2xfh - Revision history

OCA at 10:30, 20 December 2023

2023-12-20T10:30:29Z

←Older revision		Revision as of 10:30, 20 December 2023
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	<StructureSection load='2xfh' size='340' side='right'caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xfh' size='340' side='right'caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [https://pdbe.org/2xfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [https://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [https://pdbe.org/2xfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [https://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ERYK_SACEN ERYK_SACEN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gianni, S]]	+	[[Category: Saccharopolyspora erythraea]]
-	[[Category: Montemiglio~~, L C~~]]	+	[[Category: Gianni S]]
-	[[Category: Savino, C]]	+	[[Category: Montemiglio LC]]
-	[[Category: Vallone, B]]	+	[[Category: Savino C]]
-	~~[[Category: Erythromycin a biosynthesis]]~~	+	[[Category: Vallone B]]
-	~~[[Category: Monoxygenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 10:51, 13 April 2022

2022-04-13T10:51:51Z

←Older revision		Revision as of 10:51, 13 April 2022
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	<StructureSection load='2xfh' size='340' side='right'caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xfh' size='340' side='right'caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XFH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XFH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [~~http~~://pdbe.org/2xfh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [https://pdbe.org/2xfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [https://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 15:13, 8 July 2020

2020-07-08T15:13:12Z

←Older revision		Revision as of 15:13, 8 July 2020
Line 1:		Line 1:

	==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==		==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==
-	<StructureSection load='2xfh' size='340' side='right' caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='2xfh' size='340' side='right'caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XFH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XFH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [http://pdbe.org/2xfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [http://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [http://pdbe.org/2xfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [http://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 29:		Line 29:

	==See Also==		==See Also==
-	*[[Cytochrome P450\|Cytochrome P450]]	+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gianni, S]]		[[Category: Gianni, S]]
	[[Category: Montemiglio, L C]]		[[Category: Montemiglio, L C]]

OCA at 09:36, 3 October 2018

2018-10-03T09:36:42Z

←Older revision		Revision as of 09:36, 3 October 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450\|Cytochrome P450]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:46, 5 August 2016

2016-08-05T13:46:39Z

←Older revision		Revision as of 13:46, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==		==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==
	<StructureSection load='2xfh' size='340' side='right' caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2xfh' size='340' side='right' caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [http://www.ebi.ac.uk/pdbsum/2xfh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [http://pdbe.org/2xfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [http://www.ebi.ac.uk/pdbsum/2xfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xfh ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xfh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xfh" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:11, 21 December 2014

2014-12-21T17:11:21Z

←Older revision		Revision as of 17:11, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_2xfh\| PDB=2xfh \| SCENE= }}~~	+	==Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.==
-	===Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.===	+	<StructureSection load='2xfh' size='340' side='right' caption='[[2xfh]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20845962}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XFH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL6:1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE'>CL6</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wio\|2wio]], [[2jjn\|2jjn]], [[2vrv\|2vrv]], [[2jjp\|2jjp]], [[2jjo\|2jjo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xfh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xfh RCSB], [http://www.ebi.ac.uk/pdbsum/2xfh PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/2xfh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	EryK is a bacterial cytochrome P450 that catalyzes the last hydroxylation occurring during the biosynthetic pathway of erythromycin A in Streptomyces erythraeus. We report the crystal structures of EryK in complex with two widely used azole inhibitors: ketoconazole and clotrimazole. Both these ligands use their imidazole moiety to coordinate the heme iron of P450s. Nevertheless, because of the different chemical and structural properties of their N1-substituent group, ketoconazole and clotrimazole trap EryK, respectively, in a closed and in an open conformation that resemble the two structures previously described for the ligand-free EryK. Indeed ligands induce a distortion of the internal helix I that affects the accessibility of the binding pocket by regulating the kink of the external helix G via a network of interactions that involves helix F. The data presented thus constitute an example of how a cytochrome P450 may be selectively trapped in different conformational states by inhibitors.

