2w48 - Revision history

OCA at 15:43, 13 December 2023

2023-12-13T15:43:26Z

←Older revision		Revision as of 15:43, 13 December 2023
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	<StructureSection load='2w48' size='340' side='right'caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2w48' size='340' side='right'caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus~~ pneumoniae~~" (schroeter 1886) flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [https://pdbe.org/2w48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [https://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [https://pdbe.org/2w48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [https://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SORC_KLEPN SORC_KLEPN]] Positively regulates, in the presence of L-sorbose, and negatively regulates, in the absence of L-sorbose, the transcription of the sor operon.	+	[https://www.uniprot.org/uniprot/SORC_KLEPN SORC_KLEPN] Positively regulates, in the presence of L-sorbose, and negatively regulates, in the absence of L-sorbose, the transcription of the sor operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Large Structures]]
-	[[Category: Carrondo, M A]]
-	[[Category: Enguita, F J]]
-	[[Category: McVey, C E]]
-	[[Category: Sanctis, D de]]
-	[[Category: Activator]]
-	[[Category: Dna-binding]]
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
-	[[Category: ~~Repressor~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Sorc~~]]	+	[[Category: Carrondo MA]]
-	[[Category: ~~Transcription~~]]	+	[[Category: Enguita FJ]]
-	[[Category: ~~Transcription regulation~~]]	+	[[Category: McVey CE]]
-	[[Category: ~~Transcription regulator~~]]	+	[[Category: De Sanctis D]]

OCA at 11:52, 30 March 2022

2022-03-30T11:52:40Z

←Older revision		Revision as of 11:52, 30 March 2022
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	<StructureSection load='2w48' size='340' side='right'caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2w48' size='340' side='right'caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2W48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [~~http~~://pdbe.org/2w48 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [https://pdbe.org/2w48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [https://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SORC_KLEPN SORC_KLEPN]] Positively regulates, in the presence of L-sorbose, and negatively regulates, in the absence of L-sorbose, the transcription of the sor operon.	+	[[https://www.uniprot.org/uniprot/SORC_KLEPN SORC_KLEPN]] Positively regulates, in the presence of L-sorbose, and negatively regulates, in the absence of L-sorbose, the transcription of the sor operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:55, 25 June 2020

2020-06-25T08:55:28Z

←Older revision		Revision as of 08:55, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of the Full-length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae==		==Crystal structure of the Full-length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae==
-	<StructureSection load='2w48' size='340' side='right' caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='2w48' size='340' side='right'caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://pdbe.org/2w48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://pdbe.org/2w48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Carrondo, M A]]		[[Category: Carrondo, M A]]
	[[Category: Enguita, F J]]		[[Category: Enguita, F J]]

OCA at 20:51, 19 September 2018

2018-09-19T20:51:00Z

←Older revision		Revision as of 20:51, 19 September 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF THE FULL~~-~~LENGTH SORBITOL OPERON REGULATOR SORC FROM KLEBSIELLA PNEUMONIAE~~==	+
		+	==Crystal structure of the Full-length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae==
	<StructureSection load='2w48' size='340' side='right' caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2w48' size='340' side='right' caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://pdbe.org/2w48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://pdbe.org/2w48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w48 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w48_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w48_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 34:
	[[Category: Carrondo, M A]]		[[Category: Carrondo, M A]]
	[[Category: Enguita, F J]]		[[Category: Enguita, F J]]
-	[[Category: ~~Mcvey~~, C E]]	+	[[Category: McVey, C E]]
-	[[Category: Sanctis, D De]]	+	[[Category: Sanctis, D de]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA at 11:17, 8 February 2016

2016-02-08T11:17:55Z

←Older revision		Revision as of 11:17, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2w48' size='340' side='right' caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2w48' size='340' side='right' caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Klebsiella_pneumoniae Klebsiella~~ pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://pdbe.org/2w48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w48 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w48" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Klebsiella pneumoniae]]
	[[Category: Carrondo, M A]]		[[Category: Carrondo, M A]]
	[[Category: Enguita, F J]]		[[Category: Enguita, F J]]
Line 37:		Line 37:
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
		+	[[Category: Klebsiella pneumoniae]]
	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Sorc]]		[[Category: Sorc]]

OCA at 22:56, 24 December 2014

2014-12-24T22:56:08Z

←Older revision		Revision as of 22:56, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SORC_KLEPN SORC_KLEPN]] Positively regulates, in the presence of L-sorbose, and negatively regulates, in the absence of L-sorbose, the transcription of the sor operon.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
-	[[Category: Carrondo, M A.]]	+	[[Category: Carrondo, M A]]
-	[[Category: Enguita, F J.]]	+	[[Category: Enguita, F J]]
-	[[Category: Mcvey, C E.]]	+	[[Category: Mcvey, C E]]
-	[[Category: Sanctis, D De.]]	+	[[Category: Sanctis, D De]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
-	[[Category: Klebsiella pneumoniae]]
	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Sorc]]		[[Category: Sorc]]

