2x7t - Revision history

OCA at 10:25, 20 December 2023

2023-12-20T10:25:53Z

←Older revision		Revision as of 10:25, 20 December 2023
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	<StructureSection load='2x7t' size='340' side='right'caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2x7t' size='340' side='right'caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [https://pdbe.org/2x7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [https://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [~~http~~://pdbe.org/2x7t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[~~http~~://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>	+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Carbonate dehydratase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Baker~~, M D~~]]	+	[[Category: Baker MD]]
-	[[Category: Cozier~~, G E~~]]	+	[[Category: Cozier GE]]
-	[[Category: Leese~~, M P~~]]	+	[[Category: Leese MP]]
-	[[Category: Lloyd~~, M D~~]]	+	[[Category: Lloyd MD]]
-	[[Category: Potter~~, B V.L~~]]	+	[[Category: Potter BVL]]
-	[[Category: Thiyagarajan, N]]	+	[[Category: Thiyagarajan N]]
-	~~[[Category: Cancer]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Sulfamate~~]]	+

OCA at 05:04, 19 November 2020

2020-11-19T05:04:49Z

←Older revision		Revision as of 05:04, 19 November 2020
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X7T FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X7T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://pdbe.org/2x7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://pdbe.org/2x7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>

OCA at 08:01, 4 November 2020

2020-11-04T08:01:08Z

←Older revision		Revision as of 08:01, 4 November 2020
Line 1:		Line 1:

	==Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.==		==Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.==
-	<StructureSection load='2x7t' size='340' side='right' caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='2x7t' size='340' side='right'caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X7T FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://pdbe.org/2x7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://pdbe.org/2x7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 34:		Line 34:

	==See Also==		==See Also==
-	*[[Carbonic anhydrase\|Carbonic anhydrase]]	+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 41:		Line 41:
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Baker, M D]]		[[Category: Baker, M D]]

OCA at 09:13, 3 October 2018

2018-10-03T09:13:24Z

←Older revision		Revision as of 09:13, 3 October 2018
Line 1:		Line 1:

-	==~~STRUCTURES OF HUMAN CARBONIC ANHYDRASE~~ II ~~INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON~~-~~STEROIDAL INHIBITORS~~.==	+	==Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.==
	<StructureSection load='2x7t' size='340' side='right' caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2x7t' size='340' side='right' caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 17:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/2x7t_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/2x7t_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:47, 5 August 2016

2016-08-05T02:47:43Z

←Older revision		Revision as of 02:47, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.==		==STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.==
	<StructureSection load='2x7t' size='340' side='right' caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='2x7t' size='340' side='right' caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X7T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X7T FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://pdbe.org/2x7t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7t ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x7t ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x7t" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 38:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Baker, M D]]		[[Category: Baker, M D]]

