2xhx - Revision history

OCA at 10:27, 9 May 2024

2024-05-09T10:27:05Z

←Older revision		Revision as of 10:27, 9 May 2024
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	<StructureSection load='2xhx' size='340' side='right'caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xhx' size='340' side='right'caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHX FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=T5M:2~~-~~TERT-BUTYL-4-(1~~,~~3-DIHYDRO-2H-ISOINDOL-~~2~~-YLCARBONYL)PHENOL'>T5M</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.801Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;'>[[1uy9\|1uy9]]~~, [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [https://pdbe.org/2xhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [https://www.ebi.ac.uk/pdbsum/2xhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [https://pdbe.org/2xhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [https://www.ebi.ac.uk/pdbsum/2xhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Callaghan, O]]	+	[[Category: Callaghan O]]
-	[[Category: Carr~~, M G~~]]	+	[[Category: Carr MG]]
-	[[Category: Chessari, G]]	+	[[Category: Chessari G]]
-	[[Category: Congreve, M]]	+	[[Category: Congreve M]]
-	[[Category: Cowan, S]]	+	[[Category: Cowan S]]
-	[[Category: Coyle~~, J E~~]]	+	[[Category: Coyle JE]]
-	[[Category: Downham, R]]	+	[[Category: Downham R]]
-	[[Category: Figueroa, E]]	+	[[Category: Figueroa E]]
-	[[Category: Frederickson, M]]	+	[[Category: Frederickson M]]
-	[[Category: Graham, B]]	+	[[Category: Graham B]]
-	[[Category: McMenamin, R]]	+	[[Category: McMenamin R]]
-	[[Category: Murray~~, C W~~]]	+	[[Category: Murray CW]]
-	[[Category: OBrien~~, M A~~]]	+	[[Category: OBrien MA]]
-	[[Category: Patel, S]]	+	[[Category: Patel S]]
-	[[Category: Phillips~~, T R~~]]	+	[[Category: Phillips TR]]
-	[[Category: Williams, G]]	+	[[Category: Williams G]]
-	[[Category: Woodhead~~, A J~~]]	+	[[Category: Woodhead AJ]]
-	[[Category: Woolford~~, A J.A]]~~	+	[[Category: Woolford AJA]]
-	~~[[Category: Atp binding domain]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Hsp90]]~~	+
-	~~[[Category: N-terminal domain]]~~	+
-	~~[[Category: Stress response~~]]	+

OCA at 08:40, 10 November 2021

2021-11-10T08:40:27Z

←Older revision		Revision as of 08:40, 10 November 2021
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	==Structure of HSP90 with small molecule inhibitor bound==		==Structure of HSP90 with small molecule inhibitor bound==
-	<StructureSection load='2xhx' size='340' side='right' caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='2xhx' size='340' side='right'caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XHX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [~~http~~://pdbe.org/2xhx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xhx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [https://pdbe.org/2xhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [https://www.ebi.ac.uk/pdbsum/2xhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Heat Shock ~~Proteins~~\|Heat Shock ~~Proteins~~]]	+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Callaghan, O]]		[[Category: Callaghan, O]]
	[[Category: Carr, M G]]		[[Category: Carr, M G]]

OCA at 09:47, 3 October 2018

2018-10-03T09:47:01Z

←Older revision		Revision as of 09:47, 3 October 2018
Line 1:		Line 1:

-	==~~STRUCTURE OF~~ HSP90 ~~WITH SMALL MOLECULE INHIBITOR BOUND~~==	+	==Structure of HSP90 with small molecule inhibitor bound==
	<StructureSection load='2xhx' size='340' side='right' caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xhx' size='340' side='right' caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhx_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhx_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 48:		Line 48:
	[[Category: Frederickson, M]]		[[Category: Frederickson, M]]
	[[Category: Graham, B]]		[[Category: Graham, B]]
-	[[Category: ~~Mcmenamin~~, R]]	+	[[Category: McMenamin, R]]
	[[Category: Murray, C W]]		[[Category: Murray, C W]]
-	[[Category: ~~Obrien~~, M A]]	+	[[Category: OBrien, M A]]
	[[Category: Patel, S]]		[[Category: Patel, S]]
	[[Category: Phillips, T R]]		[[Category: Phillips, T R]]

