2xec - Revision history

OCA at 10:29, 20 December 2023

2023-12-20T10:29:42Z

←Older revision		Revision as of 10:29, 20 December 2023
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	<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Nocfa Nocfa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocardia_farcinica_IFM_10152 Nocardia farcinica IFM 10152]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~, ~~<scene name='pdbligand=TRS:~~2~~-AMINO-~~2~~-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https:~~/~~/en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase]~~, ~~with EC number [https~~:~~//www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=5.~~2.1~~.1 5.2.1.1]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [https://pdbe.org/2xec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [https://www.ebi.ac.uk/pdbsum/2xec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [https://pdbe.org/2xec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [https://www.ebi.ac.uk/pdbsum/2xec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MAIA_NOCFA MAIA_NOCFA] Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. Shows a strict specificity for maleate, with no activity detected toward structurally related substrates including citraconate, mesaconate, dimethylmaleate, and maleamide.<ref>PMID:20677745</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Maleate isomerase]]~~	+	[[Category: Nocardia farcinica IFM 10152]]
-	~~[[Category: Nocfa~~]]	+	[[Category: Baudendistel N]]
-	[[Category: Baudendistel, N]]	+	[[Category: Bruce NC]]
-	[[Category: Bruce~~, N C~~]]	+	[[Category: Fisch F]]
-	[[Category: Fisch, F]]	+	[[Category: Grogan G]]
-	[[Category: Grogan, G]]	+	[[Category: Hart S]]
-	[[Category: Hart, S]]	+	[[Category: Hauer B]]
-	[[Category: Hauer, B]]	+	[[Category: Martinez-Fleites C]]
-	[[Category: Martinez-Fleites, C]]	+	[[Category: Turkenburg JP]]
-	[[Category: Turkenburg~~, J P]]~~	+
-	~~[[Category: Isomerase~~]]	+

OCA at 10:51, 13 April 2022

2022-04-13T10:51:08Z

←Older revision		Revision as of 10:51, 13 April 2022
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	<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [~~http~~://pdbe.org/2xec PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xec PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [https://pdbe.org/2xec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [https://www.ebi.ac.uk/pdbsum/2xec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 15:12, 8 July 2020

2020-07-08T15:12:14Z

←Older revision		Revision as of 15:12, 8 July 2020
Line 1:		Line 1:

	==Nocardia farcinica maleate cis-trans isomerase bound to TRIS==		==Nocardia farcinica maleate cis-trans isomerase bound to TRIS==
-	<StructureSection load='2xec' size='340' side='right' caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='2xec' size='340' side='right'caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://pdbe.org/2xec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://pdbe.org/2xec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Maleate isomerase]]		[[Category: Maleate isomerase]]
	[[Category: Nocfa]]		[[Category: Nocfa]]

OCA at 09:39, 3 October 2018

2018-10-03T09:39:50Z

←Older revision		Revision as of 09:39, 3 October 2018
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xec_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xec_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:00, 11 August 2016

2016-08-11T13:00:18Z

←Older revision		Revision as of 13:00, 11 August 2016
Line 1:		Line 1:
		+
	==Nocardia farcinica maleate cis-trans isomerase bound to TRIS==		==Nocardia farcinica maleate cis-trans isomerase bound to TRIS==
	<StructureSection load='2xec' size='340' side='right' caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2xec' size='340' side='right' caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Nocardia_farcinica Nocardia farcinica~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocfa Nocfa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://pdbe.org/2xec PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xec ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xec ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xec" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Maleate isomerase]]		[[Category: Maleate isomerase]]
-	[[Category: ~~Nocardia farcinica~~]]	+	[[Category: Nocfa]]
	[[Category: Baudendistel, N]]		[[Category: Baudendistel, N]]
	[[Category: Bruce, N C]]		[[Category: Bruce, N C]]

OCA at 13:00, 5 January 2015

2015-01-05T13:00:16Z

←Older revision		Revision as of 13:00, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocardia_farcinica Nocardia farcinica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocardia_farcinica Nocardia farcinica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Maleate isomerase]]		[[Category: Maleate isomerase]]
	[[Category: Nocardia farcinica]]		[[Category: Nocardia farcinica]]
-	[[Category: Baudendistel, N.]]	+	[[Category: Baudendistel, N]]
-	[[Category: Bruce, N C.]]	+	[[Category: Bruce, N C]]
-	[[Category: Fisch, F.]]	+	[[Category: Fisch, F]]
-	[[Category: Grogan, G.]]	+	[[Category: Grogan, G]]
-	[[Category: Hart, S.]]	+	[[Category: Hart, S]]
-	[[Category: Hauer, B.]]	+	[[Category: Hauer, B]]
-	[[Category: Martinez-Fleites, C.]]	+	[[Category: Martinez-Fleites, C]]
-	[[Category: Turkenburg, J P.]]	+	[[Category: Turkenburg, J P]]
	[[Category: Isomerase]]		[[Category: Isomerase]]

