2vxu - Revision history

OCA at 15:36, 13 December 2023

2023-12-13T15:36:55Z

←Older revision		Revision as of 15:36, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vxu' size='340' side='right'caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='2vxu' size='340' side='right'caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXU FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[2vxt\|2vxt]]~~, [[~~2vxv~~\|~~2vxv~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.36Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [https://pdbe.org/2vxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [https://www.ebi.ac.uk/pdbsum/2vxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [https://pdbe.org/2vxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [https://www.ebi.ac.uk/pdbsum/2vxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxu ProSAT]</span></td></tr>
	</table>		</table>
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Argiriadi~~, M A~~]]	+	[[Category: Argiriadi MA]]
-	[[Category: Borhani~~, D W~~]]	+	[[Category: Borhani DW]]
-	[[Category: Ghayur, T]]	+	[[Category: Ghayur T]]
-	[[Category: Wu, C]]	+	[[Category: Wu C]]
-	[[Category: Xiang, T]]	+	[[Category: Xiang T]]
-	~~[[Category: Autoimmunity]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Il-18]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Th1/th2 cell~~]]	+

OCA at 10:50, 7 July 2021

2021-07-07T10:50:38Z

←Older revision		Revision as of 10:50, 7 July 2021
Line 1:		Line 1:

	==Crystal structure of murine reference antibody 125-2H Fab fragment==		==Crystal structure of murine reference antibody 125-2H Fab fragment==
-	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>	+	<StructureSection load='2vxu' size='340' side='right'caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VXU FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vxt\|2vxt]], [[2vxv\|2vxv]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [~~http~~://pdbe.org/2vxu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vxu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [https://pdbe.org/2vxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [https://www.ebi.ac.uk/pdbsum/2vxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Argiriadi, M A]]		[[Category: Argiriadi, M A]]

OCA at 07:52, 6 March 2019

2019-03-06T07:52:37Z

←Older revision		Revision as of 07:52, 6 March 2019
Line 1:		Line 1:

	==Crystal structure of murine reference antibody 125-2H Fab fragment==		==Crystal structure of murine reference antibody 125-2H Fab fragment==
-	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>	+	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>

OCA at 20:34, 19 September 2018

2018-09-19T20:34:55Z

←Older revision		Revision as of 20:34, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF MURINE REFERENCE ANTIBODY~~ 125-2H ~~FAB FRAGMENT~~==	+
		+	==Crystal structure of murine reference antibody 125-2H Fab fragment==
	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://pdbe.org/2vxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://pdbe.org/2vxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vxu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:25, 10 February 2016

2016-02-10T07:25:50Z

←Older revision		Revision as of 07:25, 10 February 2016
Line 2:		Line 2:
	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://pdbe.org/2vxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vxu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vxu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Argiriadi, M A]]		[[Category: Argiriadi, M A]]
	[[Category: Borhani, D W]]		[[Category: Borhani, D W]]

OCA at 17:20, 19 January 2015

2015-01-19T17:20:22Z

←Older revision		Revision as of 17:20, 19 January 2015
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Argiriadi, M A.]]	+	[[Category: Argiriadi, M A]]
-	[[Category: Borhani, D W.]]	+	[[Category: Borhani, D W]]
-	[[Category: Ghayur, T.]]	+	[[Category: Ghayur, T]]
-	[[Category: Wu, C.]]	+	[[Category: Wu, C]]
-	[[Category: Xiang, T.]]	+	[[Category: Xiang, T]]
	[[Category: Autoimmunity]]		[[Category: Autoimmunity]]
	[[Category: Fab]]		[[Category: Fab]]

OCA at 06:24, 10 October 2014

2014-10-10T06:24:13Z

←Older revision		Revision as of 06:24, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. <br>	+	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VXU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 22:
	Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.,Argiriadi MA, Xiang T, Wu C, Ghayur T, Borhani DW J Biol Chem. 2009 Sep 4;284(36):24478-89. Epub 2009 Jun 24. PMID:19553661<ref>PMID:19553661</ref>		Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.,Argiriadi MA, Xiang T, Wu C, Ghayur T, Borhani DW J Biol Chem. 2009 Sep 4;284(36):24478-89. Epub 2009 Jun 24. PMID:19553661<ref>PMID:19553661</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 08:33, 7 May 2014

