2wel - Revision history

OCA at 15:53, 13 December 2023

2023-12-13T15:53:53Z

←Older revision		Revision as of 15:53, 13 December 2023
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	<StructureSection load='2wel' size='340' side='right'caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wel' size='340' side='right'caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [https://pdbe.org/2wel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [https://www.ebi.ac.uk/pdbsum/2wel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wel ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [https://pdbe.org/2wel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [https://www.ebi.ac.uk/pdbsum/2wel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wel ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/KCC2D_HUMAN KCC2D_HUMAN] Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.<ref>PMID:16690701</ref> <ref>PMID:17179159</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Calcium/calmodulin-dependent protein kinase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown, N]]	+	[[Category: Burgess-Brown N]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Keates T]]
-	[[Category: Keates, T]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Muniz J]]
-	[[Category: Muniz, J]]	+	[[Category: Pike ACW]]
-	[[Category: Pike~~, A C.W~~]]	+	[[Category: Rellos P]]
-	[[Category: Rellos, P]]	+	[[Category: Roos A]]
-	[[Category: Roos, A]]	+	[[Category: Salah E]]
-	[[Category: Salah, E]]	+	[[Category: Sethi R]]
-	[[Category: Sethi, R]]	+	[[Category: Weigelt J]]
-	[[Category: Weigelt, J]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Atp-binding]]~~	+
-	~~[[Category: Calmodulin binding]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Cellular differentiation]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Serine-threonine kinase]]~~	+
-	~~[[Category: Serine/threonine-protein kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Vascular smooth muscle~~]]	+

OCA at 16:42, 3 November 2021

2021-11-03T16:42:58Z

←Older revision		Revision as of 16:42, 3 November 2021
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	<StructureSection load='2wel' size='340' side='right'caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wel' size='340' side='right'caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WEL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [~~http~~://pdbe.org/2wel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wel ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [https://pdbe.org/2wel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [https://www.ebi.ac.uk/pdbsum/2wel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wel ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 13:35, 18 December 2019

2019-12-18T13:35:35Z

←Older revision		Revision as of 13:35, 18 December 2019
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	==Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin==		==Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin==
-	<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2wel' size='340' side='right'caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEL FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEL FirstGlance]. <br>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2wel" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wel" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calcium/calmodulin dependent protein kinase 3D structures\|Calcium/calmodulin dependent protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 19:05, 24 January 2018

2018-01-24T19:05:32Z

←Older revision		Revision as of 19:05, 24 January 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF~~ SU6656-~~BOUND CALCIUM~~/~~CALMODULIN~~-~~DEPENDENT PROTEIN KINASE~~ II ~~DELTA IN COMPLEX WITH CALMODULIN~~==	+	==Crystal structure of SU6656-bound calcium/calmodulin-dependent protein kinase II delta in complex with calmodulin==
	<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wel_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wel_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 37:
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	[[Category: Burgess-Brown, N]]		[[Category: Burgess-Brown, N]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A]]		[[Category: Edwards, A]]
	[[Category: Filippakopoulos, P]]		[[Category: Filippakopoulos, P]]

OCA at 20:57, 5 August 2016

2016-08-05T20:57:56Z

←Older revision		Revision as of 20:57, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN==		==CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN==
	<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [http://www.ebi.ac.uk/pdbsum/2wel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [http://pdbe.org/2wel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [http://www.ebi.ac.uk/pdbsum/2wel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wel ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wel ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wel" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 21:51, 25 December 2014

2014-12-25T21:51:28Z

←Older revision		Revision as of 21:51, 25 December 2014
Line 32:		Line 32:
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Burgess-Brown, N.]]	+	[[Category: Burgess-Brown, N]]
-	[[Category: Delft, F Von.]]	+	[[Category: Delft, F Von]]
-	[[Category: Edwards, A.]]	+	[[Category: Edwards, A]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Keates, T.]]	+	[[Category: Keates, T]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Muniz, J.]]	+	[[Category: Muniz, J]]
-	[[Category: Pike, A C.W.]]	+	[[Category: Pike, A C.W]]
-	[[Category: Rellos, P.]]	+	[[Category: Rellos, P]]
-	[[Category: Roos, A.]]	+	[[Category: Roos, A]]
-	[[Category: Salah, E.]]	+	[[Category: Salah, E]]
-	[[Category: Sethi, R.]]	+	[[Category: Sethi, R]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Calmodulin binding]]		[[Category: Calmodulin binding]]

OCA at 05:45, 10 October 2014

2014-10-10T05:45:30Z

←Older revision		Revision as of 05:45, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. <br>	+	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [http://www.ebi.ac.uk/pdbsum/2wel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [http://www.ebi.ac.uk/pdbsum/2wel PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.,Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654<ref>PMID:20668654</ref>		Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.,Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654<ref>PMID:20668654</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 08:30, 7 May 2014