OCA at 11:43, 18 December 2014

2014-12-18T11:43:42Z

←Older revision		Revision as of 11:43, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2x7t\| PDB=2x7t \| SCENE= }}~~	+	==STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.==
-	===STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.===	+	<StructureSection load='2x7t' size='340' side='right' caption='[[2x7t]], [[Resolution\|resolution]] 1.89Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20297840}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X7T FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=WZB:(9BETA,13ALPHA,14BETA,17ALPHA)-2-ETHYLESTRA-1(10),2,4-TRIENE-3,17-DIYL+DISULFAMATE'>WZB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1okl\|1okl]], [[2wej\|2wej]], [[1i9q\|1i9q]], [[1zfq\|1zfq]], [[1if7\|1if7]], [[1cam\|1cam]], [[1t9n\|1t9n]], [[1cnw\|1cnw]], [[1okn\|1okn]], [[1f2w\|1f2w]], [[1g52\|1g52]], [[2h4n\|2h4n]], [[1bnm\|1bnm]], [[1cnh\|1cnh]], [[1bnq\|1bnq]], [[1xev\|1xev]], [[1ugc\|1ugc]], [[1ugg\|1ugg]], [[1if9\|1if9]], [[1g53\|1g53]], [[1fqm\|1fqm]], [[1ca2\|1ca2]], [[1cal\|1cal]], [[1fql\|1fql]], [[1i9n\|1i9n]], [[1g4o\|1g4o]], [[2cba\|2cba]], [[1ydc\|1ydc]], [[1ccs\|1ccs]], [[1lzv\|1lzv]], [[1bnv\|1bnv]], [[1fqr\|1fqr]], [[1a42\|1a42]], [[1rzb\|1rzb]], [[1th9\|1th9]], [[1zsb\|1zsb]], [[1cnb\|1cnb]], [[1i8z\|1i8z]], [[1hed\|1hed]], [[1g48\|1g48]], [[1lg5\|1lg5]], [[1bv3\|1bv3]], [[1g0f\|1g0f]], [[1tg3\|1tg3]], [[1cvc\|1cvc]], [[1ugd\|1ugd]], [[1i90\|1i90]], [[1yo0\|1yo0]], [[2wd3\|2wd3]], [[1hva\|1hva]], [[1fsn\|1fsn]], [[1ugb\|1ugb]], [[1rze\|1rze]], [[1z9y\|1z9y]], [[2fmz\|2fmz]], [[2weh\|2weh]], [[1cnk\|1cnk]], [[1bn1\|1bn1]], [[1teq\|1teq]], [[1rza\|1rza]], [[2vvb\|2vvb]], [[1ccu\|1ccu]], [[1i9l\|1i9l]], [[2cbc\|2cbc]], [[1cvb\|1cvb]], [[1g46\|1g46]], [[1cao\|1cao]], [[1fsq\|1fsq]], [[6ca2\|6ca2]], [[5ca2\|5ca2]], [[1g1d\|1g1d]], [[1caj\|1caj]], [[2fou\|2fou]], [[1cvf\|1cvf]], [[1bn4\|1bn4]], [[1lgd\|1lgd]], [[1if6\|1if6]], [[1teu\|1teu]], [[1cra\|1cra]], [[1if4\|1if4]], [[1ze8\|1ze8]], [[1hea\|1hea]], [[1cah\|1cah]], [[1hca\|1hca]], [[1g4j\|1g4j]], [[1kwq\|1kwq]], [[1raz\|1raz]], [[1cim\|1cim]], [[1cvh\|1cvh]], [[1if8\|1if8]], [[1cin\|1cin]], [[1i9m\|1i9m]], [[1zfk\|1zfk]], [[1zsa\|1zsa]], [[1fqn\|1fqn]], [[1lg6\|1lg6]], [[1cnc\|1cnc]], [[1uga\|1uga]], [[1bnn\|1bnn]], [[2foq\|2foq]], [[1tb0\|1tb0]], [[1cai\|1cai]], [[2ax2\|2ax2]], [[1dcb\|1dcb]], [[1cnx\|1cnx]], [[1ttm\|1ttm]], [[4cac\|4cac]], [[2hd6\|2hd6]], [[5cac\|5cac]], [[1cak\|1cak]], [[1i9o\|1i9o]], [[1cni\|1cni]], [[1can\|1can]], [[1yda\|1yda]], [[2eu3\|2eu3]], [[1eou\|1eou]], [[1yo2\|1yo2]], [[2wd2\|2wd2]], [[1mua\|1mua]], [[1cct\|1cct]], [[2ca2\|2ca2]], [[1oq5\|1oq5]], [[2abe\|2abe]], [[1ugf\|1ugf]], [[1rzc\|1rzc]], [[2cbe\|2cbe]], [[1thk\|1thk]], [[1kwr\|1kwr]], [[1cay\|1cay]], [[1zgf\|1zgf]], [[1moo\|1moo]], [[1cng\|1cng]], [[1hec\|1hec]], [[2ez7\|2ez7]], [[8ca2\|8ca2]], [[9ca2\|9ca2]], [[1fr7\|1fr7]], [[1ydd\|1ydd]], [[1zh9\|1zh9]], [[1bic\|1bic]], [[1lug\|