2wlv - Revision history

OCA at 10:14, 9 May 2024

2024-05-09T10:14:06Z

←Older revision		Revision as of 10:14, 9 May 2024
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	<StructureSection load='2wlv' size='340' side='right'caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2wlv' size='340' side='right'caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hiv-2 Hiv-~~2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(ISOLATE_D194) Human immunodeficiency virus type 2 (ISOLATE D194)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>~~[[~~2wlw~~\|~~2wlw~~]]~~</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.25Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [https://pdbe.org/2wlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [https://www.ebi.ac.uk/pdbsum/2wlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wlv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [https://pdbe.org/2wlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [https://www.ebi.ac.uk/pdbsum/2wlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wlv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~Q76929_9HIV2 Q76929_9HIV2]~~] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex ~~(By similarity)~~.~~[SAAS:SAAS012344_004_008806]~~ Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).	+	[https://www.uniprot.org/uniprot/GAG_HV2RO GAG_HV2RO] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity). p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hiv-2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: James~~, L C~~]]	+	[[Category: James LC]]
-	[[Category: Lammers, M]]	+	[[Category: Lammers M]]
-	[[Category: Marzetta, F]]	+	[[Category: Marzetta F]]
-	[[Category: Price~~, A J~~]]	+	[[Category: Price AJ]]
-	[[Category: Schaller, T]]	+	[[Category: Schaller T]]
-	[[Category: Towers~~, G J~~]]	+	[[Category: Towers GJ]]
-	[[Category: Wilson~~, S J~~]]	+	[[Category: Wilson SJ]]
-	[[Category: Ylinen~~, L M.J]]~~	+	[[Category: Ylinen LMJ]]
-	~~[[Category: Aid]]~~	+
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Hiv]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Rna-binding]]~~	+
-	~~[[Category: Viral nucleoprotein]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 10:56, 7 July 2021

2021-07-07T10:56:01Z

←Older revision		Revision as of 10:56, 7 July 2021
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	<StructureSection load='2wlv' size='340' side='right'caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2wlv' size='340' side='right'caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WLV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wlw\|2wlw]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [~~http~~://pdbe.org/2wlv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wlv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wlv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [https://pdbe.org/2wlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [https://www.ebi.ac.uk/pdbsum/2wlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wlv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/Q76929_9HIV2 Q76929_9HIV2]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).	+	[[https://www.uniprot.org/uniprot/Q76929_9HIV2 Q76929_9HIV2]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	*[[Gag polyprotein\|Gag polyprotein]]		*[[Gag polyprotein\|Gag polyprotein]]
	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]		*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
		+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:18, 21 August 2019

2019-08-21T07:18:09Z

←Older revision		Revision as of 07:18, 21 August 2019
Line 1:		Line 1:

	==Structure of the N-terminal capsid domain of HIV-2==		==Structure of the N-terminal capsid domain of HIV-2==
-	<StructureSection load='2wlv' size='340' side='right' caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>	+	<StructureSection load='2wlv' size='340' side='right'caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wlv_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wlv_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2wlv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wlv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Gag polyprotein\|Gag polyprotein]]
		+	*[[Gag polyprotein 3D structures\|Gag polyprotein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Hiv-2]]		[[Category: Hiv-2]]
		+	[[Category: Large Structures]]
	[[Category: James, L C]]		[[Category: James, L C]]
	[[Category: Lammers, M]]		[[Category: Lammers, M]]

OCA at 14:34, 15 November 2017

2017-11-15T14:34:30Z

←Older revision		Revision as of 14:34, 15 November 2017
Line 1:		Line 1:
		+
	==Structure of the N-terminal capsid domain of HIV-2==		==Structure of the N-terminal capsid domain of HIV-2==
	<StructureSection load='2wlv' size='340' side='right' caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>		<StructureSection load='2wlv' size='340' side='right' caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://pdbe.org/2wlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://pdbe.org/2wlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wlv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 2wlv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wlv" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Gag polyprotein\|Gag polyprotein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:37, 7 February 2016

2016-02-07T16:37:51Z

←Older revision		Revision as of 16:37, 7 February 2016
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://pdbe.org/2wlv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wlv ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wlv" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 16:45, 24 December 2014

2014-12-24T16:45:33Z

←Older revision		Revision as of 16:45, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q76929_9HIV2 Q76929_9HIV2]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Hiv-2]]		[[Category: Hiv-2]]
-	[[Category: James, L C.]]	+	[[Category: James, L C]]
-	[[Category: Lammers, M.]]	+	[[Category: Lammers, M]]
-	[[Category: Marzetta, F.]]	+	[[Category: Marzetta, F]]
-	[[Category: Price, A J.]]	+	[[Category: Price, A J]]
-	[[Category: Schaller, T.]]	+	[[Category: Schaller, T]]
-	[[Category: Towers, G J.]]	+	[[Category: Towers, G J]]
-	[[Category: Wilson, S J.]]	+	[[Category: Wilson, S J]]
-	[[Category: Ylinen, L M.J.]]	+	[[Category: Ylinen, L M.J]]
	[[Category: Aid]]		[[Category: Aid]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]
	[[Category: Hiv]]		[[Category: Hiv]]
	[[Category: Hiv-1]]		[[Category: Hiv-1]]
-	[[Category: Hiv-2]]
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Viral nucleoprotein]]		[[Category: Viral nucleoprotein]]
	[[Category: Viral protein]]		[[Category: Viral protein]]

