2xad - Revision history

OCA at 10:37, 16 August 2023

2023-08-16T10:37:43Z

←Older revision		Revision as of 10:37, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='2xad' size='340' side='right'caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xad' size='340' side='right'caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes~~ teichomyceticus~~" parenti et al. 1978~~] and [https://en.wikipedia.org/wiki/~~Nonomuraea_sp._atcc_39727~~ Nonomuraea ~~sp. atcc 39727~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinoplanes_teichomyceticus Actinoplanes teichomyceticus] and [https://en.wikipedia.org/wiki/Nonomuraea_gerenzanensis Nonomuraea gerenzanensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAD FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=T55:8-METHYLNONANOIC+ACID'>T55</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene>, <scene name='pdbligand=T55:8-METHYLNONANOIC+ACID'>T55</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[2x9l\|2x9l]], [[2wdx\|2wdx]], [[4k3t\|4k3t]]~~</~~div~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [https://pdbe.org/2xad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [https://www.ebi.ac.uk/pdbsum/2xad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xad ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [https://pdbe.org/2xad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [https://www.ebi.ac.uk/pdbsum/2xad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xad ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6ZZJ1_ACTTI Q6ZZJ1_ACTTI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Actinoplanes teichomyceticus ~~parenti et al. 1978~~]]	+	[[Category: Actinoplanes teichomyceticus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Nonomuraea ~~sp. atcc 39727~~]]	+	[[Category: Nonomuraea gerenzanensis]]
-	[[Category: Chan~~, H C~~]]	+	[[Category: Chan HC]]
-	[[Category: Chou~~, C C~~]]	+	[[Category: Chou CC]]
-	[[Category: Huang~~, C J~~]]	+	[[Category: Huang CJ]]
-	[[Category: Huang~~, Y T~~]]	+	[[Category: Huang YT]]
-	[[Category: Li~~, T L~~]]	+	[[Category: Li TL]]
-	[[Category: Li~~, Y S~~]]	+	[[Category: Li YS]]
-	[[Category: Liu~~, Y C~~]]	+	[[Category: Liu YC]]
-	[[Category: Lyu~~, S Y~~]]	+	[[Category: Lyu SY]]
-	[[Category: Tsai~~, M D]]~~	+	[[Category: Tsai MD]]
-	~~[[Category: A40926]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Glycopeptide]]~~	+
-	~~[[Category: Oxidoreductase-antibiotic complex~~]]	+

OCA at 08:37, 10 November 2021

2021-11-10T08:37:45Z

←Older revision		Revision as of 08:37, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='2xad' size='340' side='right'caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xad' size='340' side='right'caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [~~http~~://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XAD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [https://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=T55:8-METHYLNONANOIC+ACID'>T55</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=T55:8-METHYLNONANOIC+ACID'>T55</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x9l\|2x9l]], [[2wdx\|2wdx]], [[4k3t\|4k3t]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x9l\|2x9l]], [[2wdx\|2wdx]], [[4k3t\|4k3t]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [~~http~~://pdbe.org/2xad PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xad PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xad ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [https://pdbe.org/2xad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [https://www.ebi.ac.uk/pdbsum/2xad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xad ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:22, 24 April 2019

2019-04-24T07:22:55Z

←Older revision		Revision as of 07:22, 24 April 2019
Line 1:		Line 1:

	==Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin==		==Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin==
-	<StructureSection load='2xad' size='340' side='right' caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='2xad' size='340' side='right'caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [http://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [http://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAD FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Actinoplanes teichomyceticus parenti et al. 1978]]		[[Category: Actinoplanes teichomyceticus parenti et al. 1978]]
		+	[[Category: Large Structures]]
	[[Category: Nonomuraea sp. atcc 39727]]		[[Category: Nonomuraea sp. atcc 39727]]
	[[Category: Chan, H C]]		[[Category: Chan, H C]]

OCA at 00:17, 5 August 2016

2016-08-05T00:17:13Z

←Older revision		Revision as of 00:17, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin==		==Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin==
	<StructureSection load='2xad' size='340' side='right' caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2xad' size='340' side='right' caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x9l\|2x9l]], [[2wdx\|2wdx]], [[4k3t\|4k3t]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x9l\|2x9l]], [[2wdx\|2wdx]], [[4k3t\|4k3t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [http://www.ebi.ac.uk/pdbsum/2xad PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [http://pdbe.org/2xad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [http://www.ebi.ac.uk/pdbsum/2xad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xad ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xad" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:43, 21 December 2014

