2x1o - Revision history

OCA at 05:14, 3 August 2022

2022-08-03T05:14:40Z

←Older revision		Revision as of 05:14, 3 August 2022
Line 3:		Line 3:
	<StructureSection load='2x1o' size='340' side='right'caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2x1o' size='340' side='right'caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X1O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X1O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x1q\|2x1q]], [[2x1p\|2x1p]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [~~http~~://pdbe.org/2x1o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x1o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [https://pdbe.org/2x1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [https://www.ebi.ac.uk/pdbsum/2x1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[3D ~~Structures of gelsolin~~\|3D ~~Structures of gelsolin~~]]	+	*[[Gelsolin 3D structures\|Gelsolin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:03, 8 July 2020

2020-07-08T15:03:16Z

←Older revision		Revision as of 15:03, 8 July 2020
Line 1:		Line 1:

	==Gelsolin Nanobody==		==Gelsolin Nanobody==
-	<StructureSection load='2x1o' size='340' side='right' caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>	+	<StructureSection load='2x1o' size='340' side='right'caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X1O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X1O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://pdbe.org/2x1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://pdbe.org/2x1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[~~Gelsolin~~\|~~Gelsolin~~]]	+	*[[3D Structures of gelsolin\|3D Structures of gelsolin]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Camelus glama]]		[[Category: Camelus glama]]
		+	[[Category: Large Structures]]
	[[Category: Abbeele, A Van Den]]		[[Category: Abbeele, A Van Den]]
	[[Category: Corte, V De]]		[[Category: Corte, V De]]

OCA at 09:34, 3 October 2018

2018-10-03T09:34:59Z

←Older revision		Revision as of 09:34, 3 October 2018
Line 1:		Line 1:

-	==~~GELSOLIN NANOBODY~~==	+	==Gelsolin Nanobody==
	<StructureSection load='2x1o' size='340' side='right' caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2x1o' size='340' side='right' caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 09:30, 11 August 2016

2016-08-11T09:30:16Z

←Older revision		Revision as of 09:30, 11 August 2016
Line 1:		Line 1:
		+
	==GELSOLIN NANOBODY==		==GELSOLIN NANOBODY==
	<StructureSection load='2x1o' size='340' side='right' caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>		<StructureSection load='2x1o' size='340' side='right' caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lama_glama Lama~~ glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://pdbe.org/2x1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x1o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x1o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lama~~ glama]]	+	[[Category: Camelus glama]]
	[[Category: Abbeele, A Van Den]]		[[Category: Abbeele, A Van Den]]
	[[Category: Corte, V De]]		[[Category: Corte, V De]]

OCA at 10:34, 20 January 2015

2015-01-20T10:34:48Z

←Older revision		Revision as of 10:34, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1O FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Lama glama]]		[[Category: Lama glama]]
-	[[Category: Abbeele, A Van Den.]]	+	[[Category: Abbeele, A Van Den]]
-	[[Category: Corte, V De.]]	+	[[Category: Corte, V De]]
-	[[Category: Declercq, S.]]	+	[[Category: Declercq, S]]
-	[[Category: Ganck, A De.]]	+	[[Category: Ganck, A De]]
-	[[Category: Gettemans, J.]]	+	[[Category: Gettemans, J]]
-	[[Category: Kerckhove, J Van De.]]	+	[[Category: Kerckhove, J Van De]]
-	[[Category: Loo, B Van.]]	+	[[Category: Loo, B Van]]
-	[[Category: Srinivasan, V.]]	+	[[Category: Srinivasan, V]]
-	[[Category: Steyaert, J.]]	+	[[Category: Steyaert, J]]
	[[Category: Contractile protein]]		[[Category: Contractile protein]]

