2w50 - Revision history

OCA at 10:52, 7 July 2021

2021-07-07T10:52:26Z

←Older revision		Revision as of 10:52, 7 July 2021
Line 3:		Line 3:
	<StructureSection load='2w50' size='340' side='right'caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2w50' size='340' side='right'caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [~~http~~://pdbe.org/2w50 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [https://pdbe.org/2w50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [https://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).	+	[[https://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:17, 10 May 2019

2019-05-10T12:17:25Z

←Older revision		Revision as of 12:17, 10 May 2019
Line 1:		Line 1:

	==N-terminal domain of human conserved dopamine neurotrophic factor (CDNF)==		==N-terminal domain of human conserved dopamine neurotrophic factor (CDNF)==
-	<StructureSection load='2w50' size='340' side='right' caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='2w50' size='340' side='right'caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Goldman, A]]		[[Category: Goldman, A]]
	[[Category: Kalkkinen, N]]		[[Category: Kalkkinen, N]]

OCA at 09:46, 26 September 2018

2018-09-26T09:46:20Z

←Older revision		Revision as of 09:46, 26 September 2018
Line 1:		Line 1:

-	==N-~~TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR~~ (CDNF)==	+	==N-terminal domain of human conserved dopamine neurotrophic factor (CDNF)==
	<StructureSection load='2w50' size='340' side='right' caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2w50' size='340' side='right' caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w50_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w50_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 41:		Line 41:
	[[Category: Peranen, J]]		[[Category: Peranen, J]]
	[[Category: Saarma, M]]		[[Category: Saarma, M]]
		+	[[Category: Alternative splicing]]
	[[Category: Cdnf]]		[[Category: Cdnf]]
	[[Category: Er stress]]		[[Category: Er stress]]

OCA at 07:48, 5 August 2016

2016-08-05T07:48:14Z

←Older revision		Revision as of 07:48, 5 August 2016
Line 1:		Line 1:
		+
	==N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)==		==N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)==
	<StructureSection load='2w50' size='340' side='right' caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2w50' size='340' side='right' caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [http://www.ebi.ac.uk/pdbsum/2w50 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [http://pdbe.org/2w50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [http://www.ebi.ac.uk/pdbsum/2w50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w50 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~ARMEL_HUMAN ARMEL_HUMAN~~]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).	+	[[http://www.uniprot.org/uniprot/CDNF_HUMAN CDNF_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w50 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w50" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Goldman, A]]		[[Category: Goldman, A]]
	[[Category: Kalkkinen, N]]		[[Category: Kalkkinen, N]]

OCA at 17:01, 25 December 2014

2014-12-25T17:01:32Z

←Older revision		Revision as of 17:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [http://www.ebi.ac.uk/pdbsum/2w50 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [http://www.ebi.ac.uk/pdbsum/2w50 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARMEL_HUMAN ARMEL_HUMAN]] Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Goldman, A.]]	+	[[Category: Goldman, A]]
-	[[Category: Kalkkinen, N.]]	+	[[Category: Kalkkinen, N]]
-	[[Category: Leppanen, V M.]]	+	[[Category: Leppanen, V M]]
-	[[Category: Lindholm, P.]]	+	[[Category: Lindholm, P]]
-	[[Category: Oksanen, E.]]	+	[[Category: Oksanen, E]]
-	[[Category: Parkash, V.]]	+	[[Category: Parkash, V]]
-	[[Category: Peranen, J.]]	+	[[Category: Peranen, J]]
-	[[Category: Saarma, M.]]	+	[[Category: Saarma, M]]
	[[Category: Cdnf]]		[[Category: Cdnf]]
	[[Category: Er stress]]		[[Category: Er stress]]

OCA at 02:20, 1 October 2014

2014-10-01T02:20:28Z

←Older revision		Revision as of 02:20, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2w50.~~png\|left~~\|200px]]	+	==N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)==
		+	<StructureSection load='2w50' size='340' side='right' caption='[[2w50]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W50 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w50 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w50 RCSB], [http://www.ebi.ac.uk/pdbsum/2w50 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w5/2w50_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have solved the structures of mammalian mesencephalic astrocyte-derived neurotrophic factor (MANF) and conserved dopamine neurotrophic factor (CDNF). CDNF protects and repairs midbrain dopaminergic neurons in vivo; MANF supports their survival in culture and is also cytoprotective against endoplasmic reticulum (ER) stress. Neither protein structure resembles any known growth factor but the N-terminal domain is a saposin-like lipid-binding domain. MANF and CDNF may thus bind lipids or membranes. Consistent with this, there are two patches of conserved lysines and arginines. The natively unfolded MANF C-terminus contains a CKGC disulphide bridge, such as reductases and disulphide isomerases, consistent with a role in ER stress response. The structure thus explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain. Finally, we identified three changes, (MANF)I10-->K(CDNF), (MANF)E79-->M(CDNF) and (MANF)K88-->L(CDNF), that may account for the biological differences between the proteins.

