2vok - Revision history

OCA at 07:46, 7 February 2024

2024-02-07T07:46:54Z

←Older revision		Revision as of 07:46, 7 February 2024
Line 3:		Line 3:
	<StructureSection load='2vok' size='340' side='right'caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2vok' size='340' side='right'caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2iwg\|2iwg]]~~, [[~~2vol~~\|~~2vol~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [https://pdbe.org/2vok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [https://www.ebi.ac.uk/pdbsum/2vok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [https://pdbe.org/2vok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [https://www.ebi.ac.uk/pdbsum/2vok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/RO52_MOUSE RO52_MOUSE] E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vok ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vok ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The newly identified tripartite motif (TRIM) family of proteins mediate innate immunity and other critical cellular functions. Here we show that TRIM21, which mediates the autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome, is a previously undescribed IgG receptor with a binding mechanism unlike known mammalian Fcgamma receptors. TRIM21 simultaneously targets conserved hot-spot residues on both Ig domains of the Fc fragment using a PRYSPRY domain with a preformed multisite interface. The binding sites on both TRIM21 and Fc are highly conserved to the extent that the proteins are functionally interchangeable through murine, canine, primate, and human species. Pre-steady-state analysis exposes mechanistic conservation at the level of individual residues, which make the same energetic and kinetic contributions to binding despite varying in sequence. Together, our results reveal that TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.
-
-	TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.,Keeble AH, Khan Z, Forster A, James LC Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6045-50. Epub 2008 Apr 17. PMID:18420815<ref>PMID:18420815</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2vok" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Forster, A]]	+	[[Category: Forster A]]
-	[[Category: James~~, L C~~]]	+	[[Category: James LC]]
-	[[Category: Keeble~~, A H~~]]	+	[[Category: Keeble AH]]
-	[[Category: Khan, Z]]	+	[[Category: Khan Z]]
-	~~[[Category: B30 2]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Pryspry]]~~	+
-	~~[[Category: Ribonucleoprotein]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Ro 52]]~~	+
-	~~[[Category: Spry systemic lupus erythematosus]]~~	+
-	~~[[Category: Systemic lupus erythematosus]]~~	+
-	~~[[Category: Zinc]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 11:42, 30 March 2022

2022-03-30T11:42:17Z

←Older revision		Revision as of 11:42, 30 March 2022
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	<StructureSection load='2vok' size='340' side='right'caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2vok' size='340' side='right'caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iwg\|2iwg]], [[2vol\|2vol]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [~~http~~://pdbe.org/2vok PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vok PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [https://pdbe.org/2vok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [https://www.ebi.ac.uk/pdbsum/2vok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:16, 25 June 2020

2020-06-25T08:16:05Z

←Older revision		Revision as of 08:16, 25 June 2020
Line 1:		Line 1:

	==Murine TRIM21==		==Murine TRIM21==
-	<StructureSection load='2vok' size='340' side='right' caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>	+	<StructureSection load='2vok' size='340' side='right'caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://pdbe.org/2vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://pdbe.org/2vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Forster, A]]		[[Category: Forster, A]]

OCA at 21:21, 19 September 2018

2018-09-19T21:21:50Z

←Older revision		Revision as of 21:21, 19 September 2018
Line 1:		Line 1:
-	==~~MURINE~~ TRIM21==	+
		+	==Murine TRIM21==
	<StructureSection load='2vok' size='340' side='right' caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2vok' size='340' side='right' caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://pdbe.org/2vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://pdbe.org/2vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vok ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vok_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vok_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 36:
	[[Category: Khan, Z]]		[[Category: Khan, Z]]
	[[Category: B30 2]]		[[Category: B30 2]]
		+	[[Category: Coiled coil]]
		+	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
		+	[[Category: Polymorphism]]
	[[Category: Pryspry]]		[[Category: Pryspry]]
	[[Category: Ribonucleoprotein]]		[[Category: Ribonucleoprotein]]
Line 45:		Line 49:
	[[Category: Spry systemic lupus erythematosus]]		[[Category: Spry systemic lupus erythematosus]]
	[[Category: Systemic lupus erythematosus]]		[[Category: Systemic lupus erythematosus]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 12:09, 8 February 2016

2016-02-08T12:09:35Z

←Older revision		Revision as of 12:09, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2vok' size='340' side='right' caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>		<StructureSection load='2vok' size='340' side='right' caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://pdbe.org/2vok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vok ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vok" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Forster, A]]		[[Category: Forster, A]]
	[[Category: James, L C]]		[[Category: James, L C]]