OCA at 00:55, 2 October 2014

2014-10-02T00:55:36Z

←Older revision		Revision as of 00:55, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2x1o.~~png~~\|~~left~~\|~~200px~~]]	+	==GELSOLIN NANOBODY==
		+	<StructureSection load='2x1o' size='340' side='right' caption='[[2x1o]], [[Resolution\|resolution]] 1.34Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X1O FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x1q\|2x1q]], [[2x1p\|2x1p]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x1o RCSB], [http://www.ebi.ac.uk/pdbsum/2x1o PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RNA interference has tremendously advanced our understanding of gene function but recent reports have exposed undesirable side-effects. Recombinant Camelid single-domain antibodies (VHHs) provide an attractive means for studying protein function without affecting gene expression. We raised VHHs against gelsolin (GsnVHHs), a multifunctional actin-binding protein that controls cellular actin organization and migration. GsnVHH-induced delocalization of gelsolin to mitochondria or the nucleus in mammalian cells reveals distinct subpopulations including free gelsolin and actin-bound gelsolin complexes. GsnVHH 13 specifically recognizes Ca(2+)-activated gelsolin (K (d) approximately 10 nM) while GsnVHH 11 binds gelsolin irrespective of Ca(2+) (K (d) approximately 5 nM) but completely blocks its interaction with G-actin. Both GsnVHHs trace gelsolin in membrane ruffles of EGF-stimulated MCF-7 cells and delay cell migration without affecting F-actin severing/capping or actin nucleation activities by gelsolin. We conclude that VHHs represent a potent way of blocking structural proteins and that actin nucleation by gelsolin is more complex than previously anticipated.

-	~~{{STRUCTURE_2x1o\| PDB=2x1o \| SCENE= }}~~	+	A llama-derived gelsolin single-domain antibody blocks gelsolin-G-actin interaction.,Van den Abbeele A, De Clercq S, De Ganck A, De Corte V, Van Loo B, Soror SH, Srinivasan V, Steyaert J, Vandekerckhove J, Gettemans J Cell Mol Life Sci. 2010 May;67(9):1519-35. Epub 2010 Feb 7. PMID:20140750<ref>PMID:20140750</ref>

-	~~===GELSOLIN NANOBODY===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20140750}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x1o]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lama_glama Lama glama]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA].~~	+

	==See Also==		==See Also==
	*[[Gelsolin\|Gelsolin]]		*[[Gelsolin\|Gelsolin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020140750<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Abbeele, A Van Den.]]		[[Category: Abbeele, A Van Den.]]

OCA at 10:17, 20 October 2012

2012-10-20T10:17:29Z

←Older revision		Revision as of 10:17, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x1o]] is a 2 chain structure ~~of [[Gelsolin]]~~ with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA].	+	[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA].

	==See Also==		==See Also==

OCA at 01:37, 26 July 2012

2012-07-26T01:37:14Z

←Older revision		Revision as of 01:37, 26 July 2012
Line 1:		Line 1:
	[[Image:2x1o.png\|left\|200px]]		[[Image:2x1o.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x1o", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x1o\| PDB=2x1o \| SCENE= }}		{{STRUCTURE_2x1o\| PDB=2x1o \| SCENE= }}

	===GELSOLIN NANOBODY===		===GELSOLIN NANOBODY===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20140750}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20140750 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20140750}}		{{ABSTRACT_PUBMED_20140750}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Gelsolin]]	+	*[[Gelsolin\|Gelsolin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20140750~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020140750</ref><references group="xtra"/>
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Abbeele, A Van Den.]]		[[Category: Abbeele, A Van Den.]]
Line 36:		Line 25:
	[[Category: Srinivasan, V.]]		[[Category: Srinivasan, V.]]
	[[Category: Steyaert, J.]]		[[Category: Steyaert, J.]]
		+	[[Category: Contractile protein]]

OCA at 08:11, 6 April 2011

2011-04-06T08:11:48Z

←Older revision		Revision as of 08:11, 6 April 2011
Line 1:		Line 1:
-	[[Image:2x1o.~~jpg~~\|left\|200px]]	+	[[Image:2x1o.png\|left\|200px]]

	<!--		<!--
Line 11:		Line 11:
	===GELSOLIN NANOBODY===		===GELSOLIN NANOBODY===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20140750}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20140750 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20140750}}

	==About this Structure==		==About this Structure==
-	[[2x1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA].	+	[[2x1o]] is a 2 chain structure of [[Gelsolin]] with sequence from [http://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X1O OCA].
		+
		+	==See Also==
		+	*[[Gelsolin]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20140750</ref><references group="xtra"/>
	[[Category: Lama glama]]		[[Category: Lama glama]]
	[[Category: Abbeele, A Van Den.]]		[[Category: Abbeele, A Van Den.]]

OCA: Protected "2x1o" [edit=sysop:move=sysop]

2011-01-12T05:08:15Z

Protected "2x1o" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:08, 12 January 2011