2vu2 - Revision history

OCA at 15:31, 13 December 2023

2023-12-13T15:31:49Z

←Older revision		Revision as of 15:31, 13 December 2023
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	<StructureSection load='2vu2' size='340' side='right'caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2vu2' size='340' side='right'caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_19544 Atcc 19544~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [https://pdbe.org/2vu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vu2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [https://pdbe.org/2vu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vu2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/THIL_SHIZO THIL_SHIZO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Acetyl-CoA C-acetyltransferase]]
-	[[Category: Atcc 19544]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kursula, P]]	+	[[Category: Zoogloea ramigera]]
-	[[Category: Merilainen, G]]	+	[[Category: Kursula P]]
-	[[Category: Schmitz, W]]	+	[[Category: Merilainen G]]
-	[[Category: Wierenga~~, R K]]~~	+	[[Category: Schmitz W]]
-	~~[[Category: Acyltransferase]]~~	+	[[Category: Wierenga RK]]
-	~~[[Category: Phb biosynthesis]]~~	+
-	~~[[Category: Thiolase fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 10:49, 7 July 2021

2021-07-07T10:49:02Z

←Older revision		Revision as of 10:49, 7 July 2021
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	<StructureSection load='2vu2' size='340' side='right'caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2vu2' size='340' side='right'caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_19544 Atcc 19544]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_19544 Atcc 19544]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [~~http~~://pdbe.org/2vu2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vu2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vu2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [https://pdbe.org/2vu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [https://www.ebi.ac.uk/pdbsum/2vu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vu2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	==See Also==		==See Also==
-	*[[Thiolase\|Thiolase]]	+	*[[Thiolase 3D structures\|Thiolase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:41, 24 July 2019

2019-07-24T07:41:59Z

←Older revision		Revision as of 07:41, 24 July 2019
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	==Biosynthetic thiolase from Z. ramigera. Complex with S-pantetheine-11- pivalate.==		==Biosynthetic thiolase from Z. ramigera. Complex with S-pantetheine-11- pivalate.==
-	<StructureSection load='2vu2' size='340' side='right' caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='2vu2' size='340' side='right'caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19544 Atcc 19544]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19544 Atcc 19544]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>
Line 37:		Line 37:
	[[Category: Acetyl-CoA C-acetyltransferase]]		[[Category: Acetyl-CoA C-acetyltransferase]]
	[[Category: Atcc 19544]]		[[Category: Atcc 19544]]
		+	[[Category: Large Structures]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Merilainen, G]]		[[Category: Merilainen, G]]

OCA at 20:34, 19 September 2018

2018-09-19T20:34:25Z

←Older revision		Revision as of 20:34, 19 September 2018
Line 1:		Line 1:
-	==~~BIOSYNTHETIC THIOLASE FROM~~ Z. ~~RAMIGERA~~. ~~COMPLEX WITH~~ S-~~PANTETHEINE~~-11-~~PIVALATE~~.==	+
		+	==Biosynthetic thiolase from Z. ramigera. Complex with S-pantetheine-11- pivalate.==
	<StructureSection load='2vu2' size='340' side='right' caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2vu2' size='340' side='right' caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://pdbe.org/2vu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://pdbe.org/2vu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vu2 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vu2_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vu2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:30, 8 February 2016

2016-02-08T19:30:33Z

←Older revision		Revision as of 19:30, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2vu2' size='340' side='right' caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='2vu2' size='340' side='right' caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Zoogloea_ramigera Zoogloea ramigera~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19544 Atcc 19544]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://pdbe.org/2vu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vu2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vu2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Acetyl-CoA C-acetyltransferase]]		[[Category: Acetyl-CoA C-acetyltransferase]]
-	[[Category: ~~Zoogloea ramigera~~]]	+	[[Category: Atcc 19544]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Merilainen, G]]		[[Category: Merilainen, G]]

OCA at 16:14, 19 January 2015

2015-01-19T16:14:04Z

←Older revision		Revision as of 16:14, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Acetyl-CoA C-acetyltransferase]]		[[Category: Acetyl-CoA C-acetyltransferase]]
	[[Category: Zoogloea ramigera]]		[[Category: Zoogloea ramigera]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Merilainen, G.]]	+	[[Category: Merilainen, G]]
-	[[Category: Schmitz, W.]]	+	[[Category: Schmitz, W]]
-	[[Category: Wierenga, R K.]]	+	[[Category: Wierenga, R K]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Phb biosynthesis]]		[[Category: Phb biosynthesis]]
	[[Category: Thiolase fold]]		[[Category: Thiolase fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:23, 29 September 2014

