2x14 - Revision history

OCA at 10:21, 20 December 2023

2023-12-20T10:21:32Z

←Older revision		Revision as of 10:21, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2x14' size='340' side='right'caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x14' size='340' side='right'caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X14 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=3PG:3~~-~~PHOSPHOGLYCERIC+ACID'>3PG</scene>~~, ~~<scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [https://pdbe.org/2x14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [https://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [https://pdbe.org/2x14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [https://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[https://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>	+	[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[https://omim.org/entry/300653 300653]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).	+	[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).

	==See Also==		==See Also==
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoglycerate kinase]]~~	+	[[Category: Baxter NJ]]
-	[[Category: Baxter~~, N J~~]]	+	[[Category: Blackburn GM]]
-	[[Category: Blackburn~~, G M~~]]	+	[[Category: Bowler MW]]
-	[[Category: Bowler~~, M W~~]]	+	[[Category: Cliff MJ]]
-	[[Category: Cliff~~, M J~~]]	+	[[Category: Hownslow AMH]]
-	[[Category: Hownslow~~, A M.H~~]]	+	[[Category: Marston JPM]]
-	[[Category: Marston~~, J P.M~~]]	+	[[Category: Szabo J]]
-	[[Category: Szabo, J]]	+	[[Category: Varga AV]]
-	[[Category: Varga~~, A V~~]]	+	[[Category: Vas M]]
-	[[Category: Vas, M]]	+	[[Category: Waltho JP]]
-	[[Category: Waltho~~, J P]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Disease mutation]]~~	+
-	~~[[Category: Glycolysis]]~~	+
-	~~[[Category: Hereditary hemolytic anemia]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transition state analogue~~]]	+

OCA at 10:44, 13 April 2022

2022-04-13T10:44:14Z

←Older revision		Revision as of 10:44, 13 April 2022
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	<StructureSection load='2x14' size='340' side='right'caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x14' size='340' side='right'caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X14 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [~~http~~://pdbe.org/2x14 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [https://pdbe.org/2x14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [https://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[~~http~~://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>	+	[[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[https://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).	+	[[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).

	==See Also==		==See Also==

OCA at 15:02, 8 July 2020

2020-07-08T15:02:43Z

←Older revision		Revision as of 15:02, 8 July 2020
Line 1:		Line 1:

	==The catalytically active fully closed conformation of human phosphoglycerate kinase K219A mutant in complex with AMP-PCP and 3PG==		==The catalytically active fully closed conformation of human phosphoglycerate kinase K219A mutant in complex with AMP-PCP and 3PG==
-	<StructureSection load='2x14' size='340' side='right' caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2x14' size='340' side='right'caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X14 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [http://pdbe.org/2x14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [http://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [http://pdbe.org/2x14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [http://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 15:		Line 15:

	==See Also==		==See Also==
-	*[[Phosphoglycerate ~~Kinase~~\|Phosphoglycerate ~~Kinase~~]]	+	*[[Phosphoglycerate kinase 3D structures\|Phosphoglycerate kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoglycerate kinase]]		[[Category: Phosphoglycerate kinase]]
	[[Category: Baxter, N J]]		[[Category: Baxter, N J]]

OCA at 09:37, 3 October 2018

2018-10-03T09:37:50Z

←Older revision		Revision as of 09:37, 3 October 2018
Line 1:		Line 1:

-	==~~THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE~~ K219A ~~MUTANT IN COMPLEX WITH~~ AMP-PCP ~~AND~~ 3PG==	+	==The catalytically active fully closed conformation of human phosphoglycerate kinase K219A mutant in complex with AMP-PCP and 3PG==
	<StructureSection load='2x14' size='340' side='right' caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x14' size='340' side='right' caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 03:22, 5 August 2016

2016-08-05T03:22:36Z

←Older revision		Revision as of 03:22, 5 August 2016
Line 1:		Line 1:
		+
	==THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG==		==THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG==
	<StructureSection load='2x14' size='340' side='right' caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2x14' size='340' side='right' caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X14 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X14 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [http://www.ebi.ac.uk/pdbsum/2x14 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [http://pdbe.org/2x14 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [http://www.ebi.ac.uk/pdbsum/2x14 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x14 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphoglycerate kinase]]		[[Category: Phosphoglycerate kinase]]
	[[Category: Baxter, N J]]		[[Category: Baxter, N J]]

