2vqc - Revision history

OCA at 20:55, 12 April 2023

2023-04-12T20:55:07Z

←Older revision		Revision as of 20:55, 12 April 2023
Line 3:		Line 3:
	<StructureSection load='2vqc' size='340' side='right'caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vqc' size='340' side='right'caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ssv1 Ssv1~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_spindle-shaped_virus_1 Sulfolobus spindle-shaped virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQC FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [https://pdbe.org/2vqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [https://www.ebi.ac.uk/pdbsum/2vqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [https://pdbe.org/2vqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [https://www.ebi.ac.uk/pdbsum/2vqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F112_SSV1 F112_SSV1] Essential for virus function.<ref>PMID:10430570</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ssv1~~]]	+	[[Category: Sulfolobus spindle-shaped virus 1]]
-	[[Category: Corn~~, G J~~]]	+	[[Category: Corn GJ]]
-	[[Category: Kraft, P]]	+	[[Category: Kraft P]]
-	[[Category: Lawrence~~, C M~~]]	+	[[Category: Lawrence CM]]
-	[[Category: Menon~~, S K~~]]	+	[[Category: Menon SK]]
-	[[Category: Wiedenheft, B]]	+	[[Category: Wiedenheft B]]
-	[[Category: Young~~, M J]]~~	+	[[Category: Young MJ]]
-	~~[[Category: Crenarchaeal]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Ssv]]~~	+
-	~~[[Category: Sulfolobus spindle virus]]~~	+
-	~~[[Category: Thermophilic protein]]~~	+
-	~~[[Category: Winged-helix~~]]	+

OCA at 10:48, 7 July 2021

2021-07-07T10:48:16Z

←Older revision		Revision as of 10:48, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2vqc' size='340' side='right'caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vqc' size='340' side='right'caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ssv1 Ssv1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ssv1 Ssv1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VQC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [~~http~~://pdbe.org/2vqc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vqc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [https://pdbe.org/2vqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [https://www.ebi.ac.uk/pdbsum/2vqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:13, 10 May 2019

2019-05-10T12:13:36Z

←Older revision		Revision as of 12:13, 10 May 2019
Line 1:		Line 1:

	==Structure of a DNA binding winged-helix protein, F-112, from Sulfolobus Spindle-shaped Virus 1.==		==Structure of a DNA binding winged-helix protein, F-112, from Sulfolobus Spindle-shaped Virus 1.==
-	<StructureSection load='2vqc' size='340' side='right' caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2vqc' size='340' side='right'caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ssv1 Ssv1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ssv1 Ssv1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQC FirstGlance]. <br>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ssv1]]		[[Category: Ssv1]]
	[[Category: Corn, G J]]		[[Category: Corn, G J]]

OCA at 20:45, 19 September 2018

2018-09-19T20:45:57Z

←Older revision		Revision as of 20:45, 19 September 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF A~~ DNA ~~BINDING WINGED~~-~~HELIX PROTEIN~~, F-112, ~~FROM SULFOLOBUS SPINDLE~~-~~SHAPED VIRUS~~ 1.==	+	==Structure of a DNA binding winged-helix protein, F-112, from Sulfolobus Spindle-shaped Virus 1.==
	<StructureSection load='2vqc' size='340' side='right' caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vqc' size='340' side='right' caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 28:		Line 28:
	[[Category: Young, M J]]		[[Category: Young, M J]]
	[[Category: Crenarchaeal]]		[[Category: Crenarchaeal]]
		+	[[Category: Dna binding protein]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]
	[[Category: Ssv]]		[[Category: Ssv]]

