2vod - Revision history

OCA at 10:02, 9 May 2024

2024-05-09T10:02:40Z

←Older revision		Revision as of 10:02, 9 May 2024
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	<StructureSection load='2vod' size='340' side='right'caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vod' size='340' side='right'caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1s7a\|1s7a]]~~, [[~~1yty~~\|~~1yty~~]]~~, [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [https://pdbe.org/2vod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [https://www.ebi.ac.uk/pdbsum/2vod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [https://pdbe.org/2vod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [https://www.ebi.ac.uk/pdbsum/2vod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LA_HUMAN LA_HUMAN] Binds to the 3' poly(U) terminii of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.<ref>PMID:3192525</ref> <ref>PMID:2470590</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Conte~~, M R~~]]	+	[[Category: Conte MR]]
-	[[Category: Curry, S]]	+	[[Category: Curry S]]
-	[[Category: Kotik-Kogan, O]]	+	[[Category: Kotik-Kogan O]]
-	[[Category: Sanfelice, D]]	+	[[Category: Sanfelice D]]
-	[[Category: Valentine~~, E R]]~~	+	[[Category: Valentine ER]]
-	~~[[Category: La motif]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna maturation]]~~	+
-	~~[[Category: Rna recognition motif]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Rna-binding protein]]~~	+
-	~~[[Category: Systemic lupus erythematosus~~]]	+

OCA at 11:42, 30 March 2022

2022-03-30T11:42:03Z

←Older revision		Revision as of 11:42, 30 March 2022
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	<StructureSection load='2vod' size='340' side='right'caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vod' size='340' side='right'caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [~~http~~://pdbe.org/2vod PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vod PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [https://pdbe.org/2vod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [https://www.ebi.ac.uk/pdbsum/2vod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:15, 25 June 2020

2020-06-25T08:15:21Z

←Older revision		Revision as of 08:15, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU==		==Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU==
-	<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='2vod' size='340' side='right'caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://pdbe.org/2vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://pdbe.org/2vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Conte, M R]]		[[Category: Conte, M R]]
	[[Category: Curry, S]]		[[Category: Curry, S]]

OCA at 21:03, 19 September 2018

2018-09-19T21:03:17Z

←Older revision		Revision as of 21:03, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ N-~~TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH~~ RNA ~~OLIGOMER~~ AUAUUUU==	+
		+	==Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU==
	<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://pdbe.org/2vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://pdbe.org/2vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vod ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vod_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vod_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Rna binding protein]]
	[[Category: Rna maturation]]		[[Category: Rna maturation]]
	[[Category: Rna recognition motif]]		[[Category: Rna recognition motif]]

OCA at 17:08, 7 February 2016

2016-02-07T17:08:02Z

←Older revision		Revision as of 17:08, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://pdbe.org/2vod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vod ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vod" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Conte, M R]]		[[Category: Conte, M R]]
	[[Category: Curry, S]]		[[Category: Curry, S]]

OCA at 18:07, 19 January 2015

2015-01-19T18:07:24Z

←Older revision		Revision as of 18:07, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Conte, M R.]]	+	[[Category: Conte, M R]]
-	[[Category: Curry, S.]]	+	[[Category: Curry, S]]
-	[[Category: Kotik-Kogan, O.]]	+	[[Category: Kotik-Kogan, O]]
-	[[Category: Sanfelice, D.]]	+	[[Category: Sanfelice, D]]
-	[[Category: Valentine, E R.]]	+	[[Category: Valentine, E R]]
	[[Category: La motif]]		[[Category: La motif]]
	[[Category: Nucleus]]		[[Category: Nucleus]]

