2xb5 - Revision history

OCA at 10:23, 9 May 2024

2024-05-09T10:23:52Z

←Older revision		Revision as of 10:23, 9 May 2024
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	<StructureSection load='2xb5' size='340' side='right'caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xb5' size='340' side='right'caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2x9d\|2x9d]], [[1bjz\|1bjz]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2trt\|2trt]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [https://pdbe.org/2xb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [https://pdbe.org/2xb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.	+	[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hinrichs, W]]	+	[[Category: Hinrichs W]]
-	[[Category: Kisker, C]]	+	[[Category: Kisker C]]
-	[[Category: Saenger, W]]	+	[[Category: Saenger W]]
-	~~[[Category: Antibiotic resistance]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 08:37, 10 November 2021

2021-11-10T08:37:59Z

←Older revision		Revision as of 08:37, 10 November 2021
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	<StructureSection load='2xb5' size='340' side='right'caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xb5' size='340' side='right'caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2x9d\|2x9d]], [[1bjz\|1bjz]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2trt\|2trt]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2x9d\|2x9d]], [[1bjz\|1bjz]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2trt\|2trt]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [~~http~~://pdbe.org/2xb5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [https://pdbe.org/2xb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.	+	[[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Tetracycline repressor protein\|Tetracycline repressor protein]]	+	*[[Tetracycline repressor protein 3D structures\|Tetracycline repressor protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:23, 10 May 2019

2019-05-10T12:23:29Z

←Older revision		Revision as of 12:23, 10 May 2019
Line 1:		Line 1:

	==Tet repressor (class D) in complex with 7-Iodotetracycline==		==Tet repressor (class D) in complex with 7-Iodotetracycline==
-	<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='2xb5' size='340' side='right'caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Hinrichs, W]]		[[Category: Hinrichs, W]]
	[[Category: Kisker, C]]		[[Category: Kisker, C]]

OCA at 05:38, 8 March 2018

2018-03-08T05:38:23Z

←Older revision		Revision as of 05:38, 8 March 2018
Line 1:		Line 1:

-	==~~TET REPRESSOR~~ (~~CLASS~~ D) ~~IN COMPLEX WITH~~ 7-~~IODOTETRACYCLINE~~==	+	==Tet repressor (class D) in complex with 7-Iodotetracycline==
	<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xb5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xb5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 23:23, 5 August 2016

2016-08-05T23:23:07Z

←Older revision		Revision as of 23:23, 5 August 2016
Line 1:		Line 1:
		+
	==TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE==		==TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE==
	<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2x9d\|2x9d]], [[1bjz\|1bjz]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2trt\|2trt]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2x9d\|2x9d]], [[1bjz\|1bjz]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2trt\|2trt]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [http://pdbe.org/2xb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xb5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xb5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Hinrichs, W]]		[[Category: Hinrichs, W]]
	[[Category: Kisker, C]]		[[Category: Kisker, C]]

OCA at 06:45, 25 December 2014

2014-12-25T06:45:31Z

←Older revision		Revision as of 06:45, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb5 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Hinrichs, W.]]	+	[[Category: Hinrichs, W]]
-	[[Category: Kisker, C.]]	+	[[Category: Kisker, C]]
-	[[Category: Saenger, W.]]	+	[[Category: Saenger, W]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 09:30, 5 November 2014

2014-11-05T09:30:11Z

←Older revision		Revision as of 09:30, 5 November 2014
Line 1:		Line 1:
-	[[~~Image:~~2xb5.~~png~~\|~~left~~\|200px]]	+	==TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE==
		+	<StructureSection load='2xb5' size='340' side='right' caption='[[2xb5]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XB5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=I7T:7-IODOTETRACYCLINE'>I7T</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2x6o\|2x6o]], [[1a6i\|1a6i]], [[2x9d\|2x9d]], [[1bjz\|1bjz]], [[1qpi\|1qpi]], [[2vke\|2vke]], [[2trt\|2trt]], [[2vkv\|2vkv]], [[1ork\|1ork]], [[1bj0\|1bj0]], [[2tct\|2tct]], [[1bjy\|1bjy]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2xb5 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xb5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which is responsible for active efflux of tetracycline. The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with tetracycline-magnesium reveals detailed drug recognition. The orientation of the operator-binding helix-turn-helix motifs of the repressor is inverted in comparison with other DNA binding proteins. The repressor-drug complex is unable to interact with DNA because the separation of the DNA binding motifs is 5 angstroms wider than usually observed.

-	~~{{STRUCTURE_2xb5\| PDB=2xb5 \| SCENE= }}~~	+	Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.,Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W Science. 1994 Apr 15;264(5157):418-20. PMID:8153629<ref>PMID:8153629</ref>

-	~~===TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

-	~~{{ABSTRACT_PUBMED_8153629}}~~	+	==See Also==
-		+	*[[Tetracycline repressor protein\|Tetracycline repressor protein]]
-	==~~About this Structure~~==	+	== References ==
-	[[~~2xb5~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA].	+	<references/>
-		+	__TOC__
-	==~~Reference~~==	+	</StructureSection>
-	<~~ref group="xtra">PMID:008153629<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Hinrichs, W.]]		[[Category: Hinrichs, W.]]

OCA at 13:17, 30 January 2013

2013-01-30T13:17:06Z

←Older revision		Revision as of 13:17, 30 January 2013
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	[[Image:2xb5.png\|left\|200px]]		[[Image:2xb5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xb5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xb5\| PDB=2xb5 \| SCENE= }}		{{STRUCTURE_2xb5\| PDB=2xb5 \| SCENE= }}

	===TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE===		===TET REPRESSOR (CLASS D) IN COMPLEX WITH 7-IODOTETRACYCLINE===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_8153629}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 8153629 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_8153629}}		{{ABSTRACT_PUBMED_8153629}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~8153629</ref><ref group="xtra">PMID:7707374~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:008153629</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Hinrichs, W.]]		[[Category: Hinrichs, W.]]

OCA: Protected "2xb5" [edit=sysop:move=sysop]

2011-03-15T00:35:16Z

Protected "2xb5" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:35, 15 March 2011

OCA at 00:35, 15 March 2011

2011-03-15T00:35:14Z

←Older revision		Revision as of 00:35, 15 March 2011
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-	~~{{Seed}}~~	+	[[Image:2xb5.png\|left\|200px]]
-	[[Image:2xb5.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~2XB5~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA].	+	[[2xb5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XB5 OCA].

	==Reference==		==Reference==
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	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 06:02:54 2010''