OCA at 14:03, 5 August 2016

2016-08-05T14:03:21Z

←Older revision		Revision as of 14:03, 5 August 2016
Line 1:		Line 1:
		+
	==STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND==		==STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND==
	<StructureSection load='2xhx' size='340' side='right' caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2xhx' size='340' side='right' caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [http://www.ebi.ac.uk/pdbsum/2xhx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [http://pdbe.org/2xhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [http://www.ebi.ac.uk/pdbsum/2xhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xhx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xhx ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xhx" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Callaghan, O]]		[[Category: Callaghan, O]]
	[[Category: Carr, M G]]		[[Category: Carr, M G]]

OCA at 03:06, 25 December 2014

2014-12-25T03:06:08Z

←Older revision		Revision as of 03:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [http://www.ebi.ac.uk/pdbsum/2xhx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [http://www.ebi.ac.uk/pdbsum/2xhx PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Callaghan, O.]]	+	[[Category: Callaghan, O]]
-	[[Category: Carr, M G.]]	+	[[Category: Carr, M G]]
-	[[Category: Chessari, G.]]	+	[[Category: Chessari, G]]
-	[[Category: Congreve, M.]]	+	[[Category: Congreve, M]]
-	[[Category: Cowan, S.]]	+	[[Category: Cowan, S]]
-	[[Category: Coyle, J E.]]	+	[[Category: Coyle, J E]]
-	[[Category: Downham, R.]]	+	[[Category: Downham, R]]
-	[[Category: Figueroa, E.]]	+	[[Category: Figueroa, E]]
-	[[Category: Frederickson, M.]]	+	[[Category: Frederickson, M]]
-	[[Category: Graham, B.]]	+	[[Category: Graham, B]]
-	[[Category: Mcmenamin, R.]]	+	[[Category: Mcmenamin, R]]
-	[[Category: Murray, C W.]]	+	[[Category: Murray, C W]]
-	[[Category: Obrien, M A.]]	+	[[Category: Obrien, M A]]
-	[[Category: Patel, S.]]	+	[[Category: Patel, S]]
-	[[Category: Phillips, T R.]]	+	[[Category: Phillips, T R]]
-	[[Category: Williams, G.]]	+	[[Category: Williams, G]]
-	[[Category: Woodhead, A J.]]	+	[[Category: Woodhead, A J]]
-	[[Category: Woolford, A J.A.]]	+	[[Category: Woolford, A J.A]]
	[[Category: Atp binding domain]]		[[Category: Atp binding domain]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA at 01:01, 2 October 2014

2014-10-02T01:01:53Z

←Older revision		Revision as of 01:01, 2 October 2014
Line 1:		Line 1:
-	[[~~Image:~~2xhx.~~png~~\|~~left~~\|200px]]	+	==STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND==
		+	<StructureSection load='2xhx' size='340' side='right' caption='[[2xhx]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xhx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XHX FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=T5M:2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL'>T5M</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1uy9\|1uy9]], [[2cdd\|2cdd]], [[1yes\|1yes]], [[1byq\|1byq]], [[2bsm\|2bsm]], [[1osf\|1osf]], [[2wi3\|2wi3]], [[1uy8\|1uy8]], [[2wi4\|2wi4]], [[2bug\|2bug]], [[2uwd\|2uwd]], [[2wi7\|2wi7]], [[2bt0\|2bt0]], [[1yer\|1yer]], [[2xdu\|2xdu]], [[1uyg\|1uyg]], [[2bz5\|2bz5]], [[2ccu\|2ccu]], [[2xds\|2xds]], [[2xdx\|2xdx]], [[2ccs\|2ccs]], [[1yc3\|1yc3]], [[1uyf\|1uyf]], [[1uyi\|1uyi]], [[1uyd\|1uyd]], [[2byi\|2byi]], [[2xdl\|2xdl]], [[2wi2\|2wi2]], [[1uy6\|1uy6]], [[2vci\|2vci]], [[2wi1\|2wi1]], [[2vcj\|2vcj]], [[1yc4\|1yc4]], [[2xdk\|2xdk]], [[2fwz\|2fwz]], [[2c2l\|2c2l]], [[1uyh\|1uyh]], [[1uyk\|1uyk]], [[2cct\|2cct]], [[2fwy\|2fwy]], [[1uyl\|1uyl]], [[1uye\|1uye]], [[2xab\|2xab]], [[2wi6\|2wi6]], [[1yc1\|1yc1]], [[1uyc\|1uyc]], [[1uy7\|1uy7]], [[2xht\|2xht]], [[2xhr\|2xhr]], [[1yet\|1yet]], [[2jjc\|2jjc]], [[2byh\|2byh]], [[2wi5\|2wi5]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90, HSP90A, HSP90AA1, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xhx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xhx RCSB], [http://www.ebi.ac.uk/pdbsum/2xhx PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xh/2xhx_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inhibitors of the chaperone Hsp90 are potentially useful as chemotherapeutic agents in cancer. This paper describes an application of fragment screening to Hsp90 using a combination of NMR and high throughput X-ray crystallography. The screening identified an aminopyrimidine with affinity in the high micromolar range and subsequent structure-based design allowed its optimization into a low nanomolar series with good ligand efficiency. A phenolic chemotype was also identified in fragment screening and was found to bind with affinity close to 1 mM. This fragment was optimized using structure based design into a resorcinol lead which has subnanomolar affinity for Hsp90, excellent cell potency, and good ligand efficiency. This fragment to lead campaign improved affinity for Hsp90 by over 1,000,000-fold with the addition of only six heavy atoms. The companion paper (DOI: 10.1021/jm100060b) describes how the resorcinol lead was optimized into a compound that is now in clinical trials for the treatment of cancer.

