2wam - Revision history

OCA at 07:09, 1 May 2024

2024-05-01T07:09:51Z

←Older revision		Revision as of 07:09, 1 May 2024
Line 3:		Line 3:
	<StructureSection load='2wam' size='340' side='right'caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2wam' size='340' side='right'caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [https://pdbe.org/2wam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [https://www.ebi.ac.uk/pdbsum/2wam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [https://pdbe.org/2wam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [https://www.ebi.ac.uk/pdbsum/2wam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O07213_MYCTO O07213_MYCTO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 17:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wam ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wam ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The gene Rv2714 from Mycobacterium tuberculosis, which codes for a hypothetical protein of unknown function, is a representative member of a gene family that is largely confined to the order Actinomycetales of Actinobacteria. Sequence analysis indicates the presence of two paralogous genes in most mycobacterial genomes and suggests that gene duplication was an ancient event in bacterial evolution. The crystal structure of Rv2714 has been determined at 2.6 A resolution, revealing a trimer in which the topology of the protomer core is similar to that observed in a functionally diverse set of enzymes, including purine nucleoside phosphorylases, some carboxypeptidases, bacterial peptidyl-tRNA hydrolases and even the plastidic form of an intron splicing factor. However, some structural elements, such as a beta-hairpin insertion involved in protein oligomerization and a C-terminal alpha-helical domain that serves as a lid to the putative substrate-binding (or ligand-binding) site, are only found in Rv2714 bacterial homologues and represent specific signatures of this protein family.
-
-	Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.,Grana M, Bellinzoni M, Miras I, Fiez-Vandal C, Haouz A, Shepard W, Buschiazzo A, Alzari PM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt, 10):972-7. Epub 2009 Sep 18. PMID:19851001<ref>PMID:19851001</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 2wam" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Alzari~~, P M~~]]	+	[[Category: Alzari PM]]
-	[[Category: Bellinzoni, M]]	+	[[Category: Bellinzoni M]]
-	[[Category: Buschiazzo, A]]	+	[[Category: Buschiazzo A]]
-	[[Category: Grana, M]]	+	[[Category: Grana M]]
-	[[Category: Haouz, A]]	+	[[Category: Haouz A]]
-	[[Category: Miras, I]]	+	[[Category: Miras I]]
-	~~[[Category: Unknown function~~]]	+

OCA at 11:02, 6 April 2022

2022-04-06T11:02:01Z

←Older revision		Revision as of 11:02, 6 April 2022
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	<StructureSection load='2wam' size='340' side='right'caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2wam' size='340' side='right'caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WAM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [~~http~~://pdbe.org/2wam PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wam PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [https://pdbe.org/2wam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [https://www.ebi.ac.uk/pdbsum/2wam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 08:26, 1 July 2020

2020-07-01T08:26:12Z

←Older revision		Revision as of 08:26, 1 July 2020
Line 1:		Line 1:

	==Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714==		==Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714==
-	<StructureSection load='2wam' size='340' side='right' caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='2wam' size='340' side='right'caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WAM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WAM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://pdbe.org/2wam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://pdbe.org/2wam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Alzari, P M]]		[[Category: Alzari, P M]]

OCA at 08:51, 26 September 2018

2018-09-26T08:51:10Z

←Older revision		Revision as of 08:51, 26 September 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714~~==	+	==Crystal structure of Mycobacterium tuberculosis unknown function protein Rv2714==
	<StructureSection load='2wam' size='340' side='right' caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2wam' size='340' side='right' caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 11:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wam_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wam_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:15, 5 August 2016

2016-08-05T22:15:02Z

←Older revision		Revision as of 22:15, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714==		==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714==
	<StructureSection load='2wam' size='340' side='right' caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2wam' size='340' side='right' caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://pdbe.org/2wam PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wam ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 14:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wam ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 24:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wam" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mycobacterium tuberculosis~~]]	+	[[Category: Myctu]]
	[[Category: Alzari, P M]]		[[Category: Alzari, P M]]
	[[Category: Bellinzoni, M]]		[[Category: Bellinzoni, M]]

