2w3b - Revision history

OCA at 07:09, 1 May 2024

2024-05-01T07:09:35Z

←Older revision		Revision as of 07:09, 1 May 2024
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	<StructureSection load='2w3b' size='340' side='right'caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>		<StructureSection load='2w3b' size='340' side='right'caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.27Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [https://pdbe.org/2w3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [https://www.ebi.ac.uk/pdbsum/2w3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3b ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [https://pdbe.org/2w3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [https://www.ebi.ac.uk/pdbsum/2w3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3b ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Borhani~~, D W~~]]	+	[[Category: Borhani DW]]
-	[[Category: Leung~~, A K.W~~]]	+	[[Category: Leung AKW]]
-	[[Category: Reynolds~~, R C]]~~	+	[[Category: Reynolds RC]]
-	~~[[Category: Lipophilic antifolate]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Nonclassical antifolate]]~~	+
-	~~[[Category: One-carbon metabolism]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Reductase~~]]	+

OCA at 10:51, 7 July 2021

2021-07-07T10:51:58Z

←Older revision		Revision as of 10:51, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2w3b' size='340' side='right'caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>		<StructureSection load='2w3b' size='340' side='right'caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W3B FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [~~http~~://pdbe.org/2w3b PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w3b PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3b ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [https://pdbe.org/2w3b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [https://www.ebi.ac.uk/pdbsum/2w3b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3b ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[~~http~~://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>	+	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>	+	[[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:

	==See Also==		==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]	+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:17, 10 May 2019

2019-05-10T12:17:04Z

←Older revision		Revision as of 12:17, 10 May 2019
Line 1:		Line 1:

	==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)==		==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)==
-	<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>	+	<StructureSection load='2w3b' size='340' side='right'caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>
Line 32:		Line 32:
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Borhani, D W]]		[[Category: Borhani, D W]]
	[[Category: Leung, A K.W]]		[[Category: Leung, A K.W]]

OCA at 07:53, 6 March 2019

2019-03-06T07:53:14Z

←Older revision		Revision as of 07:53, 6 March 2019
Line 1:		Line 1:

	==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)==		==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)==
-	<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>	+	<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>

OCA at 21:02, 19 September 2018

2018-09-19T21:02:50Z

←Older revision		Revision as of 21:02, 19 September 2018
Line 1:		Line 1:
-	==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)==	+
		+	==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5- DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D) PYRIMIDINE (SRI-8686)==
	<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>		<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://pdbe.org/2w3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://pdbe.org/2w3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w3b ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3b_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3b_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:45, 9 February 2016

2016-02-09T20:45:46Z

←Older revision		Revision as of 20:45, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>		<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://pdbe.org/2w3b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w3b ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Borhani, D W]]		[[Category: Borhani, D W]]
	[[Category: Leung, A K.W]]		[[Category: Leung, A K.W]]

OCA at 13:50, 19 January 2015

2015-01-19T13:50:37Z

←Older revision		Revision as of 13:50, 19 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>		[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
Line 31:		Line 31:
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Borhani, D W.]]	+	[[Category: Borhani, D W]]
-	[[Category: Leung, A K.W.]]	+	[[Category: Leung, A K.W]]
-	[[Category: Reynolds, R C.]]	+	[[Category: Reynolds, R C]]
	[[Category: Lipophilic antifolate]]		[[Category: Lipophilic antifolate]]
	[[Category: Nadp]]		[[Category: Nadp]]

OCA at 01:33, 1 October 2014

2014-10-01T01:33:24Z

←Older revision		Revision as of 01:33, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2w3b\| PDB=2w3b \| SCENE= }}~~	+	==HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)==
-	===HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)===	+	<StructureSection load='2w3b' size='340' side='right' caption='[[2w3b]], [[Resolution\|resolution]] 1.27Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W3B FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref><ref>PMID:21310277</ref>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=VG9:6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>VG9</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2w3a\|2w3a]], [[2c2s\|2c2s]], [[2w3m\|2w3m]], [[1dhf\|1dhf]], [[2dhf\|2dhf]], [[1s3w\|1s3w]], [[1s3v\|1s3v]], [[1pd8\|1pd8]], [[1dls\|1dls]], [[1dlr\|1dlr]], [[1u72\|1u72]], [[1ohk\|1ohk]], [[1yho\|1yho]], [[2c2t\|2c2t]], [[1ohj\|1ohj]], [[1pd9\|1pd9]], [[1kmv\|1kmv]], [[1hfr\|1hfr]], [[1mvt\|1mvt]], [[1u71\|1u71]], [[1kms\|1kms]], [[1pdb\|1pdb]], [[1hfq\|1hfq]], [[1mvs\|1mvs]], [[1drf\|1drf]], [[1s3u\|1s3u]], [[1hfp\|1hfp]], [[1boz\|1boz]]</td></tr>
-	==Function==	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref><ref>PMID:12096917</ref>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w3b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w3b RCSB], [http://www.ebi.ac.uk/pdbsum/2w3b PDBsum]</span></td></tr>
-		+	<table>
-	==~~About this Structure~~==	+	== Disease ==
-	[[~~2w3b~~]] ~~is a 2 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki/Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2W3B OCA~~].	+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w3b_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 18:45, 24 March 2013

2013-03-24T18:45:49Z

←Older revision		Revision as of 18:45, 24 March 2013
Line 1:		Line 1:
-	[[Image:2w3b.png\|left\|200px]]
-
	{{STRUCTURE_2w3b\| PDB=2w3b \| SCENE= }}		{{STRUCTURE_2w3b\| PDB=2w3b \| SCENE= }}
-
	===HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)===		===HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND A LIPOPHILIC ANTIFOLATE SELECTIVE FOR MYCOBACTERIUM AVIUM DHFR, 6-((2,5-DIETHOXYPHENYL)AMINOMETHYL)-2,4-DIAMINO-5-METHYLPYRIDO(2,3-D)PYRIMIDINE (SRI-8686)===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref><ref>PMID:21310277</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref><ref>PMID:12096917</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 13:
	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 15:05, 20 October 2012

2012-10-20T15:05:12Z

←Older revision		Revision as of 15:05, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2w3b]] is a 2 chain structure ~~of [[Dihydrofolate reductase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA].	+	[[2w3b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W3B OCA].

	==See Also==		==See Also==