OCA at 01:59, 1 October 2014

2014-10-01T01:59:35Z

←Older revision		Revision as of 01:59, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2w48.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE FULL-LENGTH SORBITOL OPERON REGULATOR SORC FROM KLEBSIELLA PNEUMONIAE==
		+	<StructureSection load='2w48' size='340' side='right' caption='[[2w48]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W48 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w48 RCSB], [http://www.ebi.ac.uk/pdbsum/2w48 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w4/2w48_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SorC transcriptional regulators are common regulators in prokaryotes. Here we report the first crystal structure of a full-length SorC, the sorbitol operon regulator SorC from Klebsiella pneumoniae, the prototype of its family. SorC was found to be a homotetramer (which seems to be the biologically active form) that is able to recognize its DNA operator. The tetramer can be regarded as a dimer of dimers, with each dimer being composed of two identical subunits in different conformations. The DNA-binding domains divergently protrude from the core of the tetramer, suggesting that SorC may bind its operator in two distinct regions. The sugar-binding domain presents the same fold identified in members of the SorC family that shows some features identified as specific for sugar recognition. An in silico analysis shows that the localization of the putative sugar-binding site is close to the dimeric interfaces. This supports the proposal of a new mechanism of transcriptional regulation that is in complete agreement with functional studies recently reported on a protein belonging to the same family.

-	~~{{STRUCTURE_2w48\| PDB=2w48 \| SCENE= }}~~	+	Crystal structure of the full-length sorbitol operon regulator SorC from Klebsiella pneumoniae: structural evidence for a novel transcriptional regulation mechanism.,de Sanctis D, McVey CE, Enguita FJ, Carrondo MA J Mol Biol. 2009 Apr 3;387(3):759-70. Epub 2009 Feb 14. PMID:19232357<ref>PMID:19232357</ref>

-	~~===CRYSTAL STRUCTURE OF THE FULL-LENGTH SORBITOL OPERON REGULATOR SORC FROM KLEBSIELLA PNEUMONIAE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19232357}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w48]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019232357<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
	[[Category: Carrondo, M A.]]		[[Category: Carrondo, M A.]]

OCA: Protected "2w48" [edit=sysop:move=sysop]

2013-01-07T18:43:30Z

Protected "2w48" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:43, 7 January 2013

OCA at 18:43, 7 January 2013

2013-01-07T18:43:24Z

←Older revision		Revision as of 18:43, 7 January 2013
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-	~~{{Seed}}~~	+	[[Image:2w48.png\|left\|200px]]
-	[[Image:2w48.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w48", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w48\| PDB=2w48 \| SCENE= }}		{{STRUCTURE_2w48\| PDB=2w48 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE FULL-LENGTH SORBITOL OPERON REGULATOR SORC FROM KLEBSIELLA PNEUMONIAE===		===CRYSTAL STRUCTURE OF THE FULL-LENGTH SORBITOL OPERON REGULATOR SORC FROM KLEBSIELLA PNEUMONIAE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19232357}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19232357 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19232357}}		{{ABSTRACT_PUBMED_19232357}}

	==About this Structure==		==About this Structure==
-	~~2W48~~ is a 4 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA].	+	[[2w48]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19232357~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019232357</ref><references group="xtra"/>
	[[Category: Klebsiella pneumoniae]]		[[Category: Klebsiella pneumoniae]]
	[[Category: Carrondo, M A.]]		[[Category: Carrondo, M A.]]
Line 37:		Line 25:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Transcription regulator]]		[[Category: Transcription regulator]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:19:24 2009''

OCA at 07:19, 6 May 2009

2009-05-06T07:19:25Z

←Older revision		Revision as of 07:19, 6 May 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2w48.jpg\|left\|200px]]

-	The ~~entry 2w48~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2w48", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2w48\| PDB=2w48 \| SCENE= }}

-	~~Authors: de Sanctis, D., McVey, C.E., Enguita, F.J., Carrondo, M.A.~~	+	===CRYSTAL STRUCTURE OF THE FULL-LENGTH SORBITOL OPERON REGULATOR SORC FROM KLEBSIELLA PNEUMONIAE===

-	Description: Crystal structure of the Full-length Sorbitol Operon Regulator SorC from Klebsiella pneumoniae

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec~~ 10 14:19:~~17 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19232357}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19232357 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19232357}}
		+
		+	==About this Structure==
		+	2W48 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W48 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19232357</ref><references group="xtra"/>
		+	[[Category: Klebsiella pneumoniae]]
		+	[[Category: Carrondo, M A.]]
		+	[[Category: Enguita, F J.]]
		+	[[Category: Mcvey, C E.]]
		+	[[Category: Sanctis, D De.]]
		+	[[Category: Activator]]
		+	[[Category: Dna-binding]]
		+	[[Category: Klebsiella pneumoniae]]
		+	[[Category: Repressor]]
		+	[[Category: Sorc]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Transcription regulator]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 6 10:19:24 2009''