2w73 - Revision history

OCA at 10:08, 9 May 2024

2024-05-09T10:08:55Z

←Older revision		Revision as of 10:08, 9 May 2024
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	<StructureSection load='2w73' size='340' side='right'caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w73' size='340' side='right'caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W73 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [https://pdbe.org/2w73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [https://www.ebi.ac.uk/pdbsum/2w73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w73 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [https://pdbe.org/2w73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [https://www.ebi.ac.uk/pdbsum/2w73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w73 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>	+	[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Calcineurin 3D structures\|Calcineurin 3D structures]]
	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]		*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoprotein phosphatase]]~~	+	[[Category: Kursula P]]
-	[[Category: Kursula, P]]	+	[[Category: Majava V]]
-	[[Category: Majava, V]]	+
-	~~[[Category: Acetylation]]~~	+
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Calcium]]~~	+
-	~~[[Category: Calmodulin]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Ef hand]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Metal binding protein]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metal-binding protein]]~~	+
-	~~[[Category: Methylation]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Protein phosphatase]]~~	+
-	~~[[Category: Ubl conjugation]]~~	+
-	~~[[Category: Zinc~~]]	+

OCA at 16:42, 3 November 2021

2021-11-03T16:42:07Z

←Older revision		Revision as of 16:42, 3 November 2021
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	<StructureSection load='2w73' size='340' side='right'caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w73' size='340' side='right'caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2W73 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [~~http~~://pdbe.org/2w73 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2w73 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2w73 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [https://pdbe.org/2w73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [https://www.ebi.ac.uk/pdbsum/2w73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w73 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>	+	[[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:43, 18 December 2019

2019-12-18T13:43:56Z

←Older revision		Revision as of 13:43, 18 December 2019
Line 1:		Line 1:

	==High-resolution structure of the complex between calmodulin and a peptide from calcineurin A==		==High-resolution structure of the complex between calmodulin and a peptide from calcineurin A==
-	<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='2w73' size='340' side='right'caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2w73" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2w73" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calcineurin 3D structures\|Calcineurin 3D structures]]
		+	*[[Calmodulin 3D structures\|Calmodulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]

OCA at 07:29, 17 January 2018

2018-01-17T07:29:14Z

←Older revision		Revision as of 07:29, 17 January 2018
Line 1:		Line 1:

-	==~~HIGH~~-~~RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN~~ A==	+	==High-resolution structure of the complex between calmodulin and a peptide from calcineurin A==
	<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w73_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w73_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2w73" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2w73" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Calcineurin\|Calcineurin]]
-	*[[Calmodulin\|Calmodulin]]
	== References ==		== References ==
	<references/>		<references/>
Line 42:		Line 38:
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
	[[Category: Majava, V]]		[[Category: Majava, V]]
		+	[[Category: Acetylation]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Calcium]]
	[[Category: Calmodulin]]		[[Category: Calmodulin]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
Line 48:		Line 47:
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Iron]]		[[Category: Iron]]
		+	[[Category: Metal binding protein]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Metal-binding protein]]		[[Category: Metal-binding protein]]
Line 53:		Line 53:
	[[Category: Nucleus]]		[[Category: Nucleus]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]
		+	[[Category: Ubl conjugation]]
		+	[[Category: Zinc]]

OCA at 18:23, 5 August 2016

2016-08-05T18:23:56Z

←Older revision		Revision as of 18:23, 5 August 2016
Line 1:		Line 1:
		+
	==HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A==		==HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A==
	<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [http://www.ebi.ac.uk/pdbsum/2w73 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [http://pdbe.org/2w73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [http://www.ebi.ac.uk/pdbsum/2w73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2w73 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w73 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2w73" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]

OCA at 20:56, 25 December 2014

2014-12-25T20:56:47Z

←Older revision		Revision as of 20:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [http://www.ebi.ac.uk/pdbsum/2w73 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [http://www.ebi.ac.uk/pdbsum/2w73 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
-	[[Category: Kursula, P.]]	+	[[Category: Kursula, P]]
-	[[Category: Majava, V.]]	+	[[Category: Majava, V]]
	[[Category: Calmodulin]]		[[Category: Calmodulin]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA at 06:22, 29 September 2014

