2x36 - Revision history

OCA at 10:23, 20 December 2023

2023-12-20T10:23:06Z

←Older revision		Revision as of 10:23, 20 December 2023
Line 3:		Line 3:
	<StructureSection load='2x36' size='340' side='right'caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x36' size='340' side='right'caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X36 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [https://pdbe.org/2x36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [https://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [https://pdbe.org/2x36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [https://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN]] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref>	+	[https://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bauer~~, J A~~]]	+	[[Category: Bauer JA]]
-	[[Category: Blagova, E]]	+	[[Category: Blagova E]]
-	[[Category: Garcia, J]]	+	[[Category: Garcia J]]
-	[[Category: Kutejova, E]]	+	[[Category: Kutejova E]]
-	[[Category: Levdikov~~, V M~~]]	+	[[Category: Levdikov VM]]
-	[[Category: Ondrovicova, G]]	+	[[Category: Ondrovicova G]]
-	[[Category: Wilkinson~~, A J~~]]	+	[[Category: Wilkinson AJ]]
-	[[Category: Wilson~~, K S]]~~	+	[[Category: Wilson KS]]
-	~~[[Category: Catalytic dyad]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mitochondria]]~~	+
-	~~[[Category: Transit peptide~~]]	+

OCA at 10:45, 13 April 2022

2022-04-13T10:45:12Z

←Older revision		Revision as of 10:45, 13 April 2022
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	<StructureSection load='2x36' size='340' side='right'caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x36' size='340' side='right'caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X36 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [~~http~~://pdbe.org/2x36 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [https://pdbe.org/2x36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [https://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN]] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref>	+	[[https://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN]] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:04, 8 July 2020

2020-07-08T15:04:05Z

←Older revision		Revision as of 15:04, 8 July 2020
Line 1:		Line 1:

	==Structure of the proteolytic domain of the Human Mitochondrial Lon protease==		==Structure of the proteolytic domain of the Human Mitochondrial Lon protease==
-	<StructureSection load='2x36' size='340' side='right' caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='2x36' size='340' side='right'caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X36 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://pdbe.org/2x36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://pdbe.org/2x36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bauer, J A]]		[[Category: Bauer, J A]]
	[[Category: Blagova, E]]		[[Category: Blagova, E]]

OCA at 09:40, 3 October 2018

2018-10-03T09:40:51Z

←Older revision		Revision as of 09:40, 3 October 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE~~==	+	==Structure of the proteolytic domain of the Human Mitochondrial Lon protease==
	<StructureSection load='2x36' size='340' side='right' caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x36' size='340' side='right' caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x36_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x36_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:06, 4 August 2016

2016-08-04T08:06:01Z

←Older revision		Revision as of 08:06, 4 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE==		==STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE==
	<StructureSection load='2x36' size='340' side='right' caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2x36' size='340' side='right' caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X36 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://pdbe.org/2x36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x36 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x36 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x36" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bauer, J A]]		[[Category: Bauer, J A]]
	[[Category: Blagova, E]]		[[Category: Blagova, E]]

OCA at 07:23, 24 December 2014

2014-12-24T07:23:52Z

←Older revision		Revision as of 07:23, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LONM_HUMAN LONM_HUMAN]] ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.[HAMAP-Rule:MF_03120]<ref>PMID:12198491</ref> <ref>PMID:15870080</ref> <ref>PMID:17420247</ref> <ref>PMID:8248235</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bauer, J A.]]	+	[[Category: Bauer, J A]]
-	[[Category: Blagova, E.]]	+	[[Category: Blagova, E]]
-	[[Category: Garcia, J.]]	+	[[Category: Garcia, J]]
-	[[Category: Kutejova, E.]]	+	[[Category: Kutejova, E]]
-	[[Category: Levdikov, V M.]]	+	[[Category: Levdikov, V M]]
-	[[Category: Ondrovicova, G.]]	+	[[Category: Ondrovicova, G]]
-	[[Category: Wilkinson, A J.]]	+	[[Category: Wilkinson, A J]]
-	[[Category: Wilson, K S.]]	+	[[Category: Wilson, K S]]
	[[Category: Catalytic dyad]]		[[Category: Catalytic dyad]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Mitochondria]]		[[Category: Mitochondria]]
	[[Category: Transit peptide]]		[[Category: Transit peptide]]

