2wnb - Revision history

OCA at 16:03, 13 December 2023

2023-12-13T16:03:49Z

←Older revision		Revision as of 16:03, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2wnb' size='340' side='right'caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2wnb' size='340' side='right'caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=C5P:CYTIDINE~~-~~5-MONOPHOSPHATE'>C5P</scene>~~, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PRD_900084:Thomsen-Friedenreich+antigen'>PRD_900084</scene></td></tr>
-	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2wml\|2wml]], [[2wnf\|2wnf]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>[https://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [https://pdbe.org/2wnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [https://www.ebi.ac.uk/pdbsum/2wnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [https://pdbe.org/2wnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [https://www.ebi.ac.uk/pdbsum/2wnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnb ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SIA4A_PIG SIA4A_PIG]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pig~~]]	+	[[Category: Sus scrofa]]
-	[[Category: Raikic, B]]	+	[[Category: Raikic B]]
-	[[Category: Rao~~, F V~~]]	+	[[Category: Rao FV]]
-	[[Category: Rich~~, J R~~]]	+	[[Category: Rich JR]]
-	[[Category: Strynadka~~, N C.J~~]]	+	[[Category: Strynadka NCJ]]
-	[[Category: Wakarchuk~~, W W~~]]	+	[[Category: Wakarchuk WW]]
-	[[Category: Withers~~, S G]]~~	+	[[Category: Withers SG]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Golgi apparatus]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Sialyltransferase]]~~	+
-	~~[[Category: Signal-anchor]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 10:56, 7 July 2021

2021-07-07T10:56:48Z

←Older revision		Revision as of 10:56, 7 July 2021
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	<StructureSection load='2wnb' size='340' side='right'caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2wnb' size='340' side='right'caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WNB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~A2G~~:N-~~ACETYL-2-DEOXY-2-AMINO~~-~~GALACTOSE~~'>~~A2G~~</scene>, <scene name='pdbligand=~~C5P~~:~~CYTIDINE~~-~~5-MONOPHOSPHATE~~'>~~C5P~~</scene>, <scene name='pdbligand=~~CG3~~:~~HYDROXY(~~2-~~HYDROXYPHENYL)OXOAMMONIUM~~'>~~CG3~~</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wml\|2wml]], [[2wnf\|2wnf]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [~~http~~://pdbe.org/2wnb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wnb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [https://pdbe.org/2wnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [https://www.ebi.ac.uk/pdbsum/2wnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Sialyltransferase\|Sialyltransferase]]	+	*[[Sialyltransferase 3D structures\|Sialyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Pig]]
	[[Category: Raikic, B]]		[[Category: Raikic, B]]
	[[Category: Rao, F V]]		[[Category: Rao, F V]]

OCA at 06:51, 7 August 2019

2019-08-07T06:51:33Z

←Older revision		Revision as of 06:51, 7 August 2019
Line 1:		Line 1:

	==Crystal Structure of a Mammalian Sialyltransferase in complex with disaccharide and CMP==		==Crystal Structure of a Mammalian Sialyltransferase in complex with disaccharide and CMP==
-	<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='2wnb' size='340' side='right'caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2wnb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2wnb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sialyltransferase\|Sialyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
		+	[[Category: Large Structures]]
	[[Category: Raikic, B]]		[[Category: Raikic, B]]
	[[Category: Rao, F V]]		[[Category: Rao, F V]]

OCA at 08:48, 3 August 2017

2017-08-03T08:48:43Z

←Older revision		Revision as of 08:48, 3 August 2017
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF A MAMMALIAN SIALYLTRANSFERASE IN COMPLEX WITH DISACCHARIDE AND~~ CMP==	+
		+	==Crystal Structure of a Mammalian Sialyltransferase in complex with disaccharide and CMP==
	<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Pig Pig]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~C5P~~:~~CYTIDINE~~-5-~~MONOPHOSPHATE~~'>~~C5P~~</scene>, <scene name='pdbligand=~~CG3~~:~~HYDROXY(2~~-~~HYDROXYPHENYL)OXOAMMONIUM~~'>~~CG3~~</scene>, <scene name='pdbligand=~~A2G~~:~~N-ACETYL-~~2-~~DEOXY-2-AMINO-GALACTOSE~~'>~~A2G~~</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://pdbe.org/2wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://pdbe.org/2wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wnb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
-	[[Category: Pig]]
	[[Category: Raikic, B]]		[[Category: Raikic, B]]
	[[Category: Rao, F V]]		[[Category: Rao, F V]]
Line 40:		Line 40:
	[[Category: Wakarchuk, W W]]		[[Category: Wakarchuk, W W]]
	[[Category: Withers, S G]]		[[Category: Withers, S G]]
		+	[[Category: Alternative splicing]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 09:20, 8 February 2016

