2w0t - Revision history

OCA at 07:59, 4 November 2020

2020-11-04T07:59:14Z

←Older revision		Revision as of 07:59, 4 November 2020
Line 1:		Line 1:

	==Solution structure of the FCS zinc finger domain of human LMBL2==		==Solution structure of the FCS zinc finger domain of human LMBL2==
-	<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='2w0t' size='340' side='right'caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 10:18, 30 January 2019

2019-01-30T10:18:57Z

←Older revision		Revision as of 10:18, 30 January 2019
Line 3:		Line 3:
	<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 06:19, 19 April 2017

2017-04-19T06:19:54Z

←Older revision		Revision as of 06:19, 19 April 2017
Line 1:		Line 1:

-	==~~SOLUTION STRUCTURE OF THE~~ FCS ~~ZINC FINGER DOMAIN OF HUMAN~~ LMBL2==	+	==Solution structure of the FCS zinc finger domain of human LMBL2==
	<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]
	[[Category: Lechtenberg, B C]]		[[Category: Lechtenberg, B C]]
		+	[[Category: Alternative splicing]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Lmbl2]]		[[Category: Lmbl2]]
Line 45:		Line 45:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Polycomb group]]		[[Category: Polycomb group]]
		+	[[Category: Polymorphism]]
	[[Category: Rna binding]]		[[Category: Rna binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
Line 50:		Line 51:
	[[Category: Treble clef fold]]		[[Category: Treble clef fold]]
	[[Category: Yacg]]		[[Category: Yacg]]
		+	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

OCA at 21:57, 5 August 2016

2016-08-05T21:57:15Z

←Older revision		Revision as of 21:57, 5 August 2016
Line 1:		Line 1:
		+
	==SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2==		==SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2==
	<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://pdbe.org/2w0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w0t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w0t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w0t" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Bycroft, M]]		[[Category: Bycroft, M]]

OCA at 22:15, 25 December 2014

2014-12-25T22:15:11Z

←Older revision		Revision as of 22:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LMBL2_HUMAN LMBL2_HUMAN]] Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'.<ref>PMID:19233876</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Allen, M D.]]	+	[[Category: Allen, M D]]
-	[[Category: Bycroft, M.]]	+	[[Category: Bycroft, M]]
-	[[Category: Lechtenberg, B C.]]	+	[[Category: Lechtenberg, B C]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Lmbl2]]		[[Category: Lmbl2]]

OCA at 01:39, 1 October 2014

2014-10-01T01:39:19Z

←Older revision		Revision as of 01:39, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2w0t.~~png\|left~~\|200px]]	+	==SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2==
		+	<StructureSection load='2w0t' size='340' side='right' caption='[[2w0t]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W0T FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w0t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w0t RCSB], [http://www.ebi.ac.uk/pdbsum/2w0t PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w0/2w0t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Polycomb group proteins are epigenetic regulators that maintain patterns of gene expression over multiple rounds of cell division. Many of these proteins, including polyhomeotic and the MBT repeat containing proteins SCM and dSfmbt, contain an atypical C2C2 zinc finger with a characteristic phenylalanine-cysteine-serine sequence motif. The reoccurrence of this so-called FCS zinc finger in a variety of polycomb group proteins suggests that it has an important regulatory function. We have determined the solution structure of the FCS zinc finger of the human dSfmbt homologue L(3)mbt-like 2 (L3MBTL2). The structure consists of a beta-hairpin followed by an alpha-helix. The zinc ligands are situated in the beta-hairpin and at the N-terminus of the alpha-helix an arrangement typical of the treble clef class of zinc fingers. The structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs.

-	~~{{STRUCTURE_2w0t\| PDB=2w0t \| SCENE= }}~~	+	Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2.,Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M Protein Sci. 2009 Mar;18(3):657-61. PMID:19241375<ref>PMID:19241375</ref>

-	~~===SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19241375}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w0t]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019241375<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D.]]

OCA: Protected "2w0t" [edit=sysop:move=sysop]

2013-01-07T22:30:41Z

Protected "2w0t" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:30, 7 January 2013

OCA at 22:30, 7 January 2013

2013-01-07T22:30:40Z

←Older revision		Revision as of 22:30, 7 January 2013
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	[[Image:2w0t.png\|left\|200px]]		[[Image:2w0t.png\|left\|200px]]

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	{{STRUCTURE_2w0t\| PDB=2w0t \| SCENE= }}		{{STRUCTURE_2w0t\| PDB=2w0t \| SCENE= }}

	===SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2===		===SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2===

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	{{ABSTRACT_PUBMED_19241375}}		{{ABSTRACT_PUBMED_19241375}}

	==About this Structure==		==About this Structure==
-	~~2W0T~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].	+	[[2w0t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19241375~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019241375</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D.]]
	[[Category: Bycroft, M.]]		[[Category: Bycroft, M.]]
	[[Category: Lechtenberg, B C.]]		[[Category: Lechtenberg, B C.]]
-	[[Category: Alternative splicing]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Lmbl2]]		[[Category: Lmbl2]]
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	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Polycomb group]]		[[Category: Polycomb group]]
-	[[Category: Polymorphism]]
	[[Category: Rna binding]]		[[Category: Rna binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
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	[[Category: Treble clef fold]]		[[Category: Treble clef fold]]
	[[Category: Yacg]]		[[Category: Yacg]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:58:38 2010''

OCA at 08:49, 22 September 2010

2010-09-22T08:49:40Z

←Older revision		Revision as of 08:49, 22 September 2010
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	==About this Structure==		==About this Structure==
-	2W0T is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].	+	2W0T is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].

	==Reference==		==Reference==
-	~~Solution structure of the FCS zinc finger domain of the human polycomb~~ group ~~protein L(3)mbt-like 2., Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M, Protein Sci. 2009 Mar;18(3):657-61.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/19241375 19241375]~~	+	<ref group="xtra">PMID:19241375</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Single protein~~]]	+	[[Category: Allen, M D.]]
-	[[Category: ~~Pdbx_ordinal=~~, ~~<PDBx~~:~~audit_author~~.]]	+	[[Category: Bycroft, M.]]
		+	[[Category: Lechtenberg, B C.]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
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	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar~~ 11 20:08:~~39 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 11:58:38 2010''

OCA at 18:08, 11 March 2009

2009-03-11T18:08:39Z

←Older revision		Revision as of 18:08, 11 March 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	2W0T is a ~~1 chain~~ structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].	+	2W0T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W0T OCA].

	==Reference==		==Reference==
-	~~<ref~~ group~~="xtra">~~PMID:~~19241375<~~/~~ref><references group="xtra"~~/>	+	Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2., Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M, Protein Sci. 2009 Mar;18(3):657-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19241375 19241375]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Allen, M D.~~]]	+	[[Category: Single protein]]
-	[[Category: ~~Bycroft~~, ~~M.]]~~	+	[[Category: Pdbx_ordinal=, <PDBx:audit_author.]]
-	~~[[Category~~: ~~Lechtenberg, B C~~.]]	+
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
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	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 10:55:25 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 11 20:08:39 2009''