2xkn - Revision history

OCA at 10:33, 20 December 2023

2023-12-20T10:33:27Z

←Older revision		Revision as of 10:33, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [https://pdbe.org/2xkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [https://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [https://pdbe.org/2xkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [https://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>
	</table>		</table>
Line 25:		Line 26:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Friemann, R]]	+	[[Category: Friemann R]]
-	[[Category: Krengel, U]]	+	[[Category: Krengel U]]
-	[[Category: Mackenzie, J]]	+	[[Category: Mackenzie J]]
-	[[Category: Talavera, A]]	+	[[Category: Talavera A]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 10:54, 13 April 2022

2022-04-13T10:54:58Z

←Older revision		Revision as of 10:54, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='2xkn' size='340' side='right'caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2xkn' size='340' side='right'caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2XKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XKN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [~~http~~://pdbe.org/2xkn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [https://pdbe.org/2xkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [https://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:17, 8 July 2020

2020-07-08T15:17:19Z

←Older revision		Revision as of 15:17, 8 July 2020
Line 1:		Line 1:

	==Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7==		==Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7==
-	<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='2xkn' size='340' side='right'caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2XKN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2XKN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://pdbe.org/2xkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://pdbe.org/2xkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Friemann, R]]		[[Category: Friemann, R]]

OCA at 09:09, 3 October 2018

2018-10-03T09:09:51Z

←Older revision		Revision as of 09:09, 3 October 2018
Line 1:		Line 1:

-	==~~CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI~~-EGFR ~~ANTIBODY~~ 7A7==	+	==Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7==
	<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:25, 5 August 2016

2016-08-05T14:25:12Z

←Older revision		Revision as of 14:25, 5 August 2016
Line 1:		Line 1:
		+
	==CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI-EGFR ANTIBODY 7A7==		==CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI-EGFR ANTIBODY 7A7==
	<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://pdbe.org/2xkn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xkn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 2xkn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Monoclonal Antibody~~\|~~Monoclonal Antibody~~]]	+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:38, 3 January 2015

2015-01-03T22:38:09Z

←Older revision		Revision as of 22:38, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. <br>	+	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XKN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene~~><br>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum]</span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site.,Talavera A, Mackenzie J, Garrido G, Friemann R, Lopez-Requena A, Moreno E, Krengel U Mol Immunol. 2011 Jul;48(12-13):1578-85. Epub 2011 May 18. PMID:21592580<ref>PMID:21592580</ref>		Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site.,Talavera A, Mackenzie J, Garrido G, Friemann R, Lopez-Requena A, Moreno E, Krengel U Mol Immunol. 2011 Jul;48(12-13):1578-85. Epub 2011 May 18. PMID:21592580<ref>PMID:21592580</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Friemann, R.]]	+	[[Category: Friemann, R]]
-	[[Category: Krengel, U.]]	+	[[Category: Krengel, U]]
-	[[Category: Mackenzie, J.]]	+	[[Category: Mackenzie, J]]
-	[[Category: Talavera, A.]]	+	[[Category: Talavera, A]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Immunoglobulin]]		[[Category: Immunoglobulin]]

OCA at 07:43, 14 May 2014

2014-05-14T07:43:02Z

←Older revision		Revision as of 07:43, 14 May 2014
Line 1:		Line 1:
-	[[~~Image:~~2xkn.~~png~~\|~~left\|200px~~]]	+	==CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI-EGFR ANTIBODY 7A7==
		+	<StructureSection load='2xkn' size='340' side='right' caption='[[2xkn]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkn RCSB], [http://www.ebi.ac.uk/pdbsum/2xkn PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The EGF receptor is an important target of cancer immunotherapies. The 7A7 monoclonal antibody has been raised against the murine EGFR, but it cross-reacts with the human receptor. The results from experiments using immune-competent mice can therefore, in principle, be extrapolated to the corresponding scenario in humans. In this work we report the crystal structure of the 7A7 Fab at an effective resolution of 1.4A. The antibody binding site comprises a deep pocket, located at the interface between the light and heavy chains, with major contributions from CDR loops H1, H2, H3 and L1. Binding experiments show that 7A7 recognizes a site on the EGFR extracellular domain that is not accessible in its most stable conformations, but that becomes exposed upon treatment with a tyrosine kinase inhibitor. This suggests a recognition mechanism similar to that proposed for mAb 806.

-	<!--	+	Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site.,Talavera A, Mackenzie J, Garrido G, Friemann R, Lopez-Requena A, Moreno E, Krengel U Mol Immunol. 2011 Jul;48(12-13):1578-85. Epub 2011 May 18. PMID:21592580<ref>PMID:21592580</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_2xkn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_2xkn\| PDB=2xkn \| SCENE= }}~~	+

-	~~===CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI-EGFR ANTIBODY 7A7===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_21592580}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21592580 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21592580}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[2xkn]] is a 4 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021592580<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Friemann, R.]]		[[Category: Friemann, R.]]

OCA at 05:56, 31 August 2011

2011-08-31T05:56:34Z

←Older revision		Revision as of 05:56, 31 August 2011
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-	[[Image:2xkn.~~jpg~~\|left\|200px]]	+	[[Image:2xkn.png\|left\|200px]]

	<!--		<!--

OCA: Protected "2xkn" [edit=sysop:move=sysop]

2011-06-15T06:15:55Z

Protected "2xkn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:15, 15 June 2011

OCA at 06:15, 15 June 2011

2011-06-15T06:15:48Z

←Older revision		Revision as of 06:15, 15 June 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:2xkn.jpg\|left\|200px]]

-	The ~~entry 2xkn~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_2xkn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_2xkn\| PDB=2xkn \| SCENE= }}

-	~~Authors: Talavera, A., Mackenzie, J., Friemann, R., Garrido, G., Lopez~~-~~Requena, A., Moreno, E., Krengel, U.~~	+	===CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE ANTI-EGFR ANTIBODY 7A7===

-	Description: Crystal structure of the Fab fragment of the anti-EGFR antibody 7A7

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Wed Jul 28 12~~:19:~~06 2010''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21592580}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21592580 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21592580}}
		+
		+	==About this Structure==
		+	[[2xkn]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021592580</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Friemann, R.]]
		+	[[Category: Krengel, U.]]
		+	[[Category: Mackenzie, J.]]
		+	[[Category: Talavera, A.]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin]]