2x4r - Revision history

OCA at 10:23, 20 December 2023

2023-12-20T10:23:50Z

←Older revision		Revision as of 10:23, 20 December 2023
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	<StructureSection load='2x4r' size='340' side='right'caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x4r' size='340' side='right'caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human ~~Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [~~http~~://pdbe.org/2x4r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [https://pdbe.org/2x4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [https://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~1A02_HUMAN 1A02_HUMAN]~~] Involved in the presentation of ~~foreign~~ antigens to the immune system. [[http://www.uniprot.org/uniprot/PP65_HCMVA PP65_HCMVA]] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.<ref>PMID:15452220</ref> <ref>PMID:20504932</ref>	+	[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	*[[MHC 3D structures\|MHC 3D structures]]		*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]	+	[[Category: Homo sapiens]]
		+	[[Category: Human betaherpesvirus 5]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Celie~~, P H.N~~]]	+	[[Category: Celie PHN]]
-	[[Category: Ovaa, H]]	+	[[Category: Ovaa H]]
-	[[Category: Perrakis, A]]	+	[[Category: Perrakis A]]
-	[[Category: Rodenko, B]]	+	[[Category: Rodenko B]]
-	[[Category: Schumacher~~, T N.M~~]]	+	[[Category: Schumacher TNM]]
-	[[Category: Toebes, M]]	+	[[Category: Toebes M]]
-	~~[[Category: Amyloid]]~~	+
-	~~[[Category: Amyloidosis]]~~	+
-	~~[[Category: Glycation]]~~	+
-	~~[[Category: Host-virus interaction]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Photocleavable peptide~~]]	+

OCA at 05:04, 19 November 2020

2020-11-19T05:04:26Z

←Older revision		Revision as of 05:04, 19 November 2020
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	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4R FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>
	</table>		</table>
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	==See Also==		==See Also==
	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]		*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[MHC 3D structures ~~of MHC~~\|MHC 3D structures ~~of MHC~~]]	+	*[[MHC 3D structures\|MHC 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:04, 8 July 2020

2020-07-08T15:04:49Z

←Older revision		Revision as of 15:04, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of MHC CLass I HLA-A2.1 bound to Cytomegalovirus (CMV) pp65 epitope==		==Crystal structure of MHC CLass I HLA-A2.1 bound to Cytomegalovirus (CMV) pp65 epitope==
-	<StructureSection load='2x4r' size='340' side='right' caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='2x4r' size='340' side='right'caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X4R FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]	+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
-	*[[~~Major histocompatibility complex~~\|~~Major histocompatibility complex~~]]	+	*[[MHC 3D structures of MHC\|MHC 3D structures of MHC]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Ovaa, H]]		[[Category: Ovaa, H]]

OCA at 09:30, 3 October 2018

2018-10-03T09:30:36Z

←Older revision		Revision as of 09:30, 3 October 2018
Line 1:		Line 1:
-	==~~CRYSTAL STRUCTURE OF~~ MHC ~~CLASS~~ I HLA-A2.1 ~~BOUND TO CYTOMEGALOVIRUS~~ (CMV) ~~PP65 EPITOPE~~==	+
		+	==Crystal structure of MHC CLass I HLA-A2.1 bound to Cytomegalovirus (CMV) pp65 epitope==
	<StructureSection load='2x4r' size='340' side='right' caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x4r' size='340' side='right' caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4r_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4r_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:39, 8 February 2016

2016-02-08T09:39:10Z

←Older revision		Revision as of 09:39, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='2x4r' size='340' side='right' caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2x4r' size='340' side='right' caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://pdbe.org/2x4r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4r ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x4r" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Celie, P H.N]]		[[Category: Celie, P H.N]]
	[[Category: Ovaa, H]]		[[Category: Ovaa, H]]

OCA at 22:22, 24 December 2014

2014-12-24T22:22:53Z

←Older revision		Revision as of 22:22, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4R FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4R FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/PP65_HCMVA PP65_HCMVA]] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.<ref>PMID:15452220</ref> <ref>PMID:20504932</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Celie, P H.N.]]	+	[[Category: Celie, P H.N]]
-	[[Category: Ovaa, H.]]	+	[[Category: Ovaa, H]]
-	[[Category: Perrakis, A.]]	+	[[Category: Perrakis, A]]
-	[[Category: Rodenko, B.]]	+	[[Category: Rodenko, B]]
-	[[Category: Schumacher, T N.M.]]	+	[[Category: Schumacher, T N.M]]
-	[[Category: Toebes, M.]]	+	[[Category: Toebes, M]]
	[[Category: Amyloid]]		[[Category: Amyloid]]
	[[Category: Amyloidosis]]		[[Category: Amyloidosis]]