-	~~==About this Structure==~~	+	Azole drugs trap cytochrome P450 EryK in alternative conformational states.,Montemiglio LC, Gianni S, Vallone B, Savino C Biochemistry. 2010 Sep 16. PMID:20845962<ref>PMID:20845962</ref>
-	~~[[2xfh]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]~~. ~~This structure supersedes the now removed PDB entry [http~~:~~//oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020845962</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Gianni, S.]]	+	== References ==
-	[[Category: Montemiglio, L C.]]	+	<references/>
-	[[Category: Savino, C.]]	+	__TOC__
-	[[Category: Vallone, B.]]	+	</StructureSection>
		+	[[Category: Gianni, S]]
		+	[[Category: Montemiglio, L C]]
		+	[[Category: Savino, C]]
		+	[[Category: Vallone, B]]
	[[Category: Erythromycin a biosynthesis]]		[[Category: Erythromycin a biosynthesis]]
	[[Category: Monoxygenase]]		[[Category: Monoxygenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:04, 5 February 2014

2014-02-05T08:04:38Z

←Older revision		Revision as of 08:04, 5 February 2014
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	{{STRUCTURE_2xfh\| PDB=2xfh \| SCENE= }}		{{STRUCTURE_2xfh\| PDB=2xfh \| SCENE= }}
-	===~~STRUCTURE OF CYTOCHROME~~ P450 ~~ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE~~.===	+	===Structure of cytochrome P450 EryK cocrystallized with inhibitor clotrimazole.===
	{{ABSTRACT_PUBMED_20845962}}		{{ABSTRACT_PUBMED_20845962}}
-
-	==Function==
-	[[http://www.uniprot.org/uniprot/CPXQ_SACEN CPXQ_SACEN]] Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.<ref>PMID:8416893</ref> <ref>PMID:7849045</ref>

	==About this Structure==		==About this Structure==
-	[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharopolyspora_erythraea Saccharopolyspora erythraea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].	+	[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_erythreus"_(sic)_waksman_1923 "actinomyces erythreus" (sic) waksman 1923]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2vrv 2vrv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/>
-	[[Category: Saccharopolyspora erythraea]]
	[[Category: Gianni, S.]]		[[Category: Gianni, S.]]
	[[Category: Montemiglio, L C.]]		[[Category: Montemiglio, L C.]]

OCA at 20:52, 17 April 2013

2013-04-17T20:52:10Z

←Older revision		Revision as of 20:52, 17 April 2013
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-	[[Image:2xfh.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xfh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xfh\| PDB=2xfh \| SCENE= }}		{{STRUCTURE_2xfh\| PDB=2xfh \| SCENE= }}
-
	===STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.===		===STRUCTURE OF CYTOCHROME P450 ERYK COCRYSTALLIZED WITH INHIBITOR CLOTRIMAZOLE.===
		+	{{ABSTRACT_PUBMED_20845962}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CPXQ_SACEN CPXQ_SACEN]] Responsible for the C-12 hydroxylation of the macrolactone ring of erythromycin. Thus, EryK catalyzes the hydroxylation of erythromycin D (ErD) at the C-12 position to produce erythromycin C (ErC). Erythromycin B (ErB) is not a substrate for this enzyme.<ref>PMID:8416893</ref> <ref>PMID:7849045</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20845962}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20845962 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20845962}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020845962</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020845962</ref><references group="xtra"/><references/>
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]
	[[Category: Gianni, S.]]		[[Category: Gianni, S.]]

OCA: Protected "2xfh" [edit=sysop:move=sysop]

2011-06-15T05:27:46Z

Protected "2xfh" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:27, 15 June 2011

OCA at 05:27, 15 June 2011

2011-06-15T05:27:44Z

←Older revision		Revision as of 05:27, 15 June 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:2xfh.png\|left\|200px]]
-	[[Image:2xfh.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~2XFH~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].	+	[[2xfh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharopolyspora_erythraea Saccharopolyspora erythraea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XFH OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20845962~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020845962</ref><references group="xtra"/>
	[[Category: Saccharopolyspora erythraea]]		[[Category: Saccharopolyspora erythraea]]
	[[Category: Gianni, S.]]		[[Category: Gianni, S.]]
Line 32:		Line 31:
	[[Category: Monoxygenase]]		[[Category: Monoxygenase]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:10:21 2010''