2x8j - Revision history

OCA at 10:26, 20 December 2023

2023-12-20T10:26:30Z

←Older revision		Revision as of 10:26, 20 December 2023
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	<StructureSection load='2x8j' size='340' side='right'caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2x8j' size='340' side='right'caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_700160 Atcc 700160~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Alkalihalobacillus_clausii Alkalihalobacillus clausii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8J FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.56Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CSX~~:~~S-OXY~~+~~CYSTEINE~~'>~~CSX~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>~~[[2wv7\|2wv7]], [[2wwt\|2wwt]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [https://pdbe.org/2x8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [https://www.ebi.ac.uk/pdbsum/2x8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8j ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [https://pdbe.org/2x8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [https://www.ebi.ac.uk/pdbsum/2x8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8j ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D0AB41_ALKCL D0AB41_ALKCL]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 700160~~]]	+	[[Category: Alkalihalobacillus clausii]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Subtilisin]]~~	+	[[Category: Ariza A]]
-	[[Category: Ariza, A]]	+	[[Category: Dodson E]]
-	[[Category: Dodson, E]]	+	[[Category: Gamble M]]
-	[[Category: Gamble, M]]	+	[[Category: Jones DD]]
-	[[Category: Jones~~, D D~~]]	+	[[Category: Vedodova J]]
-	[[Category: Vedodova, J]]	+	[[Category: Wilson KS]]
-	[[Category: Wilson~~, K S]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Intracellular proteinase regulation]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 08:37, 10 November 2021

2021-11-10T08:37:07Z

←Older revision		Revision as of 08:37, 10 November 2021
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	<StructureSection load='2x8j' size='340' side='right'caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2x8j' size='340' side='right'caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_700160 Atcc 700160]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_700160 Atcc 700160]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8J FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wv7\|2wv7]], [[2wwt\|2wwt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wv7\|2wv7]], [[2wwt\|2wwt]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [~~http~~://pdbe.org/2x8j PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x8j PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8j ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [https://pdbe.org/2x8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [https://www.ebi.ac.uk/pdbsum/2x8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8j ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Subtilisin\|Subtilisin]]	+	*[[Subtilisin 3D structures\|Subtilisin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:11, 25 December 2019

2019-12-25T14:11:34Z

←Older revision		Revision as of 14:11, 25 December 2019
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	==Intracellular subtilisin precursor from B. clausii==		==Intracellular subtilisin precursor from B. clausii==
-	<StructureSection load='2x8j' size='340' side='right' caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>	+	<StructureSection load='2x8j' size='340' side='right'caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700160 Atcc 700160]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700160 Atcc 700160]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2x8j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2x8j" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Subtilisin\|Subtilisin]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 700160]]		[[Category: Atcc 700160]]
		+	[[Category: Large Structures]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]
	[[Category: Ariza, A]]		[[Category: Ariza, A]]

OCA at 07:01, 28 February 2018

2018-02-28T07:01:01Z

←Older revision		Revision as of 07:01, 28 February 2018
Line 1:		Line 1:

-	==~~INTRACELLULAR SUBTILISIN PRECURSOR FROM~~ B. ~~CLAUSII~~==	+	==Intracellular subtilisin precursor from B. clausii==
	<StructureSection load='2x8j' size='340' side='right' caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2x8j' size='340' side='right' caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8j_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8j_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 2x8j" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2x8j" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Subtilisin\|Subtilisin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:50, 11 August 2016

2016-08-11T08:50:48Z

←Older revision		Revision as of 08:50, 11 August 2016
Line 1:		Line 1:
		+
	==INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII==		==INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII==
	<StructureSection load='2x8j' size='340' side='right' caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>		<StructureSection load='2x8j' size='340' side='right' caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_clausii Bacillus clausii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700160 Atcc 700160]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wv7\|2wv7]], [[2wwt\|2wwt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wv7\|2wv7]], [[2wwt\|2wwt]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [http://www.ebi.ac.uk/pdbsum/2x8j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [http://pdbe.org/2x8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [http://www.ebi.ac.uk/pdbsum/2x8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8j ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8j ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x8j" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus clausii~~]]	+	[[Category: Atcc 700160]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]
	[[Category: Ariza, A]]		[[Category: Ariza, A]]