OCA at 01:31, 1 October 2014

2014-10-01T01:31:50Z

←Older revision		Revision as of 01:31, 1 October 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2x4r\| PDB=2x4r \| SCENE= }}~~	+	==CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE==
-	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE===	+	<StructureSection load='2x4r' size='340' side='right' caption='[[2x4r]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19655750}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X4R FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uqs\|1uqs]], [[1bd2\|1bd2]], [[2esv\|2esv]], [[2ak4\|2ak4]], [[1ypz\|1ypz]], [[1im3\|1im3]], [[1uxw\|1uxw]], [[1i7u\|1i7u]], [[1c16\|1c16]], [[1hsa\|1hsa]], [[2axf\|2axf]], [[1gzp\|1gzp]], [[2bnq\|2bnq]], [[1w72\|1w72]], [[2jcc\|2jcc]], [[2bck\|2bck]], [[1de4\|1de4]], [[2vlk\|2vlk]], [[1exu\|1exu]], [[1qrn\|1qrn]], [[2hla\|2hla]], [[1mhe\|1mhe]], [[1im9\|1im9]], [[1eez\|1eez]], [[1jht\|1jht]], [[1qqd\|1qqd]], [[1qr1\|1qr1]], [[1zs8\|1zs8]], [[1hla\|1hla]], [[1jgd\|1jgd]], [[1i1y\|1i1y]], [[1vgk\|1vgk]], [[1age\|1age]], [[1ur7\|1ur7]], [[1hhg\|1hhg]], [[1s9x\|1s9x]], [[1a9e\|1a9e]], [[1duz\|1duz]], [[2clr\|2clr]], [[3hla\|3hla]], [[1m05\|1m05]], [[1tvb\|1tvb]], [[2v2w\|2v2w]], [[1onq\|1onq]], [[2vlr\|2vlr]], [[2bvo\|2bvo]], [[1a1n\|1a1n]], [[1lp9\|1lp9]], [[1zsd\|1zsd]], [[1m6o\|1m6o]], [[1hhk\|1hhk]], [[1hsb\|1hsb]], [[1zt4\|1zt4]], [[1x7q\|1x7q]], [[1ce6\|1ce6]], [[1py4\|1py4]], [[1syv\|1syv]], [[2j8u\|2j8u]], [[1sys\|1sys]], [[1ogt\|1ogt]], [[1cg9\|1cg9]], [[1p7q\|1p7q]], [[1q94\|1q94]], [[1jnj\|1jnj]], [[1agb\|1agb]], [[2d31\|2d31]], [[1aqd\|1aqd]], [[1xz0\|1xz0]], [[1lds\|1lds]], [[1hhh\|1hhh]], [[1tvh\|1tvh]], [[1xr8\|1xr8]], [[2bss\|2bss]], [[1e28\|1e28]], [[1a1m\|1a1m]], [[2bvp\|2bvp]], [[2v2x\|2v2x]], [[1xr9\|1xr9]], [[2gj6\|2gj6]], [[1qlf\|1qlf]], [[1efx\|1efx]], [[2av1\|2av1]], [[1tmc\|1tmc]], [[1qsf\|1qsf]], [[1duy\|1duy]], [[1kpr\|1kpr]], [[1jge\|1jge]], [[2hjl\|2hjl]], [[1qew\|1qew]], [[1w0v\|1w0v]], [[1k5n\|1k5n]], [[1ao7\|1ao7]], [[2bnr\|2bnr]], [[1xh3\|1xh3]], [[2bst\|2bst]], [[1mi5\|1mi5]], [[2h26\|2h26]], [[1s9y\|1s9y]], [[1a1o\|1a1o]], [[2a83\|2a83]], [[1agf\|1agf]], [[1oga\|1oga]], [[2f8o\|2f8o]], [[2cii\|2cii]], [[1i7r\|1i7r]], [[1jf1\|1jf1]], [[2c7u\|2c7u]], [[2f74\|2f74]], [[1e27\|1e27]], [[1w0w\|1w0w]], [[1gzq\|1gzq]], [[1uxs\|1uxs]], [[1akj\|1akj]], [[2hjk\|2hjk]], [[2vb5\|2vb5]], [[1agd\|1agd]], [[1r3h\|1r3h]], [[1eey\|1eey]], [[1i7t\|1i7t]], [[1ydp\|1ydp]], [[1i4f\|1i4f]], [[2vll\|2vll]], [[2bsr\|2bsr]], [[1of2\|1of2]], [[1b0g\|1b0g]], [[2vlj\|2vlj]], [[1b0r\|1b0r]], [[1hhi\|1hhi]], [[1qse\|1qse]], [[2axg\|2axg]], [[1a9b\|1a9b]], [[2bvq\|2bvq]], [[1agc\|1agc]], [[1hhj\|1hhj]], [[1qvo\|1qvo]], [[1s9w\|1s9w]], [[1ktl\|1ktl]], [[1a6z\|1a6z]], [[2cik\|2cik]], [[1i1f\|1i1f]], [[2uwe\|2uwe]], [[2av7\|2av7]], [[2x4p\|2x4p]], [[2x4u\|2x4u]], [[2x4s\|2x4s]], [[2x4t\|2x4t]], [[2x4n\|2x4n]], [[2x4o\|2x4o]], [[2x4q\|2x4q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x4r RCSB], [http://www.ebi.ac.uk/pdbsum/2x4r PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4r_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	High-throughput structure determination of protein-ligand complexes is central in drug development and structural proteomics. To facilitate such high-throughput structure determination we designed an induced replacement strategy. Crystals of a protein complex bound to a photosensitive ligand are exposed to UV light, inducing the departure of the bound ligand, allowing a new ligand to soak in. We exemplify the approach for a class of protein complexes that is especially recalcitrant to high-throughput strategies: the MHC class I proteins. We developed a UV-sensitive, "conditional", peptide ligand whose UV-induced cleavage in the crystals leads to the exchange of the low-affinity lytic fragments for full-length peptides introduced in the crystallant solution. This "in crystallo" exchange is monitored by the loss of seleno-methionine anomalous diffraction signal of the conditional peptide compared to the signal of labeled MHC beta2m subunit. This method has the potential to facilitate high-throughput crystallography in various protein families.