OCA at 12:39, 11 August 2016

2016-08-11T12:39:23Z

←Older revision		Revision as of 12:39, 11 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.==		==STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.==
	<StructureSection load='2vqc' size='340' side='right' caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2vqc' size='340' side='right' caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_virus_1 Sulfolobus virus 1~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ssv1 Ssv1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [http://www.ebi.ac.uk/pdbsum/2vqc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [http://pdbe.org/2vqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [http://www.ebi.ac.uk/pdbsum/2vqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vqc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vqc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Sulfolobus virus 1~~]]	+	[[Category: Ssv1]]
	[[Category: Corn, G J]]		[[Category: Corn, G J]]
	[[Category: Kraft, P]]		[[Category: Kraft, P]]

OCA at 06:40, 22 January 2015

2015-01-22T06:40:57Z

←Older revision		Revision as of 06:40, 22 January 2015
Line 19:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Sulfolobus virus 1]]		[[Category: Sulfolobus virus 1]]
-	[[Category: Corn, G J.]]	+	[[Category: Corn, G J]]
-	[[Category: Kraft, P.]]	+	[[Category: Kraft, P]]
-	[[Category: Lawrence, C M.]]	+	[[Category: Lawrence, C M]]
-	[[Category: Menon, S K.]]	+	[[Category: Menon, S K]]
-	[[Category: Wiedenheft, B.]]	+	[[Category: Wiedenheft, B]]
-	[[Category: Young, M J.]]	+	[[Category: Young, M J]]
	[[Category: Crenarchaeal]]		[[Category: Crenarchaeal]]
	[[Category: Dna-binding protein]]		[[Category: Dna-binding protein]]

OCA at 11:28, 20 October 2014

2014-10-20T11:28:12Z

←Older revision		Revision as of 11:28, 20 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vqc.~~png~~\|~~left\|200px~~]]	+	==STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.==
		+	<StructureSection load='2vqc' size='340' side='right' caption='[[2vqc]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_virus_1 Sulfolobus virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VQC FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vqc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vqc RCSB], [http://www.ebi.ac.uk/pdbsum/2vqc PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fuselloviridae are ubiquitous crenarchaeal viruses found in high-temperature acidic hot springs worldwide. The type virus, Sulfolobus spindle-shaped virus 1 (SSV1), has a double-stranded DNA genome that contains 34 open reading frames (ORFs). Fuselloviral genomes show little similarity to other organisms, generally precluding functional predictions. However, tertiary protein structure can provide insight into protein function. We have thus undertaken a systematic investigation of the SSV1 proteome and report here on the F112 gene product. Biochemical, proteomic and structural studies reveal a monomeric intracellular protein that adopts a winged helix DNA binding fold. Notably, the structure contains an intrachain disulfide bond, prompting analysis of cysteine usage in this and other hyperthermophilic viral genomes. The analysis supports a general abundance of disulfide bonds in the intracellular proteins of hyperthermophilic viruses, and reveals decreased cysteine content in the membrane proteins of hyperthermophilic viruses infecting Sulfolobales. The evolutionary implications of the SSV1 distribution are discussed.

-	~~{{STRUCTURE_2vqc\| PDB=2vqc \| SCENE= }}~~	+	Cysteine usage in Sulfolobus spindle-shaped virus 1 and extension to hyperthermophilic viruses in general.,Menon SK, Maaty WS, Corn GJ, Kwok SC, Eilers BJ, Kraft P, Gillitzer E, Young MJ, Bothner B, Lawrence CM Virology. 2008 Jul 5;376(2):270-8. Epub 2008 May 8. PMID:18471851<ref>PMID:18471851</ref>

-	~~===STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN~~, ~~F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18471851}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2vqc]] is a 1 chain structure with sequence from [http:~~//en.wikipedia.org/wiki/Sulfolobus_virus_1 Sulfolobus virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA].	+	</StructureSection>
	[[Category: Sulfolobus virus 1]]		[[Category: Sulfolobus virus 1]]
	[[Category: Corn, G J.]]		[[Category: Corn, G J.]]