OCA at 12:30, 18 December 2014

2014-12-18T12:30:08Z

←Older revision		Revision as of 12:30, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2x14\| PDB=2x14 \| SCENE= }}~~	+	==THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG==
-	===THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG===	+	<StructureSection load='2x14' size='340' side='right' caption='[[2x14]], [[Resolution\|resolution]] 1.90Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X14 FirstGlance]. <br>
-	[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[http://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref><ref>PMID:8043870</ref><ref>PMID:8615693</ref><ref>PMID:9744480</ref><ref>PMID:2001457</ref><ref>PMID:1586722</ref><ref>PMID:1547346</ref><ref>PMID:6941312</ref><ref>PMID:6933565</ref>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PG:3-PHOSPHOGLYCERIC+ACID'>3PG</scene>, <scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2xe7\|2xe7]], [[2y3i\|2y3i]], [[2xe6\|2xe6]], [[2wzb\|2wzb]], [[2wzc\|2wzc]], [[2x15\|2x15]], [[2wzd\|2wzd]], [[2x13\|2x13]], [[2xe8\|2xe8]]</td></tr>
-	==Function==	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x14 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x14 RCSB], [http://www.ebi.ac.uk/pdbsum/2x14 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[http://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).		[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
-
-	==About this Structure==
-	[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA].

	==See Also==		==See Also==
	*[[Phosphoglycerate Kinase\|Phosphoglycerate Kinase]]		*[[Phosphoglycerate Kinase\|Phosphoglycerate Kinase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoglycerate kinase]]		[[Category: Phosphoglycerate kinase]]
-	[[Category: Baxter, N J.]]	+	[[Category: Baxter, N J]]
-	[[Category: Blackburn, G M.]]	+	[[Category: Blackburn, G M]]
-	[[Category: Bowler, M W.]]	+	[[Category: Bowler, M W]]
-	[[Category: Cliff, M J.]]	+	[[Category: Cliff, M J]]
-	[[Category: Hownslow, A M.H.]]	+	[[Category: Hownslow, A M.H]]
-	[[Category: Marston, J P.M.]]	+	[[Category: Marston, J P.M]]
-	[[Category: Szabo, J.]]	+	[[Category: Szabo, J]]
-	[[Category: Varga, A V.]]	+	[[Category: Varga, A V]]
-	[[Category: Vas, M.]]	+	[[Category: Vas, M]]
-	[[Category: Waltho, J P.]]	+	[[Category: Waltho, J P]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Disease mutation]]		[[Category: Disease mutation]]

OCA at 10:01, 24 March 2013

2013-03-24T10:01:44Z

←Older revision		Revision as of 10:01, 24 March 2013
Line 1:		Line 1:
-	[[Image:2x14.png\|left\|200px]]
-
	{{STRUCTURE_2x14\| PDB=2x14 \| SCENE= }}		{{STRUCTURE_2x14\| PDB=2x14 \| SCENE= }}
-
	===THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG===		===THE CATALYTICALLY ACTIVE FULLY CLOSED CONFORMATION OF HUMAN PHOSPHOGLYCERATE KINASE K219A MUTANT IN COMPLEX WITH AMP-PCP AND 3PG===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[http://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref><ref>PMID:8043870</ref><ref>PMID:8615693</ref><ref>PMID:9744480</ref><ref>PMID:2001457</ref><ref>PMID:1586722</ref><ref>PMID:1547346</ref><ref>PMID:6941312</ref><ref>PMID:6933565</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).

	==About this Structure==		==About this Structure==
Line 11:		Line 13:
	==See Also==		==See Also==
	*[[Phosphoglycerate Kinase\|Phosphoglycerate Kinase]]		*[[Phosphoglycerate Kinase\|Phosphoglycerate Kinase]]
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoglycerate kinase]]		[[Category: Phosphoglycerate kinase]]

OCA at 18:19, 20 October 2012

2012-10-20T18:19:56Z

←Older revision		Revision as of 18:19, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[2x14]] is a 1 chain structure ~~of [[Phosphoglycerate Kinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA].	+	[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA].

	==See Also==		==See Also==

OCA at 03:46, 27 July 2012

2012-07-27T03:46:16Z

←Older revision		Revision as of 03:46, 27 July 2012
Line 1:		Line 1:
-	[[Image:2x14.~~jpg~~\|left\|200px]]	+	[[Image:2x14.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x14", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_2x14\| PDB=2x14 \| SCENE= }}		{{STRUCTURE_2x14\| PDB=2x14 \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	[[2x14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA].	+	[[2x14]] is a 1 chain structure of [[Phosphoglycerate Kinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X14 OCA].
		+
		+	==See Also==
		+	*[[Phosphoglycerate Kinase\|Phosphoglycerate Kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphoglycerate kinase]]		[[Category: Phosphoglycerate kinase]]

OCA: Protected "2x14" [edit=sysop:move=sysop]

2010-12-29T18:32:04Z

Protected "2x14" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:32, 29 December 2010