2014-12-21T16:43:53Z

←Older revision		Revision as of 16:43, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2xad\| PDB=2xad \| SCENE= }}~~	+	==Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin==
-	===Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin===	+	<StructureSection load='2xad' size='340' side='right' caption='[[2xad]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21267472}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xad]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [http://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GCS:D-GLUCOSAMINE'>GCS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=T55:8-METHYLNONANOIC+ACID'>T55</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3FG:(2S)-AMINO(3,5-DIHYDROXYPHENYL)ETHANOIC+ACID'>3FG</scene>, <scene name='pdbligand=3MY:3-CHLORO-D-TYROSINE'>3MY</scene>, <scene name='pdbligand=GHP:(2R)-AMINO(4-HYDROXYPHENYL)ETHANOIC+ACID'>GHP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=OMY:(BETAR)-3-CHLORO-BETA-HYDROXY-L-TYROSINE'>OMY</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x9l\|2x9l]], [[2wdx\|2wdx]], [[4k3t\|4k3t]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xad OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xad RCSB], [http://www.ebi.ac.uk/pdbsum/2xad PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lipoglycopeptide antibiotics are more effective than vancomycin against MRSA as they carry an extra aliphatic acyl side chain on glucosamine (Glm) at residue 4 (r4). The biosynthesis of the r4 N-acyl Glc moiety at teicoplanin (Tei) or A40926 has been elucidated, in which the primary amine nucleophile of Glm is freed from the r4 GlcNac pseudo-Tei precursor by Orf2* for the subsequent acylation reaction to occur. In this report, two Orf2* structures in complex with beta-d-octyl glucoside or Tei were solved. Of the complexed structures, the substrate binding site and a previously unknown hydrophobic cavity were revealed, wherein r4 GlcNac acts as the key signature for molecular recognition and the cavity allows substrates carrying longer acyl side chains in addition to the acetyl group. On the basis of the complexed structures, a triple-mutation mutant S98A/V121A/F193Y is able to regioselectively deacetylate r6 GlcNac pseudo-Tei instead of that at r4. Thereby, novel analogs can be made at the r6 sugar moiety.

-	~~==About this Structure==~~	+	Regioselective deacetylation based on teicoplanin-complexed Orf2* crystal structures.,Chan HC, Huang YT, Lyu SY, Huang CJ, Li YS, Liu YC, Chou CC, Tsai MD, Li TL Mol Biosyst. 2011 Jan 25. PMID:21267472<ref>PMID:21267472</ref>
-	~~[[2xad]] is a 8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al~~.~~_1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [http~~:~~//en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021267472</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Actinoplanes teichomyceticus parenti et al. 1978]]		[[Category: Actinoplanes teichomyceticus parenti et al. 1978]]
	[[Category: Nonomuraea sp. atcc 39727]]		[[Category: Nonomuraea sp. atcc 39727]]
-	[[Category: Chan, H C.]]	+	[[Category: Chan, H C]]
-	[[Category: Chou, C C.]]	+	[[Category: Chou, C C]]
-	[[Category: Huang, C J.]]	+	[[Category: Huang, C J]]
-	[[Category: Huang, Y T.]]	+	[[Category: Huang, Y T]]
-	[[Category: Li, T L.]]	+	[[Category: Li, T L]]
-	[[Category: Li, Y S.]]	+	[[Category: Li, Y S]]
-	[[Category: Liu, Y C.]]	+	[[Category: Liu, Y C]]
-	[[Category: Lyu, S Y.]]	+	[[Category: Lyu, S Y]]
-	[[Category: Tsai, M D.]]	+	[[Category: Tsai, M D]]
	[[Category: A40926]]		[[Category: A40926]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
	[[Category: Glycopeptide]]		[[Category: Glycopeptide]]
	[[Category: Oxidoreductase-antibiotic complex]]		[[Category: Oxidoreductase-antibiotic complex]]

