2wl7 - Revision history

OCA at 16:01, 13 December 2023

2023-12-13T16:01:03Z

←Older revision		Revision as of 16:01, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wl7' size='340' side='right'caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wl7' size='340' side='right'caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.028Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase]~~, ~~with EC number [https~~:~~//www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [https://pdbe.org/2wl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [https://pdbe.org/2wl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/DLG2_MOUSE DLG2_MOUSE] Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.<ref>PMID:12890763</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Guanylate kinase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Fiorentini, M]]	+	[[Category: Fiorentini M]]
-	[[Category: Gajhede, M]]	+	[[Category: Gajhede M]]
-	[[Category: Kallehauge, A]]	+	[[Category: Kallehauge A]]
-	[[Category: Kastrup~~, J S~~]]	+	[[Category: Kastrup JS]]
-	[[Category: Kristensen, O]]	+	[[Category: Kristensen O]]
-	~~[[Category: Chapsyn-110]]~~	+
-	~~[[Category: Delta2 receptor interacting protein]]~~	+
-	~~[[Category: Dlg2]]~~	+
-	~~[[Category: Maguk]]~~	+
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Psd93]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:10, 6 April 2022

2022-04-06T11:10:06Z

←Older revision		Revision as of 11:10, 6 April 2022
Line 3:		Line 3:
	<StructureSection load='2wl7' size='340' side='right'caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wl7' size='340' side='right'caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [~~http~~://pdbe.org/2wl7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [https://pdbe.org/2wl7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 27:		Line 27:
	</div>		</div>
	<div class="pdbe-citations 2wl7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wl7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Postsynaptic density protein 3D structures\|Postsynaptic density protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:52, 1 July 2020

2020-07-01T08:52:34Z

←Older revision		Revision as of 08:52, 1 July 2020
Line 1:		Line 1:

	==Crystal structure of the PSD93 PDZ1 domain==		==Crystal structure of the PSD93 PDZ1 domain==
-	<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>	+	<StructureSection load='2wl7' size='340' side='right'caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://pdbe.org/2wl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://pdbe.org/2wl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Fiorentini, M]]		[[Category: Fiorentini, M]]

OCA at 09:35, 26 September 2018

2018-09-26T09:35:24Z

←Older revision		Revision as of 09:35, 26 September 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE~~ PSD93 PDZ1 ~~DOMAIN~~==	+	==Crystal structure of the PSD93 PDZ1 domain==
	<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wl7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wl7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 18:22, 11 August 2016

2016-08-11T18:22:22Z

←Older revision		Revision as of 18:22, 11 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN==		==CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN==
	<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>		<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://pdbe.org/2wl7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wl7 ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wl7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wl7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Fiorentini, M]]		[[Category: Fiorentini, M]]
	[[Category: Gajhede, M]]		[[Category: Gajhede, M]]

OCA at 08:31, 20 January 2015

2015-01-20T08:31:02Z

←Older revision		Revision as of 08:31, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Fiorentini, M.]]	+	[[Category: Fiorentini, M]]
-	[[Category: Gajhede, M.]]	+	[[Category: Gajhede, M]]
-	[[Category: Kallehauge, A.]]	+	[[Category: Kallehauge, A]]
-	[[Category: Kastrup, J S.]]	+	[[Category: Kastrup, J S]]
-	[[Category: Kristensen, O.]]	+	[[Category: Kristensen, O]]
	[[Category: Chapsyn-110]]		[[Category: Chapsyn-110]]
	[[Category: Delta2 receptor interacting protein]]		[[Category: Delta2 receptor interacting protein]]

OCA at 01:38, 1 October 2014

2014-10-01T01:38:47Z

←Older revision		Revision as of 01:38, 1 October 2014
Line 1:		Line 1:
-	[[~~Image~~:2wl7.~~png\|left~~\|200px]]	+	==CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN==
		+	<StructureSection load='2wl7' size='340' side='right' caption='[[2wl7]], [[Resolution\|resolution]] 2.03Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WL7 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_kinase Guanylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.8 2.7.4.8] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wl7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wl7 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wl7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the PDZ1 domain of human PSD-93 has been determined to 2.0 A resolution. The PDZ1 domain forms a crystallographic trimer that is also predicted to be stable in solution. The main contributions to the stabilization of the trimer seem to arise from interactions involving the PDZ1-PDZ2 linker region at the extreme C-terminus of PDZ1, implying that the oligomerization that is observed is not of biological significance in full-length PSD-93. Comparison of the structures of the binding cleft of PSD-93 PDZ1 with the previously reported structures of PSD-93 PDZ2 and PDZ3 as well as of the closely related human PSD-95 PDZ1 shows that they are very similar in terms of amino-acid composition. However, the cleft is significantly narrower in PSD-95. This could be part of the basis of peptide selectivity between PSD-93 PDZ1 and PSD-95 PDZ1.

-	~~{{STRUCTURE_2wl7\| PDB=2wl7 \| SCENE= }}~~	+	Structure of the first PDZ domain of human PSD-93.,Fiorentini M, Nielsen AK, Kristensen O, Kastrup JS, Gajhede M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt, 12):1254-7. Epub 2009 Nov 27. PMID:20054121<ref>PMID:20054121</ref>

-	~~===CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20054121}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2wl7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020054121<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA: Protected "2wl7" [edit=sysop:move=sysop]

2013-01-07T21:02:29Z

Protected "2wl7" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:02, 7 January 2013

OCA at 21:02, 7 January 2013

2013-01-07T21:02:25Z

←Older revision		Revision as of 21:02, 7 January 2013
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wl7.png\|left\|200px]]		[[Image:2wl7.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wl7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wl7\| PDB=2wl7 \| SCENE= }}		{{STRUCTURE_2wl7\| PDB=2wl7 \| SCENE= }}

	===CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN===		===CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN===

		+	{{ABSTRACT_PUBMED_20054121}}

	==About this Structure==		==About this Structure==
-	~~2WL7~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA].	+	[[2wl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20054121~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020054121</ref><references group="xtra"/>
	[[Category: Guanylate kinase]]		[[Category: Guanylate kinase]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
Line 32:		Line 26:
	[[Category: Psd93]]		[[Category: Psd93]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:31:19 2010''

OCA at 13:31, 20 January 2010

2010-01-20T13:31:21Z

←Older revision		Revision as of 13:31, 20 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2wl7.png\|left\|200px]]

-	The ~~entry 2wl7~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2wl7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2wl7\| PDB=2wl7 \| SCENE= }}

-	~~Authors: Fiorentini, M., Kallehauge, A., Kristensen, O., Kastrup, J., Gajhede, M.~~	+	===CRYSTAL STRUCTURE OF THE PSD93 PDZ1 DOMAIN===

-	Description: Crystal structure of the PSD93 PDZ1 domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 22~~ 20:28:~~10 2009~~''	+	==About this Structure==
		+	2WL7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WL7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20054121</ref><references group="xtra"/>
		+	[[Category: Guanylate kinase]]
		+	[[Category: Mus musculus]]
		+	[[Category: Fiorentini, M.]]
		+	[[Category: Gajhede, M.]]
		+	[[Category: Kallehauge, A.]]
		+	[[Category: Kastrup, J S.]]
		+	[[Category: Kristensen, O.]]
		+	[[Category: Chapsyn-110]]
		+	[[Category: Delta2 receptor interacting protein]]
		+	[[Category: Dlg2]]
		+	[[Category: Maguk]]
		+	[[Category: Pdz domain]]
		+	[[Category: Psd93]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:31:19 2010''