2016-02-08T09:20:35Z

←Older revision		Revision as of 09:20, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://pdbe.org/2wnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wnb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wnb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
-	[[Category: ~~Sus scrofa~~]]	+	[[Category: Pig]]
	[[Category: Raikic, B]]		[[Category: Raikic, B]]
	[[Category: Rao, F V]]		[[Category: Rao, F V]]

OCA at 22:16, 24 December 2014

2014-12-24T22:16:26Z

←Older revision		Revision as of 22:16, 24 December 2014
Line 33:		Line 33:
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
-	[[Category: Raikic, B.]]	+	[[Category: Raikic, B]]
-	[[Category: Rao, F V.]]	+	[[Category: Rao, F V]]
-	[[Category: Rich, J R.]]	+	[[Category: Rich, J R]]
-	[[Category: Strynadka, N C.J.]]	+	[[Category: Strynadka, N C.J]]
-	[[Category: Wakarchuk, W W.]]	+	[[Category: Wakarchuk, W W]]
-	[[Category: Withers, S G.]]	+	[[Category: Withers, S G]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]

OCA at 05:59, 10 October 2014

2014-10-10T05:59:56Z

←Older revision		Revision as of 05:59, 10 October 2014
Line 2:		Line 2:
	<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. <br>	+	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WNB FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~Glucokinase Glucokinase~~], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-galactoside_alpha-2,3-sialyltransferase Beta-galactoside alpha-2,3-sialyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.4 2.4.99.4] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:
	Structural insight into mammalian sialyltransferases.,Rao FV, Rich JR, Rakic B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC Nat Struct Mol Biol. 2009 Nov;16(11):1186-8. Epub 2009 Oct 11. PMID:19820709<ref>PMID:19820709</ref>		Structural insight into mammalian sialyltransferases.,Rao FV, Rich JR, Rakic B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC Nat Struct Mol Biol. 2009 Nov;16(11):1186-8. Epub 2009 Oct 11. PMID:19820709<ref>PMID:19820709</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 08:40, 7 May 2014

2014-05-07T08:40:52Z

←Older revision		Revision as of 08:40, 7 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2wnb.~~png~~\|~~left~~\|200px]]	+	==CRYSTAL STRUCTURE OF A MAMMALIAN SIALYLTRANSFERASE IN COMPLEX WITH DISACCHARIDE AND CMP==
		+	<StructureSection load='2wnb' size='340' side='right' caption='[[2wnb]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CG3:HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM'>CG3</scene>, <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wml\|2wml]], [[2wnf\|2wnf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wnb RCSB], [http://www.ebi.ac.uk/pdbsum/2wnb PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/2wnb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mammalian cell surfaces are modified by complex arrays of glycoproteins, glycolipids and polysaccharides, many of which terminate in sialic acid and have central roles in essential processes including cell recognition, adhesion and immunogenicity. Sialylation of glycoconjugates is performed by a set of sequence-related enzymes known as sialyltransferases (STs). Here we present the crystal structure of a mammalian ST, porcine ST3Gal-I, providing a structural basis for understanding the mechanism and specificity of these enzymes and for the design of selective inhibitors.

-	~~<!--~~	+	Structural insight into mammalian sialyltransferases.,Rao FV, Rich JR, Rakic B, Buddai S, Schwartz MF, Johnson K, Bowe C, Wakarchuk WW, Defrees S, Withers SG, Strynadka NC Nat Struct Mol Biol. 2009 Nov;16(11):1186-8. Epub 2009 Oct 11. PMID:19820709<ref>PMID:19820709</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2wnb"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2wnb\| PDB=2wnb \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF A MAMMALIAN SIALYLTRANSFERASE IN COMPLEX WITH DISACCHARIDE AND CMP===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19820709}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19820709 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19820709}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2wnb]] is a 1 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019820709<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA: Protected "2wnb" [edit=sysop:move=sysop]

2011-11-16T10:16:16Z

Protected "2wnb" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:16, 16 November 2011

OCA at 10:16, 16 November 2011

2011-11-16T10:16:09Z

←Older revision		Revision as of 10:16, 16 November 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:2wnb.png\|left\|200px]]		[[Image:2wnb.png\|left\|200px]]

Line 20:		Line 19:

	==About this Structure==		==About this Structure==
-	~~2WNB~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA].	+	[[2wnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WNB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19820709~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019820709</ref><references group="xtra"/>
	[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]		[[Category: Beta-galactoside alpha-2,3-sialyltransferase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
Line 32:		Line 31:
	[[Category: Wakarchuk, W W.]]		[[Category: Wakarchuk, W W.]]
	[[Category: Withers, S G.]]		[[Category: Withers, S G.]]
-	[[Category: Alternative splicing]]
	[[Category: Disulfide bond]]		[[Category: Disulfide bond]]
	[[Category: Glycoprotein]]		[[Category: Glycoprotein]]
Line 44:		Line 42:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:59:20 2010''