OCA at 02:06, 1 October 2014

2014-10-01T02:06:34Z

←Older revision		Revision as of 02:06, 1 October 2014
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-	[[~~Image:~~2vod.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAUUUU==
		+	<StructureSection load='2vod' size='340' side='right' caption='[[2vod]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOD FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1s7a\|1s7a]], [[1yty\|1yty]], [[1zh5\|1zh5]], [[1s79\|1s79]], [[2voo\|2voo]], [[2vop\|2vop]], [[2von\|2von]], [[1owx\|1owx]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vod OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vod RCSB], [http://www.ebi.ac.uk/pdbsum/2vod PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vod_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The eukaryotic La protein recognizes the 3' poly(U) sequences of nascent RNA polymerase III transcripts to assist folding and maturation. The 3' ends of such RNAs are bound by the N-terminal domain of La (LaNTD). We have solved the crystal structures of four LaNTD:RNA complexes, each containing a different single-stranded RNA oligomer, and compared them to the structure of a previously published LaNTD:RNA complex containing partially duplex RNA. The presence of purely single-stranded RNA in the binding pocket at the interface between the La motif and RRM domains allows significantly closer contact with the 3' end of the RNA. Comparison of the different LaNTD:RNA complexes identifies a conserved set of interactions with the last two nucleotides at the 3' end of the RNA ligand that are key to binding. Strikingly, we also observe two alternative conformations of bound ssRNA, indicative of an unexpected degree of plasticity in the modes of RNA binding.

-	~~{{STRUCTURE_2vod\| PDB=2vod \| SCENE= }}~~	+	Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human La protein.,Kotik-Kogan O, Valentine ER, Sanfelice D, Conte MR, Curry S Structure. 2008 Jun;16(6):852-62. PMID:18547518<ref>PMID:18547518</ref>

-	~~===CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAUUUU===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18547518}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vod]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018547518<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Conte, M R.]]		[[Category: Conte, M R.]]

OCA: Protected "2vod" [edit=sysop:move=sysop]

2013-01-07T23:03:46Z

Protected "2vod" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:03, 7 January 2013

OCA at 23:03, 7 January 2013

2013-01-07T23:03:43Z

←Older revision		Revision as of 23:03, 7 January 2013
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-	{{Seed}}
	[[Image:2vod.png\|left\|200px]]		[[Image:2vod.png\|left\|200px]]

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	{{STRUCTURE_2vod\| PDB=2vod \| SCENE= }}		{{STRUCTURE_2vod\| PDB=2vod \| SCENE= }}

	===CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAUUUU===		===CRYSTAL STRUCTURE OF N-TERMINAL DOMAINS OF HUMAN LA PROTEIN COMPLEXED WITH RNA OLIGOMER AUAUUUU===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 18547518 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_18547518}}		{{ABSTRACT_PUBMED_18547518}}

	==About this Structure==		==About this Structure==
-	~~2VOD~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA].	+	[[2vod]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18547518~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018547518</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Conte, M R.]]		[[Category: Conte, M R.]]
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	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Rna maturation]]		[[Category: Rna maturation]]
	[[Category: Rna recognition motif]]		[[Category: Rna recognition motif]]
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	[[Category: Rna-binding protein]]		[[Category: Rna-binding protein]]
	[[Category: Systemic lupus erythematosus]]		[[Category: Systemic lupus erythematosus]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:19:51 2009''

OCA at 13:19, 16 February 2009

2009-02-16T13:19:52Z

←Older revision		Revision as of 13:19, 16 February 2009
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	==About this Structure==		==About this Structure==
-	2VOD is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA].	+	2VOD is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOD OCA].

	==Reference==		==Reference==
-	Structural analysis reveals conformational plasticity in the recognition of RNA 3' ends by the human la protein., Kotik-Kogan O, Valentine ER, Sanfelice D, Conte MR, Curry S, Structure. 2008 Jun;16(6):852-62. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18547518 18547518]~~	+	<ref group="xtra">PMID:18547518</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Single protein]]
	[[Category: Conte, M R.]]		[[Category: Conte, M R.]]
	[[Category: Curry, S.]]		[[Category: Curry, S.]]
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	[[Category: Systemic lupus erythematosus]]		[[Category: Systemic lupus erythematosus]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul 2 21~~:47:~~06 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:19:51 2009''