OCA at 22:22, 25 December 2014

2014-12-25T22:22:36Z

←Older revision		Revision as of 22:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAM FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: Alzari, P M.]]	+	[[Category: Alzari, P M]]
-	[[Category: Bellinzoni, M.]]	+	[[Category: Bellinzoni, M]]
-	[[Category: Buschiazzo, A.]]	+	[[Category: Buschiazzo, A]]
-	[[Category: Grana, M.]]	+	[[Category: Grana, M]]
-	[[Category: Haouz, A.]]	+	[[Category: Haouz, A]]
-	[[Category: Miras, I.]]	+	[[Category: Miras, I]]
	[[Category: Unknown function]]		[[Category: Unknown function]]

OCA at 01:47, 1 October 2014

2014-10-01T01:47:34Z

←Older revision		Revision as of 01:47, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2wam.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714==
		+	<StructureSection load='2wam' size='340' side='right' caption='[[2wam]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WAM FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wam OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wam RCSB], [http://www.ebi.ac.uk/pdbsum/2wam PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wa/2wam_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The gene Rv2714 from Mycobacterium tuberculosis, which codes for a hypothetical protein of unknown function, is a representative member of a gene family that is largely confined to the order Actinomycetales of Actinobacteria. Sequence analysis indicates the presence of two paralogous genes in most mycobacterial genomes and suggests that gene duplication was an ancient event in bacterial evolution. The crystal structure of Rv2714 has been determined at 2.6 A resolution, revealing a trimer in which the topology of the protomer core is similar to that observed in a functionally diverse set of enzymes, including purine nucleoside phosphorylases, some carboxypeptidases, bacterial peptidyl-tRNA hydrolases and even the plastidic form of an intron splicing factor. However, some structural elements, such as a beta-hairpin insertion involved in protein oligomerization and a C-terminal alpha-helical domain that serves as a lid to the putative substrate-binding (or ligand-binding) site, are only found in Rv2714 bacterial homologues and represent specific signatures of this protein family.

-	~~{{STRUCTURE_2wam\| PDB=2wam \| SCENE= }}~~	+	Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.,Grana M, Bellinzoni M, Miras I, Fiez-Vandal C, Haouz A, Shepard W, Buschiazzo A, Alzari PM Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 1;65(Pt, 10):972-7. Epub 2009 Sep 18. PMID:19851001<ref>PMID:19851001</ref>

-	~~===CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19851001}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wam]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019851001<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Alzari, P M.]]		[[Category: Alzari, P M.]]

OCA: Protected "2wam" [edit=sysop:move=sysop]

2013-01-07T22:40:59Z

Protected "2wam" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:40, 7 January 2013

OCA at 22:40, 7 January 2013

2013-01-07T22:40:55Z

←Older revision		Revision as of 22:40, 7 January 2013
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-	{{Seed}}
	[[Image:2wam.png\|left\|200px]]		[[Image:2wam.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wam", creates the "Structure Box" on the page.
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-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2wam\| PDB=2wam \| SCENE= }}		{{STRUCTURE_2wam\| PDB=2wam \| SCENE= }}

	===CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714===		===CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19851001}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19851001 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19851001}}		{{ABSTRACT_PUBMED_19851001}}

	==About this Structure==		==About this Structure==
-	~~2WAM~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA].	+	[[2wam]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19851001~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019851001</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Alzari, P M.]]		[[Category: Alzari, P M.]]
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	[[Category: Miras, I.]]		[[Category: Miras, I.]]
	[[Category: Unknown function]]		[[Category: Unknown function]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 09:14:40 2009''

OCA at 07:14, 4 November 2009

2009-11-04T07:14:41Z

←Older revision		Revision as of 07:14, 4 November 2009
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	{{Seed}}		{{Seed}}
-	[[Image:2wam.~~jpg~~\|left\|200px]]	+	[[Image:2wam.png\|left\|200px]]

	<!--		<!--
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	===CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714===		===CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS UNKNOWN FUNCTION PROTEIN RV2714===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19851001}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19851001 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19851001}}

	==About this Structure==		==About this Structure==
	2WAM is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA].		2WAM is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WAM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19851001</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Alzari, P M.]]		[[Category: Alzari, P M.]]
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	[[Category: Unknown function]]		[[Category: Unknown function]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct~~ ~~7 14~~:07:11 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 09:14:40 2009''