2x2z - Revision history

OCA at 16:48, 3 November 2021

2021-11-03T16:48:44Z

←Older revision		Revision as of 16:48, 3 November 2021
Line 3:		Line 3:
	<StructureSection load='2x2z' size='340' side='right'caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x2z' size='340' side='right'caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [~~http~~://pdbe.org/2x2z PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x2z PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2z ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [https://pdbe.org/2x2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [https://www.ebi.ac.uk/pdbsum/2x2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/AMA1_TOXGO AMA1_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>	+	[[https://www.uniprot.org/uniprot/AMA1_TOXGO AMA1_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:34, 3 April 2019

2019-04-03T07:34:55Z

←Older revision		Revision as of 07:34, 3 April 2019
Line 1:		Line 1:

	==Crystal structure AMA1 from Toxoplasma gondii==		==Crystal structure AMA1 from Toxoplasma gondii==
-	<StructureSection load='2x2z' size='340' side='right' caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2x2z' size='340' side='right'caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Toxgo]]		[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]

OCA at 09:44, 3 October 2018

2018-10-03T09:44:28Z

←Older revision		Revision as of 09:44, 3 October 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2z_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2z_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:34, 4 August 2016

2016-08-04T16:34:45Z

←Older revision		Revision as of 16:34, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure AMA1 from Toxoplasma gondii==		==Crystal structure AMA1 from Toxoplasma gondii==
	<StructureSection load='2x2z' size='340' side='right' caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x2z' size='340' side='right' caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii Toxoplasma gondii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [http://www.ebi.ac.uk/pdbsum/2x2z PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [http://pdbe.org/2x2z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [http://www.ebi.ac.uk/pdbsum/2x2z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x2z ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~B6KAM0_TOXGO B6KAM0_TOXGO~~]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:~~16102004~~</ref> <ref>PMID:~~11087913~~</ref> <ref>PMID:~~16000372~~</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>	+	[[http://www.uniprot.org/uniprot/AMA1_TOXGO AMA1_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16102004</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x2z ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x2z" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Toxoplasma gondii~~]]	+	[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Crawford, J]]		[[Category: Crawford, J]]

OCA at 17:04, 24 December 2014

2014-12-24T17:04:42Z

←Older revision		Revision as of 17:04, 24 December 2014
Line 2:		Line 2:
	<StructureSection load='2x2z' size='340' side='right' caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x2z' size='340' side='right' caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. <br>	+	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X2Z FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~><br>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [http://www.ebi.ac.uk/pdbsum/2x2z PDBsum]</span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [http://www.ebi.ac.uk/pdbsum/2x2z PDBsum]</span></td></tr>	+	</table>
-	<table>	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B6KAM0_TOXGO B6KAM0_TOXGO]] Essential microneme protein that plays an important role in host cell invasion. Part of the moving junction (MJ) complex, a ringlike structure formed between the plasma membranes of the apical tip of the parasite and the target host cell. During invasion, the MJ migrates from the anterior to the posterior of the parasite, leading to internalization of the parasite into a parasitophorous vacuole (PV).<ref>PMID:11083833</ref> <ref>PMID:16102004</ref> <ref>PMID:11087913</ref> <ref>PMID:16000372</ref> <ref>PMID:16244709</ref> <ref>PMID:19247437</ref> <ref>PMID:20421941</ref> <ref>PMID:21205639</ref> <ref>PMID:22523242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 24:
	Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii.,Crawford J, Tonkin ML, Grujic O, Boulanger MJ J Biol Chem. 2010 May 14;285(20):15644-52. Epub 2010 Mar 19. PMID:20304917<ref>PMID:20304917</ref>		Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii.,Crawford J, Tonkin ML, Grujic O, Boulanger MJ J Biol Chem. 2010 May 14;285(20):15644-52. Epub 2010 Mar 19. PMID:20304917<ref>PMID:20304917</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 30:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
-	[[Category: Boulanger, M J.]]	+	[[Category: Boulanger, M J]]
-	[[Category: Crawford, J.]]	+	[[Category: Crawford, J]]
-	[[Category: Grujic, O.]]	+	[[Category: Grujic, O]]
-	[[Category: Tonkin, M L.]]	+	[[Category: Tonkin, M L]]
	[[Category: Invasion]]		[[Category: Invasion]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Moving junction]]		[[Category: Moving junction]]