2014-09-29T08:23:22Z

←Older revision		Revision as of 08:23, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2vu2.~~png~~\|~~left~~\|200px]]	+	==BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX WITH S-PANTETHEINE-11-PIVALATE.==
		+	<StructureSection load='2vu2' size='340' side='right' caption='[[2vu2]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VU2 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PN5:(3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-({3-OXO-3-[(2-SULFANYLETHYL)AMINO]PROPYL}AMINO)BUTYL+2,2-DIMETHYLPROPANOATE'>PN5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1m1o\|1m1o]], [[2vtz\|2vtz]], [[1dm3\|1dm3]], [[1m4s\|1m4s]], [[1nl7\|1nl7]], [[1dlv\|1dlv]], [[1ou6\|1ou6]], [[1m3z\|1m3z]], [[1m4t\|1m4t]], [[2vu0\|2vu0]], [[2vu1\|2vu1]], [[1qfl\|1qfl]], [[1m1t\|1m1t]], [[1dlu\|1dlu]], [[1m3k\|1m3k]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetyl-CoA_C-acetyltransferase Acetyl-CoA C-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.9 2.3.1.9] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vu2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vu2 RCSB], [http://www.ebi.ac.uk/pdbsum/2vu2 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vu/2vu2_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thioesters are more reactive than oxoesters, and thioester chemistry is important for the reaction mechanisms of many enzymes, including the members of the thiolase superfamily, which play roles in both degradative and biosynthetic pathways. In the reaction mechanism of the biosynthetic thiolase, the thioester moieties of acetyl-CoA and the acetylated catalytic cysteine react with each other, forming the product acetoacetyl-CoA. Although a number of studies have been carried out to elucidate the thiolase reaction mechanism at the atomic level, relatively little is known about the factors determining the affinity of thiolases towards their substrates. We have carried out crystallographic studies on the biosynthetic thiolase from Zoogloea ramigera complexed with CoA and three of its synthetic analogues to compare the binding modes of these related compounds. The results show that both the CoA terminal SH group and the side chain SH group of the catalytic Cys89 are crucial for the correct positioning of substrate in the thiolase catalytic pocket. Furthermore, calorimetric assays indicate that the mutation of Cys89 into an alanine significantly decreases the affinity of thiolase towards CoA. Thus, although the sulfur atom of the thioester moiety is important for the reaction mechanism of thioester-dependent enzymes, its specific properties can also affect the affinity and competent mode of binding of the thioester substrates to these enzymes.

-	~~{{STRUCTURE_2vu2\| PDB=2vu2 \| SCENE= }}~~	+	The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme.,Merilainen G, Schmitz W, Wierenga RK, Kursula P FEBS J. 2008 Dec;275(24):6136-48. Epub 2008 Nov 1. PMID:19016856<ref>PMID:19016856</ref>

-	~~===BIOSYNTHETIC THIOLASE FROM Z~~. ~~RAMIGERA. COMPLEX WITH~~ S~~-PANTETHEINE-11-PIVALATE~~.~~===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19016856}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vu2]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA].~~	+

	==See Also==		==See Also==
	*[[Thiolase\|Thiolase]]		*[[Thiolase\|Thiolase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019016856<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Acetyl-CoA C-acetyltransferase]]		[[Category: Acetyl-CoA C-acetyltransferase]]
	[[Category: Zoogloea ramigera]]		[[Category: Zoogloea ramigera]]

OCA at 11:14, 20 October 2012

2012-10-20T11:14:08Z

←Older revision		Revision as of 11:14, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2vu2]] is a 4 chain structure ~~of [[Thiolase]]~~ with sequence from [http://en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA].	+	[[2vu2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Zoogloea_ramigera Zoogloea ramigera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VU2 OCA].

	==See Also==		==See Also==

OCA at 04:40, 26 July 2012

2012-07-26T04:40:23Z

←Older revision		Revision as of 04:40, 26 July 2012
Line 1:		Line 1:
	[[Image:2vu2.png\|left\|200px]]		[[Image:2vu2.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vu2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vu2\| PDB=2vu2 \| SCENE= }}		{{STRUCTURE_2vu2\| PDB=2vu2 \| SCENE= }}

	===BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX WITH S-PANTETHEINE-11-PIVALATE.===		===BIOSYNTHETIC THIOLASE FROM Z. RAMIGERA. COMPLEX WITH S-PANTETHEINE-11-PIVALATE.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19016856}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19016856 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19016856}}		{{ABSTRACT_PUBMED_19016856}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Thiolase]]	+	*[[Thiolase\|Thiolase]]

	==Reference==		==Reference==

OCA: Protected "2vu2" [edit=sysop:move=sysop]

2011-08-24T05:03:25Z

Protected "2vu2" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:03, 24 August 2011