2wov - Revision history

OCA at 10:12, 20 December 2023

2023-12-20T10:12:43Z

←Older revision		Revision as of 10:12, 20 December 2023
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	<StructureSection load='2wov' size='340' side='right'caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wov' size='340' side='right'caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FAD:FLAVIN~~-~~ADENINE+DINUCLEOTIDE'>FAD</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2woi\|2woi]], [[2wow\|2wow]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Trypanothione~~-~~disulfide_reductase Trypanothione~~-~~disulfide reductase], with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [https://pdbe.org/2wov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [https://www.ebi.ac.uk/pdbsum/2wov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wov ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [https://pdbe.org/2wov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [https://www.ebi.ac.uk/pdbsum/2wov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wov ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q389T8_TRYB2 Q389T8_TRYB2]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trypanothione-disulfide reductase~~]]	+	[[Category: Trypanosoma brucei brucei TREU927]]
-	[[Category: Alphey~~, M S~~]]	+	[[Category: Alphey MS]]
-	[[Category: Fairlamb~~, A H]]~~	+	[[Category: Fairlamb AH]]
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Redox-active center]]~~	+
-	~~[[Category: Reductase]]~~	+
-	~~[[Category: Sleeping sickness]]~~	+
-	~~[[Category: Trypanosomiasis]]~~	+
-	~~[[Category: Trypanothione~~]]	+

OCA at 10:57, 7 July 2021

2021-07-07T10:57:19Z

←Older revision		Revision as of 10:57, 7 July 2021
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	<StructureSection load='2wov' size='340' side='right'caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wov' size='340' side='right'caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2WOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2woi\|2woi]], [[2wow\|2wow]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2woi\|2woi]], [[2wow\|2wow]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [~~http~~://pdbe.org/2wov PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2wov PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2wov ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [https://pdbe.org/2wov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [https://www.ebi.ac.uk/pdbsum/2wov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wov ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 07:03, 7 August 2019

2019-08-07T07:03:51Z

←Older revision		Revision as of 07:03, 7 August 2019
Line 1:		Line 1:

	==Trypanosoma brucei trypanothione reductase with bound NADP.==		==Trypanosoma brucei trypanothione reductase with bound NADP.==
-	<StructureSection load='2wov' size='340' side='right' caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2wov' size='340' side='right'caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>		<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wov_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wov_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Trypanothione-disulfide reductase]]		[[Category: Trypanothione-disulfide reductase]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]

OCA at 09:22, 3 August 2017

2017-08-03T09:22:29Z

←Older revision		Revision as of 09:22, 3 August 2017
Line 1:		Line 1:

-	==~~TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND~~ NADP.==	+	==Trypanosoma brucei trypanothione reductase with bound NADP.==
	<StructureSection load='2wov' size='340' side='right' caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wov' size='340' side='right' caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_treu927 Trypanosoma brucei treu927]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2woi\|2woi]], [[2wow\|2wow]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2woi\|2woi]], [[2wow\|2wow]]</td></tr>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Trypanosoma brucei treu927]]
	[[Category: Trypanothione-disulfide reductase]]		[[Category: Trypanothione-disulfide reductase]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]

OCA at 22:03, 4 August 2016

2016-08-04T22:03:31Z

←Older revision		Revision as of 22:03, 4 August 2016
Line 1:		Line 1:
		+
	==TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.==		==TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.==
	<StructureSection load='2wov' size='340' side='right' caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2wov' size='340' side='right' caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_brucei~~ Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_treu927 Trypanosoma brucei treu927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2woi\|2woi]], [[2wow\|2wow]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2woi\|2woi]], [[2wow\|2wow]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [http://www.ebi.ac.uk/pdbsum/2wov PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [http://pdbe.org/2wov PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [http://www.ebi.ac.uk/pdbsum/2wov PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wov ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wov ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2wov" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Trypanosoma brucei]]	+	[[Category: Trypanosoma brucei treu927]]
	[[Category: Trypanothione-disulfide reductase]]		[[Category: Trypanothione-disulfide reductase]]
	[[Category: Alphey, M S]]		[[Category: Alphey, M S]]