2014-05-07T08:30:54Z

←Older revision		Revision as of 08:30, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2wel.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN==
		+	<StructureSection load='2wel' size='340' side='right' caption='[[2wel]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K88:(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE'>K88</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2f3z\|2f3z]], [[1j7p\|1j7p]], [[1nkf\|1nkf]], [[2jl2\|2jl2]], [[1k93\|1k93]], [[1xfv\|1xfv]], [[1sk6\|1sk6]], [[1y6w\|1y6w]], [[1iwq\|1iwq]], [[1k90\|1k90]], [[1yrt\|1yrt]], [[1lvc\|1lvc]], [[2w73\|2w73]], [[1cll\|1cll]], [[1cdl\|1cdl]], [[1xfy\|1xfy]], [[1xfu\|1xfu]], [[2f3y\|2f3y]], [[1xfx\|1xfx]], [[1s26\|1s26]], [[1j7o\|1j7o]], [[2w2c\|2w2c]], [[2vn9\|2vn9]], [[1yru\|1yru]], [[1wrz\|1wrz]], [[2v02\|2v02]], [[1xfz\|1xfz]], [[1xfw\|1xfw]], [[2v01\|2v01]], [[1pk0\|1pk0]], [[2be6\|2be6]], [[1zot\|1zot]], [[2vay\|2vay]], [[1sw8\|1sw8]], [[1aji\|1aji]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wel RCSB], [http://www.ebi.ac.uk/pdbsum/2wel PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/we/2wel_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Long-term potentiation (LTP), a long-lasting enhancement in communication between neurons, is considered to be the major cellular mechanism underlying learning and memory. LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII). CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Here we describe the crystal structure of the human CaMKIIdelta/Ca2+/CaM complex, structures of all four human CaMKII catalytic domains in their autoinhibited states, as well as structures of human CaMKII oligomerization domains in their tetradecameric and physiological dodecameric states. All four autoinhibited human CaMKIIs were monomeric in the determined crystal structures but associated weakly in solution. In the CaMKIIdelta/Ca2+/CaM complex, the inhibitory region adopted an extended conformation and interacted with an adjacent catalytic domain positioning T287 into the active site of the interacting protomer. Comparisons with autoinhibited CaMKII structures showed that binding of calmodulin leads to the rearrangement of residues in the active site to a conformation suitable for ATP binding and to the closure of the binding groove for the autoinhibitory helix by helix alphaD. The structural data, together with biophysical interaction studies, reveals the mechanism of CaMKII activation by calmodulin and explains many of the unique regulatory properties of these two essential signaling molecules. ENHANCED VERSION: This article can also be viewed as an enhanced version in which the text of the article is integrated with interactive 3-D representations and animated transitions. Please note that a web plugin is required to access this enhanced functionality. Instructions for the installation and use of the Web plugin are available in Text S1.

-	~~<!--~~	+	Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.,Rellos P, Pike AC, Niesen FH, Salah E, Lee WH, von Delft F, Knapp S PLoS Biol. 2010 Jul 27;8(7):e1000426. PMID:20668654<ref>PMID:20668654</ref>
-	~~The line below this paragraph, containing "STRUCTURE_2wel", creates~~ the ~~"Structure Box" on~~ the ~~page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2wel\| PDB=2wel \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM~~/~~CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_20668654}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20668654 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20668654}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wel]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020668654<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA: Protected "2wel" [edit=sysop:move=sysop]

2011-08-10T04:47:36Z

Protected "2wel" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:47, 10 August 2011

OCA at 04:47, 10 August 2011

2011-08-10T04:47:34Z

←Older revision		Revision as of 04:47, 10 August 2011
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-	~~{{Seed}}~~	+	[[Image:2wel.png\|left\|200px]]
-	[[Image:2wel.~~jpg~~\|left\|200px]]	+

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	===CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN===		===CRYSTAL STRUCTURE OF SU6656-BOUND CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE II DELTA IN COMPLEX WITH CALMODULIN===

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		+	The line below this paragraph, {{ABSTRACT_PUBMED_20668654}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20668654 is the PubMed ID number.
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		+	{{ABSTRACT_PUBMED_20668654}}

	==About this Structure==		==About this Structure==
-	~~2WEL~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA].	+	[[2wel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020668654</ref><references group="xtra"/>
	[[Category: Calcium/calmodulin-dependent protein kinase]]		[[Category: Calcium/calmodulin-dependent protein kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Sethi, R.]]		[[Category: Sethi, R.]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Calmodulin binding]]		[[Category: Calmodulin binding]]
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	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Serine-threonine kinase]]		[[Category: Serine-threonine kinase]]
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Vascular smooth muscle]]		[[Category: Vascular smooth muscle]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 10:24:18 2009''