OCA at 15:57, 19 January 2015

2015-01-19T15:57:52Z

←Older revision		Revision as of 15:57, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Forster, A.]]	+	[[Category: Forster, A]]
-	[[Category: James, L C.]]	+	[[Category: James, L C]]
-	[[Category: Keeble, A H.]]	+	[[Category: Keeble, A H]]
-	[[Category: Khan, Z.]]	+	[[Category: Khan, Z]]
	[[Category: B30 2]]		[[Category: B30 2]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA at 02:18, 1 October 2014

2014-10-01T02:18:10Z

←Older revision		Revision as of 02:18, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vok.~~png~~\|~~left~~\|200px]]	+	==MURINE TRIM21==
		+	<StructureSection load='2vok' size='340' side='right' caption='[[2vok]], [[Resolution\|resolution]] 1.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VOK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2iwg\|2iwg]], [[2vol\|2vol]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vok OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vok RCSB], [http://www.ebi.ac.uk/pdbsum/2vok PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2vok_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The newly identified tripartite motif (TRIM) family of proteins mediate innate immunity and other critical cellular functions. Here we show that TRIM21, which mediates the autoimmune diseases rheumatoid arthritis, systemic lupus erythematosus, and Sjogren's syndrome, is a previously undescribed IgG receptor with a binding mechanism unlike known mammalian Fcgamma receptors. TRIM21 simultaneously targets conserved hot-spot residues on both Ig domains of the Fc fragment using a PRYSPRY domain with a preformed multisite interface. The binding sites on both TRIM21 and Fc are highly conserved to the extent that the proteins are functionally interchangeable through murine, canine, primate, and human species. Pre-steady-state analysis exposes mechanistic conservation at the level of individual residues, which make the same energetic and kinetic contributions to binding despite varying in sequence. Together, our results reveal that TRIM21 is a previously undescribed type of IgG receptor based on a non-Ig scaffold whose interaction at the fundamental level-structural, thermodynamic, and kinetic-is evolutionarily conserved.

-	~~{{STRUCTURE_2vok\| PDB=2vok \| SCENE= }}~~	+	TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.,Keeble AH, Khan Z, Forster A, James LC Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6045-50. Epub 2008 Apr 17. PMID:18420815<ref>PMID:18420815</ref>

-	~~===MURINE TRIM21===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18420815}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2vok]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:018420815<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Forster, A.]]		[[Category: Forster, A.]]

OCA: Protected "2vok" [edit=sysop:move=sysop]

2013-01-07T19:03:25Z

Protected "2vok" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:03, 7 January 2013

OCA at 19:03, 7 January 2013

2013-01-07T19:03:20Z

←Older revision		Revision as of 19:03, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vok.png\|left\|200px]]		[[Image:2vok.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vok", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vok\| PDB=2vok \| SCENE= }}		{{STRUCTURE_2vok\| PDB=2vok \| SCENE= }}

	===MURINE TRIM21===		===MURINE TRIM21===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18420815}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18420815 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18420815}}		{{ABSTRACT_PUBMED_18420815}}

	==About this Structure==		==About this Structure==
-	~~2VOK~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA].	+	[[2vok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18420815~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018420815</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Forster, A.]]		[[Category: Forster, A.]]
Line 30:		Line 18:
	[[Category: Khan, Z.]]		[[Category: Khan, Z.]]
	[[Category: B30 2]]		[[Category: B30 2]]
-	[[Category: Coiled coil]]
-	[[Category: Cytoplasm]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
-	[[Category: Polymorphism]]
	[[Category: Pryspry]]		[[Category: Pryspry]]
	[[Category: Ribonucleoprotein]]		[[Category: Ribonucleoprotein]]
Line 43:		Line 28:
	[[Category: Spry systemic lupus erythematosus]]		[[Category: Spry systemic lupus erythematosus]]
	[[Category: Systemic lupus erythematosus]]		[[Category: Systemic lupus erythematosus]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:53:37 2009''

OCA at 19:53, 16 February 2009

2009-02-16T19:53:40Z

←Older revision		Revision as of 19:53, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VOK is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA].	+	2VOK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOK OCA].

	==Reference==		==Reference==
-	TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved., Keeble AH, Khan Z, Forster A, James LC, Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6045-50. Epub 2008 Apr 17. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18420815 18420815]~~	+	<ref group="xtra">PMID:18420815</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Single protein]]
	[[Category: Forster, A.]]		[[Category: Forster, A.]]
	[[Category: James, L C.]]		[[Category: James, L C.]]
Line 47:		Line 46:
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon ~~Jul 28 02~~:51:~~24 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 21:53:37 2009''