-	~~==Function==~~	+	UV-induced ligand exchange in MHC class I protein crystals.,Celie PH, Toebes M, Rodenko B, Ovaa H, Perrakis A, Schumacher TN J Am Chem Soc. 2009 Sep 2;131(34):12298-304. PMID:19655750<ref>PMID:19655750</ref>
-	~~[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved~~ in ~~the presentation of foreign antigens to the immune system~~. ~~[[http://www.uniprot.org/uniprot/PP65_HCMVA PP65_HCMVA]] Counteracts the host antiviral immune response when activated and phosphorylated~~, ~~by preventing IRF3 from entering the nucleus~~. ~~Also participates in the transactivation of viral major immediate~~-~~early genes by the recruitment of host IFI16 to the promoters pf these genes~~.~~<ref>~~PMID:~~15452220</ref>~~<ref>PMID:~~20504932~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[2x4r]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Beta-2 microglobulin\|Beta-2 microglobulin]]		*[[Beta-2 microglobulin\|Beta-2 microglobulin]]
	*[[Major histocompatibility complex\|Major histocompatibility complex]]		*[[Major histocompatibility complex\|Major histocompatibility complex]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019655750</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]

OCA at 09:47, 24 March 2013

2013-03-24T09:47:09Z

←Older revision		Revision as of 09:47, 24 March 2013
Line 1:		Line 1:
-	[[Image:2x4r.png\|left\|200px]]
-
	{{STRUCTURE_2x4r\| PDB=2x4r \| SCENE= }}		{{STRUCTURE_2x4r\| PDB=2x4r \| SCENE= }}
-
	===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE===		===CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2.1 BOUND TO CYTOMEGALOVIRUS (CMV) PP65 EPITOPE===
		+	{{ABSTRACT_PUBMED_19655750}}

-	~~{{ABSTRACT_PUBMED_19655750}}~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/PP65_HCMVA PP65_HCMVA]] Counteracts the host antiviral immune response when activated and phosphorylated, by preventing IRF3 from entering the nucleus. Also participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.<ref>PMID:15452220</ref><ref>PMID:20504932</ref>

	==About this Structure==		==About this Structure==
Line 15:		Line 14:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019655750</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019655750</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Celie, P H.N.]]		[[Category: Celie, P H.N.]]

OCA at 09:44, 20 October 2012

2012-10-20T09:44:02Z

←Older revision		Revision as of 09:44, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x4r]] is a 6 chain structure ~~of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA].	+	[[2x4r]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4R OCA].

	==See Also==		==See Also==

OCA: Protected "2x4r" [edit=sysop:move=sysop]

2012-07-25T23:47:48Z

Protected "2x4r" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:47, 25 July 2012