HIF1AN away from HIF1A (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cordle, J]]	+	[[Category: Cordle J]]
-	[[Category: Johnson, S]]	+	[[Category: Johnson S]]
-	[[Category: Lea~~, S M~~]]	+	[[Category: Lea SM]]
-	[[Category: Roversi, P]]	+	[[Category: Roversi P]]
-	[[Category: Tay~~, J Z]]~~	+	[[Category: Tay JZ]]
-	~~[[Category: Activator]]~~	+
-	~~[[Category: Ank repeat]]~~	+
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Developmental protein]]~~	+
-	~~[[Category: Differentiation]]~~	+
-	~~[[Category: Egf]]~~	+
-	~~[[Category: Egf-like domain]]~~	+
-	~~[[Category: Extracellular]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Jagged]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Notch]]~~	+
-	~~[[Category: Notch signaling pathway]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphorylation]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Signalling]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 10:46, 7 July 2021

2021-07-07T10:46:21Z

←Older revision		Revision as of 10:46, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2vj3' size='340' side='right'caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2vj3' size='340' side='right'caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [~~http~~://pdbe.org/2vj3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vj3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [https://pdbe.org/2vj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [https://www.ebi.ac.uk/pdbsum/2vj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:47, 21 August 2019

2019-08-21T07:47:27Z

←Older revision		Revision as of 07:47, 21 August 2019
Line 1:		Line 1:

	==Human Notch-1 EGFs 11-13==		==Human Notch-1 EGFs 11-13==
-	<StructureSection load='2vj3' size='340' side='right' caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2vj3' size='340' side='right'caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cordle, J]]		[[Category: Cordle, J]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]

OCA at 07:25, 16 November 2017

2017-11-16T07:25:35Z

←Older revision		Revision as of 07:25, 16 November 2017
Line 1:		Line 1:
-	==~~HUMAN NOTCH~~-1 ~~EGFS~~ 11-13==	+
		+	==Human Notch-1 EGFs 11-13==
	<StructureSection load='2vj3' size='340' side='right' caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2vj3' size='340' side='right' caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://pdbe.org/2vj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://pdbe.org/2vj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vj3 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 38:		Line 39:
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]
		+	[[Category: Calcium]]
	[[Category: Developmental protein]]		[[Category: Developmental protein]]
	[[Category: Differentiation]]		[[Category: Differentiation]]
Line 51:		Line 53:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
		+	[[Category: Polymorphism]]
	[[Category: Receptor]]		[[Category: Receptor]]
	[[Category: Signalling]]		[[Category: Signalling]]

OCA at 07:47, 7 February 2016

2016-02-07T07:47:34Z

←Older revision		Revision as of 07:47, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vj3' size='340' side='right' caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2vj3' size='340' side='right' caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://pdbe.org/2vj3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vj3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vj3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Cordle, J]]		[[Category: Cordle, J]]
	[[Category: Johnson, S]]		[[Category: Johnson, S]]

OCA at 17:07, 19 January 2015

2015-01-19T17:07:19Z

←Older revision		Revision as of 17:07, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Cordle, J.]]	+	[[Category: Cordle, J]]
-	[[Category: Johnson, S.]]	+	[[Category: Johnson, S]]
-	[[Category: Lea, S M.]]	+	[[Category: Lea, S M]]
-	[[Category: Roversi, P.]]	+	[[Category: Roversi, P]]
-	[[Category: Tay, J Z.]]	+	[[Category: Tay, J Z]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Ank repeat]]		[[Category: Ank repeat]]

OCA at 01:43, 1 October 2014

2014-10-01T01:43:03Z

←Older revision		Revision as of 01:43, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2vj3~~\| ~~PDB~~=2vj3 \| ~~SCENE~~= }}	+	==HUMAN NOTCH-1 EGFS 11-13==
-	===~~HUMAN NOTCH~~-~~1 EGFS 11~~-13===	+	<StructureSection load='2vj3' size='340' side='right' caption='[[2vj3]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_18660822}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VJ3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1toz\|1toz]], [[2f8y\|2f8y]], [[1yyh\|1yyh]], [[1pb5\|1pb5]], [[2f8x\|2f8x]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vj3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vj3 RCSB], [http://www.ebi.ac.uk/pdbsum/2vj3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vj/2vj3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Notch receptor and its ligands are key components in a core metazoan signaling pathway that regulates the spatial patterning, timing and outcome of many cell-fate decisions. Ligands contain a disulfide-rich Delta/Serrate/LAG-2 (DSL) domain required for Notch trans-activation or cis-inhibition. Here we report the X-ray structure of a receptor binding region of a Notch ligand, the DSL-EGF3 domains of human Jagged-1 (J-1(DSL-EGF3)). The structure reveals a highly conserved face of the DSL domain, and we show, by functional analysis of Drosophila melanogster ligand mutants, that this surface is required for both cis- and trans-regulatory interactions with Notch. We also identify, using NMR, a surface of Notch-1 involved in J-1(DSL-EGF3) binding. Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor.

-	~~==About this Structure==~~	+	A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.,Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, Handford PA Nat Struct Mol Biol. 2008 Aug;15(8):849-57. Epub 2008 Jul 27. PMID:18660822<ref>PMID:18660822</ref>
-	~~[[2vj3]]~~ is ~~a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2VJ3 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:018660822</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cordle, J.]]		[[Category: Cordle, J.]]

OCA at 16:49, 24 March 2013

2013-03-24T16:49:50Z

←Older revision		Revision as of 16:49, 24 March 2013
Line 1:		Line 1:
-	[[Image:2vj3.png\|left\|200px]]
-
	{{STRUCTURE_2vj3\| PDB=2vj3 \| SCENE= }}		{{STRUCTURE_2vj3\| PDB=2vj3 \| SCENE= }}
-
	===HUMAN NOTCH-1 EGFS 11-13===		===HUMAN NOTCH-1 EGFS 11-13===
-
	{{ABSTRACT_PUBMED_18660822}}		{{ABSTRACT_PUBMED_18660822}}

Line 11:		Line 7:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:018660822</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018660822</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cordle, J.]]		[[Category: Cordle, J.]]

OCA: Protected "2vj3" [edit=sysop:move=sysop]

2013-01-07T19:46:03Z

Protected "2vj3" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:46, 7 January 2013

OCA at 19:46, 7 January 2013

2013-01-07T19:46:01Z

←Older revision		Revision as of 19:46, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vj3.png\|left\|200px]]		[[Image:2vj3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vj3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vj3\| PDB=2vj3 \| SCENE= }}		{{STRUCTURE_2vj3\| PDB=2vj3 \| SCENE= }}

	===HUMAN NOTCH-1 EGFS 11-13===		===HUMAN NOTCH-1 EGFS 11-13===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18660822}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18660822 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18660822}}		{{ABSTRACT_PUBMED_18660822}}

	==About this Structure==		==About this Structure==
-	~~2VJ3~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA].	+	[[2vj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ3 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18660822~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018660822</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cordle, J.]]		[[Category: Cordle, J.]]
Line 50:		Line 38:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:22:58 2010''