2014-05-07T08:33:59Z

←Older revision		Revision as of 08:33, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2vxu.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF MURINE REFERENCE ANTIBODY 125-2H FAB FRAGMENT==
		+	<StructureSection load='2vxu' size='340' side='right' caption='[[2vxu]], [[Resolution\|resolution]] 2.36Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2vxt\|2vxt]], [[2vxv\|2vxv]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vxu RCSB], [http://www.ebi.ac.uk/pdbsum/2vxu PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/2vxu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The unique cytokine interleukin-18 (IL-18) acts synergistically with IL-12 to regulate T-helper 1 and 2 lymphocytes and, as such, seems to underlie the pathogenesis of various autoimmune and allergic diseases. Several anti-IL-18 agents are in clinical development, including the recombinant human antibody ABT-325, which is entering trials for autoimmune diseases. Given competing cytokine/receptor and cytokine/receptor decoy interactions, understanding the structural basis for recognition is critical for effective development of anti-cytokine therapies. Here we report three crystal structures: the murine antibody 125-2H Fab fragment bound to human IL-18, at 1.5 A resolution; the 125-2H Fab (2.3 A); and the ABT-325 Fab (1.5 A). These structures, along with human/mouse IL-18 chimera binding data, allow us to make three key observations relevant to the biology and antigenic recognition of IL-18 and related cytokines. First, several IL-18 residues shift dramatically (> 10 A) upon binding 125-2H, compared with unbound IL-18 (Kato, Z., Jee, J., Shikano, H., Mishima, M., Ohki, I., Ohnishi, H., Li, A., Hashimoto, K., Matsukuma, E., Omoya, K., Yamamoto, Y., Yoneda, T., Hara, T., Kondo, N., and Shirakawa, M. (2003) Nat. Struct. Biol. 10, 966-971). IL-18 thus exhibits plasticity that may be common to its interactions with other receptors. Related cytokines may exhibit similar plasticity. Second, ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes. These data allow us to define the likely ABT-325 epitope and thereby explain the distinct neutralizing mechanisms of both antibodies. Third, given the high 125-2H potency, 10 well ordered water molecules are trapped upon complex formation in a cavity between two IL-18 loops and all six 125-2H complementarity-determining regions. Thus, counterintuitively, tight and specific antibody binding may in some cases be water-mediated.

-	<!--	+	Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.,Argiriadi MA, Xiang T, Wu C, Ghayur T, Borhani DW J Biol Chem. 2009 Sep 4;284(36):24478-89. Epub 2009 Jun 24. PMID:19553661<ref>PMID:19553661</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2vxu"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2vxu\| PDB=2vxu \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF MURINE REFERENCE ANTIBODY 125-2H FAB FRAGMENT===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19553661}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19553661 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19553661}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2vxu]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019553661<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Argiriadi, M A.]]		[[Category: Argiriadi, M A.]]

OCA: Protected "2vxu" [edit=sysop:move=sysop]

2011-08-24T05:04:34Z

Protected "2vxu" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:04, 24 August 2011

OCA at 05:04, 24 August 2011

2011-08-24T05:04:33Z

←Older revision		Revision as of 05:04, 24 August 2011
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-	{{Seed}}
	[[Image:2vxu.png\|left\|200px]]		[[Image:2vxu.png\|left\|200px]]

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	===CRYSTAL STRUCTURE OF MURINE REFERENCE ANTIBODY 125-2H FAB FRAGMENT===		===CRYSTAL STRUCTURE OF MURINE REFERENCE ANTIBODY 125-2H FAB FRAGMENT===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19553661}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19553661 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19553661}}

	==About this Structure==		==About this Structure==
-	~~2VXU~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA].	+	[[2vxu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VXU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019553661</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Argiriadi, M A.]]		[[Category: Argiriadi, M A.]]
Line 26:		Line 34:
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Th1/th2 cell]]		[[Category: Th1/th2 cell]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 20:13:00 2009''