1lug]], [[1caz\|1caz]], [[7ca2\|7ca2]], [[1cvd\|1cvd]], [[1fr4\|1fr4]], [[4ca2\|4ca2]], [[1cil\|1cil]], [[2geh\|2geh]], [[1g45\|1g45]], [[1ydb\|1ydb]], [[2cbb\|2cbb]], [[1dca\|1dca]], [[1fsr\|1fsr]], [[12ca\|12ca]], [[1avn\|1avn]], [[1i9p\|1i9p]], [[1bcd\|1bcd]], [[1am6\|1am6]], [[1i91\|1i91]], [[1cve\|1cve]], [[1g3z\|1g3z]], [[1heb\|1heb]], [[2cbd\|2cbd]], [[1zsc\|1zsc]], [[3ca2\|3ca2]], [[1bnu\|1bnu]], [[2weg\|2weg]], [[1zge\|1zge]], [[1bnw\|1bnw]], [[2fov\|2fov]], [[1te3\|1te3]], [[1bnt\|1bnt]], [[1if5\|1if5]], [[2weo\|2weo]], [[1yo1\|1yo1]], [[1g54\|1g54]], [[1rzd\|1rzd]], [[1uge\|1uge]], [[2fmg\|2fmg]], [[1g0e\|1g0e]], [[1ray\|1ray]], [[1cva\|1cva]], [[1ca3\|1ca3]], [[2eu2\|2eu2]], [[1tg9\|1tg9]], [[1tbt\|1tbt]], [[1xeg\|1xeg]], [[1bn3\|1bn3]], [[1cny\|1cny]], [[1okm\|1okm]], [[1cnj\|1cnj]], [[1h9n\|1h9n]], [[2vva\|2vva]], [[2aw1\|2aw1]], [[1h4n\|1h4n]], [[2fos\|2fos]], [[1h9q\|1h9q]], [[2x7s\|2x7s]], [[2x7u\|2x7u]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x7t RCSB], [http://www.ebi.ac.uk/pdbsum/2x7t PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/2x7t_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Carbonic anhydrase (CA) catalyzes the reversible hydration of carbon dioxide to hydrogen carbonate, and its role in maintaining pH balance has made it an attractive drug target. Steroidal sulfamate esters, inhibitors of the cancer drug target steroid sulfatase (STS), are sequestered in vivo by CA II in red blood cells, which may be the origin of their excellent drug properties. Understanding the structural basis of this is important for drug design. Structures of CA II complexed with 2-methoxyestradiol 3-O-sulfamate (3), 2-ethylestradiol 3,17-O,O-bis(sulfamate) (4), and 2-methoxyestradiol 17-O-sulfamate (5) are reported to 2.10, 1.85, and 1.64 A, respectively. Inhibitor 3 interacts with the active site Zn(II) ion through the 3-O-sulfamate, while inhibitors 4 and 5 bind through their 17-O-sulfamate. Comparison of the IC(50) values for CA II inhibition gave respective values of 56, 662, 2113, 169, 770, and 86 nM for estrone 3-O-sulfamate (1), 2-methoxyestradiol 3,17-O,O-bis(sulfamate) (2), 3, 4, 5, and 5'-((4H-1,2,4-triazol-4-yl)methyl)-3-chloro-2'-cyanobiphenyl-4-yl sulfamate (6), a nonsteroidal dual aromatase-sulfatase inhibitor. Inhibitors 2, 5, and 6 showed binding to a second adjacent site that is capable of binding both steroidal and nonsteroidal ligands. Examination of both IC(50) values and crystal structures suggests that 2-substituents on the steroid nucleus hinder binding via a 3-O-sulfamate, leading to coordination through a 17-O-sulfamate if present. These results underline the influence of small structural changes on affinity and mode of binding, the degree of flexibility in the design of sulfamate-based inhibitors, and suggest a strategy for inhibitors which interact with both the active site and the second adjacent binding site simultaneously that could be both potent and selective.