OCA at 09:46, 20 January 2015

2015-01-20T09:46:49Z

←Older revision		Revision as of 09:46, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_clausii Bacillus clausii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_clausii Bacillus clausii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wv7\|2wv7]], [[2wwt\|2wwt]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wv7\|2wv7]], [[2wwt\|2wwt]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [http://www.ebi.ac.uk/pdbsum/2x8j PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [http://www.ebi.ac.uk/pdbsum/2x8j PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	[[Category: Bacillus clausii]]		[[Category: Bacillus clausii]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]
-	[[Category: Ariza, A.]]	+	[[Category: Ariza, A]]
-	[[Category: Dodson, E.]]	+	[[Category: Dodson, E]]
-	[[Category: Gamble, M.]]	+	[[Category: Gamble, M]]
-	[[Category: Jones, D D.]]	+	[[Category: Jones, D D]]
-	[[Category: Vedodova, J.]]	+	[[Category: Vedodova, J]]
-	[[Category: Wilson, K S.]]	+	[[Category: Wilson, K S]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Intracellular proteinase regulation]]		[[Category: Intracellular proteinase regulation]]
	[[Category: Serine protease]]		[[Category: Serine protease]]

OCA at 01:02, 2 October 2014

2014-10-02T01:02:18Z

←Older revision		Revision as of 01:02, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2x8j.~~png~~\|~~left~~\|200px]]	+	==INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII==
		+	<StructureSection load='2x8j' size='340' side='right' caption='[[2x8j]], [[Resolution\|resolution]] 1.56Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_clausii Bacillus clausii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8J FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wv7\|2wv7]], [[2wwt\|2wwt]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Subtilisin Subtilisin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.62 3.4.21.62] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8j RCSB], [http://www.ebi.ac.uk/pdbsum/2x8j PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8j_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The intracellular subtilisin proteases (ISPs) are the only known members of the important and ubiquitous subtilisin family that function exclusively within the cell, constituting a major component of the degradome in many Gram-positive bacteria. The first ISP structure reported herein at a spacing of 1.56 A reveals features unique among subtilisins that has enabled potential functional and physiological roles to be assigned to sequence elements exclusive to the ISPs. Unlike all other subtilisins, ISP from B. clausii is dimeric, with residues from the C terminus making a major contribution to the dimer interface by crossing over to contact the partner subunit. A short N-terminal extension binds back across the active site to provide a potential novel regulatory mechanism of intrinsic proteolytic activity: a proline residue conserved throughout the ISPs introduces a kink in the polypeptide backbone that lifts the target peptide bond out of reach of the catalytic residues.

-	~~{{STRUCTURE_2x8j\| PDB=2x8j \| SCENE= }}~~	+	Crystal structure of an intracellular subtilisin reveals novel structural features unique to this subtilisin family.,Vevodova J, Gamble M, Kunze G, Ariza A, Dodson E, Jones DD, Wilson KS Structure. 2010 Jun 9;18(6):744-55. PMID:20541512<ref>PMID:20541512</ref>

-	~~===INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20541512}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x8j]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_clausii Bacillus clausii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA].~~	+

	==See Also==		==See Also==
	*[[Subtilisin\|Subtilisin]]		*[[Subtilisin\|Subtilisin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020541512<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus clausii]]		[[Category: Bacillus clausii]]
	[[Category: Subtilisin]]		[[Category: Subtilisin]]

OCA at 10:05, 20 October 2012

2012-10-20T10:05:15Z

←Older revision		Revision as of 10:05, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2x8j]] is a 6 chain structure ~~of [[Subtilisin]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_clausii Bacillus clausii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA].	+	[[2x8j]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_clausii Bacillus clausii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8J OCA].

	==See Also==		==See Also==

OCA at 00:56, 26 July 2012

2012-07-26T00:56:11Z

←Older revision		Revision as of 00:56, 26 July 2012
Line 1:		Line 1:
	[[Image:2x8j.png\|left\|200px]]		[[Image:2x8j.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2x8j", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2x8j\| PDB=2x8j \| SCENE= }}		{{STRUCTURE_2x8j\| PDB=2x8j \| SCENE= }}

	===INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII===		===INTRACELLULAR SUBTILISIN PRECURSOR FROM B. CLAUSII===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20541512}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20541512 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20541512}}		{{ABSTRACT_PUBMED_20541512}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Subtilisin]]	+	*[[Subtilisin\|Subtilisin]]

	==Reference==		==Reference==

OCA: Protected "2x8j" [edit=sysop:move=sysop]

2011-09-21T05:05:25Z

Protected "2x8j" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 21 September 2011