2wfm - Revision history

OCA at 15:54, 13 December 2023

2023-12-13T15:54:30Z

←Older revision		Revision as of 15:54, 13 December 2023
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	<StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ophioxylon_serpentinum Ophioxylon serpentinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2wfl\|2wfl]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polyneuridine~~-~~aldehyde_esterase Polyneuridine-aldehyde esterase]~~, ~~with EC number~~ [~~https://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [https://pdbe.org/2wfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [https://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [https://pdbe.org/2wfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [https://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>	+	[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ophioxylon serpentinum]]~~	+	[[Category: Rauvolfia serpentina]]
-	~~[[Category: Polyneuridine-aldehyde esterase~~]]	+	[[Category: Hill M]]
-	[[Category: Hill, M]]	+	[[Category: Panjikar S]]
-	[[Category: Panjikar, S]]	+	[[Category: Stoeckigt J]]
-	[[Category: Stoeckigt, J]]	+	[[Category: Wang M]]
-	[[Category: Wang, M]]	+	[[Category: Yang L]]
-	[[Category: Yang, L]]	+
-	~~[[Category: Alkaloid metabolism]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Monoterpenoid indole alkaloid]]~~	+
-	~~[[Category: Pnae]]~~	+
-	~~[[Category: Serine esterase~~]]	+

OCA at 11:06, 6 April 2022

2022-04-06T11:06:10Z

←Older revision		Revision as of 11:06, 6 April 2022
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	<StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wfl\|2wfl]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [~~http~~://pdbe.org/2wfm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [https://pdbe.org/2wfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [https://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>	+	[[https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:40, 1 July 2020

2020-07-01T08:40:08Z

←Older revision		Revision as of 08:40, 1 July 2020
Line 1:		Line 1:

	==Crystal structure of polyneuridine aldehyde esterase mutant (H244A)==		==Crystal structure of polyneuridine aldehyde esterase mutant (H244A)==
-	<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WFM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://pdbe.org/2wfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://pdbe.org/2wfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ophioxylon serpentinum]]		[[Category: Ophioxylon serpentinum]]
	[[Category: Polyneuridine-aldehyde esterase]]		[[Category: Polyneuridine-aldehyde esterase]]

OCA at 09:05, 26 September 2018

2018-09-26T09:05:11Z

←Older revision		Revision as of 09:05, 26 September 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT~~ (H244A)==	+	==Crystal structure of polyneuridine aldehyde esterase mutant (H244A)==
	<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Devilpepper Devilpepper~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Devilpepper~~]]	+	[[Category: Ophioxylon serpentinum]]
	[[Category: Polyneuridine-aldehyde esterase]]		[[Category: Polyneuridine-aldehyde esterase]]
	[[Category: Hill, M]]		[[Category: Hill, M]]

OCA at 22:57, 4 August 2016

2016-08-04T22:57:20Z

←Older revision		Revision as of 22:57, 4 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)==		==CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)==
	<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rauvolfia_serpentina Rauvolfia serpentina~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Devilpepper Devilpepper]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://pdbe.org/2wfm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wfm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wfm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Devilpepper]]
	[[Category: Polyneuridine-aldehyde esterase]]		[[Category: Polyneuridine-aldehyde esterase]]
-	[[Category: Rauvolfia serpentina]]
	[[Category: Hill, M]]		[[Category: Hill, M]]
	[[Category: Panjikar, S]]		[[Category: Panjikar, S]]

OCA at 13:47, 25 December 2014

2014-12-25T13:47:47Z

←Older revision		Revision as of 13:47, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE]] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:02, 17 December 2014

2014-12-17T14:02:22Z

←Older revision		Revision as of 14:02, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wfm\| PDB=2wfm \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)==
-	===CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)===	+	<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19496101}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WFM FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wfl\|2wfl]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyneuridine-aldehyde_esterase Polyneuridine-aldehyde esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.78 3.1.1.78] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [http://www.ebi.ac.uk/pdbsum/2wfm PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cutting carbons: The three-dimensional structure of polyneuridine aldehyde esterase (PNAE) gives insight into the enzymatic mechanism of the biosynthesis of C(9)- from C(10)-monoterpenoid indole alkaloids (see scheme). PNAE is a very substrate-specific serine esterase. It harbors the catalytic triad S87-D216-H244, and is a new member of the alpha/beta-fold hydrolase superfamily. Its novel function leads to the diversification of alkaloid structures.

-	~~==About this Structure==~~	+	Structural basis and enzymatic mechanism of the biosynthesis of C9- from C10-monoterpenoid indole alkaloids.,Yang L, Hill M, Wang M, Panjikar S, Stockigt J Angew Chem Int Ed Engl. 2009;48(28):5211-3. PMID:19496101<ref>PMID:19496101</ref>
-	~~[[2wfm]] is a 5 chain structure with sequence~~ from ~~[http://en~~.~~wikipedia~~.~~org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WFM OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Polyneuridine Aldehyde Esterase\|Polyneuridine Aldehyde Esterase]]		*[[Polyneuridine Aldehyde Esterase\|Polyneuridine Aldehyde Esterase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019496101<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Polyneuridine-aldehyde esterase]]		[[Category: Polyneuridine-aldehyde esterase]]
	[[Category: Rauvolfia serpentina]]		[[Category: Rauvolfia serpentina]]
-	[[Category: Hill, M.]]	+	[[Category: Hill, M]]
-	[[Category: Panjikar, S.]]	+	[[Category: Panjikar, S]]
-	[[Category: Stoeckigt, J.]]	+	[[Category: Stoeckigt, J]]
-	[[Category: Wang, M.]]	+	[[Category: Wang, M]]
-	[[Category: Yang, L.]]	+	[[Category: Yang, L]]
	[[Category: Alkaloid metabolism]]		[[Category: Alkaloid metabolism]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:47, 11 March 2013

2013-03-11T09:47:11Z

←Older revision		Revision as of 09:47, 11 March 2013
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-	[[Image:2wfm.png\|left\|200px]]
-
-	<!--
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-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_2wfm\| PDB=2wfm \| SCENE= }}		{{STRUCTURE_2wfm\| PDB=2wfm \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)===		===CRYSTAL STRUCTURE OF POLYNEURIDINE ALDEHYDE ESTERASE MUTANT (H244A)===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19496101}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19496101 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_19496101}}		{{ABSTRACT_PUBMED_19496101}}

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	==See Also==		==See Also==
-	*[[Polyneuridine Aldehyde Esterase]]	+	*[[Polyneuridine Aldehyde Esterase\|Polyneuridine Aldehyde Esterase]]

	==Reference==		==Reference==

OCA at 05:22, 24 August 2011

2011-08-24T05:22:55Z

←Older revision		Revision as of 05:22, 24 August 2011
Line 20:		Line 20:
	==About this Structure==		==About this Structure==
	[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA].		[[2wfm]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA].
		+
		+	==See Also==
		+	*[[Polyneuridine Aldehyde Esterase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19496101~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019496101</ref><references group="xtra"/>
	[[Category: Polyneuridine-aldehyde esterase]]		[[Category: Polyneuridine-aldehyde esterase]]
	[[Category: Rauvolfia serpentina]]		[[Category: Rauvolfia serpentina]]

OCA: Protected "2wfm" [edit=sysop:move=sysop]

2011-01-02T03:11:17Z

Protected "2wfm" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:11, 2 January 2011