2x8q - Revision history

OCA at 10:22, 9 May 2024

2024-05-09T10:22:09Z

←Older revision		Revision as of 10:22, 9 May 2024
Line 3:		Line 3:
	<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>		<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Rsv~~-~~prc Rsv~~-~~prc~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_Prague_C Rous sarcoma virus - Prague C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1eoq\|1eoq]]~~, [[~~1bai~~\|~~1bai~~]]~~, [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 18.3Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [https://pdbe.org/2x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [https://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [https://pdbe.org/2x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [https://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP]] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).	+	[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rsv~~-~~prc~~]]	+	[[Category: Rous sarcoma virus - Prague C]]
-	[[Category: Hyun, J K]]	+	[[Category: K Hyun J]]
-	[[Category: Kingston~~, R L~~]]	+	[[Category: Kingston RL]]
-	[[Category: Mitra~~, A K~~]]	+	[[Category: Mitra AK]]
-	[[Category: Radjainia, M]]	+	[[Category: Radjainia M]]
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Viral matrix protein]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 10:38, 12 January 2022

2022-01-12T10:38:14Z

←Older revision		Revision as of 10:38, 12 January 2022
Line 3:		Line 3:
	<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>		<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [~~http~~://pdbe.org/2x8q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [https://pdbe.org/2x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [https://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP]] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).	+	[[https://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP]] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:06, 10 April 2020

2020-04-10T17:06:54Z

←Older revision		Revision as of 17:06, 10 April 2020
Line 3:		Line 3:
	<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>		<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://pdbe.org/2x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://pdbe.org/2x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Virus coat ~~protein~~\|Virus coat ~~protein~~]]	+	*[[Virus coat proteins 3D structures\|Virus coat proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:01, 6 March 2020

2020-03-06T17:01:01Z

←Older revision		Revision as of 17:01, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM 3D model of the icosahedral particle composed of Rous sarcoma virus capsid protein pentamers==		==Cryo-EM 3D model of the icosahedral particle composed of Rous sarcoma virus capsid protein pentamers==
-	<~~StructureSection~~ load='2x8q' size='340' side='right' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>	+	<SX load='2x8q' size='340' side='right' viewer='molstar' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
Line 34:		Line 34:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Rsv-prc]]		[[Category: Rsv-prc]]
	[[Category: Hyun, J K]]		[[Category: Hyun, J K]]

OCA at 09:48, 3 October 2018

2018-10-03T09:48:45Z

←Older revision		Revision as of 09:48, 3 October 2018
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:43, 5 August 2016

2016-08-05T07:43:13Z

←Older revision		Revision as of 07:43, 5 August 2016
Line 1:		Line 1:
		+
	==Cryo-EM 3D model of the icosahedral particle composed of Rous sarcoma virus capsid protein pentamers==		==Cryo-EM 3D model of the icosahedral particle composed of Rous sarcoma virus capsid protein pentamers==
	<StructureSection load='2x8q' size='340' side='right' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>		<StructureSection load='2x8q' size='340' side='right' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rous_sarcoma_virus_~~-~~_prague_c Rous sarcoma virus~~ - ~~prague c~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rsv-prc Rsv-prc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://pdbe.org/2x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x8q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2x8q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Rous sarcoma virus~~ - ~~prague c~~]]	+	[[Category: Rsv-prc]]
	[[Category: Hyun, J K]]		[[Category: Hyun, J K]]
	[[Category: Kingston, R L]]		[[Category: Kingston, R L]]

OCA at 00:23, 25 December 2014

2014-12-25T00:23:50Z

←Older revision		Revision as of 00:23, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_prague_c Rous sarcoma virus - prague c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_prague_c Rous sarcoma virus - prague c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GAG_RSVP GAG_RSVP]] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity). The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Rous sarcoma virus - prague c]]		[[Category: Rous sarcoma virus - prague c]]
-	[[Category: Hyun, J K.]]	+	[[Category: Hyun, J K]]
-	[[Category: Kingston, R L.]]	+	[[Category: Kingston, R L]]
-	[[Category: Mitra, A K.]]	+	[[Category: Mitra, A K]]
-	[[Category: Radjainia, M.]]	+	[[Category: Radjainia, M]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]
	[[Category: Viral matrix protein]]		[[Category: Viral matrix protein]]
	[[Category: Virus]]		[[Category: Virus]]