OCA at 13:53, 17 December 2014

2014-12-17T13:53:02Z

←Older revision		Revision as of 13:53, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2wov\| PDB=2wov \| SCENE= }}~~	+	==TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.==
-	===TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.===	+	<StructureSection load='2wov' size='340' side='right' caption='[[2wov]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21851087}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2wov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WOV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2woi\|2woi]], [[2wow\|2wow]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wov OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wov RCSB], [http://www.ebi.ac.uk/pdbsum/2wov PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wov_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Trypanothione reductase (TryR) is a genetically validated drug target in the parasite Trypanosoma brucei , the causative agent of human African trypanosomiasis. Here we report the discovery, synthesis, and development of a novel series of TryR inhibitors based on a 3,4-dihydroquinazoline scaffold. In addition, a high resolution crystal structure of TryR, alone and in complex with substrates and inhibitors from this series, is presented. This represents the first report of a high resolution complex between a noncovalent ligand and this enzyme. Structural studies revealed that upon ligand binding the enzyme undergoes a conformational change to create a new subpocket which is occupied by an aryl group on the ligand. Therefore, the inhibitor, in effect, creates its own small binding pocket within the otherwise large, solvent exposed active site. The TryR-ligand structure was subsequently used to guide the synthesis of inhibitors, including analogues that challenged the induced subpocket. This resulted in the development of inhibitors with improved potency against both TryR and T. brucei parasites in a whole cell assay.

-	~~==About this Structure==~~	+	Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography.,Patterson S, Alphey MS, Jones DC, Shanks EJ, Street IP, Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH J Med Chem. 2011 Oct 13;54(19):6514-30. Epub 2011 Sep 1. PMID:21851087<ref>PMID:21851087</ref>
-	~~[[2wov]] is~~ a ~~4 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Trypanosoma_brucei Trypanosoma brucei]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2WOV OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Trypanothione reductase\|Trypanothione reductase]]		*[[Trypanothione reductase\|Trypanothione reductase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:021851087<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Trypanothione-disulfide reductase]]		[[Category: Trypanothione-disulfide reductase]]
-	[[Category: Alphey, M S.]]	+	[[Category: Alphey, M S]]
-	[[Category: Fairlamb, A H.]]	+	[[Category: Fairlamb, A H]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 09:26, 11 March 2013

2013-03-11T09:26:10Z

←Older revision		Revision as of 09:26, 11 March 2013
Line 1:		Line 1:
-	[[Image:2wov.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2wov", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2wov\| PDB=2wov \| SCENE= }}		{{STRUCTURE_2wov\| PDB=2wov \| SCENE= }}
-
	===TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.===		===TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21851087}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21851087 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21851087}}		{{ABSTRACT_PUBMED_21851087}}

	==About this Structure==		==About this Structure==
	[[2wov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA].		[[2wov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA].
		+
		+	==See Also==
		+	*[[Trypanothione reductase\|Trypanothione reductase]]

	==Reference==		==Reference==

OCA: Protected "2wov" [edit=sysop:move=sysop]

2011-10-30T07:27:47Z

Protected "2wov" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:27, 30 October 2011

OCA at 07:27, 30 October 2011

2011-10-30T07:27:45Z

←Older revision		Revision as of 07:27, 30 October 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2wov.png\|left\|200px]]
-	[[Image:2wov.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.===		===TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21851087}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21851087 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21851087}}

	==About this Structure==		==About this Structure==
-	~~2WOV~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA].	+	[[2wov]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021851087</ref><references group="xtra"/>
	[[Category: Trypanosoma brucei]]		[[Category: Trypanosoma brucei]]
	[[Category: Trypanothione-disulfide reductase]]		[[Category: Trypanothione-disulfide reductase]]
Line 26:		Line 34:
	[[Category: Trypanosomiasis]]		[[Category: Trypanosomiasis]]
	[[Category: Trypanothione]]		[[Category: Trypanothione]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:01:42 2010''

OCA at 04:54, 4 August 2010

2010-08-04T04:54:43Z

←Older revision		Revision as of 04:54, 4 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2wov.jpg\|left\|200px]]

-	The ~~entry 2wov~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2wov", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2wov\| PDB=2wov \| SCENE= }}

-	~~Authors: Alphey, M.S., Fairlamb, A.H~~.	+	===TRYPANOSOMA BRUCEI TRYPANOTHIONE REDUCTASE WITH BOUND NADP.===

-	Description: Trypanosoma brucei trypanothione reductase with bound NADP.

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 09:33:~~44 2009~~''	+	==About this Structure==
		+	2WOV is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOV OCA].
		+	[[Category: Trypanosoma brucei]]
		+	[[Category: Trypanothione-disulfide reductase]]
		+	[[Category: Alphey, M S.]]
		+	[[Category: Fairlamb, A H.]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Redox-active center]]
		+	[[Category: Reductase]]
		+	[[Category: Sleeping sickness]]
		+	[[Category: Trypanosomiasis]]
		+	[[Category: Trypanothione]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 4 09:01:42 2010''