OCA at 07:48, 14 May 2014

2014-05-14T07:48:03Z

←Older revision		Revision as of 07:48, 14 May 2014
Line 1:		Line 1:
-	[[~~Image~~:2x2z.~~png\|left~~\|200px]]	+	==Crystal structure AMA1 from Toxoplasma gondii==
		+	<StructureSection load='2x2z' size='340' side='right' caption='[[2x2z]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x2z RCSB], [http://www.ebi.ac.uk/pdbsum/2x2z PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x2/2x2z_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apical membrane antigen 1 (AMA1) is an essential component of the moving junction complex used by Apicomplexan parasites to invade host cells. We report the 2.0 A resolution x-ray crystal structure of the full ectodomain (domains I, II, and III) of AMA1 from the pervasive protozoan parasite Toxoplasma gondii. The structure of T. gondii AMA1 (TgAMA1) is the most complete of any AMA1 structure to date, with more than 97.5% of the ectodomain unambiguously modeled. Comparative sequence analysis reveals discrete segments of divergence in TgAMA1 that map to areas of established functional importance in AMA1 from Plasmodium vivax (PvAMA1) and Plasmodium falciparum (PfAMA1). Inspection of the TgAMA1 structure reveals a network of apical surface loops, reorganized in both size and chemistry relative to PvAMA1/PfAMA1, that appear to serve as structural filters restricting access to a central hydrophobic groove. The terminal portion of this groove is formed by an extended loop from DII that is 14 residues shorter in TgAMA1. A pair of tryptophan residues (Trp(353) and Trp(354)) anchor the DII loop in the hydrophobic groove and frame a conserved tyrosine (Tyr(230)), forming a contiguous surface that may be critical for moving junction assembly. The minimalist DIII structure folds into a cystine knot that probably stabilizes and orients the bulk of the ectodmain without providing excess surface area to which invasion-inhibitory antibodies can be generated. The detailed structural characterization of TgAMA1 provides valuable insight into the mechanism of host cell invasion by T. gondii.

-	~~<!--~~	+	Structural characterization of apical membrane antigen 1 (AMA1) from Toxoplasma gondii.,Crawford J, Tonkin ML, Grujic O, Boulanger MJ J Biol Chem. 2010 May 14;285(20):15644-52. Epub 2010 Mar 19. PMID:20304917<ref>PMID:20304917</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2x2z"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_2x2z\| PDB=2x2z \| SCENE= }}~~	+

-	~~===Crystal structure AMA1 from Toxoplasma gondii===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_20304917}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 20304917 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_20304917}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x2z]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020304917<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
	[[Category: Boulanger, M J.]]		[[Category: Boulanger, M J.]]

OCA: Protected "2x2z" [edit=sysop:move=sysop]

2012-01-11T05:33:29Z

Protected "2x2z" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:33, 11 January 2012

OCA at 05:33, 11 January 2012

2012-01-11T05:33:28Z

←Older revision		Revision as of 05:33, 11 January 2012
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-	{{Seed}}
	[[Image:2x2z.png\|left\|200px]]		[[Image:2x2z.png\|left\|200px]]

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	{{STRUCTURE_2x2z\| PDB=2x2z \| SCENE= }}		{{STRUCTURE_2x2z\| PDB=2x2z \| SCENE= }}

-	===~~CRYSTAL STRUCTURE~~ AMA1 ~~FROM TOXOPLASMA GONDII~~===	+	===Crystal structure AMA1 from Toxoplasma gondii===


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	==About this Structure==		==About this Structure==
-	~~2X2Z~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA].	+	[[2x2z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20304917~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020304917</ref><references group="xtra"/>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
	[[Category: Boulanger, M J.]]		[[Category: Boulanger, M J.]]
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	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Moving junction]]		[[Category: Moving junction]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 12:32:16 2010''

OCA at 09:32, 31 March 2010

2010-03-31T09:32:17Z

←Older revision		Revision as of 09:32, 31 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:2x2z.~~jpg~~\|left\|200px]]	+	[[Image:2x2z.png\|left\|200px]]

	<!--		<!--
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	===CRYSTAL STRUCTURE AMA1 FROM TOXOPLASMA GONDII===		===CRYSTAL STRUCTURE AMA1 FROM TOXOPLASMA GONDII===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20304917}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20304917 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20304917}}

	==About this Structure==		==About this Structure==
	2X2Z is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA].		2X2Z is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20304917</ref><references group="xtra"/>
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
	[[Category: Boulanger, M J.]]		[[Category: Boulanger, M J.]]
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	[[Category: Moving junction]]		[[Category: Moving junction]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar ~~17 09~~:37:37 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 12:32:16 2010''

OCA at 07:37, 17 March 2010

2010-03-17T07:37:38Z

←Older revision		Revision as of 07:37, 17 March 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:2x2z.jpg\|left\|200px]]

-	The ~~entry 2x2z~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2x2z", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2x2z\| PDB=2x2z \| SCENE= }}

-	~~Authors: Crawford, J., Tonkin, M.L., Grujic, O., Boulanger, M.J.~~	+	===CRYSTAL STRUCTURE AMA1 FROM TOXOPLASMA GONDII===

-	Description: Crystal structure AMA1 from Toxoplasma gondii

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 3~~ 09:12:58 2010''	+	==About this Structure==
		+	2X2Z is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X2Z OCA].
		+	[[Category: Toxoplasma gondii]]
		+	[[Category: Boulanger, M J.]]
		+	[[Category: Crawford, J.]]
		+	[[Category: Grujic, O.]]
		+	[[Category: Tonkin, M L.]]
		+	[[Category: Invasion]]
		+	[[Category: Membrane protein]]
		+	[[Category: Moving junction]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:37:37 2010''