-	~~{{STRUCTURE_2w50\| PDB=2w50 \| SCENE= }}~~	+	The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional.,Parkash V, Lindholm P, Peranen J, Kalkkinen N, Oksanen E, Saarma M, Leppanen VM, Goldman A Protein Eng Des Sel. 2009 Apr;22(4):233-41. Epub 2009 Mar 3. PMID:19258449<ref>PMID:19258449</ref>

-	~~===N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19258449}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2w50]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019258449<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Goldman, A.]]		[[Category: Goldman, A.]]

OCA: Protected "2w50" [edit=sysop:move=sysop]

2013-01-07T20:31:45Z

Protected "2w50" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:31, 7 January 2013

OCA at 20:31, 7 January 2013

2013-01-07T20:31:41Z

←Older revision		Revision as of 20:31, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2w50.png\|left\|200px]]		[[Image:2w50.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w50", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w50\| PDB=2w50 \| SCENE= }}		{{STRUCTURE_2w50\| PDB=2w50 \| SCENE= }}

	===N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)===		===N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19258449}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19258449 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19258449}}		{{ABSTRACT_PUBMED_19258449}}

	==About this Structure==		==About this Structure==
-	~~2W50~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA].	+	[[2w50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19258449~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019258449</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Goldman, A.]]		[[Category: Goldman, A.]]
Line 33:		Line 21:
	[[Category: Peranen, J.]]		[[Category: Peranen, J.]]
	[[Category: Saarma, M.]]		[[Category: Saarma, M.]]
-	[[Category: Alternative splicing]]
	[[Category: Cdnf]]		[[Category: Cdnf]]
	[[Category: Er stress]]		[[Category: Er stress]]
Line 42:		Line 29:
	[[Category: Saposin]]		[[Category: Saposin]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:20:37 2009''

OCA at 13:20, 2 April 2009

2009-04-02T13:20:37Z

←Older revision		Revision as of 13:20, 2 April 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2w50.png\|left\|200px]]

-	The ~~entry 2w50~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2w50", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2w50\| PDB=2w50 \| SCENE= }}

-	~~Authors: Parkash, V., Lindholm, P., Peranen, J., Kalkkinen,~~ N~~., Oksanen, E., Saarma, M., Leppanen, V.M., Goldman, A.~~	+	===N-TERMINAL DOMAIN OF HUMAN CONSERVED DOPAMINE NEUROTROPHIC FACTOR (CDNF)===

-	Description: N-terminal domain of human conserved dopamine neurotrophic factor ( CDNF)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Dec 24 11~~:24:~~53 2008~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19258449}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19258449 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19258449}}
		+
		+	==About this Structure==
		+	2W50 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W50 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19258449</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Goldman, A.]]
		+	[[Category: Kalkkinen, N.]]
		+	[[Category: Leppanen, V M.]]
		+	[[Category: Lindholm, P.]]
		+	[[Category: Oksanen, E.]]
		+	[[Category: Parkash, V.]]
		+	[[Category: Peranen, J.]]
		+	[[Category: Saarma, M.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cdnf]]
		+	[[Category: Er stress]]
		+	[[Category: Growth factor]]
		+	[[Category: Hormone]]
		+	[[Category: Manf]]
		+	[[Category: Neurotrophic factor]]
		+	[[Category: Saposin]]
		+	[[Category: Secreted]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr 2 16:20:37 2009''

OCA at 09:24, 24 December 2008

2008-12-24T09:24:53Z

←Older revision		Revision as of 09:24, 24 December 2008
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 2w50 is ON HOLD	+	The entry 2w50 is ON HOLD until Paper Publication

	Authors: Parkash, V., Lindholm, P., Peranen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppanen, V.M., Goldman, A.		Authors: Parkash, V., Lindholm, P., Peranen, J., Kalkkinen, N., Oksanen, E., Saarma, M., Leppanen, V.M., Goldman, A.
Line 7:		Line 7:
	Description: N-terminal domain of human conserved dopamine neurotrophic factor ( CDNF)		Description: N-terminal domain of human conserved dopamine neurotrophic factor ( CDNF)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~10 14~~:20:03 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 24 11:24:53 2008''