2vxk - Revision history

OCA at 10:05, 9 May 2024

2024-05-09T10:05:34Z

←Older revision		Revision as of 10:05, 9 May 2024
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	<StructureSection load='2vxk' size='340' side='right'caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2vxk' size='340' side='right'caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=16G:N~~-~~ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>~~, ~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2vez\|2vez]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [https://pdbe.org/2vxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [https://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [https://pdbe.org/2vxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [https://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4WCU5_ASPFU Q4WCU5_ASPFU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Glucosamine-phosphate N-acetyltransferase~~]]	+	[[Category: Aspergillus fumigatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Aalten, D M.F van]]~~	+	[[Category: Hurtado-Guerrero R]]
-	[[Category: Hurtado-Guerrero, R]]	+	[[Category: Ibrahim AFM]]
-	[[Category: Ibrahim~~, A F.M~~]]	+	[[Category: Min J]]
-	[[Category: Min, J]]	+	[[Category: Plotnikov AN]]
-	[[Category: Plotnikov~~, A N~~]]	+	[[Category: Raimi OG]]
-	[[Category: Raimi~~, O G~~]]	+	[[Category: Shepherd S]]
-	[[Category: Shepherd, S]]	+	[[Category: Vallius L]]
-	[[Category: Vallius, L]]	+	[[Category: Wu H]]
-	[[Category: Wu, H]]	+	[[Category: Zeng H]]
-	[[Category: Zeng, H]]	+	[[Category: Van Aalten DMF]]
-	[[Category: ~~Inhibitor design]]~~	+
-	~~[[Category: Kinetic]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Udp-glcnac~~]]	+

OCA at 11:48, 30 March 2022

2022-03-30T11:48:42Z

←Older revision		Revision as of 11:48, 30 March 2022
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	<StructureSection load='2vxk' size='340' side='right'caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2vxk' size='340' side='right'caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VXK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vez\|2vez]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [~~http~~://pdbe.org/2vxk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [https://pdbe.org/2vxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [https://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:39, 25 June 2020

2020-06-25T08:39:53Z

OCA at 20:53, 19 September 2018

2018-09-19T20:53:18Z

←Older revision		Revision as of 20:53, 19 September 2018
Line 1:		Line 1:
-	==~~STRUCTURAL COMPARISON BETWEEN ASPERGILLUS FUMIGATUS AND HUMAN~~ GNA1==	+
		+	==Structural comparison between Aspergillus fumigatus and human GNA1==
	<StructureSection load='2vxk' size='340' side='right' caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2vxk' size='340' side='right' caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://pdbe.org/2vxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://pdbe.org/2vxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Glucosamine-phosphate N-acetyltransferase]]		[[Category: Glucosamine-phosphate N-acetyltransferase]]
-	[[Category: Aalten, D M.F ~~Van~~]]	+	[[Category: Aalten, D M.F van]]
	[[Category: Hurtado-Guerrero, R]]		[[Category: Hurtado-Guerrero, R]]
	[[Category: Ibrahim, A F.M]]		[[Category: Ibrahim, A F.M]]

OCA at 06:00, 8 February 2016

2016-02-08T06:00:48Z

←Older revision		Revision as of 06:00, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2vxk' size='340' side='right' caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2vxk' size='340' side='right' caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://pdbe.org/2vxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vxk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vxk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aspergillus fumigatus]]
	[[Category: Glucosamine-phosphate N-acetyltransferase]]		[[Category: Glucosamine-phosphate N-acetyltransferase]]
	[[Category: Aalten, D M.F Van]]		[[Category: Aalten, D M.F Van]]

OCA at 16:40, 19 January 2015

2015-01-19T16:40:38Z

←Older revision		Revision as of 16:40, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXK FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Glucosamine-phosphate N-acetyltransferase]]		[[Category: Glucosamine-phosphate N-acetyltransferase]]
-	[[Category: Aalten, D M.F Van.]]	+	[[Category: Aalten, D M.F Van]]
-	[[Category: Hurtado-Guerrero, R.]]	+	[[Category: Hurtado-Guerrero, R]]
-	[[Category: Ibrahim, A F.M.]]	+	[[Category: Ibrahim, A F.M]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: Plotnikov, A N.]]	+	[[Category: Plotnikov, A N]]
-	[[Category: Raimi, O G.]]	+	[[Category: Raimi, O G]]
-	[[Category: Shepherd, S.]]	+	[[Category: Shepherd, S]]
-	[[Category: Vallius, L.]]	+	[[Category: Vallius, L]]
-	[[Category: Wu, H.]]	+	[[Category: Wu, H]]
-	[[Category: Zeng, H.]]	+	[[Category: Zeng, H]]
	[[Category: Inhibitor design]]		[[Category: Inhibitor design]]
	[[Category: Kinetic]]		[[Category: Kinetic]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Udp-glcnac]]		[[Category: Udp-glcnac]]

OCA at 01:26, 1 October 2014

2014-10-01T01:26:33Z

←Older revision		Revision as of 01:26, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vxk.~~png~~\|~~left~~\|200px]]	+	==STRUCTURAL COMPARISON BETWEEN ASPERGILLUS FUMIGATUS AND HUMAN GNA1==
		+	<StructureSection load='2vxk' size='340' side='right' caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXK FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aspergillus fumigatus is the causative agent of aspergillosis, a frequently invasive colonization of the lungs of immunocompromised patients. GNA1 (D-glucosamine-6-phosphate N-acetyltransferase) catalyses the acetylation of GlcN-6P (glucosamine-6-phosphate) to GlcNAc-6P (N-acetylglucosamine-6-phosphate), a key intermediate in the UDP-GlcNAc biosynthetic pathway. Gene disruption of gna1 in yeast and Candida albicans has provided genetic validation of the enzyme as a potential target. An understanding of potential active site differences between the human and A. fumigatus enzymes is required to enable further work aimed at identifying selective inhibitors for the fungal enzyme. In the present study, we describe crystal structures of both human and A. fumigatus GNA1, as well as their kinetic characterization. The structures show significant differences in the sugar-binding site with, in particular, several non-conservative substitutions near the phosphate-binding pocket. Mutagenesis targeting these differences revealed drastic effects on steady-state kinetics, suggesting that the differences could be exploitable with small-molecule inhibitors.