OCA at 05:21, 3 October 2014

2014-10-03T05:21:30Z

←Older revision		Revision as of 05:21, 3 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wlv\| PDB=2wlv \| SCENE= }}~~	+	==Structure of the N-terminal capsid domain of HIV-2==
-	===Structure of the N-terminal capsid domain of HIV-2===	+	<StructureSection load='2wlv' size='340' side='right' caption='[[2wlv]], [[Resolution\|resolution]] 1.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19767750}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WLV FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wlw\|2wlw]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wlv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wlv RCSB], [http://www.ebi.ac.uk/pdbsum/2wlv PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wl/2wlv_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	TRIMCyps are primate antiretroviral proteins that potently inhibit HIV replication. Here we describe how rhesus macaque TRIMCyp (RhTC) has evolved to target and restrict HIV-2. We show that the ancestral cyclophilin A (CypA) domain of RhTC targets HIV-2 capsid with weak affinity, which is strongly increased in RhTC by two mutations (D66N and R69H) at the expense of HIV-1 binding. These mutations disrupt a constraining intramolecular interaction in CypA, triggering the complete restructuring (>16 A) of an active site loop. This new configuration discriminates between divergent HIV-1 and HIV-2 loop conformations mediated by capsid residue 88. Viral sensitivity to RhTC restriction can be conferred or abolished by mutating position 88. Furthermore, position 88 determines the susceptibility of naturally occurring HIV-1 sequences to restriction. Our results reveal the complex molecular, structural and thermodynamic changes that underlie the ongoing evolutionary race between virus and host.

-	~~==Function==~~	+	Active site remodeling switches HIV specificity of antiretroviral TRIMCyp.,Price AJ, Marzetta F, Lammers M, Ylinen LM, Schaller T, Wilson SJ, Towers GJ, James LC Nat Struct Mol Biol. 2009 Oct;16(10):1036-42. Epub 2009 Sep 20. PMID:19767750<ref>PMID:19767750</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/Q76929_9HIV2 Q76929_9HIV2]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex~~ (~~By similarity~~)~~.[SAAS~~:~~SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA~~. ~~Binds these RNAs through its zinc fingers (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2wlv]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Hiv-2 Hiv-2]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Gag polyprotein\|Gag polyprotein]]		*[[Gag polyprotein\|Gag polyprotein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019767750</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Hiv-2]]		[[Category: Hiv-2]]
	[[Category: James, L C.]]		[[Category: James, L C.]]

OCA at 14:15, 12 March 2014

2014-03-12T14:15:09Z

←Older revision		Revision as of 14:15, 12 March 2014
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_immunodeficiency_virus_type_2_(isolate_d194) Human immunodeficiency virus type~~ 2 ~~(isolate d194)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].	+	[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].

	==See Also==		==See Also==
Line 14:		Line 14:
	==Reference==		==Reference==
	<ref group="xtra">PMID:019767750</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:019767750</ref><references group="xtra"/><references/>
		+	[[Category: Hiv-2]]
	[[Category: James, L C.]]		[[Category: James, L C.]]
	[[Category: Lammers, M.]]		[[Category: Lammers, M.]]

OCA at 10:05, 24 April 2013

2013-04-24T10:05:39Z

←Older revision		Revision as of 10:05, 24 April 2013
Line 1:		Line 1:
-	[[Image:2wlv.png\|left\|200px]]
-
	{{STRUCTURE_2wlv\| PDB=2wlv \| SCENE= }}		{{STRUCTURE_2wlv\| PDB=2wlv \| SCENE= }}
		+	===Structure of the N-terminal capsid domain of HIV-2===
		+	{{ABSTRACT_PUBMED_19767750}}

-	==~~=STRUCTURE OF THE N-TERMINAL CAPSID DOMAIN OF HIV-2=~~==	+	==Function==
-		+	[[http://www.uniprot.org/uniprot/Q76929_9HIV2 Q76929_9HIV2]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806] Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).
-	~~{{ABSTRACT_PUBMED_19767750}}~~	+

	==About this Structure==		==About this Structure==
-	[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Viruses Viruses~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].	+	[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(isolate_d194) Human immunodeficiency virus type 2 (isolate d194)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019767750</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019767750</ref><references group="xtra"/><references/>
-	~~[[Category: Viruses]]~~	+
	[[Category: James, L C.]]		[[Category: James, L C.]]
	[[Category: Lammers, M.]]		[[Category: Lammers, M.]]
Line 31:		Line 29:
	[[Category: Rna-binding]]		[[Category: Rna-binding]]
	[[Category: Viral nucleoprotein]]		[[Category: Viral nucleoprotein]]
-	[[Category: ~~Virus~~ protein]]	+	[[Category: Viral protein]]

OCA at 07:15, 20 October 2012

2012-10-20T07:15:06Z

←Older revision		Revision as of 07:15, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wlv]] is a 2 chain structure ~~of [[Gag polyprotein]]~~ with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].	+	[[2wlv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WLV OCA].

	==See Also==		==See Also==