OCA at 09:25, 5 November 2014

2014-11-05T09:25:30Z

←Older revision		Revision as of 09:25, 5 November 2014
Line 1:		Line 1:
-	[[~~Image~~:2x36.~~png\|left~~\|200px]]	+	==STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE==
		+	<StructureSection load='2x36' size='340' side='right' caption='[[2x36]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x36]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X36 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x36 RCSB], [http://www.ebi.ac.uk/pdbsum/2x36 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x3/2x36_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	ATP-dependent proteases are crucial for cellular homeostasis. By degrading short-lived regulatory proteins, they play an important role in the control of many cellular pathways and, through the degradation of abnormally misfolded proteins, protect the cell from a buildup of aggregates. Disruption or disregulation of mammalian mitochondrial Lon protease leads to severe changes in the cell, linked with carcinogenesis, apoptosis, and necrosis. Here we present the structure of the proteolytic domain of human mitochondrial Lon at 2 A resolution. The fold resembles those of the three previously determined Lon proteolytic domains from Escherichia coli, Methanococcus jannaschii, and Archaeoglobus fulgidus. There are six protomers in the asymmetric unit, four arranged as two dimers. The intersubunit interactions within the two dimers are similar to those between adjacent subunits of the hexameric ring of E. coli Lon, suggesting that the human Lon proteolytic domain also forms hexamers. The active site contains a 3(10) helix attached to the N-terminal end of alpha-helix 2, which leads to the insertion of Asp852 into the active site, as seen in M. jannaschii. Structural considerations make it likely that this conformation is proteolytically inactive. When comparing the intersubunit interactions of human with those of E. coli Lon taken with biochemical data leads us to propose a mechanism relating the formation of Lon oligomers with a conformational shift in the active site region coupled to a movement of a loop in the oligomer interface, converting the proteolytically inactive form seen here to the active one in the E. coli hexamer.

-	~~{{STRUCTURE_2x36\| PDB=2x36 \| SCENE= }}~~	+	Structure of the catalytic domain of the human mitochondrial Lon protease: proposed relation of oligomer formation and activity.,Garcia-Nafria J, Ondrovicova G, Blagova E, Levdikov VM, Bauer JA, Suzuki CK, Kutejova E, Wilkinson AJ, Wilson KS Protein Sci. 2010 May;19(5):987-99. PMID:20222013<ref>PMID:20222013</ref>

-	~~===STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20222013}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2x36]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020222013<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bauer, J A.]]		[[Category: Bauer, J A.]]

OCA at 13:07, 30 January 2013

2013-01-30T13:07:01Z

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	{{STRUCTURE_2x36\| PDB=2x36 \| SCENE= }}		{{STRUCTURE_2x36\| PDB=2x36 \| SCENE= }}

	===STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE===		===STRUCTURE OF THE PROTEOLYTIC DOMAIN OF THE HUMAN MITOCHONDRIAL LON PROTEASE===

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20222013~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020222013</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bauer, J A.]]		[[Category: Bauer, J A.]]
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	[[Category: Wilkinson, A J.]]		[[Category: Wilkinson, A J.]]
	[[Category: Wilson, K S.]]		[[Category: Wilson, K S.]]
		+	[[Category: Catalytic dyad]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mitochondria]]
		+	[[Category: Transit peptide]]

OCA: Protected "2x36" [edit=sysop:move=sysop]

2011-03-09T05:50:30Z

Protected "2x36" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 9 March 2011

OCA at 05:50, 9 March 2011

2011-03-09T05:50:28Z

←Older revision		Revision as of 05:50, 9 March 2011
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-	{{Seed}}
	[[Image:2x36.png\|left\|200px]]		[[Image:2x36.png\|left\|200px]]

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	==About this Structure==		==About this Structure==
-	~~2X36~~ is a 6 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA].	+	[[2x36]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X36 OCA].

	==Reference==		==Reference==
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	[[Category: Wilkinson, A J.]]		[[Category: Wilkinson, A J.]]
	[[Category: Wilson, K S.]]		[[Category: Wilson, K S.]]
-	[[Category: Catalytic dyad]]
-	[[Category: Hydrolase]]
-	[[Category: Mitochondria]]
-	[[Category: Transit peptide]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:18:44 2010''