OCA at 07:06, 15 January 2014

2014-01-15T07:06:12Z

←Older revision		Revision as of 07:06, 15 January 2014
Line 1:		Line 1:
-	[[Image:2xad.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xad", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xad\| PDB=2xad \| SCENE= }}		{{STRUCTURE_2xad\| PDB=2xad \| SCENE= }}
-		+	===Crystal structure of deacetylase-teicoplanin complex in biosynthesis pathway of teicoplanin===
-	===~~CRYSTAL STRUCTURE OF DEACETYLASE~~-~~TEICOPLANIN COMPLEX IN BIOSYNTHESIS PATHWAY OF TEICOPLANIN~~===	+
-		+
-		+
-	~~<!--~~	+
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21267472}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at http://www.pubmed.gov), where 21267472 is the PubMed ID number.~~	+
-	~~-->~~	+
	{{ABSTRACT_PUBMED_21267472}}		{{ABSTRACT_PUBMED_21267472}}

	==About this Structure==		==About this Structure==
-	[[2xad]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Actinoplanes_teichomyceticus Actinoplanes~~ teichomyceticus] and [http://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA].	+	[[2xad]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinoplanes_teichomyceticus"_parenti_et_al._1978 "actinoplanes teichomyceticus" parenti et al. 1978] and [http://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:021267472</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021267472</ref><references group="xtra"/><references/>
-	[[Category: Actinoplanes teichomyceticus]]	+	[[Category: Actinoplanes teichomyceticus parenti et al. 1978]]
	[[Category: Nonomuraea sp. atcc 39727]]		[[Category: Nonomuraea sp. atcc 39727]]
	[[Category: Chan, H C.]]		[[Category: Chan, H C.]]

OCA at 05:11, 27 July 2011

2011-07-27T05:11:54Z

←Older revision		Revision as of 05:11, 27 July 2011
Line 34:		Line 34:
	[[Category: Lyu, S Y.]]		[[Category: Lyu, S Y.]]
	[[Category: Tsai, M D.]]		[[Category: Tsai, M D.]]
		+	[[Category: A40926]]
		+	[[Category: Antibiotic]]
		+	[[Category: Glycopeptide]]
		+	[[Category: Oxidoreductase-antibiotic complex]]

OCA at 05:56, 25 May 2011

2011-05-25T05:56:07Z

←Older revision		Revision as of 05:56, 25 May 2011
Line 1:		Line 1:
-	[[Image:2xad.~~jpg~~\|left\|200px]]	+	[[Image:2xad.png\|left\|200px]]

	<!--		<!--
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21267472~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021267472</ref><references group="xtra"/>
	[[Category: Actinoplanes teichomyceticus]]		[[Category: Actinoplanes teichomyceticus]]
	[[Category: Nonomuraea sp. atcc 39727]]		[[Category: Nonomuraea sp. atcc 39727]]

OCA at 06:58, 2 March 2011

2011-03-02T06:58:25Z

←Older revision		Revision as of 06:58, 2 March 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:2xad.jpg\|left\|200px]]

-	The ~~entry 2xad~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xad", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xad\| PDB=2xad \| SCENE= }}

-	~~Authors: Chan, H.C., Huang, Y.T., Lyu, S.Y., Huang, C.J., Li, Y.S., Liu, Y.C., Chou, C.C., Tsai, M.D., Li, T.L.~~	+	===CRYSTAL STRUCTURE OF DEACETYLASE-TEICOPLANIN COMPLEX IN BIOSYNTHESIS PATHWAY OF TEICOPLANIN===

-	~~Description~~: ~~Crystal~~ structure ~~of deacetylase~~-~~teicoplanin complex in biosynthesis pathway of teicoplanin~~	+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21267472}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21267472 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21267472}}
		+
		+	==About this Structure==
		+	[[2xad]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinoplanes_teichomyceticus Actinoplanes teichomyceticus] and [http://en.wikipedia.org/wiki/Nonomuraea_sp._atcc_39727 Nonomuraea sp. atcc 39727]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAD OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21267472</ref><references group="xtra"/>
		+	[[Category: Actinoplanes teichomyceticus]]
		+	[[Category: Nonomuraea sp. atcc 39727]]
		+	[[Category: Chan, H C.]]
		+	[[Category: Chou, C C.]]
		+	[[Category: Huang, C J.]]
		+	[[Category: Huang, Y T.]]
		+	[[Category: Li, T L.]]
		+	[[Category: Li, Y S.]]
		+	[[Category: Liu, Y C.]]
		+	[[Category: Lyu, S Y.]]
		+	[[Category: Tsai, M D.]]

OCA: Protected "2xad" [edit=sysop:move=sysop]

2011-02-23T09:28:01Z

Protected "2xad" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:28, 23 February 2011