2vya - Revision history

OCA at 15:37, 13 December 2023

2023-12-13T15:37:30Z

←Older revision		Revision as of 15:37, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mt5\|1mt5]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amidase Amidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [https://pdbe.org/2vya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [https://www.ebi.ac.uk/pdbsum/2vya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [https://pdbe.org/2vya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [https://www.ebi.ac.uk/pdbsum/2vya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Amidase]]
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ahn, K]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Bhattacharya, K]]	+	[[Category: Ahn K]]
-	[[Category: Cravatt~~, B F~~]]	+	[[Category: Bhattacharya K]]
-	[[Category: Everdeen~~, D S~~]]	+	[[Category: Cravatt BF]]
-	[[Category: Johnson~~, D S~~]]	+	[[Category: Everdeen DS]]
-	[[Category: Kamtekar, S]]	+	[[Category: Johnson DS]]
-	[[Category: Liimatta, M]]	+	[[Category: Kamtekar S]]
-	[[Category: Mileni, M]]	+	[[Category: Liimatta M]]
-	[[Category: Nugent~~, R A~~]]	+	[[Category: Mileni M]]
-	[[Category: Pabst, B]]	+	[[Category: Nugent RA]]
-	[[Category: Stevens~~, R C~~]]	+	[[Category: Pabst B]]
-	[[Category: Wang, Z]]	+	[[Category: Stevens RC]]
-	~~[[Category: Chimera]]~~	+	[[Category: Wang Z]]
-	~~[[Category: Covalent]]~~	+
-	~~[[Category: Drug- like]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Faah]]~~	+
-	~~[[Category: Fatty acid amide hydrolyse]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Humanized]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 11:49, 30 March 2022

2022-03-30T11:49:11Z

←Older revision		Revision as of 11:49, 30 March 2022
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	<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mt5\|1mt5]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Amidase Amidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Amidase Amidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [~~http~~://pdbe.org/2vya PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2vya PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [https://pdbe.org/2vya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [https://www.ebi.ac.uk/pdbsum/2vya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:42, 25 June 2020

2020-06-25T08:42:05Z

←Older revision		Revision as of 08:42, 25 June 2020
Line 1:		Line 1:

	==Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750==		==Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750==
-	<StructureSection load='2vya' size='340' side='right' caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='2vya' size='340' side='right'caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2VYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://pdbe.org/2vya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://pdbe.org/2vya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Ahn, K]]		[[Category: Ahn, K]]
	[[Category: Bhattacharya, K]]		[[Category: Bhattacharya, K]]

OCA at 21:29, 19 September 2018

2018-09-19T21:29:22Z

←Older revision		Revision as of 21:29, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG~~-~~LIKE INHIBITOR~~ PF-750==	+
		+	==Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750==
	<StructureSection load='2vya' size='340' side='right' caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2vya' size='340' side='right' caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://pdbe.org/2vya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://pdbe.org/2vya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vya ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vya_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vya_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:55, 7 February 2016

2016-02-07T21:55:24Z

←Older revision		Revision as of 21:55, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='2vya' size='340' side='right' caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>		<StructureSection load='2vya' size='340' side='right' caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VYA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://pdbe.org/2vya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vya ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2vya" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Amidase]]		[[Category: Amidase]]
-	[[Category: ~~Rattus norvegicus~~]]	+	[[Category: Buffalo rat]]
	[[Category: Ahn, K]]		[[Category: Ahn, K]]
	[[Category: Bhattacharya, K]]		[[Category: Bhattacharya, K]]

OCA at 16:06, 19 January 2015

2015-01-19T16:06:31Z

←Older revision		Revision as of 16:06, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VYA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Ahn, K.]]	+	[[Category: Ahn, K]]
-	[[Category: Bhattacharya, K.]]	+	[[Category: Bhattacharya, K]]
-	[[Category: Cravatt, B F.]]	+	[[Category: Cravatt, B F]]
-	[[Category: Everdeen, D S.]]	+	[[Category: Everdeen, D S]]
-	[[Category: Johnson, D S.]]	+	[[Category: Johnson, D S]]
-	[[Category: Kamtekar, S.]]	+	[[Category: Kamtekar, S]]
-	[[Category: Liimatta, M.]]	+	[[Category: Liimatta, M]]
-	[[Category: Mileni, M.]]	+	[[Category: Mileni, M]]
-	[[Category: Nugent, R A.]]	+	[[Category: Nugent, R A]]
-	[[Category: Pabst, B.]]	+	[[Category: Pabst, B]]
-	[[Category: Stevens, R C.]]	+	[[Category: Stevens, R C]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
	[[Category: Chimera]]		[[Category: Chimera]]
	[[Category: Covalent]]		[[Category: Covalent]]