OCA: Protected "2vqc" [edit=sysop:move=sysop]

2013-01-07T22:03:02Z

Protected "2vqc" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:03, 7 January 2013

OCA at 22:03, 7 January 2013

2013-01-07T22:03:00Z

←Older revision		Revision as of 22:03, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vqc.png\|left\|200px]]		[[Image:2vqc.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2vqc\| PDB=2vqc \| SCENE= }}		{{STRUCTURE_2vqc\| PDB=2vqc \| SCENE= }}

	===STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.===		===STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.===

-
-	<!--
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	{{ABSTRACT_PUBMED_18471851}}		{{ABSTRACT_PUBMED_18471851}}

	==About this Structure==		==About this Structure==
-	~~2VQC is a~~ [[~~Single protein~~]] structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_virus_1 Sulfolobus virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA].	+	[[2vqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_virus_1 Sulfolobus virus 1]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2cmx 2cmx]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VQC OCA].
-		+
-	~~==Reference==~~	+
-	Cysteine usage in Sulfolobus spindle-shaped virus 1 and extension to hyperthermophilic viruses in general., Menon SK, Maaty WS, Corn GJ, Kwok SC, Eilers BJ, Kraft P, Gillitzer E, Young MJ, Bothner B, Lawrence CM, Virology. 2008 Jul 5;376(2):270-8. Epub 2008 May 8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18471851 18471851]	+
-	~~[[Category: Single protein]]~~	+
	[[Category: Sulfolobus virus 1]]		[[Category: Sulfolobus virus 1]]
	[[Category: Corn, G J.]]		[[Category: Corn, G J.]]
Line 38:		Line 22:
	[[Category: Thermophilic protein]]		[[Category: Thermophilic protein]]
	[[Category: Winged-helix]]		[[Category: Winged-helix]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:17:37 2008''

OCA at 03:17, 28 July 2008

2008-07-28T03:17:39Z

←Older revision		Revision as of 03:17, 28 July 2008
Line 1:		Line 1:
-	[[Image:2vqc.~~jpg~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:2vqc.png\|left\|200px]]

	<!--		<!--
Line 9:		Line 10:
	{{STRUCTURE_2vqc\| PDB=2vqc \| SCENE= }}		{{STRUCTURE_2vqc\| PDB=2vqc \| SCENE= }}

-	~~'''~~STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.~~'''~~	+	===STRUCTURE OF A DNA BINDING WINGED-HELIX PROTEIN, F-112, FROM SULFOLOBUS SPINDLE-SHAPED VIRUS 1.===


-	~~==Overview==~~	+	<!--
-	~~Fuselloviridae are ubiquitous crenarchaeal viruses found in high-temperature acidic hot springs worldwide.~~ The ~~type virus~~, ~~Sulfolobus spindle-shaped virus 1 (SSV1)~~, ~~has a double-stranded DNA genome that contains 34 open reading frames (ORFs). Fuselloviral genomes show little similarity~~ to ~~other organisms, generally precluding functional predictions. However, tertiary protein structure can provide insight into protein function. We have thus undertaken a systematic investigation of~~ the ~~SSV1 proteome and report here~~ on ~~the F112 gene product~~. ~~Biochemical, proteomic and structural studies reveal a monomeric intracellular protein that adopts a winged helix DNA binding fold~~. ~~Notably~~, the structure contains an intrachain disulfide bond, prompting analysis of cysteine usage in this and other hyperthermophilic viral genomes. The analysis supports a general abundance of disulfide bonds in the intracellular proteins of hyperthermophilic viruses, and reveals decreased cysteine content in the membrane proteins of hyperthermophilic viruses infecting Sulfolobales. The evolutionary implications of the SSV1 distribution are discussed.	+	The line below this paragraph, {{ABSTRACT_PUBMED_18471851}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 18471851 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_18471851}}

	==About this Structure==		==About this Structure==
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	[[Category: Thermophilic protein]]		[[Category: Thermophilic protein]]
	[[Category: Winged-helix]]		[[Category: Winged-helix]]
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