2wmn - Revision history

OCA at 16:02, 13 December 2023

2023-12-13T16:02:33Z

←Older revision		Revision as of 16:02, 13 December 2023
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	<StructureSection load='2wmn' size='340' side='right'caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='2wmn' size='340' side='right'caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WMN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WMN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GDP:GUANOSINE~~-~~5-DIPHOSPHATE'>GDP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.391Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [https://pdbe.org/2wmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [https://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [https://pdbe.org/2wmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [https://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>	+	[https://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Barford, D]]	+	[[Category: Barford D]]
-	[[Category: Roe~~, S M~~]]	+	[[Category: Roe SM]]
-	[[Category: Yang, J]]	+	[[Category: Yang J]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cdc42]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: Dock9]]~~	+
-	~~[[Category: Gef]]~~	+
-	~~[[Category: Gtp-binding]]~~	+
-	~~[[Category: Guanine-nucleotide releasing factor]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Methylation]]~~	+
-	~~[[Category: Nucleotide]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polymorphism]]~~	+
-	~~[[Category: Prenylation~~]]	+

OCA at 11:10, 6 April 2022

2022-04-06T11:10:53Z

←Older revision		Revision as of 11:10, 6 April 2022
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	<StructureSection load='2wmn' size='340' side='right'caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='2wmn' size='340' side='right'caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2WMN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WMN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [~~http~~://pdbe.org/2wmn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [https://pdbe.org/2wmn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [https://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>	+	[[https://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:55, 1 July 2020

2020-07-01T08:55:22Z

←Older revision		Revision as of 08:55, 1 July 2020
Line 1:		Line 1:

	==Structure of the complex between DOCK9 and Cdc42-GDP.==		==Structure of the complex between DOCK9 and Cdc42-GDP.==
-	<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>	+	<StructureSection load='2wmn' size='340' side='right'caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WMN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2WMN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://pdbe.org/2wmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://pdbe.org/2wmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Dedicator of cytokinesis protein\|Dedicator of cytokinesis protein]]		*[[Dedicator of cytokinesis protein\|Dedicator of cytokinesis protein]]
-	*[[GTP-binding protein\|GTP-binding protein]]	+	*[[Dedicator of cytokinesis protein 3D structures\|Dedicator of cytokinesis protein 3D structures]]
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Roe, S M]]		[[Category: Roe, S M]]

OCA at 09:46, 26 September 2018

2018-09-26T09:46:01Z

←Older revision		Revision as of 09:46, 26 September 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF THE COMPLEX BETWEEN~~ DOCK9 ~~AND CDC42~~-GDP.==	+	==Structure of the complex between DOCK9 and Cdc42-GDP.==
	<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 9:		Line 9:
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>	+	[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:

	==See Also==		==See Also==
		+	*[[Dedicator of cytokinesis protein\|Dedicator of cytokinesis protein]]
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
Line 40:		Line 41:
	[[Category: Roe, S M]]		[[Category: Roe, S M]]
	[[Category: Yang, J]]		[[Category: Yang, J]]
		+	[[Category: Alternative splicing]]
	[[Category: Cdc42]]		[[Category: Cdc42]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
		+	[[Category: Coiled coil]]
	[[Category: Dock9]]		[[Category: Dock9]]
	[[Category: Gef]]		[[Category: Gef]]
Line 53:		Line 56:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
	[[Category: Prenylation]]		[[Category: Prenylation]]

OCA at 16:47, 5 August 2016

2016-08-05T16:47:31Z

←Older revision		Revision as of 16:47, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.==		==STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.==
	<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WMN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WMN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://pdbe.org/2wmn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wmn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wmn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Barford, D]]		[[Category: Barford, D]]
	[[Category: Roe, S M]]		[[Category: Roe, S M]]

OCA at 20:24, 25 December 2014

2014-12-25T20:24:30Z

←Older revision		Revision as of 20:24, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WMN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WMN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DOCK9_HUMAN DOCK9_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation.<ref>PMID:12172552</ref> <ref>PMID:19745154</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Barford, D.]]	+	[[Category: Barford, D]]
-	[[Category: Roe, S M.]]	+	[[Category: Roe, S M]]
-	[[Category: Yang, J.]]	+	[[Category: Yang, J]]
	[[Category: Cdc42]]		[[Category: Cdc42]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 09:20, 29 September 2014