OCA at 02:22, 1 October 2014

2014-10-01T02:22:12Z

←Older revision		Revision as of 02:22, 1 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2vya.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG-LIKE INHIBITOR PF-750==
		+	<StructureSection load='2vya' size='340' side='right' caption='[[2vya]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VYA FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PF7:4-(QUINOLIN-3-YLMETHYL)PIPERIDINE-1-CARBOXYLIC+ACID'>PF7</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mt5\|1mt5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vya OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vya RCSB], [http://www.ebi.ac.uk/pdbsum/2vya PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vya_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The integral membrane enzyme fatty acid amide hydrolase (FAAH) hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Genetic or pharmacological inactivation of FAAH produces analgesic, anxiolytic, and antiinflammatory phenotypes but not the undesirable side effects of direct cannabinoid receptor agonists, indicating that FAAH may be a promising therapeutic target. Structure-based inhibitor design has, however, been hampered by difficulties in expressing the human FAAH enzyme. Here, we address this problem by interconverting the active sites of rat and human FAAH using site-directed mutagenesis. The resulting humanized rat (h/r) FAAH protein exhibits the inhibitor sensitivity profiles of human FAAH but maintains the high-expression yield of the rat enzyme. We report a 2.75-A crystal structure of h/rFAAH complexed with an inhibitor, N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide (PF-750), that shows strong preference for human FAAH. This structure offers compelling insights to explain the species selectivity of FAAH inhibitors, which should guide future drug design programs.

-	~~{{STRUCTURE_2vya\| PDB=2vya \| SCENE= }}~~	+	Structure-guided inhibitor design for human FAAH by interspecies active site conversion.,Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. Epub 2008 Aug 27. PMID:18753625<ref>PMID:18753625</ref>

-	~~===CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG-LIKE INHIBITOR PF-750===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_18753625}}~~	+	==See Also==
-		+	*[[Fatty acid amide hydrolase\|Fatty acid amide hydrolase]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2vya~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:018753625<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]

OCA: Protected "2vya" [edit=sysop:move=sysop]

2013-01-07T19:09:20Z

Protected "2vya" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:09, 7 January 2013

OCA at 19:09, 7 January 2013

2013-01-07T19:09:18Z

←Older revision		Revision as of 19:09, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2vya.png\|left\|200px]]		[[Image:2vya.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2vya", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2vya\| PDB=2vya \| SCENE= }}		{{STRUCTURE_2vya\| PDB=2vya \| SCENE= }}

	===CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG-LIKE INHIBITOR PF-750===		===CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE CONJUGATED WITH THE DRUG-LIKE INHIBITOR PF-750===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_18753625}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 18753625 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_18753625}}		{{ABSTRACT_PUBMED_18753625}}

	==About this Structure==		==About this Structure==
-	~~2VYA~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA].	+	[[2vya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~18753625~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:018753625</ref><references group="xtra"/>
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
Line 50:		Line 38:
	[[Category: Membrane]]		[[Category: Membrane]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:45:37 2009''

OCA at 14:45, 16 February 2009

2009-02-16T14:45:38Z

←Older revision		Revision as of 14:45, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2VYA is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA].	+	2VYA is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VYA OCA].

	==Reference==		==Reference==
-	Structure-guided inhibitor design for human FAAH by interspecies active site conversion., Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC, Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. Epub 2008 Aug 27. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/18753625 18753625]~~	+	<ref group="xtra">PMID:18753625</ref><references group="xtra"/>
	[[Category: Amidase]]		[[Category: Amidase]]
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
-	[[Category: Single protein]]
	[[Category: Ahn, K.]]		[[Category: Ahn, K.]]
	[[Category: Bhattacharya, K.]]		[[Category: Bhattacharya, K.]]
Line 52:		Line 51:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Sep 17 13~~:10:~~51 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:45:37 2009''