OCA at 07:49, 9 July 2014

2014-07-09T07:49:23Z

←Older revision		Revision as of 07:49, 9 July 2014
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-	[[~~Image~~:2xec.~~png\|left~~\|200px]]	+	==Nocardia farcinica maleate cis-trans isomerase bound to TRIS==
		+	<StructureSection load='2xec' size='340' side='right' caption='[[2xec]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocardia_farcinica Nocardia farcinica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XEC FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Maleate_isomerase Maleate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.1 5.2.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xec OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xec RCSB], [http://www.ebi.ac.uk/pdbsum/2xec PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/2xec_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Maleate isomerase (MI), a member of the Asp/Glu racemase superfamily, catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. Mutational studies, in conjunction with the structure of the C194A mutant of Nocardia farcinica MI cocrystallized with maleate, have revealed an unprecedented mode of catalysis for the superfamily in which the isomerization reaction is initiated by nucleophilic attack of cysteine at the double bond, yielding a covalent succinylcysteine-like intermediate.

-	~~{{STRUCTURE_2xec\| PDB=2xec \| SCENE= }}~~	+	A Covalent Succinylcysteine-like Intermediate in the Enzyme-Catalyzed Transformation of Maleate to Fumarate by Maleate Isomerase.,Fisch F, Fleites CM, Delenne M, Baudendistel N, Hauer B, Turkenburg JP, Hart S, Bruce NC, Grogan G J Am Chem Soc. 2010 Aug 2. PMID:20677745<ref>PMID:20677745</ref>

-	~~===Nocardia farcinica maleate cis-trans isomerase bound to TRIS===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20677745}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[2xec]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Nocardia_farcinica Nocardia farcinica]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:020677745<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Maleate isomerase]]		[[Category: Maleate isomerase]]
	[[Category: Nocardia farcinica]]		[[Category: Nocardia farcinica]]

OCA at 06:32, 3 October 2012

2012-10-03T06:32:05Z

←Older revision		Revision as of 06:32, 3 October 2012
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	[[Image:2xec.png\|left\|200px]]		[[Image:2xec.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_2xec\| PDB=2xec \| SCENE= }}		{{STRUCTURE_2xec\| PDB=2xec \| SCENE= }}

-	===~~NOCARDIA FARCINICA MALEATE CIS~~-~~TRANS ISOMERASE BOUND TO~~ TRIS===	+	===Nocardia farcinica maleate cis-trans isomerase bound to TRIS===

-
-	<!--
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	{{ABSTRACT_PUBMED_20677745}}		{{ABSTRACT_PUBMED_20677745}}

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	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20677745~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020677745</ref><references group="xtra"/>
	[[Category: Maleate isomerase]]		[[Category: Maleate isomerase]]
	[[Category: Nocardia farcinica]]		[[Category: Nocardia farcinica]]
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	[[Category: Martinez-Fleites, C.]]		[[Category: Martinez-Fleites, C.]]
	[[Category: Turkenburg, J P.]]		[[Category: Turkenburg, J P.]]
		+	[[Category: Isomerase]]

OCA: Protected "2xec" [edit=sysop:move=sysop]

2011-04-21T10:02:17Z

Protected "2xec" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:02, 21 April 2011

OCA at 10:02, 21 April 2011

2011-04-21T10:02:15Z

←Older revision		Revision as of 10:02, 21 April 2011
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-	~~{{Seed}}~~	+	[[Image:2xec.png\|left\|200px]]
-	[[Image:2xec.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~2XEC~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Nocardia_farcinica Nocardia farcinica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA].	+	[[2xec]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Nocardia_farcinica Nocardia farcinica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XEC OCA].

	==Reference==		==Reference==
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	[[Category: Martinez-Fleites, C.]]		[[Category: Martinez-Fleites, C.]]
	[[Category: Turkenburg, J P.]]		[[Category: Turkenburg, J P.]]
-	[[Category: Isomerase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:37:34 2010''