-	~~==Disease==~~	+	Structures of Human Carbonic Anhydrase II/Inhibitor Complexes Reveal a Second Binding Site for Steroidal and Nonsteroidal Inhibitors (,).,Cozier GE, Leese MP, Lloyd MD, Baker MD, Thiyagarajan N, Acharya KR, Potter BV Biochemistry. 2010 Mar 29. PMID:20297840<ref>PMID:20297840</ref>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3~~ (~~OPTB3~~) ~~[MIM:[http://omim~~.~~org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis~~, ~~carbonic anhydrase II deficiency syndrome~~, ~~Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone~~, ~~due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero~~, ~~infancy~~, ~~or childhood~~, ~~and a benign autosomal dominant form occurring in adolescence or adulthood~~. ~~Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts~~. ~~OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>~~PMID:~~1928091</ref><ref>PMID:1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref>~~<ref>PMID:~~15300855~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration~~ of ~~carbon dioxide~~. ~~Can hydrate cyanamide to urea~~. ~~Involved in the regulation~~ of ~~fluid secretion into the anterior chamber of the eye~~.<~~ref~~>~~PMID:10550681~~</~~ref~~>~~<ref>PMID:11831900</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA].	+

	==See Also==		==See Also==
	*[[Carbonic anhydrase\|Carbonic anhydrase]]		*[[Carbonic anhydrase\|Carbonic anhydrase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020297840</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Acharya, K R.]]	+	[[Category: Acharya, K R]]
-	[[Category: Baker, M D.]]	+	[[Category: Baker, M D]]
-	[[Category: Cozier, G E.]]	+	[[Category: Cozier, G E]]
-	[[Category: Leese, M P.]]	+	[[Category: Leese, M P]]
-	[[Category: Lloyd, M D.]]	+	[[Category: Lloyd, M D]]
-	[[Category: Potter, B V.L.]]	+	[[Category: Potter, B V.L]]
-	[[Category: Thiyagarajan, N.]]	+	[[Category: Thiyagarajan, N]]
	[[Category: Cancer]]		[[Category: Cancer]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Sulfamate]]		[[Category: Sulfamate]]

OCA at 09:08, 24 March 2013

2013-03-24T09:08:57Z

←Older revision		Revision as of 09:08, 24 March 2013
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-	[[Image:2x7t.png\|left\|200px]]
-
	{{STRUCTURE_2x7t\| PDB=2x7t \| SCENE= }}		{{STRUCTURE_2x7t\| PDB=2x7t \| SCENE= }}
-
	===STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.===		===STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.===
		+	{{ABSTRACT_PUBMED_20297840}}

-	~~{{ABSTRACT_PUBMED_20297840}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[http://omim.org/entry/259730 259730]]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref><ref>PMID:1542674</ref><ref>PMID:8834238</ref><ref>PMID:9143915</ref><ref>PMID:15300855</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN]] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref><ref>PMID:11831900</ref>

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
-	<ref group="xtra">PMID:020297840</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020297840</ref><references group="xtra"/><references/>
	[[Category: Carbonate dehydratase]]		[[Category: Carbonate dehydratase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 09:38, 20 October 2012

2012-10-20T09:38:45Z

←Older revision		Revision as of 09:38, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[2x7t]] is a 1 chain structure ~~of [[Carbonic anhydrase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA].	+	[[2x7t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7T OCA].

	==See Also==		==See Also==

OCA at 23:32, 25 July 2012

2012-07-25T23:32:35Z

←Older revision		Revision as of 23:32, 25 July 2012
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	[[Image:2x7t.png\|left\|200px]]		[[Image:2x7t.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2x7t\| PDB=2x7t \| SCENE= }}		{{STRUCTURE_2x7t\| PDB=2x7t \| SCENE= }}

	===STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.===		===STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS.===

-
-	<!--
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	{{ABSTRACT_PUBMED_20297840}}		{{ABSTRACT_PUBMED_20297840}}

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	==See Also==		==See Also==
-	*[[Carbonic anhydrase]]	+	*[[Carbonic anhydrase\|Carbonic anhydrase]]

	==Reference==		==Reference==
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	[[Category: Potter, B V.L.]]		[[Category: Potter, B V.L.]]
	[[Category: Thiyagarajan, N.]]		[[Category: Thiyagarajan, N.]]
		+	[[Category: Cancer]]
		+	[[Category: Lyase]]
		+	[[Category: Sulfamate]]

OCA: Protected "2x7t" [edit=sysop:move=sysop]

2011-06-01T04:53:01Z

Protected "2x7t" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:53, 1 June 2011