-	~~{{STRUCTURE_2xhx\| PDB=2xhx \| SCENE= }}~~	+	Fragment-based drug discovery applied to hsp90. Discovery of two lead series with high ligand efficiency.,Murray CW, Carr MG, Callaghan O, Chessari G, Congreve M, Cowan S, Coyle JE, Downham R, Figueroa E, Frederickson M, Graham B, McMenamin R, O'Brien MA, Patel S, Phillips TR, Williams G, Woodhead AJ, Woolford AJ J Med Chem. 2010 Aug 26;53(16):5942-55. PMID:20718493<ref>PMID:20718493</ref>

-	~~===STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20718493}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xhx]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA].~~	+

	==See Also==		==See Also==
	*[[Heat Shock Proteins\|Heat Shock Proteins]]		*[[Heat Shock Proteins\|Heat Shock Proteins]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020718493<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Callaghan, O.]]		[[Category: Callaghan, O.]]

OCA at 11:56, 20 October 2012

2012-10-20T11:56:37Z

←Older revision		Revision as of 11:56, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[2xhx]] is a 1 chain structure ~~of [[Heat Shock Proteins]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA].	+	[[2xhx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA].

	==See Also==		==See Also==

OCA at 07:06, 26 July 2012

2012-07-26T07:06:11Z

←Older revision		Revision as of 07:06, 26 July 2012
Line 1:		Line 1:
	[[Image:2xhx.png\|left\|200px]]		[[Image:2xhx.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_2xhx", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_2xhx\| PDB=2xhx \| SCENE= }}		{{STRUCTURE_2xhx\| PDB=2xhx \| SCENE= }}

	===STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND===		===STRUCTURE OF HSP90 WITH SMALL MOLECULE INHIBITOR BOUND===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20718493}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20718493 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20718493}}		{{ABSTRACT_PUBMED_20718493}}

Line 22:		Line 11:

	==See Also==		==See Also==
-	*[[Heat Shock Proteins]]	+	*[[Heat Shock Proteins\|Heat Shock Proteins]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20718493~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020718493</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Callaghan, O.]]		[[Category: Callaghan, O.]]

OCA: Protected "2xhx" [edit=sysop:move=sysop]

2010-12-26T09:21:13Z

Protected "2xhx" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:21, 26 December 2010

OCA at 09:21, 26 December 2010

2010-12-26T09:21:11Z

←Older revision		Revision as of 09:21, 26 December 2010
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-	~~{{Seed}}~~	+	[[Image:2xhx.png\|left\|200px]]
-	[[Image:2xhx.~~jpg~~\|left\|200px]]	+

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	==About this Structure==		==About this Structure==
-	~~2XHX~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA].	+	[[2xhx]] is a 1 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XHX OCA].
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		+	==See Also==
		+	*[[Heat Shock Proteins]]

	==Reference==		==Reference==
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	[[Category: N-terminal domain]]		[[Category: N-terminal domain]]
	[[Category: Stress response]]		[[Category: Stress response]]
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-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:46:05 2010''