2014-09-29T09:20:55Z

←Older revision		Revision as of 09:20, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~2wmn.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.==
		+	<StructureSection load='2wmn' size='340' side='right' caption='[[2wmn]], [[Resolution\|resolution]] 2.39Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WMN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1wg7\|1wg7]], [[1am4\|1am4]], [[1nf3\|1nf3]], [[1doa\|1doa]], [[1aje\|1aje]], [[1ki1\|1ki1]], [[1gzs\|1gzs]], [[1kzg\|1kzg]], [[1cee\|1cee]], [[2dfk\|2dfk]], [[1ees\|1ees]], [[1an0\|1an0]], [[1kz7\|1kz7]], [[1e0a\|1e0a]], [[2wm9\|2wm9]], [[1a4r\|1a4r]], [[2ase\|2ase]], [[1cf4\|1cf4]], [[2ngr\|2ngr]], [[1grn\|1grn]], [[2wmo\|2wmo]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wmn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wmn RCSB], [http://www.ebi.ac.uk/pdbsum/2wmn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/2wmn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation of Rho guanosine triphosphatases (GTPases) to the guanine triphosphate (GTP)-bound state is a critical event in their regulation of the cytoskeleton and cell signaling. Members of the DOCK family of guanine nucleotide exchange factors (GEFs) are important activators of Rho GTPases, but the mechanism of activation by their catalytic DHR2 domain is unknown. Through structural analysis of DOCK9-Cdc42 complexes, we identify a nucleotide sensor within the alpha10 helix of the DHR2 domain that contributes to release of guanine diphosphate (GDP) and then to discharge of the activated GTP-bound Cdc42. Magnesium exclusion, a critical factor in promoting GDP release, is mediated by a conserved valine residue within this sensor, whereas binding of GTP-Mg2+ to the nucleotide-free complex results in magnesium-inducing displacement of the sensor to stimulate discharge of Cdc42-GTP. These studies identify an unusual mechanism of GDP release and define the complete GEF catalytic cycle from GDP dissociation followed by GTP binding and discharge of the activated GTPase.

-	~~{{STRUCTURE_2wmn\| PDB=2wmn \| SCENE= }}~~	+	Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.,Yang J, Zhang Z, Roe SM, Marshall CJ, Barford D Science. 2009 Sep 11;325(5946):1398-402. PMID:19745154<ref>PMID:19745154</ref>

-	~~===STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19745154}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wmn]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA].~~	+

	==See Also==		==See Also==
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019745154<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barford, D.]]		[[Category: Barford, D.]]

OCA at 21:05, 20 October 2012

2012-10-20T21:05:00Z

←Older revision		Revision as of 21:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2wmn]] is a 2 chain structure ~~of [[GTP-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA].	+	[[2wmn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA].

	==See Also==		==See Also==

OCA: Protected "2wmn" [edit=sysop:move=sysop]

2012-07-27T12:32:54Z

Protected "2wmn" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:32, 27 July 2012

OCA at 12:32, 27 July 2012

2012-07-27T12:32:50Z

←Older revision		Revision as of 12:32, 27 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2wmn.png\|left\|200px]]
-	[[Image:2wmn.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wmn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wmn\| PDB=2wmn \| SCENE= }}		{{STRUCTURE_2wmn\| PDB=2wmn \| SCENE= }}

	===STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.===		===STRUCTURE OF THE COMPLEX BETWEEN DOCK9 AND CDC42-GDP.===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19745154}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19745154 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19745154}}		{{ABSTRACT_PUBMED_19745154}}

	==About this Structure==		==About this Structure==
-	~~2WMN~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA].	+	[[2wmn]] is a 2 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMN OCA].
		+
		+	==See Also==
		+	*[[GTP-binding protein\|GTP-binding protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19745154~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019745154</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Barford, D.]]		[[Category: Barford, D.]]
	[[Category: Roe, S M.]]		[[Category: Roe, S M.]]
	[[Category: Yang, J.]]		[[Category: Yang, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Cdc42]]		[[Category: Cdc42]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
-	[[Category: Coiled coil]]
	[[Category: Dock9]]		[[Category: Dock9]]
	[[Category: Gef]]		[[Category: Gef]]
Line 43:		Line 32:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Prenylation]]		[[Category: Prenylation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:49:12 2009''