2014-09-29T06:22:48Z

←Older revision		Revision as of 06:22, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2w73.~~png~~\|~~left~~\|200px]]	+	==HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A==
		+	<StructureSection load='2w73' size='340' side='right' caption='[[2w73]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W73 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j7p\|1j7p]], [[2f3z\|2f3z]], [[1mf8\|1mf8]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1xfv\|1xfv]], [[1k93\|1k93]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfu\|1xfu]], [[1xfy\|1xfy]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[1aui\|1aui]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[1m63\|1m63]], [[2be6\|2be6]], [[1zot\|1zot]], [[1sw8\|1sw8]], [[2vay\|2vay]], [[1aji\|1aji]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w73 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w73 RCSB], [http://www.ebi.ac.uk/pdbsum/2w73 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w7/2w73_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Calmodulin (CaM) is a ubiquitously expressed calcium sensor that engages in regulatory interactions with a large number of cellular proteins. Previously, a unique mode of CaM target recognition has been observed in the crystal structure of a complex between CaM and the CaM-binding domain of calcineurin A. METHODOLOGY/PRINCIPAL FINDINGS: We have solved a high-resolution crystal structure of a complex between CaM and the CaM-binding domain of calcineurin A in a novel crystal form, which shows a dimeric assembly of calmodulin, as observed before in the crystal state. We note that the conformation of CaM in this complex is very similar to that of unliganded CaM, and a detailed analysis revels that the CaM-binding motif in calcineurin A is of a novel '1-11' type. However, using small-angle X-ray scattering (SAXS), we show that the complex is fully monomeric in solution, and a structure of a canonically collapsed CaM-peptide complex can easily be fitted into the SAXS data. This result is also supported by size exclusion chromatography, where the addition of the ligand peptide decreases the apparent size of CaM. In addition, we studied the energetics of binding by isothermal titration calorimetry and found them to closely resemble those observed previously for ligand peptides from CaM-dependent kinases. CONCLUSIONS/SIGNIFICANCE: Our results implicate that CaM can also form a complex with the CaM-binding domain of calcineurin in a 1 ratio 1 stoichiometry, in addition to the previously observed 2 ratio 2 arrangement in the crystal state. At the structural level, going from 2 ratio 2 association to two 1 ratio 1 complexes will require domain swapping in CaM, accompanied by the characteristic bending of the central linker helix between the two lobes of CaM.

-	~~{{STRUCTURE_2w73\| PDB=2w73 \| SCENE= }}~~	+	Domain swapping and different oligomeric States for the complex between calmodulin and the calmodulin-binding domain of calcineurin a.,Majava V, Kursula P PLoS ONE. 2009;4(4):e5402. Epub 2009 Apr 30. PMID:19404396<ref>PMID:19404396</ref>

-	~~===HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19404396}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2w73]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA].~~	+

	==See Also==		==See Also==
	*[[Calcineurin\|Calcineurin]]		*[[Calcineurin\|Calcineurin]]
	*[[Calmodulin\|Calmodulin]]		*[[Calmodulin\|Calmodulin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019404396<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]

OCA at 21:32, 20 October 2012

2012-10-20T21:32:41Z

←Older revision		Revision as of 21:32, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2w73]] is a 8 chain structure ~~of [[Calcineurin]] and [[Calmodulin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA].	+	[[2w73]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA].

	==See Also==		==See Also==

OCA at 13:34, 27 July 2012

2012-07-27T13:34:39Z

←Older revision		Revision as of 13:34, 27 July 2012
Line 1:		Line 1:
	[[Image:2w73.png\|left\|200px]]		[[Image:2w73.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2w73", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2w73\| PDB=2w73 \| SCENE= }}		{{STRUCTURE_2w73\| PDB=2w73 \| SCENE= }}

	===HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A===		===HIGH-RESOLUTION STRUCTURE OF THE COMPLEX BETWEEN CALMODULIN AND A PEPTIDE FROM CALCINEURIN A===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19404396}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19404396 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19404396}}		{{ABSTRACT_PUBMED_19404396}}

	==About this Structure==		==About this Structure==
-	[[2w73]] is a 8 chain structure of [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA].	+	[[2w73]] is a 8 chain structure of [[Calcineurin]] and [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W73 OCA].

	==See Also==		==See Also==
-	*[[Calmodulin]]	+	*[[Calcineurin\|Calcineurin]]
		+	*[[Calmodulin\|Calmodulin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19404396~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019404396</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Kursula, P.]]		[[Category: Kursula, P.]]
	[[Category: Majava, V.]]		[[Category: Majava, V.]]
-	[[Category: Acetylation]]
-	[[Category: Alternative splicing]]
-	[[Category: Calcium]]
	[[Category: Calmodulin]]		[[Category: Calmodulin]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
Line 43:		Line 30:
	[[Category: Methylation]]		[[Category: Methylation]]
	[[Category: Nucleus]]		[[Category: Nucleus]]
-	[[Category: Peptide]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Protein phosphatase]]		[[Category: Protein phosphatase]]
-	[[Category: Ubl conjugation]]
-	[[Category: Zinc]]

OCA: Protected "2w73" [edit=sysop:move=sysop]

2010-12-26T23:42:33Z

Protected "2w73" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:42, 26 December 2010