OCA at 01:02, 2 October 2014

2014-10-02T01:02:44Z

←Older revision		Revision as of 01:02, 2 October 2014
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-	[[~~Image:~~2x8q.~~png~~\|~~left~~\|200px]]	+	==Cryo-EM 3D model of the icosahedral particle composed of Rous sarcoma virus capsid protein pentamers==
		+	<StructureSection load='2x8q' size='340' side='right' caption='[[2x8q]], [[Resolution\|resolution]] 18.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rous_sarcoma_virus_-_prague_c Rous sarcoma virus - prague c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X8Q FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1eoq\|1eoq]], [[1bai\|1bai]], [[1em9\|1em9]], [[2rsp\|2rsp]], [[1a6s\|1a6s]], [[1p7n\|1p7n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x8q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x8q RCSB], [http://www.ebi.ac.uk/pdbsum/2x8q PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x8/2x8q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In a mature and infectious retroviral particle, the capsid protein (CA) forms a shell surrounding the genomic RNA and the replicative machinery of the virus. The irregular nature of this capsid shell precludes direct atomic resolution structural analysis. CA hexamers and pentamers are the fundamental building blocks of the capsid, however the pentameric state, in particular, remains poorly characterized. We have developed an efficient in vitro protocol for studying the assembly of Rous sarcoma virus (RSV) CA that involves mild acidification and produces structures modeling the authentic viral capsid. These structures include regular spherical particles with T = 1 icosahedral symmetry, built from CA pentamers alone. These particles were subject to cryoelectron microscopy (cryo-EM) and image processing, and a pseudo-atomic model of the icosahedron was created by docking atomic structures of the constituent CA domains into the cryo-EM-derived three-dimensional density map. The N-terminal domain (NTD) of CA forms pentameric turrets, which decorate the surface of the icosahedron, while the C-terminal domain (CTD) of CA is positioned underneath, linking the pentamers. Biophysical analysis of the icosahedral particle preparation reveals that CA monomers and icosahedra are the only detectable species and that these exist in reversible equilibrium at pH 5. These same acidic conditions are known to promote formation of a RSV CA CTD dimer, present within the icosahedral particle, which facilitates capsid assembly. The results are consistent with a model in which RSV CA assembly is a nucleation-limited process driven by very weak protein-protein interactions.

-	~~{{STRUCTURE_2x8q\| PDB=2x8q \| SCENE= }}~~	+	Proton-driven assembly of the Rous Sarcoma virus capsid protein results in the formation of icosahedral particles.,Hyun JK, Radjainia M, Kingston RL, Mitra AK J Biol Chem. 2010 May 14;285(20):15056-64. Epub 2010 Mar 12. PMID:20228062<ref>PMID:20228062</ref>

-	~~===CRYO-EM 3D MODEL OF THE ICOSAHEDRAL PARTICLE COMPOSED OF ROUS SARCOMA VIRUS CAPSID PROTEIN PENTAMERS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20228062}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2x8q]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Viruses Viruses]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA].~~	+

	==See Also==		==See Also==
	*[[Virus coat protein\|Virus coat protein]]		*[[Virus coat protein\|Virus coat protein]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020228062<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
-	[[Category: ~~Viruses~~]]	+	</StructureSection>
		+	[[Category: Rous sarcoma virus - prague c]]
	[[Category: Hyun, J K.]]		[[Category: Hyun, J K.]]
	[[Category: Kingston, R L.]]		[[Category: Kingston, R L.]]

OCA: Protected "2x8q" [edit=sysop:move=sysop]

2012-10-20T10:38:15Z

Protected "2x8q" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:38, 20 October 2012

OCA at 10:38, 20 October 2012

2012-10-20T10:38:12Z

←Older revision		Revision as of 10:38, 20 October 2012
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-	~~{{Seed}}~~	+	[[Image:2x8q.png\|left\|200px]]
-	[[Image:2x8q.~~jpg~~\|left\|200px]]	+

-	<!--
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	{{STRUCTURE_2x8q\| PDB=2x8q \| SCENE= }}		{{STRUCTURE_2x8q\| PDB=2x8q \| SCENE= }}

	===CRYO-EM 3D MODEL OF THE ICOSAHEDRAL PARTICLE COMPOSED OF ROUS SARCOMA VIRUS CAPSID PROTEIN PENTAMERS===		===CRYO-EM 3D MODEL OF THE ICOSAHEDRAL PARTICLE COMPOSED OF ROUS SARCOMA VIRUS CAPSID PROTEIN PENTAMERS===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20228062}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20228062 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20228062}}		{{ABSTRACT_PUBMED_20228062}}

	==About this Structure==		==About this Structure==
-	~~2X8Q~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA].	+	[[2x8q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X8Q OCA].
		+
		+	==See Also==
		+	*[[Virus coat protein\|Virus coat protein]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20228062~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020228062</ref><references group="xtra"/>
	[[Category: Viruses]]		[[Category: Viruses]]
	[[Category: Hyun, J K.]]		[[Category: Hyun, J K.]]
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	[[Category: Viral matrix protein]]		[[Category: Viral matrix protein]]
	[[Category: Virus]]		[[Category: Virus]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:35:11 2010''