-	~~{{STRUCTURE_2vxk\| PDB=2vxk \| SCENE= }}~~	+	Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.,Hurtado-Guerrero R, Raimi OG, Min J, Zeng H, Vallius L, Shepherd S, Ibrahim AF, Wu H, Plotnikov AN, van Aalten DM Biochem J. 2008 Oct 15;415(2):217-23. PMID:18601654<ref>PMID:18601654</ref>

-	~~===STRUCTURAL COMPARISON BETWEEN ASPERGILLUS FUMIGATUS AND HUMAN GNA1===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_18601654}}~~	+	== References ==
-		+	<references/>
-	==~~About this Structure~~==	+	__TOC__
-	~~[[2vxk]] is a 1 chain structure with sequence from [http:~~//~~en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA].~~	+	</StructureSection>
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Glucosamine-phosphate N-acetyltransferase]]		[[Category: Glucosamine-phosphate N-acetyltransferase]]

OCA: Protected "2vxk" [edit=sysop:move=sysop]

2013-01-07T22:07:53Z

Protected "2vxk" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:07, 7 January 2013

OCA at 22:07, 7 January 2013

2013-01-07T22:07:51Z

←Older revision		Revision as of 22:07, 7 January 2013
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-	{{Seed}}
	[[Image:2vxk.png\|left\|200px]]		[[Image:2vxk.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vxk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vxk\| PDB=2vxk \| SCENE= }}		{{STRUCTURE_2vxk\| PDB=2vxk \| SCENE= }}

	===STRUCTURAL COMPARISON BETWEEN ASPERGILLUS FUMIGATUS AND HUMAN GNA1===		===STRUCTURAL COMPARISON BETWEEN ASPERGILLUS FUMIGATUS AND HUMAN GNA1===

		+	{{ABSTRACT_PUBMED_18601654}}

	==About this Structure==		==About this Structure==
-	~~2VXK~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA].	+	[[2vxk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA].
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
-	[[Category: Glucosamine 6-phosphate N-acetyltransferase]]	+	[[Category: Glucosamine-phosphate N-acetyltransferase]]
		+	[[Category: Aalten, D M.F Van.]]
	[[Category: Hurtado-Guerrero, R.]]		[[Category: Hurtado-Guerrero, R.]]
-	[[Category: Ibrahim, A.]]	+	[[Category: Ibrahim, A F.M.]]
	[[Category: Min, J.]]		[[Category: Min, J.]]
	[[Category: Plotnikov, A N.]]		[[Category: Plotnikov, A N.]]
-	[[Category: Raimi, O.]]	+	[[Category: Raimi, O G.]]
-	[[Category: ~~Shepard~~, S.]]	+	[[Category: Shepherd, S.]]
	[[Category: Vallius, L.]]		[[Category: Vallius, L.]]
-	[[Category: Vanaalten, D M.F.]]
	[[Category: Wu, H.]]		[[Category: Wu, H.]]
	[[Category: Zeng, H.]]		[[Category: Zeng, H.]]
-	[[Category: Acyltransferase]]
-	[[Category: Aspergillus fumigatus]]
	[[Category: Inhibitor design]]		[[Category: Inhibitor design]]
	[[Category: Kinetic]]		[[Category: Kinetic]]
-	[[Category: Mutagenesis]]
-	[[Category: Protein structure]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Udp-glcnac]]		[[Category: Udp-glcnac]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:38:43 2009''

OCA at 17:38, 16 February 2009

2009-02-16T17:38:44Z

←Older revision		Revision as of 17:38, 16 February 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2vxk.~~jpg~~\|left\|200px]]	+	[[Image:2vxk.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	2VXK is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA].	+	2VXK is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA].
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Glucosamine 6-phosphate N-acetyltransferase]]		[[Category: Glucosamine 6-phosphate N-acetyltransferase]]
-	[[Category: Single protein]]
	[[Category: Hurtado-Guerrero, R.]]		[[Category: Hurtado-Guerrero, R.]]
	[[Category: Ibrahim, A.]]		[[Category: Ibrahim, A.]]
Line 37:		Line 36:
	[[Category: Udp-glcnac]]		[[Category: Udp-glcnac]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jul~~ 16 10:44:~~52 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:38:43 2009''

←Older revision		Revision as of 08:39, 25 June 2020
Line 1:		Line 1:

	==Structural comparison between Aspergillus fumigatus and human GNA1==		==Structural comparison between Aspergillus fumigatus and human GNA1==
-	<StructureSection load='2vxk' size='340' side='right' caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='2vxk' size='340' side='right'caption='[[2vxk]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VXK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXK OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VXK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=16G:N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE'>16G</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vez\|2vez]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosamine-phosphate_N-acetyltransferase Glucosamine-phosphate N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.4 2.3.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://pdbe.org/2vxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxk OCA], [http://pdbe.org/2vxk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxk RCSB], [http://www.ebi.ac.uk/pdbsum/2vxk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Glucosamine-phosphate N-acetyltransferase]]		[[Category: Glucosamine-phosphate N-acetyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]
	[[Category: Hurtado-Guerrero, R]]		[[Category: Hurtado-Guerrero, R]]